Protein Alignment Pi3K59F and Pik3c2a

DIOPT Version :10

• Sequence 1: NP_477133.1
• Gene: Pi3K59F / 37733
• FlyBaseID: FBgn0015277
• Length: 949
• Species: Drosophila melanogaster
• Sequence 2: NP_001101970.1
• Gene: Pik3c2a / 361632
• RGDID: 1310389
• Length: 1687
• Species: Rattus norvegicus
• Alignment Length: 923
• Identity: 219/923 - (23%)
• Similarity: 341/923 - (36%)
• Gaps: 285/923 - (30%)

  Fly    66 NQGRPYCLPVTS----SYKAFGKRWSWNEWVTLPLQFSDLPRSAMLVLTIL----DCSGAGQTT- 121
            :.|:....|:.|    :||.|.....|:|.:..|:|.|.||..::|.||:.    ..||:...:
  Rat   716 HNGKDLFKPIQSKKVGTYKNFFYLIKWDELIIFPIQISQLPLESVLHLTLFGVLNQSSGSSPDSN 780

  Fly   122 -------VIGGTSISMFGKDGMFRQGMYDLRVWLGVEGDGNFPSRTPGKGKESSKSQMQRLGKLA 179
                   .:|..|:::|........|...|.:|.. ....:.|...|.|
  Rat   781 KQRKGPEALGKVSLTLFDFKRFLTCGTKLLYLWTS-SHTNSIPGAIPQK---------------- 828

  Fly   180 KKHRNGQVQKVDWLDRLTFREIEVINEREKRMSDYMFLMIEFPAIVVDDMYNYAVVYFEPEGD-- 242
                                  ..:.||       :.|.::||:...|      ::|..|:.|
  Rat   829 ----------------------SYVMER-------IVLQVDFPSPAFD------IIYTSPQIDRN 858

  Fly   243 --VKYKLPAKPKLVSVPDSEIQMENLVERKHHRLARSERSGISDRDAKPTASIRDQLHTIVYRYP 305
              .:|||.|             :||                          .|:.:|..||:| .
  Rat   859 IIQQYKLEA-------------LEN--------------------------EIKGKLLDIVHR-D 883

  Fly   306 PTYVLSSEEQDLVWKFRFYLSSHKKALTKFL-KCINWKLEDEVTQALWMLANWAPMDVEDALELL 369
            .::.||.|::..:|:.|:|...|...|.|.| ...|||..: :.:...:|..|.|:....|||||
  Rat   884 SSFGLSKEDKAFLWEKRYYCLKHPNCLPKILASAPNWKWAN-LAKTYSLLHQWPPLCPLAALELL 947

  Fly   370 SPTFTHPQVRKYAVSRLAQAPDEDLLLYLLQLVQALKYEDPRHIVHLHGCIFPERDVVRSILDDN 434
            ...|...:||..|||.:....|::|...|.|.|||||||     ::|:
  Rat   948 DAKFADQEVRSLAVSWIEAISDDELTDLLPQFVQALKYE-----IYLN----------------- 990

  Fly   435 GSLLDQSSLSDLSATSSGLHGSVIPANQRAASVLAAIKSDKSVSPGSAGGSGSGGQGSVALPNPS 499
                                                                             
  Rat   991 ----------------------------------------------------------------- 990

  Fly   500 APATPGSSSLPCDSNSNALMLAEGISFGSVPANLCTFLIQRACTNATLANYFYWYLSIEVEEVES 564
                                           ::|..||:.||..|..:|:..||.|...:
  Rat   991 -------------------------------SSLVRFLLSRALGNIQIAHSLYWLLKDAL----- 1019

  Fly   565 VRKQDERAHDMYAMVLKMFLKVLENGNFNLRGIFYNLRKQRRFIDELVKLVKLVAKEPGNRNKKT 629
               .|.|....|..||...|.|   |.   :|:...|.||.:.:..|..:.:.|.:..|:.
  Rat  1020 ---HDTRFGSRYEHVLGALLSV---GG---KGLREELSKQMKLVQLLGGVAEKVRQASGSA---- 1071

  Fly   630 EKFQKLLAEQDMFKV-NFTNFEPIPFPLDPEIYITKIVPMRTSLFKSALMPAKLTFVTS-IAHHE 692
               ::::.::.|.:| :|........||.|.:...::.....|.|.|..||.|:|.|.: ....|
  Rat  1072 ---RQVVLQKSMERVQSFFLRNKCRVPLKPSLVAKELNIKSCSFFSSNAMPLKVTMVNADPLGEE 1133

  Fly   693 YAAIFKHGDDLRQDQLILQMITLMDKLLRRENLDLKLTPYKVLATSSKHGFLQYVD-SCTVAEVL 756
            ...:||.|:|||||.|.||||.:|||:..:|.|||::..:|.|:|....|.::.|. |.|:.::.
  Rat  1134 INVMFKVGEDLRQDMLALQMIKIMDKIWLKEGLDLRMVIFKCLSTGRDQGMVELVPASDTLRKIQ 1198

  Fly   757 AREGNIHNF--------FRKHHPCDNGPYGISAEVMDTYIKSCAGYCVITYLLGVGDRHLDNLLL 813
            ...|...:|        .||::|.:. .|..::|   .:|.||||.||.||:||:.|||.||::|
  Rat  1199 VEYGVTGSFKDKPLAEWLRKYNPSEE-EYEKASE---NFIYSCAGCCVATYVLGICDRHNDNIML 1259

  Fly   814 TTNGKLFHIDFGYILG---------RDPKPMPPPMKLSKEMVEAMGGISSE--HHHEFRKQCYTA 867
            .:.|.:||||||..||         ||    ..|..|:.:|...:.|....  ....|...|..|
  Rat  1260 RSTGHMFHIDFGKFLGHAQMFGSFKRD----RAPFVLTSDMAYVINGGEKPTIRFQLFVDLCCQA 1320

  Fly   868 YLHLRRHANVMLNLFSLMVDATVPDIALEPDKAVKKVEENLQLGLTDEEAVQHLQSLLDVSITAV 932
            |..:|:..|:.|||.|||:.:.:|::....|  :|.|.:.||...||.||......|::.|:.::
  Rat  1321 YNLIRKQTNLFLNLLSLMIPSGLPELTSIQD--LKYVRDALQPQTTDAEATIFFTRLIESSLGSI 1383

  Fly   933 MPALVEQIHRFTQ 945
            .......||...|
  Rat  1384 ATKFNFFIHNLAQ 1396

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K59F	NP_477133.1	C2_PI3K_class_III	27..186	CDD:176042	27/135 (20%)
		PI3Ka_III	284..561	CDD:238442	54/277 (19%)
		PI3Kc_III	601..945	CDD:270628	113/365 (31%)
Pik3c2a	NP_001101970.1	PI3K_rbd	421..514	CDD:395642
		C2A_PI3K_class_II	678..850	CDD:175979	33/185 (18%)
		PI3Ka_II	871..1039	CDD:238441	61/298 (20%)
		PI3Kc_C2_alpha	1044..1396	CDD:270720	113/368 (31%)
		PX_PI3K_C2_alpha	1427..1535	CDD:132822
		C2B_PI3K_class_II	1561..1682	CDD:176027