Protein Alignment Pi3K59F and age-1

DIOPT Version :10

• Sequence 1: NP_477133.1
• Gene: Pi3K59F / 37733
• FlyBaseID: FBgn0015277
• Length: 949
• Species: Drosophila melanogaster
• Sequence 2: NP_496462.2
• Gene: age-1 / 174762
• WormBaseID: WBGene00000090
• Length: 1182
• Species: Caenorhabditis elegans
• Alignment Length: 877
• Identity: 198/877 - (22%)
• Similarity: 318/877 - (36%)
• Gaps: 285/877 - (32%)

  Fly    88 WN-EWVTLPLQFSDLPRSAMLVLTILDCSGAGQTTV------IGGTSISMFGKDGMFRQGMYDLR 145
            || |..|..|...|:|.||:|.:.:|    .|:..:      :|..::|:.......|||.:...
 Worm   477 WNKEMYTFDLYMKDMPPSAVLSIRVL----YGKVKLKSEEFEVGWVNMSLTDWRDELRQGQFLFH 537

  Fly   146 VWLGVEGDGNFPSRTPGKGKESSKSQMQRLGKLAKKHRNGQVQKVDWLDRLTFREIEVINEREKR 210
            :|.        |..|..:         .|:|:      ||
 Worm   538 LWA--------PEPTANR---------SRIGE------NG------------------------- 554

  Fly   211 MSDYMFLMIEFPAIVVDDMYNYAVVYFEPEGDVKYKLPAKPKLVSVPDSEIQMENLVERKHHRLA 275
                  ..|...|.|..::.:|.       |.|  ::|          |:.|...||:   ||..
 Worm   555 ------ARIGTNAAVTIEISSYG-------GRV--RMP----------SQGQYTYLVK---HRST 591

  Fly   276 RSERSGISDRDAKPTASIRD----QLHTIVYRYPPTYVLSSEEQDLVWKFRFYLSSHKKALTKFL 336
            .:|...|...|.:  :.|||    :|..:|.::....||..:||..||.:|.|:...:..|...|
 Worm   592 WTETLNIMGDDYE--SCIRDPGYKKLQMLVKKHESGIVLEEDEQRHVWMWRRYIQKQEPDLLIVL 654

  Fly   337 K--CINWKLEDEVTQALWMLANWAPMDVEDALELLSPTFTHPQVRKYAVSRL-AQAPDEDLLLYL 398
            .  ...|...:..::...||..|.|..|..||.||....|...:||:||.:| .|.......|::
 Worm   655 SELAFVWTDRENFSELYVMLEKWKPPSVAAALTLLGKRCTDRVIRKFAVEKLNEQLSPVTFHLFI 719

  Fly   399 LQLVQALKYEDPRHIVHLHGCIFPERDVVRSILDDNGSLLDQSSLSDLSATSSGLHGSVIPANQR 463
            |.|:|||||| ||
 Worm   720 LPLIQALKYE-PR---------------------------------------------------- 731

  Fly   464 AASVLAAIKSDKSVSPGSAGGSGSGGQGSVALPNPSAPATPGSSSLPCDSNSNALMLAEGISFGS 528
                                     .|..|.:
 Worm   732 -------------------------AQSEVGM--------------------------------- 738

  Fly   529 VPANLCTFLIQRACTNATLANYFYWYLSIEVEEVESVRKQDERAHDMYAMVLKMFLKVLENGNFN 593
                   .|:.||..:..:.:..:|.|..|:..:.....:.|. :...:::::.:|:    ||..
 Worm   739 -------MLLTRALCDYRIGHRLFWLLRAEIARLRDCDLKSEE-YRRISLLMEAYLR----GNEE 791

  Fly   594 LRGIFYNLRKQRRFIDELVKLVKLVAKEPGNRNKKTEKFQKLLAEQDMFKVNFTNFEPIPFPLDP 658
            ...|   :.:|...:|||.::..||...|     |.....||   :|..:......|.:..||||
 Worm   792 HIKI---ITRQVDMVDELTRISTLVKGMP-----KDVATMKL---RDELRSISHKMENMDSPLDP 845

  Fly   659 EIYITKIVPMRTSLFKSALMPAKLTFVT----SIAHHEYAA-IFKHGDDLRQDQLILQMITLMDK 718
            ...:.:::..:..:..||..|..|.:..    |..|..:.| |||:|||||||.|:||::.:||.
 Worm   846 VYKLGEMIIDKAIVLGSAKRPLMLHWKNKNPKSDLHLPFCAMIFKNGDDLRQDMLVLQVLEVMDN 910

  Fly   719 LLRRENLDLKLTPYKVLATSSKHGFLQYVDSC-TVAEVLAREGNIHNFFRKHHP----------C 772
            :.:..|:|..|.||.||......|.::.|.:| |:.|:....|.::...|...|          |
 Worm   911 IWKAANIDCCLNPYAVLPMGEMIGIIEVVPNCKTIFEIQVGTGFMNTAVRSIDPSFMNKWIRKQC 975

  Fly   773 -----------DNGPYGISAEV------------MDTYIKSCAGYCVITYLLGVGDRHLDNLLLT 814
                       |:....|..::            :|.::.||.||.|.||::|:.|||.|||:||
 Worm   976 GIEDEKKKSKKDSTKNPIEKKIDNTQAMKKYFESVDRFLYSCVGYSVATYIMGIKDRHSDNLMLT 1040

  Fly   815 TNGKLFHIDFGYILG---------RDPKPMPPPMKLSKEMVEAMGGISSE-HHHE---FRKQCYT 866
            .:||.||||||:|||         ||.:|.   :.....|.....|.|.: :.||   |:..|..
 Worm  1041 EDGKYFHIDFGHILGHGKTKLGIQRDRQPF---ILTEHFMTVIRSGKSVDGNSHELQKFKTLCVE 1102

  Fly   867 AYLHLRRHANVMLNLFSLMVDATVPDIALEPD 898
            ||..:..:.::.::||:||:...:|:::.:.|
 Worm  1103 AYEVMWNNRDLFVSLFTLMLGMELPELSTKAD 1134

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K59F	NP_477133.1	C2_PI3K_class_III	27..186	CDD:176042	23/104 (22%)
		PI3Ka_III	284..561	CDD:238442	52/283 (18%)
		PI3Kc_III	601..945	CDD:270628	102/350 (29%)
age-1	NP_496462.2	PI3K_p85B	98..177	CDD:197539
		PI3K_rbd	241..360	CDD:197540
		C2_PI3K_like	420..574	CDD:176026	29/161 (18%)
		PI3Ka	606..798	CDD:214537	56/317 (18%)
		Protein Kinases, catalytic domain	793..1181	CDD:473864	103/356 (29%)