Protein Alignment Pi3K59F and pik3cd

DIOPT Version :10

• Sequence 1: NP_477133.1
• Gene: Pi3K59F / 37733
• FlyBaseID: FBgn0015277
• Length: 949
• Species: Drosophila melanogaster
• Sequence 2: NP_957493.1
• Gene: pik3cd / 394174
• ZFINID: ZDB-GENE-040426-1128
• Length: 1039
• Species: Danio rerio
• Alignment Length: 979
• Identity: 220/979 - (22%)
• Similarity: 370/979 - (37%)
• Gaps: 301/979 - (30%)

  Fly     7 HFRYIHSSSL---------------HERVQIKVGTLEGKKRQPDYEKLLEDP----ILRFSGLYS 52
            |...:|.||:               ..|.|.|...|..|::.......:::|    :|:.|.:.:
Zfish   272 HLTMVHYSSIVKYQEEQSGLSNQVSRSRAQSKPPPLPLKRQNTCSLWSIQEPFYIYLLQGSRVNA 336

  Fly    53 EEHPSFQVRLQVFNQGRPYCLPVTSSYKAFGKRWSWNEWVTLPLQFSDLPRSAMLVLTI------ 111
            :|.....|:..:|:.....|..|||:..:......|::.:...:..|||||.:.|...:
Zfish   337 DEGMKLVVQAGLFHGSELLCKVVTSNEVSVCFDPVWDQKLVFDINVSDLPRMSRLCFALYGVIEK 401

  Fly   112 ------------LDCSGAGQTTVIGGTSISMFGKDGMFRQGMYDLRVWLGVEGDGNFPSRTPGKG 164
                        .||..|...|::       |......:.|.:.|..|         ||....||
Zfish   402 TKKRPTKKKNKRADCPLAWVNTMV-------FDYKDQLKTGEFSLSTW---------PSVPDDKG 450

  Fly   165 KESSKSQMQRLGKLAKKHRNGQVQKVDWLDRLTFREIEVINEREKRMSDYMFLMIEFPAIVVDDM 229
                 ..:..:|.:                           |:...:.....|:|.||.|....:
Zfish   451 -----DLLNPMGTV---------------------------EKNPNIDSTAGLLIRFPNIRPHPL 483

  Fly   230 YNYAVVYFEPEGDVKYKLPAKPKLVSVPDSEIQMENLVERKHHRLARSERSGISDRDAKPTASIR 294
                  |:.|...:....|...|:::..:...:::.:|:.|:                 .|....
Zfish   484 ------YYPPIEKLNELGPNGEKVIATKEEHQKLKEIVDNKN-----------------STEFFE 525

  Fly   295 DQLHTIVYRYPPTYVLSSEEQDLVWKFRFYLS-SHKKALTKFLKCINWKLEDEVTQALWMLANWA 358
            |                  |::.:||.|..|. .:.::|.|.|....|...::|.|.:.:|..|.
Zfish   526 D------------------EKEPLWKLREELRLKYPESLPKLLLITKWNKHEDVAQMVGLLQKWP 572

  Fly   359 PMDVEDALELLSPTFTHPQVRKYAVSRLAQAPDEDLLLYLLQLVQALKYEDPRHIVHLHGCIFPE 423
            .:....|||||..:|..|.||.:.:..|.:.||:.|..|||||||.||||
Zfish   573 ELPALHALELLDYSFPDPHVRFFTIRCLRKLPDDKLFQYLLQLVQVLKYE--------------- 622

  Fly   424 RDVVRSILDDNGSLLDQSSLSDLSATSSGLHGSVIPANQRAASVLAAIKSDKSVSPGSAGGSGSG 488
                                                                             
Zfish   623 ----------------------------------------------------------------- 622

  Fly   489 GQGSVALPNPSAPATPGSSSLPCDSNSNALMLAEGISFGSVPANLCTFLIQRACTNATLANYFYW 553
                              |.|.||                    |.:||::||..|..:.::.:|
Zfish   623 ------------------SYLDCD--------------------LTSFLLERALANKKIGHFLFW 649

  Fly   554 YLSIEVEEVESVRKQDERAHDMYAMVLKMFLKVLENGNFNLRG-IFY--NLRKQRRFIDELVKLV 615
            :|..|: .|.||..:       :.::|:.:          .|| ||:  :|.||...::::..|.
Zfish   650 HLRSEM-HVPSVSLR-------FGLILEAY----------CRGSIFHIKSLMKQNEALNKMKALN 696

  Fly   616 KLV--AKEPGNRNKKTEKFQKLLAEQDMFKVNFTNFEPIPFPLDPEIYITKIVPMRTSLFKSALM 678
            ..|  |.:...|.:.||. .|:..:|:.:....::   :..||.|.|.:.::...:.....|.:.
Zfish   697 DFVKSASQKATRIQTTED-MKVCIKQETYMEALSD---VVSPLSPSIILCELCADKCKFMDSKMK 757

  Fly   679 PAKLTFVTSIAHHEYAAIFKHGDDLRQDQLILQMITLMDKLLRRENLDLKLTPYKVLATSSKHGF 743
            |..|.:.:.  :.....|||:|||||||.|.||||.:||.|.:.|.|||::.||..|:|.:|.|.
Zfish   758 PLWLMYKSK--YDSVGIIFKNGDDLRQDMLTLQMIQIMDILWKTEGLDLRMQPYGCLSTGNKTGL 820

  Fly   744 LQYV-DSCTVAEVLAREGN-----------IHNFFRKHHPCDNGPYGISAEVMDTYIKSCAGYCV 796
            ::.| :|.|:|.:.....|           :.|:.:..:|.|.     ..:.::.:..|||||||
Zfish   821 IEVVKNSDTIANIQRNNSNSAATAAFNKDALLNWLKSKNPGDK-----LDQAIEEFTLSCAGYCV 880

  Fly   797 ITYLLGVGDRHLDNLLLTTNGKLFHIDFGYILGRDPKPM-----PPPMKLSKEMVEAM--GGI-S 853
            .||:||:||||.||:::..:|:|||||||:.||......     ..|..|:.:.|..:  |.. :
Zfish   881 ATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKSKFGINRERVPFILTYDFVHVIQEGRTNN 945

  Fly   854 SEHHHEFRKQCYTAYLHLRRHANVMLNLFSLMVDATVPDIALEPDKAVKKVEENLQLGLTDEEAV 918
            ||....||..|..||..|.|:..:.:|||:||..|.:|:  |...|.::.::::|.||.::|||:
Zfish   946 SEKFERFRVCCEQAYKILCRNGTLFVNLFALMKAAGLPE--LNSSKDIQYLKDSLALGKSEEEAL 1008

  Fly   919 QHLQ 922
            ::.:
Zfish  1009 KNFK 1012

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K59F	NP_477133.1	C2_PI3K_class_III	27..186	CDD:176042	32/180 (18%)
		PI3Ka_III	284..561	CDD:238442	52/277 (19%)
		PI3Kc_III	601..945	CDD:270628	109/344 (32%)
pik3cd	NP_957493.1	PI3K_p85B	34..107	CDD:460483
		PI3K_rbd	188..280	CDD:413336	2/7 (29%)
		C2_PI3K_class_I_beta_delta	315..481	CDD:176075	36/213 (17%)
		PI3Ka_I	505..676	CDD:238444	60/341 (18%)
		PI3Kc_IA_delta	676..1038	CDD:270718	111/350 (32%)