DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pi3K59F and MTOR

DIOPT Version :9

Sequence 1:NP_477133.1 Gene:Pi3K59F / 37733 FlyBaseID:FBgn0015277 Length:949 Species:Drosophila melanogaster
Sequence 2:NP_001373429.1 Gene:MTOR / 2475 HGNCID:3942 Length:2549 Species:Homo sapiens


Alignment Length:895 Identity:174/895 - (19%)
Similarity:302/895 - (33%) Gaps:267/895 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   129 SMFGKDGMFRQGMYDLRVWLGVEGDGNFPSRTPGKGKESSKSQMQRLGKLAKK-----HRNGQVQ 188
            |:.||.|........|.:.|||:.........|....:.:.:.|:.:.|.|:|     |....||
Human  1658 SLCGKSGRLALAHKTLVLLLGVDPSRQLDHPLPTVHPQVTYAYMKNMWKSARKIDAFQHMQHFVQ 1722

  Fly   189 KVDW----------------LDRLTFR----------EIEVINERE-KRMSDYMFLMIEFPAIVV 226
            .:..                |.:|..|          .::.|||.. .::..|.....|......
Human  1723 TMQQQAQHAIATEDQQHKQELHKLMARCFLKLGEWQLNLQGINESTIPKVLQYYSAATEHDRSWY 1787

  Fly   227 DDMYNYAVVYFEPEGDVKYKLPAKPKLVSVPDSEIQMENLVERKHHRLARSER------SGISDR 285
            ...:.:||:.||.                          ::..||...||.|:      ||.:..
Human  1788 KAWHAWAVMNFEA--------------------------VLHYKHQNQARDEKKKLRHASGANIT 1826

  Fly   286 DAKPTASIRDQLHTIVYRYPPTYVLSSEEQDLVWKFRFYLSSHKKALTKFLKCINWKLEDEVTQA 350
            :|...|:......|..    .|...:||.:         ..|.:.:.|.  ..:..|:.:::::.
Human  1827 NATTAATTAATATTTA----STEGSNSESE---------AESTENSPTP--SPLQKKVTEDLSKT 1876

  Fly   351 LWMLANWAPM------------DVEDALELLSPTFTH---PQVRKYAVSRLAQAPDEDLLLYLLQ 400
            |.|....|..            :::|.|.:|:..|.:   |.|.:..|..:.....:..|..:.|
Human  1877 LLMYTVPAVQGFFRSISLSRGNNLQDTLRVLTLWFDYGHWPDVNEALVEGVKAIQIDTWLQVIPQ 1941

  Fly   401 LVQALKYEDPRHIVHLHGCIFPERDVVRSILDDNGSLLDQSSLSDLSATSSGLHGSVIPANQRAA 465
            |:  .:.:.||.:|         ..::..:|.|.|....|:.:..|:..|.    |...|...||
Human  1942 LI--ARIDTPRPLV---------GRLIHQLLTDIGRYHPQALIYPLTVASK----STTTARHNAA 1991

  Fly   466 SVLAAIKSDKSVSPGSAGGSGSGGQGSVALPNPSAPATPGSSSLPCDSNSNALMLAEGISFGSVP 530
            :.:                          |.|            .|: :||.|:..         
Human  1992 NKI--------------------------LKN------------MCE-HSNTLVQQ--------- 2008

  Fly   531 ANLCTFLIQRACTNATLANYFYWYLSIEVEEVESVRKQDERAHDMYAMVLKMFLKVLENGNFNLR 595
                ..::........:..:..|:..:  ||...:...:.....|:. ||:....::|.|...|:
Human  2009 ----AMMVSEELIRVAILWHEMWHEGL--EEASRLYFGERNVKGMFE-VLEPLHAMMERGPQTLK 2066

  Fly   596 GIFYNLRKQRRFIDELVKLVKLVAKEPGNRNKKTEKFQKLLAEQDMFKVNF----------TNFE 650
            ...:|....|..::         |:|...:..|:...:.|....|::...|          |:.|
Human  2067 ETSFNQAYGRDLME---------AQEWCRKYMKSGNVKDLTQAWDLYYHVFRRISKQLPQLTSLE 2122

  Fly   651 ----------------PIPFPLDPEIYITKIVPMRTSL--FKSALMPAKLTFVTSIAHHEYAAIF 697
                            .:|...||...|.:|..:..||  ..|...|.|||.:.|.. ||:..:.
Human  2123 LQYVSPKLLMCRDLELAVPGTYDPNQPIIRIQSIAPSLQVITSKQRPRKLTLMGSNG-HEFVFLL 2186

  Fly   698 KHGDDLRQDQLILQMITLMDKLLR------RENLDLKLTPYKVLATSSKHGFLQYVDSCTVAEVL 756
            |..:|||||:.::|:..|::.||.      |:||.::  .|.|:..|:..|.:.:|..|.....|
Human  2187 KGHEDLRQDERVMQLFGLVNTLLANDPTSLRKNLSIQ--RYAVIPLSTNSGLIGWVPHCDTLHAL 2249

  Fly   757 AREG--------NI-HNFFRK-----------------HHPCDN-------------GPYGISAE 782
            .|:.        || |....:                 .|..:|             .|   |:|
Human  2250 IRDYREKKKILLNIEHRIMLRMAPDYDHLTLMQKVEVFEHAVNNTAGDDLAKLLWLKSP---SSE 2311

  Fly   783 V----MDTYIKSCAGYCVITYLLGVGDRHLDNLLL-TTNGKLFHIDFG----YILGRDPKPMPPP 838
            |    ...|.:|.|...::.|:||:||||..||:| ..:||:.|||||    ..:.|:..|...|
Human  2312 VWFDRRTNYTRSLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFGDCFEVAMTREKFPEKIP 2376

  Fly   839 MKLSKEMVEAM--GGISSEHHHEFRKQCYTAYLHLRRHANVMLNLFSLMV 886
            .:|::.:..||  .|:..    .:|..|:|....||.|.:.::.:....|
Human  2377 FRLTRMLTNAMEVTGLDG----NYRITCHTVMEVLREHKDSVMAVLEAFV 2422

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pi3K59FNP_477133.1 C2_PI3K_class_III 27..186 CDD:176042 14/61 (23%)
PI3Ka_III 284..561 CDD:238442 42/291 (14%)
PI3Kc_III 601..945 CDD:270628 88/370 (24%)
MTORNP_001373429.1 Interaction with NBN. /evidence=ECO:0000269|PubMed:23762398 1..651
TEL1 363..2549 CDD:227365 174/895 (19%)
HEAT 16 637..683
HEAT repeat 655..681 CDD:293787
HEAT 17 686..724
HEAT repeat 691..721 CDD:293787
HEAT 18 727..766
HEAT repeat 729..759 CDD:293787
HEAT 19 769..811
HEAT repeat 772..805 CDD:293787
HEAT 20 814..853
HEAT repeat 817..847 CDD:293787
HEAT 21 857..893
HEAT 22 894..942
HEAT 23 943..988
HEAT repeat 955..981 CDD:293787
HEAT 24 989..1027
HEAT repeat 993..1021 CDD:293787
HEAT 25 1029..1068
HEAT repeat 1033..1062 CDD:293787
HEAT 26 1069..1105
HEAT repeat 1073..1099 CDD:293787
HEAT 27 1106..1144
HEAT repeat 1111..1142 CDD:293787
HEAT 28 1145..1188
HEAT repeat 1154..1180 CDD:293787
HEAT 29 1189..1225
HEAT 30 1226..1273
HEAT 31 1274..1311
HEAT 32 1312..1345
TPR 1 1346..1382
TPR 2 1383..1408
TPR 3 1409..1442
TPR 4 1443..1473
TPR 5 1474..1507
TPR 6 1508..1541
TPR 7 1542..1574
TPR 8 1575..1614
TPR 9 1615..1649
TPR 10 1650..1693 9/34 (26%)
TPR 11 1694..1731 7/36 (19%)
TPR 12 1732..1786 8/53 (15%)
TPR 13 1787..1846 15/88 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1812..1867 11/69 (16%)
TPR 14 1898..1930 7/31 (23%)
TPR 15 1931..1970 9/49 (18%)
TPR 16 1971..2005 11/76 (14%)
Sufficient for interaction with the FKBP1A/rapamycin complex. /evidence=ECO:0000250 2012..2144 20/143 (14%)
Interaction with MLST8 2258..2296 5/37 (14%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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