DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pi3K59F and Pik3c2b

DIOPT Version :9

Sequence 1:	NP_477133.1	Gene:	Pi3K59F / 37733	FlyBaseID:	FBgn0015277	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	NP_001092746.2	Gene:	Pik3c2b / 240752	MGIID:	2685045	Length:	1632	Species:	Mus musculus

Alignment Length:	958	Identity:	210/958 - (21%)
Similarity:	342/958 - (35%)	Gaps:	323/958 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 LYSEEHPSFQVRLQVFNQGRPYCLPVTSSYKAFGKRW----SWNEWVTLPLQFSDLPRSAMLVLT 110
            :::..:..|.:...:.:.|:..|.|:.:....|.|..    .|::.:..|:|.:.|||..:|..|
Mouse   643 IWATSYEDFYLSCSLSHGGKELCSPLQTRRAHFSKYLFHLIIWDQQICFPVQVNRLPRETLLCAT 707

  Fly   111 ILDCSGAGQTTVIGGTSISMFGKDGMFRQGMYDLRVWLGVEGDGNFPSRTPGKGKESSKSQM--Q 173
                                          :|.|            |...||...|::|.:.  :
Mouse   708 ------------------------------LYAL------------PVPPPGGSSEANKQKRVPE 730

  Fly   174 RLGKLAKKHRNGQVQKVDWLDRLTFREIEVINEREKRMS---------------------DYMFL 217
            .||               |:....|...:|:....|.:.                     |.:.|
Mouse   731 ALG---------------WVTTPLFNFRQVLTCGRKLLGLWPATQENSGARWSAPNFHQPDSVIL 780

  Fly   218 MIEFPAIVVDDMYNYAVVYFEPEGDVKYKLPAKPKLVSVPDSEIQMENLVERKHHRLARSERSGI 282
            .|:||:...|      :.:..|.|| |:.                            .|.|...:
Mouse   781 QIDFPSSAFD------IKFTSPPGD-KFS----------------------------PRYEFGSL 810

  Fly   283 SDRDAKPTASIRDQLHTIVYRYPPTYVLSSEEQDLVWKFRFYLSSHKKALTKFL-KCINWKLEDE 346
            .:.|.:....|..:        ...|.|:..::..:|:.|:|..:...:|...| ...:|:
Mouse   811 REEDQRKLKDITQK--------ESLYWLTDADKKQLWEKRYYCHTEVSSLPLVLASAPSWE---- 863

  Fly   347 VTQALW--------MLANWAPMDVEDALELLSPTFTHPQVRKYAVSRLAQAPDEDLLLYLLQLVQ 403
                 |        :|..|..|:.:|||.||..||...:||:.||..:....|.:||.||.||||
Mouse   864 -----WACLPDIYALLQQWTHMNHQDALGLLHATFPDQEVRRMAVQWIGSLSDAELLDYLPQLVQ 923

  Fly   404 ALKYEDPRHIVHLHGCIFPERDVVRSILDDNGSLLDQSSLSDLSATSSGLHGSVIPANQRAASVL 468
            |||||          |                 .||
Mouse   924 ALKYE----------C-----------------YLD----------------------------- 932

  Fly   469 AAIKSDKSVSPGSAGGSGSGGQGSVALPNPSAPATPGSSSLPCDSNSNALMLAEGISFGSVPANL 533
                     ||                                                     |
Mouse   933 ---------SP-----------------------------------------------------L 935

  Fly   534 CTFLIQRACTNATLANYFYWYLSIEVEEVE-SVRKQDERAHDMYAMVLKMFLKVLENGNFNLRGI 597
            ..||::||.::..:.:||:|.|...:::.: |:|         |..:|...|.....|   ||..
Mouse   936 VRFLLKRAISDLRVTHYFFWLLKDSLKDSQFSIR---------YQYLLAALLCCCGKG---LREE 988

  Fly   598 FYNLRKQRRFIDELVKLVKLVAKEPGNRNKKTEKFQKLLAEQDMFKVNFTNFEPI-------PFP 655
            |   .:|...::.|.||.:.|.:...:            |.|.:.:|.....:..       ..|
Mouse   989 F---NRQCWLVNTLAKLAQQVREATPS------------ARQGILRVGLEEVKQFFALNGSCRLP 1038

  Fly   656 LDPEIYITKIVPMRTSLFKSALMPAKLTF--VTSIAHHEYAAIFKHGDDLRQDQLILQMITLMDK 718
            |.|.:.:..|||...|.|.|..:|.||.|  |..:..: ...|||.|||||||.|.||||.:|.|
Mouse  1039 LSPSLLVKGIVPRDCSYFNSNAVPLKLAFQNVDPLGEN-IRVIFKCGDDLRQDMLTLQMIRIMSK 1102

  Fly   719 LLRRENLDLKLTPYKVLATSSKHGFLQYVDSC-TVAEVLAREGNIHNF--------FRKHHPCDN 774
            :..:|.||:::..::..:|....|.::.:.:. |:.::....|...:|        .:||:|.::
Mouse  1103 IWVQEGLDMRMVIFRCFSTGRGKGMVEMIPNAETLRKIQVEHGVTGSFKDRPLADWLQKHNPGED 1167

  Fly   775 GPYGISAEVMDTYIKSCAGYCVITYLLGVGDRHLDNLLLTTNGKLFHIDFGYILGR-----DPKP 834
             .|   .:.::.:|.||||.||.||:||:.|||.||::|.|.|.:||||||..||.     :.|.
Mouse  1168 -EY---EKAVENFIYSCAGCCVATYILGICDRHNDNIMLKTTGHMFHIDFGRFLGHAQMFGNIKR 1228

  Fly   835 MPPPMKLSKEMVEAMGG--ISSEHHHEFRKQCYTAYLHLRRHANVMLNLFSLMVDATVPDIALEP 897
            ...|...:.:|...:.|  ..|...|:|...|..||..:|:|.::.|||..||:...:|:::...
Mouse  1229 DRAPFVFTSDMAYVINGGDKPSSRFHDFVDLCCQAYNLIRKHTHLFLNLLGLMLSCGIPELSDLE 1293

  Fly   898 DKAVKKVEENLQLGLTDEEAVQHLQSLLDVSITAVMPALVEQIHRFTQ 945
            |  :|.|.:.|:...|:..|..:...|::.|:.:|...|...||...|
Mouse  1294 D--LKYVYDALRPQDTEANATTYFTRLIESSLGSVATKLNFFIHNLAQ 1339

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K59F	NP_477133.1	C2_PI3K_class_III	27..186	CDD:176042	23/141 (16%)
		PI3Ka_III	284..561	CDD:238442	53/285 (19%)
		PI3Kc_III	601..945	CDD:270628	108/368 (29%)
Pik3c2b	NP_001092746.2	PI3K_rbd	363..465	CDD:366310
		C2A_PI3K_class_II	621..793	CDD:175979	33/212 (16%)
		PI3Ka_II	812..980	CDD:238441	58/311 (19%)
		PI3Kc_C2_beta	986..1339	CDD:119421	110/374 (29%)
		PX_PI3K_C2_beta	1368..1476	CDD:132823
		C2B_PI3K_class_II	1504..1626	CDD:176027
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810