DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pi3K59F and PIK3C2B

DIOPT Version :9

Sequence 1:	NP_477133.1	Gene:	Pi3K59F / 37733	FlyBaseID:	FBgn0015277	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	NP_001364263.1	Gene:	PIK3C2B / 5287	HGNCID:	8972	Length:	1634	Species:	Homo sapiens

Alignment Length:	961	Identity:	212/961 - (22%)
Similarity:	346/961 - (36%)	Gaps:	329/961 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 LYSEEHPSFQVRLQVFNQGRPYCLPVTSSYKAFGKRW----SWNEWVTLPLQFSDLPRSAMLVLT 110
            :::..:..|.:...:.:.|:..|.|:.:....|.|..    .|::.:..|:|.:.|||..:|..|
Human   644 IWATSYEDFYLSCSLSHGGKELCSPLQTRRAHFSKYLFHLIVWDQQICFPVQVNRLPRETLLCAT 708

  Fly   111 ILDCSGAGQTTVIGGTSISMFGKDGMFRQGMYDLRVWLGVEGDGNFPSRTPGKGKESSKSQM--Q 173
                                          :|.|            |...||...|::|.:.  :
Human   709 ------------------------------LYAL------------PIPPPGSSSEANKQRRVPE 731

  Fly   174 RLGKLAKKHRNGQVQKVDWLDRLTFREIEVINEREKRMS---------------------DYMFL 217
            .||               |:....|...:|:....|.:.                     |.:.|
Human   732 ALG---------------WVTTPLFNFRQVLTCGRKLLGLWPATQENPSARWSAPNFHQPDSVIL 781

  Fly   218 MIEFPAIVVDDMYNYAVVYFEPEGDVKYKLPAKPKLVSVPDSEIQMENLVERKHHRLARSERSGI 282
            .|:||....|      :.:..|.|| |:.                            .|.|...:
Human   782 QIDFPTSAFD------IKFTSPPGD-KFS----------------------------PRYEFGSL 811

  Fly   283 SDRDAKPTASIRDQLHTIVYRYPPTYVLSSEEQDLVWKFRFYLSSHKKALTKFL-KCINWKLEDE 346
            .:.|.:   .::|     :.:....|.|:..::..:|:.|:|..|...:|...| ...:|:
Human   812 REEDQR---KLKD-----IMQKESLYWLTDADKKRLWEKRYYCHSEVSSLPLVLASAPSWE---- 864

  Fly   347 VTQALW--------MLANWAPMDVEDALELLSPTFTHPQVRKYAVSRLAQAPDEDLLLYLLQLVQ 403
                 |        :|..|..|:.:|||.||..||...:||:.||..:....|.:||.||.||||
Human   865 -----WACLPDIYVLLKQWTHMNHQDALGLLHATFPDQEVRRMAVQWIGSLSDAELLDYLPQLVQ 924

  Fly   404 ALKYEDPRHIVHLHGCIFPERDVVRSILDDNGSLLDQSSLSDLSATSSGLHGSVIPANQRAASVL 468
            |||||          |                 .||
Human   925 ALKYE----------C-----------------YLD----------------------------- 933

  Fly   469 AAIKSDKSVSPGSAGGSGSGGQGSVALPNPSAPATPGSSSLPCDSNSNALMLAEGISFGSVPANL 533
                     ||                                                     |
Human   934 ---------SP-----------------------------------------------------L 936

  Fly   534 CTFLIQRACTNATLANYFYWYLSIEVEEVE-SVRKQDERAHDMYAMVLKMFLKVLENGNFNLRGI 597
            ..||::||.::..:.:||:|.|...:::.: |:|         |..:|...|.....|   ||..
Human   937 VRFLLKRAVSDLRVTHYFFWLLKDGLKDSQFSIR---------YQYLLAALLCCCGKG---LREE 989

  Fly   598 FYNLRKQRRFIDELVKLVKLVAKEPGNRNKKTEKFQKLLAEQDMFKVNFTNFEPIP--------- 653
            |   .:|...::.|.||.:.|.:...:            |.|.:.:   |..|.:.
Human   990 F---NRQCWLVNALAKLAQQVREAAPS------------ARQGILR---TGLEEVKQFFALNGSC 1036

  Fly   654 -FPLDPEIYITKIVPMRTSLFKSALMPAKLTF--VTSIAHHEYAAIFKHGDDLRQDQLILQMITL 715
             .||.|.:.:..|||...|.|.|..:|.||:|  |..:..: ...|||.|||||||.|.||||.:
Human  1037 RLPLSPSLLVKGIVPRDCSYFNSNAVPLKLSFQNVDPLGEN-IRVIFKCGDDLRQDMLTLQMIRI 1100

  Fly   716 MDKLLRRENLDLKLTPYKVLATSSKHGFLQYVDSC-TVAEVLAREGNIHNF--------FRKHHP 771
            |.|:..:|.||:::..::..:|....|.::.:.:. |:.::....|...:|        .:||:|
Human  1101 MSKIWVQEGLDMRMVIFRCFSTGRGRGMVEMIPNAETLRKIQVEHGVTGSFKDRPLADWLQKHNP 1165

  Fly   772 CDNGPYGISAEVMDTYIKSCAGYCVITYLLGVGDRHLDNLLLTTNGKLFHIDFGYILGR-----D 831
            .:: .|   .:.::.:|.||||.||.||:||:.|||.||::|.|.|.:||||||..||.     :
Human  1166 GED-EY---EKAVENFIYSCAGCCVATYVLGICDRHNDNIMLKTTGHMFHIDFGRFLGHAQMFGN 1226

  Fly   832 PKPMPPPMKLSKEMVEAMGG--ISSEHHHEFRKQCYTAYLHLRRHANVMLNLFSLMVDATVPDIA 894
            .|....|...:.:|...:.|  ..|...|:|...|..||..:|:|.::.|||..||:...:|:::
Human  1227 IKRDRAPFVFTSDMAYVINGGDKPSSRFHDFVDLCCQAYNLIRKHTHLFLNLLGLMLSCGIPELS 1291

  Fly   895 LEPDKAVKKVEENLQLGLTDEEAVQHLQSLLDVSITAVMPALVEQIHRFTQ 945
            ...|  :|.|.:.|:...|:..|..:...|::.|:.:|...|...||...|
Human  1292 DLED--LKYVYDALRPQDTEANATTYFTRLIESSLGSVATKLNFFIHNLAQ 1340

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K59F	NP_477133.1	C2_PI3K_class_III	27..186	CDD:176042	23/141 (16%)
		PI3Ka_III	284..561	CDD:238442	54/285 (19%)
		PI3Kc_III	601..945	CDD:270628	109/371 (29%)
PIK3C2B	NP_001364263.1	Interaction with GRB2. /evidence=ECO:0000269\|PubMed:11533253	2..298
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	45..188
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	259..315
		PI3K_rbd	364..466	CDD:395642
		C2A_PI3K_class_II	622..794	CDD:175979	33/212 (16%)
		PI3Ka_II	813..981	CDD:238441	59/311 (19%)
		PI3Kc_C2_beta	987..1340	CDD:119421	111/377 (29%)
		PX_PI3K_C2_beta	1369..1477	CDD:132823
		C2B_PI3K_class_II	1505..1627	CDD:176027
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D204282at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820