DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pi3K59F and Prkdc

DIOPT Version :9

Sequence 1:	NP_477133.1	Gene:	Pi3K59F / 37733	FlyBaseID:	FBgn0015277	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	NP_035289.2	Gene:	Prkdc / 19090	MGIID:	104779	Length:	4128	Species:	Mus musculus

Alignment Length:	1287	Identity:	239/1287 - (18%)
Similarity:	428/1287 - (33%)	Gaps:	475/1287 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 IKVGTLEGKKRQPDYEKLLEDPILRFSGLYSEEHPSFQVRLQVFNQGRPYCLP--------VTSS 78
            ::||.| ...:||...:|||:.:||   |..:|.|:.:||      |:. |||        :...
Mouse  2877 VRVGCL-ASLQQPGGIRLLEEALLR---LMPKEPPTKRVR------GKT-CLPPDVLRWMELAKL 2930

  Fly    79 YKAFGKR------WSWNEWVTLPLQ-------FSDLPRSAMLV---------------------- 108
            |::.|:.      :|.....|...|       .||..::|.|.
Mouse  2931 YRSIGEYDVLRGIFSSELGTTQDTQNALLAEARSDYCQAAKLYDEALNKLEWVDGEPTEAEKEFW 2995

  Fly   109 -LTILDCSG----------AGQTTVIGGTSISMFGKDGMFRQGMYD---------LRVWLGVEGD 153
             |..|||..          .....::...|:.:   ..|:.:..|.         .::.|.::|:
Mouse  2996 ELASLDCYNNLSKWKELEYCSTVNIVSENSLDL---SKMWSEPFYQETYLPYVIRSKLKLLLQGE 3057

  Fly   154 GN-----FPSRTPGKGKESSKSQMQRLGKLAKKH-------------RNG-QV--QKVDWLDRLT 197
            ||     |......|..:.:..::|...:|:..:             :|| |:  |....:|.|.
Mouse  3058 GNQSLLTFVDEAMNKELQKTVLELQYSQELSLLYILQDDIDRATYYIKNGIQIFMQNYSSIDVLL 3122

  Fly   198 FR-------EIEVINEREKRMS------DYMFL----------MIEFPAIVVDDMYNYAVV---- 235
            :|       .::.:.|.|:.:|      |...|          ...:|.:|.|.|:.:..:
Mouse  3123 YRSRLAKLQSVQTLAEIEEFLSFICKHGDLSSLGPLRRLLKTWTSRYPDVVTDPMHIWDDIITNR 3187

  Fly   236 -YFEPEGDVKYKLPAKPKLVSVPDSEIQMENLVERKHHRLARSERSGISDRDA-KPTASIRDQLH 298
             :|..:.:.:...|:....:||.:.|   |::                 ||:. :|...:|..|.
Mouse  3188 CFFLSKIEERLTAPSGDHSMSVDEDE---ESI-----------------DREVYEPKEDVRCMLQ 3232

  Fly   299 TIVYRYPPTYVLSSEEQDLVWK-FRFYLS------SHKKALTKFLKCINW------------KLE 344
            :.      .:.:..:..:..|| ..|.||      .||::.|:.:..:.|            ..:
Mouse  3233 SC------RFTMKMKMIESAWKQSNFSLSMKLLKEMHKESKTREIWRVQWLHSYSQLNHCRSHTQ 3291

  Fly   345 DEVTQALWMLANWAPMDVEDALELLSPTFTHPQVRKYAVSRLAQAPDEDLLL--YLLQLVQALKY 407
            ....|.|.||.....:|..|             :..|....:..:.|:.:||  ....:..||..
Mouse  3292 SPREQVLNMLKTITLLDESD-------------ISNYLNKNIQASCDQSILLGTTCRIMADALSR 3343

  Fly   408 EDPRHIVHLHGCIFPERDVVRSILDDNGSLLDQSSLSDLSATSSGLHGSVIPANQRAASVLA-AI 471
            | |..:..|      |.:.|.|||..:|     |:..:.....:||:       |||...|: |:
Mouse  3344 E-PACLSDL------EENKVNSILTLSG-----SNAENTETVITGLY-------QRAFHHLSKAV 3389

  Fly   472 KSDKSVSPGSAGGSGSGGQGS-------------------VALPNPSA-----PA---------- 502
            :|.:..:..|..|..:..:.:                   .|....||     ||
Mouse  3390 QSAEEETQLSCWGHEAAAERAHAYMTLVGFCDQQLRKVEESASQKTSAEMEAYPALVVEKMLRAL 3454

  Fly   503 -----------------------------TPGSSSLPC--------------------------- 511
                                         |...||:||
Mouse  3455 KLNSSEARLKFPRLLQIIEQYSEETLNIMTKEISSIPCWQFIGWISHMMALLDKEEAIAVQHTVE 3519

  Fly   512 ---DSNSNALML-----AEGISFGSVPA--NLCTFL-----------IQRACTNA--TLAN---Y 550
               |:...|::.     :|..||.:..:  |...|:           :..:..||  .|:|   .
Mouse  3520 EIADNYPQAIIYPFIISSESYSFKNTSSGHNNKAFVERIKSKLDHGEVIHSFINALDQLSNPDLL 3584

  Fly   551 FYWYLSIEVEEV-------ESVRKQDERAH----DMYAMVL------------KMFLKVLENGNF 592
            |..::|...:|:       :::.|..||.:    |:.|..|            |.|:|...||..
Mouse  3585 FKDWVSDTKDELGKNPVNKKNIEKLYERMYAALGDLRAPGLGPFRRRFIQAFGKEFVKSFGNGGS 3649

  Fly   593 NLRGIFYNLRKQRRFIDELVKL-------VKLVAKEPGNRNKKTEKFQKLLAEQDMFKVNFTNFE 650
            .|..:         .:|:..|:       :|..:|.|||    .:::...::|   ||..|...|
Mouse  3650 KLLTM---------KVDDFCKITGSLLVRMKKDSKLPGN----LKEYSPWMSE---FKAQFLKNE 3698

  Fly   651 -PIPFPLD------PEIYITKIVPMRTSLFKS------ALMPAKLTFVTSIAHHEYAAIFKHGDD 702
             .||...|      ||.::      |.|.|..      :|...|...:......||..:.|.|:|
Mouse  3699 LEIPGQYDGKSKPLPEYHV------RISGFDERVKVMLSLRKPKRIVIRGHDEKEYPFLVKGGED 3757

  Fly   703 LRQDQLILQMITLMDKLLRRE----NLDLKLTPYKVLATSSKHGFLQYVD-SCTVAEVL----AR 758
            |||||.|.|:..:|:.:|.::    ..:::|..|:|:..:|:.|.::::: :.|:.::|    ::
Mouse  3758 LRQDQRIEQIFEVMNAILSQDAACSQRNMQLRTYRVVPMTSRLGLIEWIENTMTLKDLLLSNMSQ 3822

  Fly   759 EGNIHN--------------FFRKHHPCDNGPYGI-----------------SAEV--------- 783
            |..:.|              ..:.....|.|.|.:                 .::|
Mouse  3823 EEKVANNSDPKAPIRDYKDWLMKVSGKSDAGAYVLMYSRANRTETVVAFRRRESQVPPDLLKRAF 3887

  Fly   784 --MDT-----------YIKSCAGYCVITYLLGVGDRHLDNLLLT-TNGKLFHIDFGYILGRD--- 831
              |.|           :..|.|..|:..:|||:|||||:|.::. ..|.:..||||:..|..
Mouse  3888 VKMSTSPEAFLALRSHFASSHALLCISHWLLGIGDRHLNNFMVAMETGSVIGIDFGHAFGSATQF 3952

  Fly   832 -PKPMPPPMKLSKEMVEAMGGISSEHHHEFRKQCYTAYLHLRRHANVMLNLFSLMVDATVPDIAL 895
             |.|...|.:|:::.|..|..:.     |....| |..:|..|   ...:...|:.| |:.....
Mouse  3953 LPVPELMPFRLTRQFVSLMLPMK-----ETGLMC-TVMVHALR---AFRSCAGLLTD-TMEIFVK 4007

  Fly   896 EPDKAVKKVEENL---------QLGLTDEE-AVQHLQSLLDVSITAVMPALV 937
            ||....|..|:.:         ::.:|::. ..||........:....||::
Mouse  4008 EPSFDWKSFEQTMLRKGGSWIQEINVTEKNWYPQHKIRYAKRKLAGANPAVI 4059

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K59F	NP_477133.1	C2_PI3K_class_III	27..186	CDD:176042	43/240 (18%)
		PI3Ka_III	284..561	CDD:238442	69/415 (17%)
		PI3Kc_III	601..945	CDD:270628	92/434 (21%)
Prkdc	NP_035289.2	HEAT 1	288..323
		HEAT 2	1001..1037
		HEAT 3	1050..1086
		Interaction with C1D. /evidence=ECO:0000250	1501..1536
		Leucine-zipper	1501..1536
		TPR 1	1720..1753
		ArAE_1_C	<1766..1822	CDD:288564
		NUC194	1812..2198	CDD:285387
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2049..2071
		KIP-binding. /evidence=ECO:0000250	2432..3213		63/349 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2614..2635
		FAT	3024..3470	CDD:280429	84/506 (17%)
		PIKKc_DNA-PK	3719..4014	CDD:270716	67/304 (22%)
		FATC	4097..4128	CDD:280430
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900