DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pi3K59F and Pik3c2a

DIOPT Version :9

Sequence 1:NP_477133.1 Gene:Pi3K59F / 37733 FlyBaseID:FBgn0015277 Length:949 Species:Drosophila melanogaster
Sequence 2:NP_035213.2 Gene:Pik3c2a / 18704 MGIID:1203729 Length:1686 Species:Mus musculus


Alignment Length:927 Identity:217/927 - (23%)
Similarity:346/927 - (37%) Gaps:293/927 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    66 NQGRPYCLPVTS----SYKAFGKRWSWNEWVTLPLQFSDLPRSAMLVLTIL----DCSGAGQTT- 121
            :.|:....|:.|    :||.|.....|:|.:..|:|.|.||..::|.||:.    ..||:...: 
Mouse   715 HNGKDLFKPIQSKKVGTYKNFFYLIKWDELIIFPIQISQLPLESVLHLTLFGVLNQSSGSSPDSN 779

  Fly   122 -------VIGGTSISMFGKDGMFRQGMYDLRVWLGVEGDGNFPSRTPGKGKESSKSQMQRLGKLA 179
                   .:|..|:::|........|...|.:|                               .
Mouse   780 KQRKGPEALGKVSLTLFDFKRFLTCGTKLLYLW-------------------------------T 813

  Fly   180 KKHRN---GQVQKVDWLDRLTFREIEVINEREKRMSDYMFLMIEFPAIVVDDMYNYAVVYFEPEG 241
            ..|.|   |.:.|..:           :.||       :.|.::||:...|      ::|..|:.
Mouse   814 SSHTNSIPGAIPKKSY-----------VMER-------IVLQVDFPSPAFD------IIYTSPQI 854

  Fly   242 DVKYKLPAKPKLVSVPDSEIQMENLVERKHHRLARSERSGISDRDAKPTASIRDQLHTIVYRYPP 306
            |                     .|::::              |:.....:.|:.:|..|::| ..
Mouse   855 D---------------------RNIIQQ--------------DKLETLESDIKGKLLDIIHR-DS 883

  Fly   307 TYVLSSEEQDLVWKFRFYLSSHKKALTKFL-KCINWKLEDEVTQALWMLANWAPMDVEDALELLS 370
            ::.||.|::..:|:.|:|...|...|.|.| ...|||..: :.:...:|..|.|:....|||||.
Mouse   884 SFGLSKEDKVFLWENRYYCLKHPNCLPKILASAPNWKWAN-LAKTYSLLHQWPPLCPLAALELLD 947

  Fly   371 PTFTHPQVRKYAVSRLAQAPDEDLLLYLLQLVQALKYEDPRHIVHLHGCIFPERDVVRSILDDNG 435
            ..|...:||..|||.:....|::|...|.|.|||||||     ::|:                  
Mouse   948 AKFADQEVRSLAVSWMEAISDDELADLLPQFVQALKYE-----IYLN------------------ 989

  Fly   436 SLLDQSSLSDLSATSSGLHGSVIPANQRAASVLAAIKSDKSVSPGSAGGSGSGGQGSVALPNPSA 500
                                                                             
Mouse   990 ----------------------------------------------------------------- 989

  Fly   501 PATPGSSSLPCDSNSNALMLAEGISFGSVPANLCTFLIQRACTNATLANYFYWYLSIEVEEVESV 565
                                          ::|..||:.||..|..:|:..||.|.         
Mouse   990 ------------------------------SSLVRFLLSRALGNIQIAHSLYWLLK--------- 1015

  Fly   566 RKQDERAHD-----MYAMVLKMFLKVLENGNFNLRGIFYNLRKQRRFIDELVKLVKLVAKEPGNR 625
                :..||     .|..||...|.|   |.   :|:...|.||.:    ||:|:..||::....
Mouse  1016 ----DALHDTHFGSRYEHVLGALLSV---GG---KGLREELSKQMK----LVQLLGGVAEKVRQA 1066

  Fly   626 NKKTEKFQKLLAEQDMFKV-NFTNFEPIPFPLDPEIYITKIVPMRTSLFKSALMPAKLTFVTS-I 688
            :..|   ::::.::.|.:| :|........||.|.:...::.....|.|.|..||.|:|.|.: .
Mouse  1067 SGST---RQVVLQKSMERVQSFFLRNKCRLPLKPSLVAKELNIKSCSFFSSNAMPLKVTMVNADP 1128

  Fly   689 AHHEYAAIFKHGDDLRQDQLILQMITLMDKLLRRENLDLKLTPYKVLATSSKHGFLQYVD-SCTV 752
            ...|...:||.|:|||||.|.||||.:|||:..:|.|||::..::.|:|....|.::.|. |.|:
Mouse  1129 LGEEINVMFKVGEDLRQDMLALQMIKIMDKIWLKEGLDLRMVIFRCLSTGRDRGMVELVPASDTL 1193

  Fly   753 AEVLAREGNIHNF--------FRKHHPCDNGPYGISAEVMDTYIKSCAGYCVITYLLGVGDRHLD 809
            .::....|...:|        .||::|.:. .|..::|   .:|.||||.||.||:||:.|||.|
Mouse  1194 RKIQVEYGVTGSFKDKPLAEWLRKYNPSEE-EYEKASE---NFIYSCAGCCVATYVLGICDRHND 1254

  Fly   810 NLLLTTNGKLFHIDFGYILG---------RDPKPMPPPMKLSKEMVEAMGGISSE--HHHEFRKQ 863
            |::|.:.|.:||||||..||         ||    ..|..|:.:|...:.|....  ....|...
Mouse  1255 NIMLRSTGHMFHIDFGKFLGHAQMFGSFKRD----RAPFVLTSDMAYVINGGEKPTIRFQLFVDL 1315

  Fly   864 CYTAYLHLRRHANVMLNLFSLMVDATVPDIALEPDKAVKKVEENLQLGLTDEEAVQHLQSLLDVS 928
            |..||..:|:..|:.|||.|||:.:.:|::....|  :|.|.:.||...||.||......|::.|
Mouse  1316 CCQAYNLIRKQTNLFLNLLSLMIPSGLPELTSIQD--LKYVRDALQPQTTDAEATIFFTRLIESS 1378

  Fly   929 ITAVMPALVEQIHRFTQ 945
            :.::.......||...|
Mouse  1379 LGSIATKFNFFIHNLAQ 1395

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pi3K59FNP_477133.1 C2_PI3K_class_III 27..186 CDD:176042 26/138 (19%)
PI3Ka_III 284..561 CDD:238442 54/277 (19%)
PI3Kc_III 601..945 CDD:270628 115/365 (32%)
Pik3c2aNP_035213.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..26
Interaction with clathrin, sufficient to induce clathrin assembly. /evidence=ECO:0000250|UniProtKB:O00443 2..142
ETS_PEA3_N <40..>210 CDD:368026
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 41..68
PI3K_rbd 421..513 CDD:366310
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 615..640
C2A_PI3K_class_II 677..849 CDD:175979 34/188 (18%)
PI3Ka_II 869..1038 CDD:238441 60/304 (20%)
PI3Kc_C2_alpha 1043..1395 CDD:270720 115/368 (31%)
PX_PI3K_C2_alpha 1426..1534 CDD:132822
Interaction with PtdIns(4,5)P2-containing membranes. /evidence=ECO:0000269|PubMed:16338929 1488..1493
C2B_PI3K_class_II 1560..1681 CDD:176027
Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:O00443 1606..1617
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D204282at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.820

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