Protein Alignment Pi3K59F and Pik3cg

DIOPT Version :10

• Sequence 1: NP_477133.1
• Gene: Pi3K59F / 37733
• FlyBaseID: FBgn0015277
• Length: 949
• Species: Drosophila melanogaster
• Sequence 2: NP_064668.2
• Gene: Pik3cg / 30955
• MGIID: 1353576
• Length: 1102
• Species: Mus musculus
• Alignment Length: 981
• Identity: 226/981 - (23%)
• Similarity: 379/981 - (38%)
• Gaps: 312/981 - (31%)

  Fly    17 HERVQIKVGTLEGKKRQPDYEKLLED--------------PIL-RFSGLYSEEHPSFQVRLQVFN 66
            ||::     |:.||..:..:...|.|              |:| |.:.|......:.|...||..
Mouse   336 HEQL-----TIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLC 395

  Fly    67 QGRPYCLPVTSSYKAFGKRWSWNEWVTLPLQFSDLPRSAMLVLTILDC----------------S 115
            |.|       :|.|.|.:...||.|:...::..|||:.|:|.|.|..|                .
Mouse   396 QRR-------TSPKPFAEEVLWNVWLEFGIKIKDLPKGALLNLQIYCCKTPSLSSKASAETPGSE 453

  Fly   116 GAGQTTVIGGTSISMFGKDGMFRQGMYDLRVWLGVEGDGNFPSRTPGKGKESSKSQMQRLGKLAK 180
            ..|:..::...::.:.....:.|.|.|.|.:|           :..||.:|.....
Mouse   454 SKGKAQLLYYVNLLLIDHRFLLRHGDYVLHMW-----------QISGKAEEQGSFN--------- 498

  Fly   181 KHRNGQVQKVDWLDRLTFREIEVIN-EREKRMSDYMFLMIEFPAIVVDDMYNYAVVYFEPEGDVK 244
                        .|:||    ...| ::|..||..:.|          |.|.:.:
Mouse   499 ------------ADKLT----SATNPDKENSMSISILL----------DNYCHPI---------- 527

  Fly   245 YKLPAKPKLVSVPDSEIQMENLVERKHHRLARSERSGISDR-DAKPTASIRDQLHTIVYRYPPTY 308
                |.||....||.|                      .|| .|:....:|.||..|: ...|..
Mouse   528 ----ALPKHRPTPDPE----------------------GDRVRAEMPNQLRKQLEAII-ATDPLN 565

  Fly   309 VLSSEEQDLVWKFRFYLSSHKKALTKFLKCINWKLEDEVTQALWMLAN---W--APMDVEDALEL 368
            .|::|:::|:|.||:....|.||..|....:.|..::.|.:...:||.   |  :.:||...::|
Mouse   566 PLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREIWDQSALDVGLTMQL 630

  Fly   369 LSPTFTHPQVRKYAVSRLAQAPDEDLLLYLLQLVQALKYEDPRHIVHLHGCIFPERDVVRSILDD 433
            |...|:...||..||.:|....|:|:|.||||||||:|:| |.|
Mouse   631 LDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFE-PYH--------------------- 673

  Fly   434 NGSLLDQSSLSDLSATSSGLHGSVIPANQRAASVLAAIKSDKSVSPGSAGGSGSGGQGSVALPNP 498
                                                                             
Mouse   674 ----------------------------------------------------------------- 673

  Fly   499 SAPATPGSSSLPCDSNSNALMLAEGISFGSVPANLCTFLIQRACTNATLANYFYWYLSIEVEEVE 563
                         ||                  .|..||::|...|..:.::.:|:|..|:
Mouse   674 -------------DS------------------ALARFLLKRGLRNKRIGHFLFWFLRSEI---- 703

  Fly   564 SVRKQDERAHDMYAMVLKMFLKVLENGNFNLRG----IFYNLRKQRRFIDELVKL---VKLVAKE 621
               .|.......:|::|:.:          |||    :..:..:|...|:.|.|:   :|.::.|
Mouse   704 ---AQSRHYQQRFAVILEAY----------LRGCGTAMLQDFTQQVHVIEMLQKVTIDIKSLSAE 755

  Fly   622 PGNRNKKTEKFQKLLAE--QDMFKVNFTNF-EPIPFPLDPEIYITKIVPMRTSLFKSALMPAKLT 683
                  |.:...:::::  |.:..:..:|. |....|.||.:....:|..:..:..|...|..|.
Mouse   756 ------KYDVSSQVISQLKQKLESLQNSNLPESFRVPYDPGLKAGTLVIEKCKVMASKKKPLWLE 814

  Fly   684 F----VTSIAHHEYAAIFKHGDDLRQDQLILQMITLMDKLLRRENLDLKLTPYKVLATSSKHGFL 744
            |    .|.:::.....|||||||||||.||||::.:|:.:...|:|||.|.||..::|..|.|.:
Mouse   815 FKCADPTVLSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMI 879

  Fly   745 QYV-DSCTVAEV-LAREGN--------IHNFFRKHHPCDNGPYGISAEVMDTYIKSCAGYCVITY 799
            :.| |:.|:|:: .:..||        ::::.::..|.:.   ...|.| :.::.|||||||.|:
Mouse   880 EIVKDATTIAQIQQSTVGNTGAFKDEVLNHWLKEKCPIEE---KFQAAV-ERFVYSCAGYCVATF 940

  Fly   800 LLGVGDRHLDNLLLTTNGKLFHIDFGYILGRDPKPM-----PPPMKLSKEMVEAMGGI---SSEH 856
            :||:||||.||::::..|.|||||||:|||.....:     ..|..|:.:.:..||..   :|.|
Mouse   941 VLGIGDRHNDNIMISETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGSSGKKTSPH 1005

  Fly   857 HHEFRKQCYTAYLHLRRHANVMLNLFSLMVDATVPDIALEPDKAVKKVEENLQLGLTDEEAVQHL 921
            ..:|:..|..|||.||.|.|:::.|||:|:...:|.:..:.|  ::.:.:.|.:|.::|:|.::.
Mouse  1006 FQKFQDVCVRAYLALRHHTNLLIILFSMMLMTGMPQLTSKED--IEYIRDALTVGKSEEDAKKYF 1068

  Fly   922 QSLLDV 927
            ...::|
Mouse  1069 LDQIEV 1074

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K59F	NP_477133.1	C2_PI3K_class_III	27..186	CDD:176042	36/189 (19%)
		PI3Ka_III	284..561	CDD:238442	58/282 (21%)
		PI3Kc_III	601..945	CDD:270628	107/355 (30%)
Pik3cg	NP_064668.2	PIK3CG_ABD	1..192	CDD:466155
		PI3K_rbd	203..312	CDD:197540
		C2_PI3K_class_I_gamma	350..527	CDD:176044	44/229 (19%)
		PI3Ka_I	549..725	CDD:238444	61/311 (20%)
		PI3Kc_IB_gamma	729..1095	CDD:270627	107/358 (30%)
		G-loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269	803..809		1/5 (20%)
		Catalytic loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269	943..951		5/7 (71%)
		Activation loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269	962..988		9/25 (36%)