DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pi3K59F and PIK3C3

DIOPT Version :9

Sequence 1:	NP_477133.1	Gene:	Pi3K59F / 37733	FlyBaseID:	FBgn0015277	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	NP_002638.2	Gene:	PIK3C3 / 5289	HGNCID:	8974	Length:	887	Species:	Homo sapiens

Alignment Length:	951	Identity:	523/951 - (54%)
Similarity:	670/951 - (70%)	Gaps:	75/951 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 DHFRYIHSSSLHERVQIKVGTLEGKKRQPDYEKLLEDPILRFSGLYSEEHPSFQVRLQVFNQGRP 70
            :.|.||:|..|...||:|:|:||||:.|..|:.:||||:|:|||||.|......|..|||.:|:|
Human     5 EKFHYIYSCDLDINVQLKIGSLEGKREQKSYKAVLEDPMLKFSGLYQETCSDLYVTCQVFAEGKP 69

  Fly    71 YCLPVTSSYKAFGKRWSWNEWVTLPLQFSDLPRSAMLVLTILDCSGAGQTTVIGGTSISMFGKDG 135
            ..|||.:|||||..||:||||:.||:::.||||:|.:.|||.|..|.|:...:|||::|:|||.|
Human    70 LALPVRTSYKAFSTRWNWNEWLKLPVKYPDLPRNAQVALTIWDVYGPGKAVPVGGTTVSLFGKYG 134

  Fly   136 MFRQGMYDLRVWLGVEGDGNFPSRTPGKGKES-SKSQMQRLGKLAKKHRNGQVQKVDWLDRLTFR 199
            ||||||:||:||..||.||:.|::|||:...: |:.||.||.||.|.||.|.:.|||||||||||
Human   135 MFRQGMHDLKVWPNVEADGSEPTKTPGRTSSTLSEDQMSRLAKLTKAHRQGHMVKVDWLDRLTFR 199

  Fly   200 EIEVINEREKRMSDYMFLMIEFPAIVVDDMYNYAVVYFEPEGDVKYKLPAKPKLVSVPDSEIQME 264
            |||:|||.|||.|::|:||:||..:..||. .|.:||:|.:||....:....:||.|||.::.||
Human   200 EIEMINESEKRSSNFMYLMVEFRCVKCDDK-EYGIVYYEKDGDESSPILTSFELVKVPDPQMSME 263

  Fly   265 NLVERKHHRLARSERSGISDRDAKPTASIRDQLHTIVYRYPPTYVLSSEEQDLVWKFRFYLSSHK 329
            ||||.|||:||||.|||.||.|.||.|:.||||:.|| .||||..|:.||||||||||:||::.:
Human   264 NLVESKHHKLARSLRSGPSDHDLKPNAATRDQLNIIV-SYPPTKQLTYEEQDLVWKFRYYLTNQE 327

  Fly   330 KALTKFLKCINWKLEDEVTQALWMLANWAPMDVEDALELLSPTFTHPQVRKYAVSRLAQAPDEDL 394
            |||||||||:||.|..|..|||.:|..|.||||||:|||||..:|:|.||:|||:||.||.||||
Human   328 KALTKFLKCVNWDLPQEAKQALELLGKWKPMDVEDSLELLSSHYTNPTVRRYAVARLRQADDEDL 392

  Fly   395 LLYLLQLVQALKYEDPRHIVHLHGCIFPERDVVRSILDDNGSLLD------QSSLSDLSATSSGL 453
            |:||||||||||||:                     .||..:.|:      |||:|: :.::||:
Human   393 LMYLLQLVQALKYEN---------------------FDDIKNGLEPTKKDSQSSVSE-NVSNSGI 435

  Fly   454 HGSVIPANQRAASVLAAIKSDKSVSPGSAGGSGSGGQGSVALPNPSAPATPGSSSLPCDSNSNAL 518
            :.:.|.::|...|                           .||:.|:| .|.|.:.......|
Human   436 NSAEIDSSQIITS---------------------------PLPSVSSP-PPASKTKEVPDGEN-- 470

  Fly   519 MLAEGISFGSVPANLCTFLIQRACTNATLANYFYWYLSIEVEEVESVRKQDERAHDMYAMVLKMF 583
                      :..:||||||.|||.|:|||||.|||:.:|.|: :..:::|.:.|:||..|::.|
Human   471 ----------LEQDLCTFLISRACKNSTLANYLYWYVIVECED-QDTQQRDPKTHEMYLNVMRRF 524

  Fly   584 LKVLENGNFNLRGIFYNLRKQRRFIDELVKLVKLVAKEPGNRNKKTEKFQKLLAEQDMFKVNFTN 648
            .:.|..|:.::|.:...|..|:.|:|.||.|:|.|.:|.|||.||.|:.|.||.:.:  |:|.::
Human   525 SQALLKGDKSVRVMRSLLAAQQTFVDRLVHLMKAVQRESGNRKKKNERLQALLGDNE--KMNLSD 587

  Fly   649 FEPIPFPLDPEIYITKIVPMRTSLFKSALMPAKLTFVTSIAHHEYAAIFKHGDDLRQDQLILQMI 713
            .|.||.||:|::.|..|:|...:|||||||||:|.|.|... .:|..||||||||||||||||:|
Human   588 VELIPLPLEPQVKIRGIIPETATLFKSALMPAQLFFKTEDG-GKYPVIFKHGDDLRQDQLILQII 651

  Fly   714 TLMDKLLRRENLDLKLTPYKVLATSSKHGFLQYVDSCTVAEVLAREGNIHNFFRKHHPCDNGPYG 778
            :|||||||:||||||||||||||||:||||:|::.|..|||||..||:|.|||||:.|.:|||.|
Human   652 SLMDKLLRKENLDLKLTPYKVLATSTKHGFMQFIQSVPVAEVLDTEGSIQNFFRKYAPSENGPNG 716

  Fly   779 ISAEVMDTYIKSCAGYCVITYLLGVGDRHLDNLLLTTNGKLFHIDFGYILGRDPKPMPPPMKLSK 843
            |||||||||:|||||||||||:||||||||||||||..||||||||||||||||||:||||||:|
Human   717 ISAEVMDTYVKSCAGYCVITYILGVGDRHLDNLLLTKTGKLFHIDFGYILGRDPKPLPPPMKLNK 781

  Fly   844 EMVEAMGGISSEHHHEFRKQCYTAYLHLRRHANVMLNLFSLMVDATVPDIALEPDKAVKKVEENL 908
            ||||.|||..||.:.|||||||||:|||||::|::||||||||||.:|||||||||.||||::..
Human   782 EMVEGMGGTQSEQYQEFRKQCYTAFLHLRRYSNLILNLFSLMVDANIPDIALEPDKTVKKVQDKF 846

  Fly   909 QLGLTDEEAVQHLQSLLDVSITAVMPALVEQIHRFTQYWRK 949
            :|.|:|||||.::|||:|.|:.|:..|:|||||:|.|||||
Human   847 RLDLSDEEAVHYMQSLIDESVHALFAAVVEQIHKFAQYWRK 887

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K59F	NP_477133.1	C2_PI3K_class_III	27..186	CDD:176042	86/159 (54%)
		PI3Ka_III	284..561	CDD:238442	123/282 (44%)
		PI3Kc_III	601..945	CDD:270628	233/343 (68%)
PIK3C3	NP_002638.2	C2_PI3K_class_III	26..186	CDD:176042	86/159 (54%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	149..170		9/20 (45%)
		PI3Ka_III	283..503	CDD:238442	123/282 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	447..467		7/47 (15%)
		PI3Kc_III	539..883	CDD:270628	233/346 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159501
Domainoid	1	1.000	234	1.000	Domainoid score	I2398
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1986
Inparanoid	1	1.050	1007	1.000	Inparanoid score	I291
Isobase	1	0.950	-	0	Normalized mean entropy	S1375
OMA	1	1.010	-	-		QHG54334
OrthoDB	1	1.010	-	-		D204282at2759
OrthoFinder	1	1.000	-	-		FOG0005021
OrthoInspector	1	1.000	-	-		oto91755
orthoMCL	1	0.900	-	-		OOG6_101850
Panther	1	1.100	-	-	LDO	PTHR10048
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1651
SonicParanoid	1	1.000	-	-		X3549
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750