DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pi3K59F and Pik3cd

DIOPT Version :9

Sequence 1:	NP_477133.1	Gene:	Pi3K59F / 37733	FlyBaseID:	FBgn0015277	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	XP_038966422.1	Gene:	Pik3cd / 366508	RGDID:	1310990	Length:	1048	Species:	Rattus norvegicus

Alignment Length:	993	Identity:	234/993 - (23%)
Similarity:	373/993 - (37%)	Gaps:	322/993 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 HFRYIHSSSL-------------HERVQIKVGTLEGKKRQPDYEKL--LEDP----ILRFSGLYS 52
            |...:||||:             .::.::|...:..||  |....|  ||.|    ::....:.:
  Rat   273 HLTMVHSSSILAMRDEQSNPAPQVQKPRVKPPPIPAKK--PSSVSLWSLEQPFCIELIEGRKVNA 335

  Fly    53 EEHPSFQVRLQVFNQGRPYCLPVTSSYKAFGKRWSWNEWVTLPLQFSDLPRSAMLVLTI------ 111
            :|.....|:..:|:.....|..|:||.........|.:.:...:...||||.|.|...:
  Rat   336 DERMKLVVQAGLFHGNEMLCKTVSSSEVNVCSEPVWKQRLEFDISICDLPRMARLCFALYAVVEK 400

  Fly   112 -------------LDCSGAGQTTVIGGTSISMFGKDGMFRQGMYDLRVWLGVEGDGNFPSRTPGK 163
                         .||.       |...::.:|......:.|...|.:|         ||....|
  Rat   401 AKKARSTKKKSKKADCP-------IAWANLMLFDYKDQLKTGERCLYMW---------PSVPDEK 449

  Fly   164 GKESSKSQMQRLGKLAKKHRNGQVQKVDWLDRLTFREIEVINEREKRMSDYMFLMIEFPAIVVDD 228
            |                                     |::|                ||..|..
  Rat   450 G-------------------------------------ELMN----------------PAGTVRG 461

  Fly   229 MYN----YAVVYFEPEGDVKYKLPAKPKLVSVPDSEIQMENLVERKHHRLARSERSGISDRDAKP 289
            ..|    .|:|.:.||        ..|..|..|    .:|.::|...|    .||..|::.:
  Rat   462 NPNTESAAALVIYLPE--------VAPHPVYFP----ALEKILELGRH----GERGRITEEE--- 507

  Fly   290 TASIRDQLHTIVYRYPPTYVLSSEEQDLVWKFRFYLSSH-KKALTKFLKCINW-KLED--EVTQA 350
                :.||..|:.| ..:..|...|:|||||.|..:..| .:||.:.|....| |.||  :::|.
  Rat   508 ----QLQLREILER-RGSGELYEHEKDLVWKMRHEVQEHFPEALARLLLVTKWNKHEDVAQLSQM 567

  Fly   351 LWMLANWAPMDVEDALELLSPTFTHPQVRKYAVSRLAQAPDEDLLLYLLQLVQALKYEDPRHIVH 415
            |::|.:|..:.|..|||||..:|....|..:|:..|.:..|::|..|||||||.||||
  Rat   568 LYLLCSWPELPVLSALELLDFSFPDCYVGSFAIKSLRKLTDDELFQYLLQLVQVLKYE------- 625

  Fly   416 LHGCIFPERDVVRSILDDNGSLLDQSSLSDLSATSSGLHGSVIPANQRAASVLAAIKSDKSVSPG 480

  Rat   626 ----------------------------------------------------------------- 625

  Fly   481 SAGGSGSGGQGSVALPNPSAPATPGSSSLPCDSNSNALMLAEGISFGSVPANLCTFLIQRACTNA 545
                                      |.|.|:                    |..||:.||..|.
  Rat   626 --------------------------SYLDCE--------------------LTKFLLGRALANR 644

  Fly   546 TLANYFYWYLSIEVEEVESVRKQDERAHDMYAMVLKMFLKVLENGNFNLRGIFYNLR---KQRRF 607
            .:.::.:|:|..|: .|.||..:       :.::::.:          .||..::::   ||...
  Rat   645 KIGHFLFWHLRSEM-HVPSVALR-------FGLIMEAY----------CRGSTHHMKVLMKQGEA 691

  Fly   608 IDELVKLVKLV-AKEPGNRNKKTEKFQKLLAEQDMFKVNFTNFEPIPFPLDPEIYITKIVPMRTS 671
            :.:|..|...| |........:|::...:...|:.:....::.:.   ||||...:.::..:...
  Rat   692 LSKLKALNDFVKASSQKTTKPQTKEMMHMCMRQETYMEALSHLQS---PLDPSTLLEEVCSVEQC 753

  Fly   672 LF-KSALMPAKLTFVTSIA--HHEYAAIFKHGDDLRQDQLILQMITLMDKLLRRENLDLKLTPYK 733
            .| .|.:.|..:.:.:..|  ......|||:|||||||.|.||||.|||.|.::|.|||::|||.
  Rat   754 TFMDSKMKPLWIMYSSEKAGGAGSVGIIFKNGDDLRQDMLTLQMIQLMDFLWKQEGLDLRMTPYG 818

  Fly   734 VLATSSKHGFLQYV-DSCTVAEVLAREGN-----------IHNFFRKHHPCDNGPYGISAEVMDT 786
            .|.|..:.|.::.| .|.|:|.:...:.|           :.|:.:..:|         .|.:|.
  Rat   819 CLPTGDRTGLIEVVLHSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNP---------GEALDR 874

  Fly   787 YIK----SCAGYCVITYLLGVGDRHLDNLLLTTNGKLFHIDFGYILGRDPKPM-----PPPMKLS 842
            .|:    |||||||.||:||:||||.||:::..:|:|||||||:.||......     ..|..|:
  Rat   875 AIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILT 939

  Fly   843 KEMVEAM--GGI-SSEHHHEFRKQCYTAYLHLRRHANVMLNLFSLMVDATVPDIALEPDKAVKKV 904
            .:.|..:  |.. :||....||..|..||..||||..:.|:||:||..|.:|:::...|  ::.:
  Rat   940 YDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKD--IQYL 1002

  Fly   905 EENLQLGLTDEEAVQHLQ 922
            :::|.||.|:|||::|.:
  Rat  1003 KDSLALGKTEEEALKHFR 1020

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K59F	NP_477133.1	C2_PI3K_class_III	27..186	CDD:176042	32/183 (17%)
		PI3Ka_III	284..561	CDD:238442	59/280 (21%)
		PI3Kc_III	601..945	CDD:270628	113/353 (32%)
Pik3cd	XP_038966422.1	PI3K_p85B	32..107	CDD:396665
		PI3K_rbd	182..281	CDD:395642	3/7 (43%)
		C2_PI3K_class_I_beta_delta	314..481	CDD:176075	39/243 (16%)
		PI3Ka	504..687	CDD:214537	64/326 (20%)
		PI3Kc_IA_delta	679..1046	CDD:270718	113/356 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D204282at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820