DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pi3K59F and SMG1

DIOPT Version :9

Sequence 1:	NP_477133.1	Gene:	Pi3K59F / 37733	FlyBaseID:	FBgn0015277	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	XP_005255239.1	Gene:	SMG1 / 23049	HGNCID:	30045	Length:	3689	Species:	Homo sapiens

Alignment Length:	1284	Identity:	234/1284 - (18%)
Similarity:	398/1284 - (30%)	Gaps:	470/1284 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 FRYIHSSSLH-----------------ERVQIKVGTLEGKKRQPDYEKLLEDPILRFSGLYSEEH 55
            |.||.|.|..                 |.:.:..|   |.|.:.|.:|||.:       :.|.:.
Human  1228 FNYIKSLSSFESGKFVECTEQLELLPGENINLLAG---GSKEKIDMKKLLPN-------MLSPDP 1282

  Fly    56 PSFQVRLQVFNQGRPYCL-----PVTSSYKAFGKRWSWNEWVTL-----------------PLQF 98
            ...|..::|.......||     |:....|          |.::                 ||:.
Human  1283 RELQKSIEVQLLRSSVCLATALNPIEQDQK----------WQSITENVVKYLKQTSRIAIGPLRL 1337

  Fly    99 SDLPRSAML-VLTILD--CSGAGQTTVIGGTS-----ISMFGKDGMFRQGMYDLRVWLGVEGDGN 155
            |.|..|..| ||:.|.  ||.|.:.||....|     |.:| .:.:.....:|:|.|:.......
Human  1338 STLTVSQSLPVLSTLQLYCSSALENTVSNRLSTEDCLIPLF-SEALRSCKQHDVRPWMQALRYTM 1401

  Fly   156 FPSRTPGKGKESS---KSQMQRLG----KLAKKHRN--------GQVQKVDWLDRLT-------- 197
            :.::...|.||.:   :|.:..||    |.|:|..|        .|..:|. |.:.|
Human  1402 YQNQLLEKIKEQTVPIRSHLMELGLTAAKFARKRGNVSLATRLLAQCSEVQ-LGKTTTAQDLVQH 1465

  Fly   198 FREIEVINEREKRMSDYMFLMIEFPAIVVD--------DMYNYAVVYF----EPEGDVKYKLPAK 250
            |:::....:.:::....  |.||...::..        :|.:...:.|    :.|..|...:...
Human  1466 FKKLSTQGQVDEKWGPE--LDIEKTKLLYTAGQSTHAMEMLSSCAISFCKSVKAEYAVAKSILTL 1528

  Fly   251 PKLVSVPDSEI--QMENLVERKHHRLARSERSGISDRDAKPTASIR-DQLHTIVYRYP-----PT 307
            .|.:.....||  |::.:...:|    :...:|:|.........|. ..::|:...||     .|
Human  1529 AKWIQAEWKEISGQLKQVYRAQH----QQNFTGLSTLSKNILTLIELPSVNTMEEEYPRIESEST 1589

  Fly   308 YVLSSEEQDLVWKFRFYLSSHKKALTKFLKCINWKLEDEVTQALWMLANWA-------------- 358
            ..:...|.|.:....::|||.:              ..||.::...||:||
Human  1590 VHIGVGEPDFILGQLYHLSSVQ--------------APEVAKSWAALASWAYRWGRKVVDNASQG 1640

  Fly   359 ------PMDVEDALELLSPTFTHPQVRK------YAVSRLAQAPDEDLLLYLL------------ 399
                  |.:..:...||..|.|..:..:      .||.|.|...|||:.|.:.
Human  1641 EGVRLLPREKSEVQNLLPDTITEEEKERIYGILGQAVCRPAGIQDEDITLQITESEDNEEDDMVD 1705

  Fly   400 ----QLVQA-------------------------------------------------LKYEDPR 411
                ||:.:                                                 |..:|||
Human  1706 VIWRQLISSCPWLSELDESATEGVIKVWRKVVDRIFSLYKLSCSAYFTFLKLNAGQIPLDEDDPR 1770

  Fly   412 HIVHLHGCIFPERD---------VVRSILDDNGSLLDQSSLSDLSATSSGLHGSVIP-------- 459
              :||...:....|         ::|.::...|. |.|.....|..|.:.....:||
Human  1771 --LHLSHRVEQSTDDMIVMATLRLLRLLVKHAGE-LRQYLEHGLETTPTAPWRGIIPQLFSRLNH 1832

  Fly   460 ----ANQRAASVLAAIKSDKSVSPG-------------SAGGSGSGGQGSVALP----------- 496
                ..|...::|..:..|   ||.             |:....||.:.|.|:|
Human  1833 PEVYVRQSICNLLCRVAQD---SPHLILYPAIVGTISLSSESQASGNKFSTAIPTLLGNIQGEEL 1894

  Fly   497 ------NPSAPATPGS------SSLPCD---------------SNSNALMLAEGISFGSVPANLC 534
                  ..|.||:..|      |.|..|               |::|..|:.: :..........
Human  1895 LVSECEGGSPPASQDSNKDEPKSGLNEDQAMMQDCYSKIVDKLSSANPTMVLQ-VQMLVAELRRV 1958

  Fly   535 TFLIQRACTNATLANYFY-----WYLSIEVEEVE---SVRKQDERA--HDMYAMVLKMFLKVLEN 589
            |.|.........|..:.|     ..|..||:.|:   ::||:::.|  .:.:..::|..:..||
Human  1959 TVLWDELWLGVLLQQHMYVLRRIQQLEDEVKRVQNNNTLRKEEKIAIMREKHTALMKPIVFALE- 2022

  Fly   590 GNFNLRGIF---YNLRKQRRFIDE--------LVKL-VKLVAKEPGN--------------RNKK 628
               ::|.|.   .....::.|.|.        |.|| ..|...:||:              |.:|
Human  2023 ---HVRSITAAPAETPHEKWFQDNYGDAIENALEKLKTPLNPAKPGSSWIPFKEIMLSLQQRAQK 2084

  Fly   629 TEKFQKLLAEQDMFKVNFTNFE-PIPFPLDPEIYIT--------KIVPMRTSLFKSALMPAKLTF 684
            ...:...|.|...:....||.| .:|..:.....:|        .|:|.:|.       |.||.|
Human  2085 RASYILRLEEISPWLAAMTNTEIALPGEVSARDTVTIHSVGGTITILPTKTK-------PKKLLF 2142

  Fly   685 VTSIAHHEYAAIFKHGDDLRQDQLILQMITLMDKLL----RRENLDLKLTPYKVLATSSKHGFLQ 745
            :.|.. ..|..:||..:||..|:.|:|.:::::.:.    |:|........|.|....::.|.:|
Human  2143 LGSDG-KSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQ 2206

  Fly   746 YVDSCT--------------------------------------------VAEVLAREGNIHNFF 766
            :||..|                                            :...|...|...:..
Human  2207 WVDGATPLFGLYKRWQQREAALQAQKAQDSYQTPQNPGIVPRPSELYYSKIGPALKTVGLSLDVS 2271

  Fly   767 RKHHP-----------CDNGPYGISAE--------------VMDTYIKSCAGYCVITYLLGVGDR 806
            |:..|           .:..|..:.|:              |..:|.:|.|...::.|::|:|||
Human  2272 RRDWPLHVMKAVLEELMEATPPNLLAKELWSSCTTPDEWWRVTQSYARSTAVMSMVGYIIGLGDR 2336

  Fly   807 HLDNLLL-TTNGKLFHIDFGYIL------------------------------GRDPK-PMPPPM 839
            ||||:|: .|.|::.|||:....                              |:..: |...|.
Human  2337 HLDNVLIDMTTGEVVHIDYNVCFEKGNIKVDFTFMRAKCFLVKGQKYNDLSFQGKSLRVPEKVPF 2401

  Fly   840 KLSKEMVEAMG--GISSEHHHEFRKQCYTAYLHLRRHANVMLNLFSLMV 886
            ::::.:..|:|  |:..    .||..|......:||....:|.|....|
Human  2402 RMTQNIETALGVTGVEG----VFRLSCEQVLHIMRRGRETLLTLLEAFV 2446

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K59F	NP_477133.1	C2_PI3K_class_III	27..186	CDD:176042	44/203 (22%)
		PI3Ka_III	284..561	CDD:238442	74/450 (16%)
		PI3Kc_III	601..945	CDD:270628	81/425 (19%)
SMG1	XP_005255239.1	SMG1	631..1242	CDD:292413	5/13 (38%)
		PIKKc_SMG1	2121..2454	CDD:270714	64/338 (19%)
		FATC	3659..3688	CDD:280430
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900