DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Pi3K59F and pik3cd

DIOPT Version :9

Sequence 1:NP_477133.1 Gene:Pi3K59F / 37733 FlyBaseID:FBgn0015277 Length:949 Species:Drosophila melanogaster
Sequence 2:NP_957493.1 Gene:pik3cd / 394174 ZFINID:ZDB-GENE-040426-1128 Length:1039 Species:Danio rerio


Alignment Length:979 Identity:220/979 - (22%)
Similarity:370/979 - (37%) Gaps:301/979 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 HFRYIHSSSL---------------HERVQIKVGTLEGKKRQPDYEKLLEDP----ILRFSGLYS 52
            |...:|.||:               ..|.|.|...|..|::.......:::|    :|:.|.:.:
Zfish   272 HLTMVHYSSIVKYQEEQSGLSNQVSRSRAQSKPPPLPLKRQNTCSLWSIQEPFYIYLLQGSRVNA 336

  Fly    53 EEHPSFQVRLQVFNQGRPYCLPVTSSYKAFGKRWSWNEWVTLPLQFSDLPRSAMLVLTI------ 111
            :|.....|:..:|:.....|..|||:..:......|::.:...:..|||||.:.|...:      
Zfish   337 DEGMKLVVQAGLFHGSELLCKVVTSNEVSVCFDPVWDQKLVFDINVSDLPRMSRLCFALYGVIEK 401

  Fly   112 ------------LDCSGAGQTTVIGGTSISMFGKDGMFRQGMYDLRVWLGVEGDGNFPSRTPGKG 164
                        .||..|...|::       |......:.|.:.|..|         ||....||
Zfish   402 TKKRPTKKKNKRADCPLAWVNTMV-------FDYKDQLKTGEFSLSTW---------PSVPDDKG 450

  Fly   165 KESSKSQMQRLGKLAKKHRNGQVQKVDWLDRLTFREIEVINEREKRMSDYMFLMIEFPAIVVDDM 229
                 ..:..:|.:                           |:...:.....|:|.||.|....:
Zfish   451 -----DLLNPMGTV---------------------------EKNPNIDSTAGLLIRFPNIRPHPL 483

  Fly   230 YNYAVVYFEPEGDVKYKLPAKPKLVSVPDSEIQMENLVERKHHRLARSERSGISDRDAKPTASIR 294
                  |:.|...:....|...|:::..:...:::.:|:.|:                 .|....
Zfish   484 ------YYPPIEKLNELGPNGEKVIATKEEHQKLKEIVDNKN-----------------STEFFE 525

  Fly   295 DQLHTIVYRYPPTYVLSSEEQDLVWKFRFYLS-SHKKALTKFLKCINWKLEDEVTQALWMLANWA 358
            |                  |::.:||.|..|. .:.::|.|.|....|...::|.|.:.:|..|.
Zfish   526 D------------------EKEPLWKLREELRLKYPESLPKLLLITKWNKHEDVAQMVGLLQKWP 572

  Fly   359 PMDVEDALELLSPTFTHPQVRKYAVSRLAQAPDEDLLLYLLQLVQALKYEDPRHIVHLHGCIFPE 423
            .:....|||||..:|..|.||.:.:..|.:.||:.|..|||||||.||||               
Zfish   573 ELPALHALELLDYSFPDPHVRFFTIRCLRKLPDDKLFQYLLQLVQVLKYE--------------- 622

  Fly   424 RDVVRSILDDNGSLLDQSSLSDLSATSSGLHGSVIPANQRAASVLAAIKSDKSVSPGSAGGSGSG 488
                                                                             
Zfish   623 ----------------------------------------------------------------- 622

  Fly   489 GQGSVALPNPSAPATPGSSSLPCDSNSNALMLAEGISFGSVPANLCTFLIQRACTNATLANYFYW 553
                              |.|.||                    |.:||::||..|..:.::.:|
Zfish   623 ------------------SYLDCD--------------------LTSFLLERALANKKIGHFLFW 649

  Fly   554 YLSIEVEEVESVRKQDERAHDMYAMVLKMFLKVLENGNFNLRG-IFY--NLRKQRRFIDELVKLV 615
            :|..|: .|.||..:       :.::|:.:          .|| ||:  :|.||...::::..|.
Zfish   650 HLRSEM-HVPSVSLR-------FGLILEAY----------CRGSIFHIKSLMKQNEALNKMKALN 696

  Fly   616 KLV--AKEPGNRNKKTEKFQKLLAEQDMFKVNFTNFEPIPFPLDPEIYITKIVPMRTSLFKSALM 678
            ..|  |.:...|.:.||. .|:..:|:.:....::   :..||.|.|.:.::...:.....|.:.
Zfish   697 DFVKSASQKATRIQTTED-MKVCIKQETYMEALSD---VVSPLSPSIILCELCADKCKFMDSKMK 757

  Fly   679 PAKLTFVTSIAHHEYAAIFKHGDDLRQDQLILQMITLMDKLLRRENLDLKLTPYKVLATSSKHGF 743
            |..|.:.:.  :.....|||:|||||||.|.||||.:||.|.:.|.|||::.||..|:|.:|.|.
Zfish   758 PLWLMYKSK--YDSVGIIFKNGDDLRQDMLTLQMIQIMDILWKTEGLDLRMQPYGCLSTGNKTGL 820

  Fly   744 LQYV-DSCTVAEVLAREGN-----------IHNFFRKHHPCDNGPYGISAEVMDTYIKSCAGYCV 796
            ::.| :|.|:|.:.....|           :.|:.:..:|.|.     ..:.::.:..|||||||
Zfish   821 IEVVKNSDTIANIQRNNSNSAATAAFNKDALLNWLKSKNPGDK-----LDQAIEEFTLSCAGYCV 880

  Fly   797 ITYLLGVGDRHLDNLLLTTNGKLFHIDFGYILGRDPKPM-----PPPMKLSKEMVEAM--GGI-S 853
            .||:||:||||.||:::..:|:|||||||:.||......     ..|..|:.:.|..:  |.. :
Zfish   881 ATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKSKFGINRERVPFILTYDFVHVIQEGRTNN 945

  Fly   854 SEHHHEFRKQCYTAYLHLRRHANVMLNLFSLMVDATVPDIALEPDKAVKKVEENLQLGLTDEEAV 918
            ||....||..|..||..|.|:..:.:|||:||..|.:|:  |...|.::.::::|.||.::|||:
Zfish   946 SEKFERFRVCCEQAYKILCRNGTLFVNLFALMKAAGLPE--LNSSKDIQYLKDSLALGKSEEEAL 1008

  Fly   919 QHLQ 922
            ::.:
Zfish  1009 KNFK 1012

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pi3K59FNP_477133.1 C2_PI3K_class_III 27..186 CDD:176042 32/180 (18%)
PI3Ka_III 284..561 CDD:238442 52/277 (19%)
PI3Kc_III 601..945 CDD:270628 109/344 (32%)
pik3cdNP_957493.1 PI3K_p85B 32..107 CDD:280372
PI3K_rbd 188..280 CDD:295323 2/7 (29%)
C2_PI3K_class_I_beta_delta 315..481 CDD:176075 36/213 (17%)
PI3Ka_I 505..676 CDD:238444 60/341 (18%)
PI3Kc_IA_delta 676..1038 CDD:270718 111/350 (32%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D204282at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
43.820

Return to query results.
Submit another query.