DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pi3K59F and PIK3CB

DIOPT Version :9

Sequence 1:	NP_477133.1	Gene:	Pi3K59F / 37733	FlyBaseID:	FBgn0015277	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	NP_006210.1	Gene:	PIK3CB / 5291	HGNCID:	8976	Length:	1070	Species:	Homo sapiens

Alignment Length:	947	Identity:	232/947 - (24%)
Similarity:	370/947 - (39%)	Gaps:	295/947 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 ILRFSGLYSEEHPSFQVRLQVFNQGRPYCLPVTSSYKAFGKRWSWNEWVTLPLQFSDLPRSAML- 107
            :::.:.|.:||.....||..:|:.....|..:.||..:......|||.:...:...||||.|.|
Human   337 LVKGNKLNTEETVKVHVRAGLFHGTELLCKTIVSSEVSGKNDHIWNEPLEFDINICDLPRMARLC 401

  Fly   108 --VLTILDCSGAGQTTVIGGTSISMFGKDGMFRQGMYDLRVWLGVEGDGNFPSRTPGKGKESSK- 169
              |..:||                               :|                |.|:|:|
Human   402 FAVYAVLD-------------------------------KV----------------KTKKSTKT 419

  Fly   170 ---SQMQRLGKLAKKHRNGQVQKVDWLDRLTF------REIEVINEREKRMSDYMFLMIEFPAIV 225
               |:.|.:.|..|.|     ..|.|::.:.|      |..::|........|.:
Human   420 INPSKYQTIRKAGKVH-----YPVAWVNTMVFDFKGQLRTGDIILHSWSSFPDEL---------- 469

  Fly   226 VDDMYNYAVVYFEPEGDVK---YKLPAKPKLVSVPDSEIQ------MENLVERKHHRLARSERSG 281
             ::|.|       |.|.|:   |...|....|..|:::.|      .:.::| |...:|.|:.:.
Human   470 -EEMLN-------PMGTVQTNPYTENATALHVKFPENKKQPYYYPPFDKIIE-KAAEIASSDSAN 525

  Fly   282 ISDRDAKPTASIRDQLHTIVYRYPPTYVLSSEEQDLVWKFR------FYLSSHKKALTKFLKCIN 340
            :|.|..|....:   |..|:.| .|...|...|.||:|..|      |     .::|.|.|..|.
Human   526 VSSRGGKKFLPV---LKEILDR-DPLSQLCENEMDLIWTLRQDCREIF-----PQSLPKLLLSIK 581

  Fly   341 W-KLEDEVTQALWMLANWAPMDVEDALELLSPTFTHPQVRKYAVSRLAQAPDEDLLLYLLQLVQA 404
            | |||| |.|...:|..|..:...:|||||...:....||:|||..|.|..||:|..|||||||.
Human   582 WNKLED-VAQLQALLQIWPKLPPREALELLDFNYPDQYVREYAVGCLRQMSDEELSQYLLQLVQV 645

  Fly   405 LKYEDPRHIVHLHGCIFPERDVVRSILDDNGSLLDQSSLSDLSATSSGLHGSVIPANQRAASVLA 469
            ||||                           ..||
Human   646 LKYE---------------------------PFLD------------------------------ 653

  Fly   470 AIKSDKSVSPGSAGGSGSGGQGSVALPNPSAPATPGSSSLPCDSNSNALMLAEGISFGSVPANLC 534
                                                                         ..|.
Human   654 -------------------------------------------------------------CALS 657

  Fly   535 TFLIQRACTNATLANYFYWYLSIEVEEVESVRKQDERAHDMYAMVLKMF-------LKVLENGNF 592
            .||::||..|..:..:.:|:|..|| .:.:|..|       :.::|:.:       :|||.....
Human   658 RFLLERALGNRRIGQFLFWHLRSEV-HIPAVSVQ-------FGVILEAYCRGSVGHMKVLSKQVE 714

  Fly   593 NLRGIFYNLRKQRRFIDELVKL--VKLVAKEPGNRNKKTEKFQKLLAEQDMFKVNFTNFEPIPFP 655
            .|..:        :.::.|:||  |||      ||.|..|.....| :|..::...::.:.   |
Human   715 ALNKL--------KTLNSLIKLNAVKL------NRAKGKEAMHTCL-KQSAYREALSDLQS---P 761

  Fly   656 LDPEIYITKIVPMRTSLFKSALMPAKLTFVTSI-AHHEYAAIFKHGDDLRQDQLILQMITLMDKL 719
            |:|.:.::::...:.....|.:.|..|.:...: .......|||:|||||||.|.|||:.|||.|
Human   762 LNPCVILSELYVEKCKYMDSKMKPLWLVYNNKVFGEDSVGVIFKNGDDLRQDMLTLQMLRLMDLL 826

  Fly   720 LRRENLDLKLTPYKVLATSSKHGFLQYVD-SCTVAEVLAREGNIH-----------NFFRKHHPC 772
            .:...|||::.||..|||..:.|.::.|. |.|:|::.....|:.           |:.::::..
Human   827 WKEAGLDLRMLPYGCLATGDRSGLIEVVSTSETIADIQLNSSNVAAAAAFNKDALLNWLKEYNSG 891

  Fly   773 DNGPYGISAEVMDTYIKSCAGYCVITYLLGVGDRHLDNLLLTTNGKLFHIDFGYILGR-----DP 832
            |:     ....::.:..|||||||.:|:||:||||.||:::...|:|||||||:|||.     ..
Human   892 DD-----LDRAIEEFTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGI 951

  Fly   833 KPMPPPMKLSKEMVEAM-----GGISSEHHHEFRKQCYTAYLHLRRHANVMLNLFSLMVDATVPD 892
            |....|..|:.:.:..:     |  ::|....||:.|..|||.||||.|:.:.||:||:.|.:|:
Human   952 KRERVPFILTYDFIHVIQQGKTG--NTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPE 1014

  Fly   893 IALEPDKAVKKVEENLQLGLTDEEAVQHLQSLLDVSI 929
            :....|  ::.::::|.||.::|||::..:...|.::
Human  1015 LTSVKD--IQYLKDSLALGKSEEEALKQFKQKFDEAL 1049

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K59F	NP_477133.1	C2_PI3K_class_III	27..186	CDD:176042	31/148 (21%)
		PI3Ka_III	284..561	CDD:238442	64/283 (23%)
		PI3Kc_III	601..945	CDD:270628	109/354 (31%)
PIK3CB	NP_006210.1	PI3K_p85B	41..118	CDD:197539
		PI3K_rbd	180..288	CDD:197540
		C2_PI3K_class_I_beta_delta	324..501	CDD:176075	46/233 (20%)
		Nuclear localization signal	410..418		4/23 (17%)
		PI3Ka_I	532..702	CDD:238444	66/305 (22%)
		PI3Kc_IA_beta	706..1067	CDD:270717	113/371 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D204282at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920