DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pi3K59F and Pik3cd

DIOPT Version :9

Sequence 1:	NP_477133.1	Gene:	Pi3K59F / 37733	FlyBaseID:	FBgn0015277	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	XP_006538704.1	Gene:	Pik3cd / 18707	MGIID:	1098211	Length:	1074	Species:	Mus musculus

Alignment Length:	1019	Identity:	232/1019 - (22%)
Similarity:	370/1019 - (36%)	Gaps:	348/1019 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 HFRYIHSSSL-------------HERVQIKVGTLEGKKRQPDYEKL--LEDP----ILRFSGLYS 52
            |...:||||:             .::.:.|...:..||  |....|  ||.|    ::....:.:
Mouse   273 HLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKK--PSSVSLWSLEQPFSIELIEGRKVNA 335

  Fly    53 EEHPSFQVRLQVFNQGRPYCLPVTSSYKAFGKRWSWNEWVTLPLQFSDLPRSAMLVLTI------ 111
            :|.....|:..:|:.....|..|:||.........|.:.:...:...||||.|.|...:
Mouse   336 DERMKLVVQAGLFHGNEMLCKTVSSSEVNVCSEPVWKQRLEFDISVCDLPRMARLCFALYAVVEK 400

  Fly   112 -------------LDCSGAGQTTVIGGTSISMFGKDGMFRQGMYDLRVWLGVEGDGNFPSRTPGK 163
                         .||.       |...::.:|......:.|...|.:|         ||....|
Mouse   401 AKKARSTKKKSKKADCP-------IAWANLMLFDYKDQLKTGERCLYMW---------PSVPDEK 449

  Fly   164 GKESSKSQMQRLGKLAKKHRNGQVQKVDWLDRLTFREIEVINEREKRMSDYMFLMIEFPAIVVDD 228
            |                                     |::|                ||..|..
Mouse   450 G-------------------------------------ELLN----------------PAGTVRG 461

  Fly   229 MYN----YAVVYFEPEGDVKYKLPAKPKLVSVPDSEIQMENLVERKHHRLARSERSGISDRDAKP 289
            ..|    .|:|.:.||        ..|..|..|    .:|.::|...|    .||..|::.:
Mouse   462 NPNTESAAALVIYLPE--------VAPHPVYFP----ALEKILELGRH----GERGRITEEE--- 507

  Fly   290 TASIRDQLHTIVYRYPPTYVLSSEEQDLVWKFRFYLSSH-KKALTKFLKCINWKLEDEV------ 347
                :.||..|:.| ..:..|...|:|||||.|..:..| .:||.:.|....|...::|
Mouse   508 ----QLQLREILER-RGSGELYEHEKDLVWKMRHEVQEHFPEALARLLLVTKWNKHEDVAQVSRE 567

  Fly   348 -----------------------TQALWMLANWAPMDVEDALELLSPTFTHPQVRKYAVSRLAQA 389
                                   :|.|::|.:|..:.|..|||||..:|....|..:|:..|.:.
Mouse   568 GGSGRQPRGRWTVPAHPYLTTKLSQMLYLLCSWPELPVLSALELLDFSFPDCYVGSFAIKSLRKL 632

  Fly   390 PDEDLLLYLLQLVQALKYEDPRHIVHLHGCIFPERDVVRSILDDNGSLLDQSSLSDLSATSSGLH 454
            .|::|..|||||||.||||
Mouse   633 TDDELFQYLLQLVQVLKYE---------------------------------------------- 651

  Fly   455 GSVIPANQRAASVLAAIKSDKSVSPGSAGGSGSGGQGSVALPNPSAPATPGSSSLPCDSNSNALM 519
                                                                |.|.|:
Mouse   652 ----------------------------------------------------SYLDCE------- 657

  Fly   520 LAEGISFGSVPANLCTFLIQRACTNATLANYFYWYLSIEVEEVESVRKQDERAHDMYAMVLKMFL 584
                         |..||:.||..|..:.::.:|:|..|: .|.||..:       :.::::.:
Mouse   658 -------------LTKFLLGRALANRKIGHFLFWHLRSEM-HVPSVALR-------FGLIMEAY- 700

  Fly   585 KVLENGNFNLRGIFYNLR---KQRRFIDELVKLVKLVAKEPGNRNK-KTEKFQKLLAEQDMFKVN 645
                     .||..::::   ||...:.:|..|...|........| :|::...:...|:.:...
Mouse   701 ---------CRGSTHHMKVLMKQGEALSKLKALNDFVKVSSQKTTKPQTKEMMHMCMRQETYMEA 756

  Fly   646 FTNFEPIPFPLDPEIYITKIVPMRTSLF-KSALMPAKLTFVTSIAHH--EYAAIFKHGDDLRQDQ 707
            .::.:.   ||||...:.::..:....| .|.:.|..:.:.:..|..  ....|||:|||||||.
Mouse   757 LSHLQS---PLDPSTLLEEVCSVEQCTFMDSKMKPLWIMYSSEEAGSAGNVGIIFKNGDDLRQDM 818

  Fly   708 LILQMITLMDKLLRRENLDLKLTPYKVLATSSKHGFLQYV-DSCTVAEVLAREGN---------- 761
            |.||||.|||.|.::|.|||::|||..|.|..:.|.::.| .|.|:|.:...:.|
Mouse   819 LTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLHSDTIANIQLNKSNMAATAAFNKD 883

  Fly   762 -IHNFFRKHHPCDNGPYGISAEVMDTYIK----SCAGYCVITYLLGVGDRHLDNLLLTTNGKLFH 821
             :.|:.:..:|         .|.:|..|:    |||||||.||:||:||||.||:::..:|:|||
Mouse   884 ALLNWLKSKNP---------GEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFH 939

  Fly   822 IDFGYILGRDPKPM-----PPPMKLSKEMVEAM--GGI-SSEHHHEFRKQCYTAYLHLRRHANVM 878
            ||||:.||......     ..|..|:.:.|..:  |.. :||....||..|..||..||||..:.
Mouse   940 IDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLF 1004

  Fly   879 LNLFSLMVDATVPDIALEPDKAVKKVEENLQLGLTDEEAVQHLQ 922
            |:||:||..|.:|:::...|  ::.::::|.||.|:|||::|.:
Mouse  1005 LHLFALMRAAGLPELSCSKD--IQYLKDSLALGKTEEEALKHFR 1046

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K59F	NP_477133.1	C2_PI3K_class_III	27..186	CDD:176042	32/183 (17%)
		PI3Ka_III	284..561	CDD:238442	57/306 (19%)
		PI3Kc_III	601..945	CDD:270628	113/353 (32%)
Pik3cd	XP_006538704.1	PI3K_p85B	32..107	CDD:396665
		PI3K_rbd	182..281	CDD:395642	3/7 (43%)
		C2_PI3K_class_I_beta_delta	314..481	CDD:176075	39/243 (16%)
		PI3Ka	504..713	CDD:214537	62/352 (18%)
		PI3Kc_IA_delta	705..1072	CDD:270718	113/356 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D204282at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820