DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pi3K59F and Pi3K92E

DIOPT Version :9

Sequence 1:	NP_477133.1	Gene:	Pi3K59F / 37733	FlyBaseID:	FBgn0015277	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	NP_001262770.1	Gene:	Pi3K92E / 42446	FlyBaseID:	FBgn0015279	Length:	1088	Species:	Drosophila melanogaster

Alignment Length:	806	Identity:	191/806 - (23%)
Similarity:	338/806 - (41%)	Gaps:	222/806 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   171 QMQRLGKLAKKHRNGQVQKVD---------WLDRLTFREIEVINEREKRMSDYMFLMIEFPAIVV 226
            ::.::.:..|...|..:...|         |::...|...:::......:..:.:         .
  Fly   425 EVTKMSRSKKSSNNKDIALKDVPYNKNPLAWVNTTIFDHKDILRTGRHTLYTWTY---------A 480

  Fly   227 DDMYNYAVVYFEPEGDVKYKLPAKPK--------------LVSVPDSEIQMENLVERKH-HRLAR 276
            ||:.:..|  |.|.|.::.. |.|.:              .|..|..|:.::...:|:. :||.|
  Fly   481 DDIQSVEV--FHPLGTIEPN-PRKEECALVDLTFLSSGTGTVRYPSEEVVLQYAADREQVNRLQR 542

  Fly   277 SERSGISDRDAKPTASIRDQLHTIVYRY---PPTYVLSSEEQDLVWKFR-FYLSSHKKALTKFLK 337
                    :.|.|...|: :|..::..|   ...|.:..::::.:|:.| ..|....:.|:..|.
  Fly   543 --------QLAGPEKPIK-ELKELMANYTGLDKIYEMVDQDRNAIWERRNDILRELPEELSILLH 598

  Fly   338 CINWKLEDEVTQALWMLANWAPMDVEDALELLSPTFTHPQVRKYAVSRLAQAPDEDLLLYLLQLV 402
            |:.||..|:|....::|..|..:.:|.:||||...:..|.||::|:..|....||||||||||||
  Fly   599 CVYWKERDDVADMWYLLKQWPLISIERSLELLDYAYPDPAVRRFAIRCLHFLKDEDLLLYLLQLV 663

  Fly   403 QALKYEDPRHIVHLHGCIFPERDVVRSILDDNGSLLDQSSLSDLSATSSGLHGSVIPANQRAASV 467
            ||:|:|
  Fly   664 QAIKHE----------------------------------------------------------- 669

  Fly   468 LAAIKSDKSVSPGSAGGSGSGGQGSVALPNPSAPATPGSSSLPCDSNSNALMLAEGISFGSVPAN 532
             :.::||
  Fly   670 -SYLESD---------------------------------------------------------- 675

  Fly   533 LCTFLIQRACTNATLANYFYWYLSIEVEEVESVRKQDERAHDMYAMVLKMFLKVLENGNFNLRGI 597
            |..||::||..|..:.:||:|:|..|:        |.......:.::|:::||          |.
  Fly   676 LVVFLLERALRNQRIGHYFFWHLRSEM--------QTPSMQTRFGLLLEVYLK----------GC 722

  Fly   598 FYN---LRKQRRFIDELVKLVKLVAKEPGNRNKKTEKFQKLLAEQDMFKVNFTNFEPIPFPLDPE 659
            .::   ||||...:::| |...|:||: |::.|.....|..|.:|.    |...|:.|..||:|.
  Fly   723 KHHVAPLRKQLHVLEKL-KQGSLIAKK-GSKEKVKTMLQDFLRDQR----NSAVFQNIQNPLNPS 781

  Fly   660 IYITKIVPMRTSLFKSALMPAKLTFVTS-IAHHEYAAIFKHGDDLRQDQLILQMITLMDKLLRRE 723
            ...:.:.|.|..:..|.:.|..:.|..: :...:...|||:|||||||.|.|||:.:||:|.:|:
  Fly   782 FRCSGVTPDRCKVMDSKMRPLWVVFENADVNASDVHIIFKNGDDLRQDMLTLQMLRVMDQLWKRD 846

  Fly   724 NLDLKLTPYKVLATSSKHGFLQYVDSC-TVAEVLA-----------REGNIHNFFRKHHPCDNGP 776
            .:|.::..|..::.....|.::.|... |:|.:..           ::|::.::.::|    |.|
  Fly   847 GMDFRMNIYNCISMEKSLGMIEVVRHAETIANIQKEKGMFSATSPFKKGSLLSWLKEH----NKP 907

  Fly   777 YGISAEVMDTYIKSCAGYCVITYLLGVGDRHLDNLLLTTNGKLFHIDFGYILGRDPKPM-----P 836
            .....:.::.:..|||||||.||:|||.|||.||:::..||:|||||||:|||...:.:     .
  Fly   908 ADKLNKAINEFTLSCAGYCVATYVLGVADRHSDNIMVKRNGQLFHIDFGHILGHFKEKLGVRRER 972

  Fly   837 PPMKLSKEMVEAMG-GISSEHHHE---FRKQCYTAYLHLRRHANVMLNLFSLMVDATVPDIALEP 897
            .|..|:.:.|..:. |.:.....|   |::.|..|:|.||:|..::|:|||:|:...:|:::.|.
  Fly   973 VPFVLTHDFVYVINKGFNDRESKEFCHFQELCERAFLVLRKHGCLILSLFSMMISTGLPELSSEK 1037

  Fly   898 DKAVKKVEENLQLGLTDEEAVQHLQS 923
            |  :..:.|.|.|..|:|:|.:|.::
  Fly  1038 D--LDYLRETLVLDYTEEKAREHFRA 1061

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K59F	NP_477133.1	C2_PI3K_class_III	27..186	CDD:176042	2/14 (14%)
		PI3Ka_III	284..561	CDD:238442	57/280 (20%)
		PI3Kc_III	601..945	CDD:270628	109/345 (32%)
Pi3K92E	NP_001262770.1	PI3K_p85B	56..132	CDD:295322
		PI3K_rbd	200..307	CDD:197540
		C2_PI3K_class_I_beta_delta	339..517	CDD:176075	13/103 (13%)
		PI3Ka_I	552..723	CDD:238444	59/307 (19%)
		PI3Kc_I	727..1084	CDD:270709	109/347 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447458
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D204282at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10048
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850