DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Pi3K59F and Pik3c3

DIOPT Version :9

Sequence 1:NP_477133.1 Gene:Pi3K59F / 37733 FlyBaseID:FBgn0015277 Length:949 Species:Drosophila melanogaster
Sequence 2:NP_852079.2 Gene:Pik3c3 / 225326 MGIID:2445019 Length:887 Species:Mus musculus


Alignment Length:947 Identity:524/947 - (55%)
Similarity:666/947 - (70%) Gaps:67/947 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 DHFRYIHSSSLHERVQIKVGTLEGKKRQPDYEKLLEDPILRFSGLYSEEHPSFQVRLQVFNQGRP 70
            :.|.||:|..|...||:|:|:||||:.|..|:.:||||:|:|||||.|......|..|||.:|:|
Mouse     5 EKFHYIYSCDLDINVQLKIGSLEGKREQKSYKAVLEDPMLKFSGLYQETCSDLYVTCQVFAEGKP 69

  Fly    71 YCLPVTSSYKAFGKRWSWNEWVTLPLQFSDLPRSAMLVLTILDCSGAGQTTVIGGTSISMFGKDG 135
            ..|||.:|||||..||:||||:.||:::.||||:|.:.|||.|..|.|....:|||::|:|||.|
Mouse    70 LALPVRTSYKAFSTRWNWNEWLKLPVKYPDLPRNAQVALTIWDVYGPGSAVPVGGTTVSLFGKYG 134

  Fly   136 MFRQGMYDLRVWLGVEGDGNFPSRTPGKGKES-SKSQMQRLGKLAKKHRNGQVQKVDWLDRLTFR 199
            ||||||:||:||..||.||:.|:||||:...: |:.||.||.||.|.||.|.:.|||||||||||
Mouse   135 MFRQGMHDLKVWPNVEADGSEPTRTPGRTSSTLSEDQMSRLAKLTKAHRQGHMVKVDWLDRLTFR 199

  Fly   200 EIEVINEREKRMSDYMFLMIEFPAIVVDDMYNYAVVYFEPEGDVKYKLPAKPKLVSVPDSEIQME 264
            |||:|||.|||.|::|:||:||..:..||. .|.:||:|.:||....:....:||.|||.::.||
Mouse   200 EIEMINESEKRSSNFMYLMVEFRCVKCDDK-EYGIVYYEKDGDESSPILTSFELVKVPDPQMSME 263

  Fly   265 NLVERKHHRLARSERSGISDRDAKPTASIRDQLHTIVYRYPPTYVLSSEEQDLVWKFRFYLSSHK 329
            ||||.|||:||||.|||.||.|.||.|:.||||:.|| .||||..|:.||||||||||:||::.:
Mouse   264 NLVESKHHKLARSLRSGPSDHDLKPNATTRDQLNIIV-SYPPTKQLTYEEQDLVWKFRYYLTNQE 327

  Fly   330 KALTKFLKCINWKLEDEVTQALWMLANWAPMDVEDALELLSPTFTHPQVRKYAVSRLAQAPDEDL 394
            |||||||||:||.|..|..|||.:|..|.||||||:|||||..:|:|.||:|||:||.||.||||
Mouse   328 KALTKFLKCVNWDLPQEAKQALELLGKWKPMDVEDSLELLSSHYTNPTVRRYAVARLRQADDEDL 392

  Fly   395 LLYLLQLVQALKYEDPRHIVHLHGCIFPERDVVRSILDDNGSLLDQSSLSDLSATSSGLHGSVIP 459
            |:||||||||||||:                     .||..:.|:.:.....::.|..|      
Mouse   393 LMYLLQLVQALKYEN---------------------FDDIKNGLEPTKKDSQTSASESL------ 430

  Fly   460 ANQRAASVLAAIKSDKSVSPGSAGGSGSGGQGSVALPNPSAP-ATPGSSSLPCDSNSNALMLAEG 523
                         |:..||.|..       ..|..:.||..| |:|..:|           .|:.
Mouse   431 -------------SNSGVSSGDI-------DSSQIITNPLPPVASPPPAS-----------KAKE 464

  Fly   524 ISFG-SVPANLCTFLIQRACTNATLANYFYWYLSIEVEEVESVRKQDERAHDMYAMVLKMFLKVL 587
            :|.| ::..:||||||.|||.|:|||||.|||:.:|.|: :..:::|.:.|:||..|::.|.:.|
Mouse   465 VSDGENLEQDLCTFLISRACKNSTLANYLYWYVIVECED-QDTQQRDPKTHEMYLNVMRRFSQAL 528

  Fly   588 ENGNFNLRGIFYNLRKQRRFIDELVKLVKLVAKEPGNRNKKTEKFQKLLAEQDMFKVNFTNFEPI 652
            ..|:.::|.:...|..|:.|:|.||.|:|.|.:|.|||.||.|:.|.||.:.:  |:|.::.|.|
Mouse   529 LKGDKSVRVMRSLLAAQQTFVDRLVHLMKAVQRESGNRKKKNERLQALLGDNE--KMNLSDVELI 591

  Fly   653 PFPLDPEIYITKIVPMRTSLFKSALMPAKLTFVTSIAHHEYAAIFKHGDDLRQDQLILQMITLMD 717
            |.||:|::.|..|:|...:|||||||||:|.|.|... .:|..||||||||||||||||:|:|||
Mouse   592 PLPLEPQVKIRGIIPETATLFKSALMPAQLFFKTEDG-GKYPVIFKHGDDLRQDQLILQIISLMD 655

  Fly   718 KLLRRENLDLKLTPYKVLATSSKHGFLQYVDSCTVAEVLAREGNIHNFFRKHHPCDNGPYGISAE 782
            ||||:||||||||||||||||:||||:|::.|..|||||..||:|.|||||:.|.:.||||||||
Mouse   656 KLLRKENLDLKLTPYKVLATSTKHGFMQFIQSVPVAEVLDTEGSIQNFFRKYAPSETGPYGISAE 720

  Fly   783 VMDTYIKSCAGYCVITYLLGVGDRHLDNLLLTTNGKLFHIDFGYILGRDPKPMPPPMKLSKEMVE 847
            |||||:|||||||||||:||||||||||||||..||||||||||||||||||:||||||:|||||
Mouse   721 VMDTYVKSCAGYCVITYILGVGDRHLDNLLLTKTGKLFHIDFGYILGRDPKPLPPPMKLNKEMVE 785

  Fly   848 AMGGISSEHHHEFRKQCYTAYLHLRRHANVMLNLFSLMVDATVPDIALEPDKAVKKVEENLQLGL 912
            .|||..||.:.|||||||||:|||||::|::||||||||||.:|||||||||.||||::..:|.|
Mouse   786 GMGGTQSEQYQEFRKQCYTAFLHLRRYSNLILNLFSLMVDANIPDIALEPDKTVKKVQDKFRLDL 850

  Fly   913 TDEEAVQHLQSLLDVSITAVMPALVEQIHRFTQYWRK 949
            :|||||.::|||:|.|:.|:..|:|||||:|.|||||
Mouse   851 SDEEAVHYMQSLIDESVHALFAAVVEQIHKFAQYWRK 887

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pi3K59FNP_477133.1 C2_PI3K_class_III 27..186 CDD:176042 87/159 (55%)
PI3Ka_III 284..561 CDD:238442 123/278 (44%)
PI3Kc_III 601..945 CDD:270628 233/343 (68%)
Pik3c3NP_852079.2 C2_PI3K_class_III 26..186 CDD:176042 87/159 (55%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 149..170 10/20 (50%)
PI3Ka_III 283..503 CDD:238442 123/278 (44%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 415..466 15/87 (17%)
PI3Kc_III 539..883 CDD:270628 233/346 (67%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167849874
Domainoid 1 1.000 235 1.000 Domainoid score I2368
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H1986
Inparanoid 1 1.050 1006 1.000 Inparanoid score I291
Isobase 1 0.950 - 0 Normalized mean entropy S1375
OMA 1 1.010 - - QHG54334
OrthoDB 1 1.010 - - D204282at2759
OrthoFinder 1 1.000 - - FOG0005021
OrthoInspector 1 1.000 - - oto95334
orthoMCL 1 0.900 - - OOG6_101850
Panther 1 1.100 - - LDO PTHR10048
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1651
SonicParanoid 1 1.000 - - X3549
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1817.750

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