DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pi3K59F and Pik3c2b

DIOPT Version :9

Sequence 1:NP_477133.1 Gene:Pi3K59F / 37733 FlyBaseID:FBgn0015277 Length:949 Species:Drosophila melanogaster
Sequence 2:XP_006249816.1 Gene:Pik3c2b / 289021 RGDID:1306541 Length:1633 Species:Rattus norvegicus


Alignment Length:957 Identity:214/957 - (22%)
Similarity:344/957 - (35%) Gaps:321/957 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    50 LYSEEHPSFQVRLQVFNQGRPYCLPVTSSYKAFGKRW----SWNEWVTLPLQFSDLPRSAMLVLT 110
            :::..:..|.:...:.:.|:..|.|:.:....|.|..    .|::.:..|:|.:.|||..:|..|
  Rat   643 IWATSYEEFYLSCSLSHGGKELCSPLQTRRAHFSKYLFHLIIWDQQICFPVQVNRLPRETLLCAT 707

  Fly   111 ILDCSGAGQTTVIGGTSISMFGKDGMFRQGMYDLRVWLGVEGDGNFPSRTPGKGKESSKSQM--Q 173
                                          :|.|            |...||...|::|.:.  :
  Rat   708 ------------------------------LYAL------------PIPPPGSSSEANKQKRVPE 730

  Fly   174 RLGKLAKKHRNGQVQKVDWLDRLTFREIEVINEREKRMS---------------------DYMFL 217
            .||               |:....|...:|:....|.:.                     |.:.|
  Rat   731 ALG---------------WVTTPLFNFRQVLTCGRKLLGLWPATQENSSARWSAPNFHQPDSVIL 780

  Fly   218 MIEFPAIVVDDMYNYAVVYFEPEGDVKYKLPAKPKLVSVPDSEIQMENLVERKHHRLARSERSGI 282
            .|:||....|      :.:..|.|| |:.                            .|.|...:
  Rat   781 QIDFPTSAFD------IKFTSPPGD-KFS----------------------------PRYEFGSL 810

  Fly   283 SDRDAKPTASIRDQLHTIVYRYPPTYVLSSEEQDLVWKFRFYLSSHKKALTKFL-KCINWKLEDE 346
            .:.|.:....|..:        ...|.||..::..:|:.|:|..:...:|...| ...:|:    
  Rat   811 REEDQRKLKDITQK--------ESLYWLSDADKKQLWEKRYYCHTEVSSLPLVLASAPSWE---- 863

  Fly   347 VTQALW--------MLANWAPMDVEDALELLSPTFTHPQVRKYAVSRLAQAPDEDLLLYLLQLVQ 403
                 |        :|..|..|:.:|||.||..||...:||:.||..:....|.:||.||.||||
  Rat   864 -----WACLPDIYALLQQWTHMNHQDALGLLHATFPDQEVRRMAVQWIGSLSDAELLDYLPQLVQ 923

  Fly   404 ALKYEDPRHIVHLHGCIFPERDVVRSILDDNGSLLDQSSLSDLSATSSGLHGSVIPANQRAASVL 468
            |||||          |                 .||                             
  Rat   924 ALKYE----------C-----------------YLD----------------------------- 932

  Fly   469 AAIKSDKSVSPGSAGGSGSGGQGSVALPNPSAPATPGSSSLPCDSNSNALMLAEGISFGSVPANL 533
                     ||                                                     |
  Rat   933 ---------SP-----------------------------------------------------L 935

  Fly   534 CTFLIQRACTNATLANYFYWYLSIEVEEVE-SVRKQDERAHDMYAMVLKMFLKVLENGNFNLRGI 597
            ..||::||.::..:.:||:|.|...:::.: |:|         |..:|...|.....|   ||..
  Rat   936 VRFLLKRAISDLRVTHYFFWLLKDSLKDSQFSIR---------YQYLLAALLCCCGKG---LREE 988

  Fly   598 FYNLRKQRRFIDELVKLVKLVAK-EPGNRNKKTEKFQKLLAE-----QDMFKVNFTNFEPIPFPL 656
            |   .:|...::.|.||.:.|.: .|..|       |.:|..     :..|.:|.:    ...||
  Rat   989 F---NRQCWLVNTLAKLAQQVREATPSAR-------QGILRAGLEEVRQFFALNGS----CRLPL 1039

  Fly   657 DPEIYITKIVPMRTSLFKSALMPAKLTF--VTSIAHHEYAAIFKHGDDLRQDQLILQMITLMDKL 719
            .|.:.:..|||...|.|.|..:|.||.|  |..:..: ...|||.|||||||.|.||||.:|.|:
  Rat  1040 SPSLLVKGIVPRDCSYFNSNAVPLKLAFQNVDPLGEN-IRVIFKCGDDLRQDMLTLQMIRIMSKI 1103

  Fly   720 LRRENLDLKLTPYKVLATSSKHGFLQYVDSC-TVAEVLAREGNIHNF--------FRKHHPCDNG 775
            ..:|.||:::..::..:|....|.::.:.:. |:.::....|...:|        .:||:|.:: 
  Rat  1104 WVQEGLDMRMVIFRCFSTGRGKGMVEMIPNAETLRKIQVEHGVTGSFKDRPLADWLQKHNPGED- 1167

  Fly   776 PYGISAEVMDTYIKSCAGYCVITYLLGVGDRHLDNLLLTTNGKLFHIDFGYILGR-----DPKPM 835
            .|   .:.::.:|.||||.||.||:||:.|||.||::|.|.|.:||||||..||.     :.|..
  Rat  1168 EY---EKAVENFIYSCAGCCVATYILGICDRHNDNIMLKTTGHMFHIDFGRFLGHAQMFGNIKRD 1229

  Fly   836 PPPMKLSKEMVEAMGG--ISSEHHHEFRKQCYTAYLHLRRHANVMLNLFSLMVDATVPDIALEPD 898
            ..|...:.:|...:.|  ..|...|:|...|..||..:|:|.::.|||..||:...:|:::...|
  Rat  1230 RAPFVFTSDMAYVINGGDKPSSRFHDFVDLCCQAYNLIRKHTHLFLNLLGLMLSCGIPELSDLED 1294

  Fly   899 KAVKKVEENLQLGLTDEEAVQHLQSLLDVSITAVMPALVEQIHRFTQ 945
              :|.|.:.|:...|:..|..:...|::.|:.:|...|...||...|
  Rat  1295 --LKYVYDALRPQDTEANATTYFTRLIESSLGSVATKLNFFIHNLAQ 1339

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pi3K59FNP_477133.1 C2_PI3K_class_III 27..186 CDD:176042 23/141 (16%)
PI3Ka_III 284..561 CDD:238442 54/285 (19%)
PI3Kc_III 601..945 CDD:270628 111/367 (30%)
Pik3c2bXP_006249816.1 PI3K_rbd 363..465 CDD:395642
C2A_PI3K_class_II 621..793 CDD:175979 33/212 (16%)
PI3Ka_II 812..980 CDD:238441 59/311 (19%)
PI3Kc_C2_beta 986..1339 CDD:119421 113/373 (30%)
PX_PI3K_C2_beta 1368..1476 CDD:132823
C2B_PI3K_class_II 1504..1626 CDD:176027
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D204282at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.820

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