Protein Alignment Pi3K59F and Pik3cg

DIOPT Version :10

• Sequence 1: NP_477133.1
• Gene: Pi3K59F / 37733
• FlyBaseID: FBgn0015277
• Length: 949
• Species: Drosophila melanogaster
• Sequence 2: NP_001358229.1
• Gene: Pik3cg / 298947
• RGDID: 1306468
• Length: 1102
• Species: Rattus norvegicus
• Alignment Length: 979
• Identity: 226/979 - (23%)
• Similarity: 378/979 - (38%)
• Gaps: 308/979 - (31%)

  Fly    17 HERVQIKVGTLEGKKRQPDYEKLLED--------------PIL-RFSGLYSEEHPSFQVRLQVFN 66
            ||::     |:.||..:..:...|.|              |:| |.:.|......:.|...||..
  Rat   336 HEQL-----TIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLC 395

  Fly    67 QGRPYCLPVTSSYKAFGKRWSWNEWVTLPLQFSDLPRSAMLVLTILDC----------------S 115
            |.|       :|.|.|.:...||.|:...::..|||:.|:|.|.|..|                .
  Rat   396 QRR-------TSPKLFTEEVLWNVWLEFGIKIKDLPKGALLNLQIYCCKTPSLSSKASVETPGSE 453

  Fly   116 GAGQTTVIGGTSISMFGKDGMFRQGMYDLRVWLGVEGDGNFPSRTPGKGKESSKSQMQRLGKLAK 180
            ..|:..::...::.:.....:.|.|.|.|.:|           :..||.:|.....
  Rat   454 SKGKAQLLYYVNLLLIDHRFLLRHGGYVLHMW-----------QISGKAEEQGSFN--------- 498

  Fly   181 KHRNGQVQKVDWLDRLTFREIEVIN-EREKRMSDYMFLMIEFPAIVVDDMYNYAVVYFEPEGDVK 244
                        .|:||    ...| ::|..||..:.|          |.|.:.:
  Rat   499 ------------ADKLT----SATNPDKENSMSISILL----------DNYCHPI---------- 527

  Fly   245 YKLPAKPKLVSVPDSEIQMENLVERKHHRLARSERSGISDR-DAKPTASIRDQLHTIVYRYPPTY 308
                |.||....||.|                      .|| .|:....:|.||..|: ...|..
  Rat   528 ----ALPKHRPTPDPE----------------------GDRVRAEMPNQLRKQLEAII-ATDPLN 565

  Fly   309 VLSSEEQDLVWKFRFYLSSHKKALTKFLKCINWKLEDEVTQALWMLAN---W--APMDVEDALEL 368
            .|::|:::|:|.||:....|.||..|....:.|..::.|.:...:||.   |  :.:||...::|
  Rat   566 PLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREIWDQSALDVGLTMQL 630

  Fly   369 LSPTFTHPQVRKYAVSRLAQAPDEDLLLYLLQLVQALKYEDPRHIVHLHGCIFPERDVVRSILDD 433
            |...|:...||..||.:|....|:|:|.||||||||:|:| |.|
  Rat   631 LDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFE-PYH--------------------- 673

  Fly   434 NGSLLDQSSLSDLSATSSGLHGSVIPANQRAASVLAAIKSDKSVSPGSAGGSGSGGQGSVALPNP 498
                                                                             
  Rat   674 ----------------------------------------------------------------- 673

  Fly   499 SAPATPGSSSLPCDSNSNALMLAEGISFGSVPANLCTFLIQRACTNATLANYFYWYLSIEVEEVE 563
                         ||                  .|..||::|...|..:.::.:|:|..|:
  Rat   674 -------------DS------------------ALARFLLKRGLRNKRIGHFLFWFLRSEI---- 703

  Fly   564 SVRKQDERAHDMYAMVLKMFLKVLENGNFNLRGIFYNLRKQRRFIDELVKL---VKLVAKEPGNR 625
               .|.......:|::|:.:|:...      :.:..:..:|...|:.|.|:   :|.::.|..:.
  Rat   704 ---AQSRHYQQRFAVILEAYLRGCG------KAMLQDFTQQVHVIEMLQKVTIDIKSLSAEKYDV 759

  Fly   626 NKK--TEKFQKLLAEQDMFKVNFTNFEPIPFPLDPEIYITKIVPMRTSLFKSALMPAKLTF---- 684
            :.:  ::..|||.:.|     |.:..|....|.||.:....:|..:..:..|...|..|.|
  Rat   760 SSQVISQLKQKLESLQ-----NSSLPESFRVPYDPGLKAGTLVIEKCKVMASKKKPLWLEFKRAD 819

  Fly   685 VTSIAHHEYAAIFKHGDDLRQDQLILQMITLMDKLLRRENLDLKLTPYKVLATSSKHGFLQYV-D 748
            .|.:::.....|||||||||||.||||::.:|:.:...|:|||.|.||..::|..|.|.::.| |
  Rat   820 PTVLSNETIGIIFKHGDDLRQDMLILQILRIMESIWEAESLDLCLLPYGCISTGDKIGMIEIVKD 884

  Fly   749 SCTVAEV-LAREGN--------IHNFFRKHHPCDNGPYGISAEVMDTYIKSCAGYCVITYLLGVG 804
            :.|:|:: .:..||        ::::.::..|.:.   ...|.| :.::.|||||||.|::||:|
  Rat   885 ATTIAQIQQSTVGNTGAFKDEVLNHWLKEKCPIEE---KFQAAV-ERFVYSCAGYCVATFVLGIG 945

  Fly   805 DRHLDNLLLTTNGKLFHIDFGYILG-----------RDPKPMPPPMKLSKEMVEAMGGISSEHHH 858
            |||.||::::..|.|||||||:|||           |.|..:.|....   ::...|..:|.|..
  Rat   946 DRHNDNIMISETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLF---VMGTSGKKTSPHFQ 1007

  Fly   859 EFRKQCYTAYLHLRRHANVMLNLFSLMVDATVPDIALEPDKAVKKVEENLQLGLTDEEAVQHLQS 923
            :|:..|..|||.||.|.|:::.|||:|:...:|.:..:.|  ::.:.:.|.:|.::|:|.::...
  Rat  1008 KFQDVCVRAYLALRHHTNLLIILFSMMLMTGMPQLTSKED--IEYIRDALMVGRSEEDAKKYFLD 1070

  Fly   924 LLDV 927
            .::|
  Rat  1071 QIEV 1074

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K59F	NP_477133.1	C2_PI3K_class_III	27..186	CDD:176042	36/189 (19%)
		PI3Ka_III	284..561	CDD:238442	58/282 (21%)
		PI3Kc_III	601..945	CDD:270628	109/357 (31%)
Pik3cg	NP_001358229.1	PIK3CG_ABD	1..192	CDD:466155
		PI3K_rbd	203..312	CDD:197540
		C2_PI3K_class_I_gamma	350..527	CDD:176044	44/229 (19%)
		PI3Ka_I	549..725	CDD:238444	59/301 (20%)
		PI3Kc_IB_gamma	729..1095	CDD:270627	109/360 (30%)