Protein Alignment Pi3K59F and SH3PXD2B

DIOPT Version :9

• Sequence 1: NP_477133.1
• Gene: Pi3K59F / 37733
• FlyBaseID: FBgn0015277
• Length: 949
• Species: Drosophila melanogaster
• Sequence 2: XP_016864840.1
• Gene: SH3PXD2B / 285590
• HGNCID: 29242
• Length: 939
• Species: Homo sapiens
• Alignment Length: 509
• Identity: 101/509 - (19%)
• Similarity: 152/509 - (29%)
• Gaps: 197/509 - (38%)

  Fly   134 DGMFRQ--GMYDLRVWLGVEGDGNFPSR--TPGKGKESSKSQMQRLG-----------KLAKKHR 183
            ||:.||  .:...:..|..:.||.|..|  ..|..|:.|....||..           .|.|...
Human   329 DGVSRQQNAVGREKELLSSQRDGRFEGRPVPDGDAKQRSPKMRQRPPPRRDMTIPRGLNLPKPPI 393

  Fly   184 NGQVQKVDWL---------DRLTFR---EIEVINEREKRMSDYMFLMIE-----FPAIVVDDMYN 231
            ..||::..:.         |.::|:   ::|||   ||.:|.:.::.||     .||..:|
Human   394 PPQVEEEYYTIAEFQTTIPDGISFQAGLKVEVI---EKNLSGWWYIQIEDKEGWAPATFID---- 451

  Fly   232 YAVVYFEPEGDVKYKL---PAKPK-LVSVPDSEIQ--------MEN------------LVERKHH 272
                        |||.   .::|. |..:|....|        :||            |.:..|.
Human   452 ------------KYKKTSNASRPNFLAPLPHEVTQLRLGEAAALENNTGSEATGPSRPLPDAPHG 504

  Fly   273 -------------------RLARSERSG------ISDRDAKPTASIRDQLHTIVYR--------- 303
                               |.|.|:.|.      |||.|.:...|:..:..:|:..
Human   505 VMDSGLPWSKDWKGSKDVLRKASSDMSASAGYEEISDPDMEEKPSLPPRKESIIKSEGELLERER 569

  Fly   304 -------------YPPTYVL-------------SSEEQDLVWKFRFY-------LSSHKKALTKF 335
                         .||..:|             |...:....|.|.:       |....|.|.|.
Human   570 ERQRTEQLRGPTPKPPGVILPMMPAKHIPPARDSRRPEPKPDKSRLFQLKNDMGLECGHKVLAKE 634

  Fly   336 LKCINWKLEDEVTQALWMLANWAPMDVEDALELLSPTFTHPQVR-KYAVSRLAQAPDEDLLLYLL 399
            :|..|.:...:....|       |.:..||........:.|||| |.|.|...:.|
Human   635 VKKPNLRPISKSKTDL-------PEEKPDATPQNPFLKSRPQVRPKPAPSPKTEPP--------- 683

  Fly   400 QLVQALKYEDPRHIVHLHGCIFPERDVVRSILDDNGSLLDQSSLSDLSATSSGLHGSVIPANQRA 464
                  :.||...|.:|...:.|.:...:|:||..|.  ......|::.:.|.|.|.
Human   684 ------QGEDQVDICNLRSKLRPAKSQDKSLLDGEGP--QAVGGQDVAFSRSFLPGE-------- 732

  Fly   465 ASVLAAIKSDKSVSPGSAGGSGSGGQGSV--------ALPNPSAPATPGSSSLP 510
                         .||.| ...:|.|..:        |.|.|:....|.|.|:|
Human   733 -------------GPGRA-QDRTGKQDGLSPKEISCRAPPRPAKTTDPVSKSVP 772

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K59F	NP_477133.1	C2_PI3K_class_III	27..186	CDD:176042	16/66 (24%)
		PI3Ka_III	284..561	CDD:238442	53/278 (19%)
		PI3Kc_III	601..945	CDD:270628
SH3PXD2B	XP_016864840.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900