Protein Alignment Pi3K59F and PIK3C2G

DIOPT Version :10

• Sequence 1: NP_477133.1
• Gene: Pi3K59F / 37733
• FlyBaseID: FBgn0015277
• Length: 949
• Species: Drosophila melanogaster
• Sequence 2: XP_016874960.1
• Gene: PIK3C2G / 5288
• HGNCID: 8973
• Length: 1492
• Species: Homo sapiens
• Alignment Length: 960
• Identity: 213/960 - (22%)
• Similarity: 344/960 - (35%)
• Gaps: 338/960 - (35%)

  Fly    66 NQGRPYCLPVT------------SSYKAF---------GKRW-------------------SWNE 90
            |.|.|..|..|            .|||||         ||:.                   :|||
Human   518 NPGLPSHLSFTVYAAHNIPETWVHSYKAFSFTCWLTYAGKKLCQVRNYRNIPDKKLFFFLVNWNE 582

  Fly    91 WVTLPLQFSDLPRSAMLVLTILDCSGA-GQTTVIGGTSISMFGKDGMFRQGMYDLRVWLGVEGDG 154
            .:..||:...|||.:||.:.:...:.| ....::..|.:.:|.|:   :..:..:...:.::.:.
Human   583 TINFPLEIKSLPRESMLTVKLFGIACATNNANLLAWTCLPLFPKE---KSILGSMLFSMTLQSEP 644

  Fly   155 NFPSRTPGKGKESSKSQMQRLGKLAKKHRNGQVQKVDWLDRLTFREIEVINEREKRMSDYMFLMI 219
            .....|||....|..|.:.                                           |.|
Human   645 PVEMITPGVWDVSQPSPVT-------------------------------------------LQI 666

  Fly   220 EFPAIVVDDMYNYAVVYFEPEGDVKYKLPAKPKLVSVPDSEIQMENLVER-----KHHRLARSER 279
            :|||...:.|                          .||||....||.|.     ||  :||..:
Human   667 DFPATGWEYM--------------------------KPDSEENRSNLEEPLKECIKH--IARLSQ 703

  Fly   280 SGISDRDAKPTASIRDQLHTIVYRYPPTYVLSSEEQDLVWKFRFYLSSHKKALTKFL-KCINWKL 343
                    |.|                ..:||.|::..:|.:|||.::...:|...| ....|.
Human   704 --------KQT----------------PLLLSEEKKRYLWFYRFYCNNENCSLPLVLGSAPGWD- 743

  Fly   344 EDEVTQALWMLANWAPMDVEDALELLSPTFTHPQVRKYAVSRLAQAPDEDLLLYLLQLVQALKYE 408
            |..|::...:|..|......:||.||:.:|...::||.||.:|....:::||.||.|||||:|:|
Human   744 ERTVSEMHTILRRWTFSQPLEALGLLTSSFPDQEIRKVAVQQLDNLLNDELLEYLPQLVQAVKFE 808

  Fly   409 DPRHIVHLHGCIFPERDVVRSILDDNGSLLDQSSLSDLSATSSGLHGSVIPANQRAASVLAAIKS 473
                                                                             
Human   809 ----------------------------------------------------------------- 808

  Fly   474 DKSVSPGSAGGSGSGGQGSVALPNPSAPATPGSSSLPCDSNSNALMLAEGISFGSVPANLCTFLI 538
                                                                 .::.:.|...|:
Human   809 -----------------------------------------------------WNLESPLVQLLL 820

  Fly   539 QRACTNATLANYFYWYLSIEVEEVESVRKQDERAHDMYAMVLKMFLKVLE-------NGNFNLRG 596
            .|:..:..:|:..||.|          :..:..|:  :....:..|..|:       |..|:
Human   821 HRSLQSIQVAHRLYWLL----------KNAENEAY--FKSWYQKLLAALQFCAGKALNDEFS--- 870

  Fly   597 IFYNLRKQRRFIDELVKLVKLVAKEPGNRNKKTEKFQKLLAEQDMFKVN-------FTNFEPIPF 654
                  |::       ||:|::. :.|.|.|.....|:    |::.|..       |.:......
Human   871 ------KEQ-------KLIKILG-DIGERVKSASDHQR----QEVLKKEIGRLEEFFQDVNTCHL 917

  Fly   655 PLDPEIYITKIVPMRTSLFKSALMPAKLTFV-TSIAHHEYAAIFKHGDDLRQDQLILQMITLMDK 718
            ||:|.:.|..|.....|.|.|..:|.|:||: .:......:.|||.|||||||.|:||:|.:||.
Human   918 PLNPALCIKGIDHDACSYFTSNALPLKITFINANPMGKNISIIFKAGDDLRQDMLVLQLIQVMDN 982

  Fly   719 LLRRENLDLKLTPYKVLATSSKHGFLQYV-DSCTVAEV--------LAREGNIHNFFRKHHPCDN 774
            :..:|.||:::..|:.|:|....|.:|.| |:.|:|::        ..:|..|..:|.:|:.. .
Human   983 IWLQEGLDMQMIIYRCLSTGKDQGLVQMVPDAVTLAKIHRHSGLIGPLKENTIKKWFSQHNHL-K 1046

  Fly   775 GPYGISAEVMDTYIKSCAGYCVITYLLGVGDRHLDNLLLTTNGKLFHIDFGYILG---------R 830
            ..|   .:.:..:..||||:||:|::|||.|||.||::||.:|.:||||||..||         |
Human  1047 ADY---EKALRNFFYSCAGWCVVTFILGVCDRHNDNIMLTKSGHMFHIDFGKFLGHAQTFGGIKR 1108

  Fly   831 DPKPMPPPMKLSKEMVEAMGGISSEHHHEFRKQCYTAYLHLRRHANVMLNLFSLMVDATVPDIAL 895
            |..|.....::...:.|  ||.:.:|..:|.:.|..||..:|:|:.::|||..:|:.|.:|:::.
Human  1109 DRAPFIFTSEMEYFITE--GGKNPQHFQDFVELCCRAYNIIRKHSQLLLNLLEMMLYAGLPELSG 1171

  Fly   896 EPDKAVKKVEENLQLGLTDEEAVQHLQSLLDVSITAVMPALVEQIHRFTQ 945
            ..|  :|.|..||:...||.||..|....:..|:......|...||...|
Human  1172 IQD--LKYVYNNLRPQDTDLEATSHFTKKIKESLECFPVKLNNLIHTLAQ 1219

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K59F	NP_477133.1	C2_PI3K_class_III	27..186	CDD:176042	31/160 (19%)
		PI3Ka_III	284..561	CDD:238442	44/277 (16%)
		PI3Kc_III	601..945	CDD:270628	115/369 (31%)
PIK3C2G	XP_016874960.1	PI3K_rbd	287..369	CDD:413336
		C2A_PI3K_class_II	520..678	CDD:175979	36/229 (16%)
		PI3Ka_II	692..860	CDD:238441	51/324 (16%)
		PI3Kc_C2_gamma	866..1219	CDD:270721	117/381 (31%)
		PX_PI3K_C2_gamma	1248..1348	CDD:132806
		C2	1370..>1436	CDD:472691