DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pi3K59F and Pik3cg

DIOPT Version :9

Sequence 1:	NP_477133.1	Gene:	Pi3K59F / 37733	FlyBaseID:	FBgn0015277	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	NP_001358229.1	Gene:	Pik3cg / 298947	RGDID:	1306468	Length:	1102	Species:	Rattus norvegicus

Alignment Length:	978	Identity:	223/978 - (22%)
Similarity:	375/978 - (38%)	Gaps:	306/978 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 HERVQIKVGTLEGKKRQPDYEKLLED--------------PIL-RFSGLYSEEHPSFQVRLQVFN 66
            ||::     |:.||..:..:...|.|              |:| |.:.|......:.|...||..
  Rat   336 HEQL-----TIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLC 395

  Fly    67 QGRPYCLPVTSSYKAFGKRWSWNEWVTLPLQFSDLPRSAMLVLTILDC----------------S 115
            |.|       :|.|.|.:...||.|:...::..|||:.|:|.|.|..|                .
  Rat   396 QRR-------TSPKLFTEEVLWNVWLEFGIKIKDLPKGALLNLQIYCCKTPSLSSKASVETPGSE 453

  Fly   116 GAGQTTVIGGTSISMFGKDGMFRQGMYDLRVWLGVEGDGNFPSRTPGKGKESSKSQMQRLGKLAK 180
            ..|:..::...::.:.....:.|.|.|.|.:|           :..||.:|.......:|.....
  Rat   454 SKGKAQLLYYVNLLLIDHRFLLRHGGYVLHMW-----------QISGKAEEQGSFNADKLTSATN 507

  Fly   181 KHRNGQVQKVDWLDRLTFREIEVINEREKRMSDYMFLMIEFPAIVVDDMYNYAVVYFEPEGDVKY 245
            .                        ::|..||..:.|          |.|.:.:
  Rat   508 P------------------------DKENSMSISILL----------DNYCHPI----------- 527

  Fly   246 KLPAKPKLVSVPDSEIQMENLVERKHHRLARSERSGISDR-DAKPTASIRDQLHTIVYRYPPTYV 309
               |.||....||.|                      .|| .|:....:|.||..|: ...|...
  Rat   528 ---ALPKHRPTPDPE----------------------GDRVRAEMPNQLRKQLEAII-ATDPLNP 566

  Fly   310 LSSEEQDLVWKFRFYLSSHKKALTKFLKCINWKLEDEVTQALWMLAN---W--APMDVEDALELL 369
            |::|:::|:|.||:....|.||..|....:.|..::.|.:...:||.   |  :.:||...::||
  Rat   567 LTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREIWDQSALDVGLTMQLL 631

  Fly   370 SPTFTHPQVRKYAVSRLAQAPDEDLLLYLLQLVQALKYEDPRHIVHLHGCIFPERDVVRSILDDN 434
            ...|:...||..||.:|....|:|:|.||||||||:|:| |.|
  Rat   632 DCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFE-PYH---------------------- 673

  Fly   435 GSLLDQSSLSDLSATSSGLHGSVIPANQRAASVLAAIKSDKSVSPGSAGGSGSGGQGSVALPNPS 499

  Rat   674 ----------------------------------------------------------------- 673

  Fly   500 APATPGSSSLPCDSNSNALMLAEGISFGSVPANLCTFLIQRACTNATLANYFYWYLSIEVEEVES 564
                        ||                  .|..||::|...|..:.::.:|:|..|:
  Rat   674 ------------DS------------------ALARFLLKRGLRNKRIGHFLFWFLRSEI----- 703

  Fly   565 VRKQDERAHDMYAMVLKMFLKVLENGNFNLRGIFYNLRKQRRFIDELVKL---VKLVAKEPGNRN 626
              .|.......:|::|:.:|:...      :.:..:..:|...|:.|.|:   :|.::.|..:.:
  Rat   704 --AQSRHYQQRFAVILEAYLRGCG------KAMLQDFTQQVHVIEMLQKVTIDIKSLSAEKYDVS 760

  Fly   627 KK--TEKFQKLLAEQDMFKVNFTNFEPIPFPLDPEIYITKIVPMRTSLFKSALMPAKLTF----V 685
            .:  ::..|||.:.|     |.:..|....|.||.:....:|..:..:..|...|..|.|    .
  Rat   761 SQVISQLKQKLESLQ-----NSSLPESFRVPYDPGLKAGTLVIEKCKVMASKKKPLWLEFKRADP 820

  Fly   686 TSIAHHEYAAIFKHGDDLRQDQLILQMITLMDKLLRRENLDLKLTPYKVLATSSKHGFLQYV-DS 749
            |.:::.....|||||||||||.||||::.:|:.:...|:|||.|.||..::|..|.|.::.| |:
  Rat   821 TVLSNETIGIIFKHGDDLRQDMLILQILRIMESIWEAESLDLCLLPYGCISTGDKIGMIEIVKDA 885

  Fly   750 CTVAEV-LAREGN--------IHNFFRKHHPCDNGPYGISAEVMDTYIKSCAGYCVITYLLGVGD 805
            .|:|:: .:..||        ::::.::..|.:.   ...|.| :.::.|||||||.|::||:||
  Rat   886 TTIAQIQQSTVGNTGAFKDEVLNHWLKEKCPIEE---KFQAAV-ERFVYSCAGYCVATFVLGIGD 946

  Fly   806 RHLDNLLLTTNGKLFHIDFGYILG-----------RDPKPMPPPMKLSKEMVEAMGGISSEHHHE 859
            ||.||::::..|.|||||||:|||           |.|..:.|....   ::...|..:|.|..:
  Rat   947 RHNDNIMISETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLF---VMGTSGKKTSPHFQK 1008

  Fly   860 FRKQCYTAYLHLRRHANVMLNLFSLMVDATVPDIALEPDKAVKKVEENLQLGLTDEEAVQHLQSL 924
            |:..|..|||.||.|.|:::.|||:|:...:|.:..:.|  ::.:.:.|.:|.::|:|.::....
  Rat  1009 FQDVCVRAYLALRHHTNLLIILFSMMLMTGMPQLTSKED--IEYIRDALMVGRSEEDAKKYFLDQ 1071

  Fly   925 LDV 927
            ::|
  Rat  1072 IEV 1074

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K59F	NP_477133.1	C2_PI3K_class_III	27..186	CDD:176042	37/189 (20%)
		PI3Ka_III	284..561	CDD:238442	58/282 (21%)
		PI3Kc_III	601..945	CDD:270628	109/357 (31%)
Pik3cg	NP_001358229.1	PI3K_rbd	203..312	CDD:197540
		C2_PI3K_class_I_gamma	350..527	CDD:176044	41/228 (18%)
		PI3Ka_I	549..725	CDD:238444	59/301 (20%)
		PI3Kc_IB_gamma	729..1095	CDD:270627	109/360 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D204282at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920