DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pi3K59F and Pi4ka

DIOPT Version :9

Sequence 1:NP_477133.1 Gene:Pi3K59F / 37733 FlyBaseID:FBgn0015277 Length:949 Species:Drosophila melanogaster
Sequence 2:NP_001360884.1 Gene:Pi4ka / 224020 MGIID:2448506 Length:2105 Species:Mus musculus


Alignment Length:989 Identity:197/989 - (19%)
Similarity:349/989 - (35%) Gaps:303/989 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 IHSSSLHERVQIKVGTLEGKKRQ------PDYEKLLEDPILRFSGLYSEEHPSFQV----RLQVF 65
            |.||.|...:.:.:|...|...:      |.: |||   .|..|.|:::..|:..:    |.:::
Mouse  1322 IFSSLLQRSMSLNIGGARGSMNRHVAAIGPRF-KLL---TLGLSLLHADVVPNATIRNVLREKIY 1382

  Fly    66 NQGRPY--CLPVTSSYKAFGKRWSWNEWVTLPLQFSDLPRSAMLVLTILDCSGAGQTTVIGGTSI 128
            :....|  |.|   .:...|:: ...|.:::.::|.....|....||.................|
Mouse  1383 STAFDYFSCPP---KFPTQGEK-RLREDISIMIKFWTAMFSDKKYLTASQLVPPDNQDTRSNLDI 1443

  Fly   129 SMFGKDGMFRQGMYDLRVWLGVEGDGNFPSRTPGKGKESSKSQMQRLGKLAKKHRNGQVQKVDWL 193
            :: |......||      |:     ..:| .:.|....|.||.|.:     |.:|..|:.|. ::
Mouse  1444 TV-GSRQQATQG------WI-----NTYP-LSSGMSTISKKSGMSK-----KTNRGSQLHKY-YM 1489

  Fly   194 DRLTFREIEVINEREKRMSDYMFLMIEFPAIVVDDMYNYAVVYFEPEGDVKYKLPAKPKLVSVPD 258
            .|.|                   |::...|..::.:    :.::.|              :|.|:
Mouse  1490 KRRT-------------------LLLSLLATEIERL----ITWYNP--------------LSAPE 1517

  Fly   259 SEIQM--ENLVERKHHRLARSERSGISDRDAKPTASIRDQLH-----TIVYRYPPTYVLSSEEQD 316
            .|:..  ||.|..     .||:...:|::..|...::...:.     .:..|:..|..:.:|...
Mouse  1518 LELDQAGENSVAN-----WRSKYISLSEKQWKDNVNLAWSISPYLAVQLPARFKNTEAIGNEVTR 1577

  Fly   317 LVWKFRFYLSSHKKALTKFLKCINWKLEDEVTQALWMLANWAPMDVEDALELLSPTF-THPQVRK 380
            ||......:|...:|: |||  :.|...|.....|..:..|||.|....|...|..: .||...:
Mouse  1578 LVRLDPGAVSDVPEAI-KFL--VTWHTIDADAPELSHVLCWAPTDPPTGLSYFSSMYPPHPLTAQ 1639

  Fly   381 YAVSRLAQAPDEDLLLYLLQLVQALKYEDPRHIVHLHGCIFPERDVVRSILDDNGSLLDQSSLSD 445
            |.|..|...|.:.:|.|:.|:||||:|:...::                                
Mouse  1640 YGVKVLRSFPPDAILFYIPQIVQALRYDKMGYV-------------------------------- 1672

  Fly   446 LSATSSGLHGSVIPANQRAASVLAAIKSDKSVSPGSAGGSGSGGQGSVALPNPSAPATPGSSSLP 510
                             |...:.||.||.                                    
Mouse  1673 -----------------REYILWAAAKSQ------------------------------------ 1684

  Fly   511 CDSNSNALMLAEGISFGSVPANLCTFLIQRACTNATLANYFYWYLSIEVEEVESVRKQDERAHDM 575
                                               .||:.|.|.:...:       ..||..|..
Mouse  1685 -----------------------------------LLAHQFIWNMKTNI-------YLDEEGHQK 1707

  Fly   576 YAMVLKMFLKVLENGNFNLRG---IFYNLRKQRRFIDELVKLVKLVAKEP-GNRNKKTEKFQKLL 636
            ...:..:..:::|....:|.|   .||  :::..|.:::..:..::...| |:..||.     .|
Mouse  1708 DPDIGDLLEQLVEEITGSLSGPAKDFY--QREFDFFNKITNVSAIIKPYPKGDERKKA-----CL 1765

  Fly   637 AEQDMFKVNFTNFEP-IPFPLDPEIYITKI-----VPMRTSLFKSALMPAKLTFVT--------- 686
            :.....||     :| ...|.:||..:..|     .||:::        ||..::.         
Mouse  1766 SALSEVKV-----QPGCYLPSNPEAIVLDIDYKSGTPMQSA--------AKAPYLAKFKVKRCGV 1817

  Fly   687 -----------SIAHHE-------------YAAIFKHGDDLRQDQLILQMITLMDKLLRRENLDL 727
                       |.|..|             .|||||.|||.|||.|.||:|.|...:.:...|||
Mouse  1818 SELEKEGLQCRSDAEDECFSQEADGKKICWQAAIFKVGDDCRQDMLALQIIDLFKNIFQLVGLDL 1882

  Fly   728 KLTPYKVLATSSKHGFLQYVDSCTVAEVLAREGN--IHNFFRKHHPCDNGPYGISA-----EVMD 785
            .:.||:|:||:...|.::.:..||..:.|.|:.:  ::::|.:.       ||..:     :...
Mouse  1883 FVFPYRVVATAPGCGVIECIPDCTSRDQLGRQTDFGMYDYFTRQ-------YGDESTLAFQQARY 1940

  Fly   786 TYIKSCAGYCVITYLLGVGDRHLDNLLLTTNGKLFHIDFGYILGRDP---KPMPPPMKLSKEMVE 847
            .:|:|.|.|.::.:||.:.|||..|::|...|.:.|||||::....|   ....|.:||:.|||.
Mouse  1941 NFIRSMAAYSLLLFLLQIKDRHNGNIMLDKKGHIIHIDFGFMFESSPGGNLGWEPDIKLTDEMVM 2005

  Fly   848 AMGG-ISSEHHHEFRKQCYTAYLHLRRHANVMLNLFSLMVDATVPDIALEPDKAVKKVEENLQLG 911
            .||| :.:.....|.:.|...||.:|.:.:.:::|.:||:|..:|...   .:.:|.::......
Mouse  2006 IMGGKMEATPFKWFMEMCVRGYLAVRPYMDAVVSLVTLMLDTGLPCFR---GQTIKLLKHRFSPN 2067

  Fly   912 LTDEEAVQHLQSLL 925
            :|:.||...:..::
Mouse  2068 MTEREAANFIMKVI 2081

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pi3K59FNP_477133.1 C2_PI3K_class_III 27..186 CDD:176042 32/170 (19%)
PI3Ka_III 284..561 CDD:238442 43/282 (15%)
PI3Kc_III 601..945 CDD:270628 93/376 (25%)
Pi4kaNP_001360884.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..24
PI4Ka 1550..1725 CDD:238443 46/304 (15%)
PI4Kc_III_alpha 1786..2104 CDD:270711 81/314 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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