DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pi3K59F and pifk-1

DIOPT Version :9

Sequence 1:	NP_477133.1	Gene:	Pi3K59F / 37733	FlyBaseID:	FBgn0015277	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	NP_508177.2	Gene:	pifk-1 / 180443	WormBaseID:	WBGene00018076	Length:	666	Species:	Caenorhabditis elegans

Alignment Length:	788	Identity:	162/788 - (20%)
Similarity:	292/788 - (37%)	Gaps:	210/788 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   240 EGDVKYKLPAKPKLVSVP--------------------DSEIQMENLVERKHHRLARSERSGISD 284
            |.||:|.: .:|.|..||                    |.||::|                  .:
Worm     4 ESDVEYTI-KQPDLTDVPTQSAKNLADGTIIVGENDTSDKEIEIE------------------KE 49

  Fly   285 RDAKPTASIRDQLHTIVYRYPPTYVLSSEEQDLVWKFRFYLSSHKKALTKFLKCINWKLEDEVTQ 349
            ...|||                     .:.|.  |..|...|          :..|
Worm    50 DTTKPT---------------------HDRQS--WTMRLISS----------ESFN--------- 72

  Fly   350 ALWMLANWAPMDVEDALELLSPTFTHPQVRKYAVSRLAQAPDEDLLLYLLQLVQA-LKYEDPRHI 413
                    |||    |:|.|:.....|.: .:...||...|::||..||.||:.. :...|...:
Worm    73 --------APM----AVEYLNSIQDKPSL-TFLGKRLFDLPEKDLDFYLPQLMYLYVTKVDAASV 124

  Fly   414 VHLH-------------GCIFPERDVVRSILD--DNGSLLDQSSLSDLSATSSGLHGSVIPANQR 463
            .|.:             .||:......:::.:  :|.:|:.:|.||          .|.:|...:
Worm   125 SHAYIEERNKKDAQFTVLCIWLLNCFTKNVPNKYENHALMLKSLLS----------RSNVPGTSQ 179

  Fly   464 AASVLAAIKSDK----SVSPGSAGGSGSGGQGSVALPNPSAPATPGSSSLPCDSNSNALMLAEGI 524
            :|..:..:..|:    :.:.||:.|..:|.....|:...|.                  :.||..
Worm   180 SADNMITLSLDRLEETNWTVGSSYGKSAGALARAAIQKEST------------------LTAEHD 226

  Fly   525 SFGSVPANLCTFLIQRACTNATLANYF--YWYLSIEVEEVESVRKQDERAHDMYAMVLKMFLKVL 587
            |:   ..:.|..:..:..||.  .|:.  ..|:.:::.|...:..:.|:...:.: .|.|...:|
Worm   227 SY---EKSRCGPISTKLLTNQ--QNFIGRLVYIGVKLTEHHLLSSKQEKTIALQS-ELSMLNSML 285

  Fly   588 ENG---NFNLRGIFYNLRKQRRFI----DEL--VKLVKLVAKEPG-NRNKKT-----EKFQKLLA 637
            .|.   .|:.....:|:......:    |::  |...:::...|. |.|.||     .:.:|..:
Worm   286 PNSVWIPFDFENTMFNICVNESAVLNSKDKVPYVFFAEVIRSSPNYNSNIKTLSSVEPRIKKSQS 350

  Fly   638 EQDMFKVNFTNFEPIPFPLDPEIYITKIVPMRTSLFKS--ALMPAKLTFVTSIAHHE----YAAI 696
            |..:.| |.:..:    ..||.|          ::|..  |...|::...:...:|:    ...|
Worm   351 ESVLLK-NKSYHD----STDPSI----------AVFAESWAEKKARIRGSSRYENHQKWDLIPVI 400

  Fly   697 FKHGDDLRQDQLILQMITLMDKLLRRENLDLKLTPYKVLATSSKHGFLQYV-DSCT-------VA 753
            .|.||||.|:....|::.....|...|.:.|.|.|||::...|..|.::.| |:.:       :.
Worm   401 VKTGDDLSQEAFAQQLLFTFKDLWHEEGVPLYLRPYKIVCIGSDAGLIEPVLDTLSLHQIKRHLT 465

  Fly   754 EVLAREGNIHNFFRKHH------PCDNGPYGISAEVMDTYIKSCAGYCVITYLLGVGDRHLDNLL 812
            .|....||:.....|||      |.::..| ::|:  ..:|:|.|.|.:::|.|.:.|||..|:|
Worm   466 NVFRMNGNVTTPSLKHHFENVFGPVNSETY-VNAQ--KNFIQSTAAYSLVSYYLQLKDRHNGNIL 527

  Fly   813 LTTNGKLFHIDFGYILGRDPKPM---PPPMKLSKEMVEAMGGISSEHHHEFRKQCYTAYLHLRRH 874
            |..:|.|.|||:|::|...|:.:   ..|.||:.|:::.||||.|:....|:.......:..|:|
Worm   528 LDMDGHLIHIDYGFLLSSSPRNLGFETAPFKLTTEIIDVMGGIDSDMFLYFKSLLLRGLMAARKH 592

  Fly   875 ANVMLNLFSLMVDATVPDIALEPDKAVKKVEENLQLGLTDEEAVQHLQSLLDVSITAVMPALVEQ 939
            ...:::|..:|...:.........:.|:.:|....:..|||:    ||.|:|..:.....:...:
Worm   593 HRRIVSLAEIMSAGSKMQCFRAGAETVRALEARFHVSSTDEQ----LQQLVDTLVEGSRDSYTTR 653

  Fly   940 IHRFTQYW 947
            .:...||:
Worm   654 FYDSFQYY 661

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K59F	NP_477133.1	C2_PI3K_class_III	27..186	CDD:176042
		PI3Ka_III	284..561	CDD:238442	51/298 (17%)
		PI3Kc_III	601..945	CDD:270628	89/378 (24%)
pifk-1	NP_508177.2	PI4Kc_III_beta	367..666	CDD:270712	78/312 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810