DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pi3K59F and pik3

DIOPT Version :9

Sequence 1:NP_477133.1 Gene:Pi3K59F / 37733 FlyBaseID:FBgn0015277 Length:949 Species:Drosophila melanogaster
Sequence 2:NP_594699.1 Gene:pik3 / 2543444 PomBaseID:SPAC458.05 Length:801 Species:Schizosaccharomyces pombe


Alignment Length:965 Identity:339/965 - (35%)
Similarity:503/965 - (52%) Gaps:194/965 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 FRYIHSSSLHERVQIKVGTLEGKKRQPDYEKLLEDP----ILRFSGLYSEEHPSFQVRLQVFNQG 68
            |.|..||.:..|..:|...:|.:..|        :|    |..|||   .|..|...:..|....
pombe     6 FSYCPSSKVTARFLVKFCFIEYQDSQ--------EPCICTIQLFSG---NESGSLMQKCFVSKIP 59

  Fly    69 RPYCLPVTSSYKAFGKRWSWNEWVTLPLQFSDLPRSAMLVLTILDCSGAGQTT--VIGGTSISMF 131
            ....||...|      :.|.:||:...:..|:|..:|..|::....|...:..  .:|.|:..:|
pombe    60 NKSLLPTELS------KISTHEWLDFGVTVSELSLNAKFVVSAWKPSFNDEEVYEFVGCTTYRLF 118

  Fly   132 GKDGMFRQGMYDLRVWLGVEGDGNFPSRTPGKGKESSKSQMQ--------RLGKLAKKHRNGQVQ 188
            .::.:.|||:..:            |.:|..:.|:.|.:.::        ||..|..|.:.|.|.
pombe   119 DENNLLRQGLQKI------------PLQTSKEIKKYSPTSLELEQVKEINRLDGLLLKLQLGDVP 171

  Fly   189 KVDWLDRLTFREIEVINEREKRMSDYMFLMIEFPAIVVDDM-YNYAVV-----YFEPEGDVKYKL 247
            .|:|||.::|.:|:  :.|.|.||     ::..|.:.:|.: :::.||     |.:.|..|.|  
pombe   172 SVNWLDDISFGKIK--DFRSKHMS-----LVTIPILYLDFLQFSFPVVFQRSYYPKSENRVYY-- 227

  Fly   248 PAKPKLVSVPDSEIQMENLVERKHHRLARSERSGISDRDAKPTASIRDQLHTIVYRYPPTYVLSS 312
                   |..|.|:.:::..|.||.||.||:|:|..|:|.||.:.||.:|.:|: .|||:..||.
pombe   228 -------SSFDLELNLDSPAELKHRRLVRSQRNGPLDKDLKPNSKIRKELESIL-SYPPSEELSL 284

  Fly   313 EEQDLVWKFRFYLSSHKKALTKFLKCINWKLEDEVTQALWMLANWAPMDVEDALELLSPTFTHPQ 377
            ||:||:|||||||:.:|||:|||||.:.|....||.|||.:|.:|..:|::||||||||:|.||:
pombe   285 EEKDLIWKFRFYLTRNKKAMTKFLKSVVWTDSSEVNQALSLLDSWTEIDIDDALELLSPSFVHPK 349

  Fly   378 VRKYAVSRLAQAPDEDLLLYLLQLVQALKYEDPRHIVHLHGCIFPERDVVRSILDDNGSLLDQSS 442
            ||.||||||..|.:|:||||||||||||:|::|                                
pombe   350 VRAYAVSRLETASNEELLLYLLQLVQALRYDNP-------------------------------- 382

  Fly   443 LSDLSATSSGLHGSVIPANQRAASVLAAIKSDKSVSPGSAGGSGSGGQGSVALPNPSAPATPGSS 507
                                        |.||:...                             
pombe   383 ----------------------------ISSDERFQ----------------------------- 390

  Fly   508 SLPCDSNSNALMLAEGISFGSVPANLCTFLIQRACTNATLANYFYWYLSIEVEEVESVRKQDERA 572
                                  |:.|..||:.||.::.::.|..||||.:|:|        ||..
pombe   391 ----------------------PSPLALFLVNRAISSPSIGNDLYWYLVVEIE--------DEPV 425

  Fly   573 HDMYAMVLKMFLKVLENGNFNLRGIFYNLRKQRRFIDELVKLVKLVAKEPGNRNKKTEKFQKLLA 637
            ..:::.|:.:|.|.|.. :...|.|...|..|.:|:::|:::.|.|....|.|.||.|..:.||.
pombe   426 SKLFSSVMFLFQKELSK-SVEGRLIRETLSAQAKFVEKLLRISKSVQSFRGTRLKKIEYLKVLLE 489

  Fly   638 EQDMFKVNFTNFEPIPFPLDPEIYITKIVPMRTSLFKSALMPAKLTFVTSIAHHEYAAIFKHGDD 702
            :.   |.:..:|..:|.||||.:.|..|:|...::|||.:.|.:|.|..... .:|..|||:|||
pombe   490 DH---KYHLLDFHALPLPLDPSVNIVGIIPDACTVFKSTMQPLRLLFKCQDG-SKYPIIFKNGDD 550

  Fly   703 LRQDQLILQMITLMDKLLRRENLDLKLTPYKVLATSSKHGFLQYVDSCTVAEVLAR-EGNIHNFF 766
            ||||||::|::|||||||::|.|||.|.||::|||...||.:|:|.|.|:|.:||. .|::..:.
pombe   551 LRQDQLVIQILTLMDKLLKKEKLDLHLKPYRILATGPTHGAVQFVPSKTLATILAEYHGSVLAYL 615

  Fly   767 RKHHPCD---NGPYGISAEVMDTYIKSCAGYCVITYLLGVGDRHLDNLLLTTNGKLFHIDFGYIL 828
            |:::|.|   :..|||....||.|::|||||||||||||||||||||||:|.:|..||.||||||
pombe   616 RENNPDDGLNSANYGIDPVAMDNYVRSCAGYCVITYLLGVGDRHLDNLLITKDGHFFHADFGYIL 680

  Fly   829 GRDPKPMPPPMKLSKEMVEAMGGISSEHHHEFRKQCYTAYLHLRRHANVMLNLFSLMVDATVPDI 893
            |||||...|.|||||||||.|||.:|..:.:|:..|||.:..||:.:|::||||||||||.:|||
pombe   681 GRDPKLFSPAMKLSKEMVEGMGGYNSPFYQQFKSYCYTTFTALRKSSNLILNLFSLMVDANIPDI 745

  Fly   894 ALEPDKAVKKVEENLQLGLTDEEAVQHLQSLLDVSITAVMPALVEQIHRFTQYWR 948
            ..:.:|.|.||:|...|.:::.:|:::.:.|::.|::|:.|.:::::|...||.|
pombe   746 KFDKEKVVYKVKERFCLQMSESDAIKYFEQLINDSVSALFPQIIDRMHNLAQYMR 800

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pi3K59FNP_477133.1 C2_PI3K_class_III 27..186 CDD:176042 35/172 (20%)
PI3Ka_III 284..561 CDD:238442 91/276 (33%)
PI3Kc_III 601..945 CDD:270628 163/347 (47%)
pik3NP_594699.1 TEL1 <1..801 CDD:227365 339/965 (35%)
C2 30..181 CDD:301316 40/179 (22%)
PI3Ka_III 257..422 CDD:238442 92/284 (32%)
PI3Kc_III 450..797 CDD:270628 163/350 (47%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Domainoid 1 1.000 190 1.000 Domainoid score I729
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H1986
Inparanoid 1 1.050 568 1.000 Inparanoid score I182
OMA 1 1.010 - - QHG54334
OrthoFinder 1 1.000 - - FOG0005021
OrthoInspector 1 1.000 - - oto102130
orthoMCL 1 0.900 - - OOG6_101850
Panther 1 1.100 - - LDO PTHR10048
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1651
SonicParanoid 1 1.000 - - X3549
TreeFam 1 0.960 - -
1413.860

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