DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pi3K59F and vps-34

DIOPT Version :9

Sequence 1:	NP_477133.1	Gene:	Pi3K59F / 37733	FlyBaseID:	FBgn0015277	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	NP_491741.1	Gene:	vps-34 / 172280	WormBaseID:	WBGene00006932	Length:	901	Species:	Caenorhabditis elegans

Alignment Length:	991	Identity:	353/991 - (35%)
Similarity:	515/991 - (51%)	Gaps:	150/991 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 PDDHFRYIHSSSLHERVQIKVGTLEGKKRQPDYEKLLEDPILRFSGLYSEEHPSFQVRLQVFNQ- 67
            |.:.|.:::|..|...||:||...||..|.      :.:|:.|.:.|::|      :.:...||
Worm     9 PTESFSFVYSCDLQTNVQVKVAEFEGIFRD------VLNPVRRLNQLFAE------ITVYCNNQQ 61

  Fly    68 -GRPYC----LPVTSSYKAFGKR-WSWNEWVTLPLQFSDLPRSAMLVLTIL---DCSGAGQTT-- 121
             |.|.|    .|..||..|..|. ..||||:|||:::|||.|.|.|.:||.   |......:|
Worm    62 IGYPVCTSFHTPPDSSQLARQKLIQKWNEWLTLPIRYSDLSRDAFLHITIWEHEDDEIVNNSTFS 126

  Fly   122 --VIGGTSISMFGKDGMFRQGMYDLRVWLGVEGDGNFPSRTPGKGKESSKSQMQRLGKLAKKHRN 184
              ::..:.:|||.|.|:.:.|:.|:::.:....|.........|..::...::..|.|...:...
Worm   127 RRLVAQSKLSMFSKRGILKSGVIDVQMNVSTTPDPFVKQPETWKYSDAWGDEIDLLFKQVTRQSR 191

  Fly   185 GQVQKVDWLDRLTFREIEVINEREKRMSD--YMFLMIEFPAIVVDDMYNYAVVYFEPEGD---VK 244
            |.|:.|.|||....|.||:|..:.|..|.  ::||::|..||.:...: |.|||:|.|..   |.
Worm   192 GLVEDVPWLDPFASRRIEMIRAKYKYSSPDRHVFLVLEMAAIRLGPTF-YKVVYYEDETKNMRVS 255

  Fly   245 YKLPAKPKLVS------VPDSEIQMENLVERKHHRLARSERSGISD---RDAKPTASIRDQLHTI 300
            ..:.....:||      |.|.|:.:|:|.|.||..:.|..|. :.|   |..||....:|:|.||
Worm   256 TSVNGGVGIVSACTRYCVADPELLLESLAEVKHSAMTRRIRD-VEDERHRQVKPNKQAKDRLETI 319

  Fly   301 VYRYPPTYVLSSEEQDLVWKFRFYLSSHKKALTKFLKCINWKLEDEVTQALWMLANWAPMDVEDA 365
            | ..|.:.||:.|::|||||||.||....|||.|:|:.:||....||..||.::.:|..::.|||
Worm   320 V-NLPSSQVLTREQRDLVWKFRHYLRQFPKALNKYLRSVNWVHPQEVKTALALMNDWELIEAEDA 383

  Fly   366 LELLSPTFTHPQVRKYAVSRLAQAPD-EDLLLYLLQLVQALKYEDPRHIVHLHGCIFPERDVVRS 429
            |||||..||||.||.|:||||.:|.. |.:||||.|||||||||..:.:        ||
Worm   384 LELLSSAFTHPAVRAYSVSRLLEAASPEQVLLYLPQLVQALKYEQGQQL--------PE------ 434

  Fly   430 ILDDNGSLLDQSSLSDLSATSSGLHGSVIPANQRAASVLAAIKSDKSVSPGSAGGSGSGGQGSVA 494
                                    .|:.:|           :.|::              :|.:
Worm   435 ------------------------EGNPVP-----------VVSEE--------------EGKI- 449

  Fly   495 LPNPSAPATPGSS----SLPCDSNSNALMLAEGISFGSVPANLCTFLIQRACTNATLANYFYWYL 555
               ||...||...    .:...:...|...|.|        :|.||||..|..:..::||.||:|
Worm   450 ---PSVATTPTEELEGRDMTVVTKKEARKAASG--------DLATFLIDYALASPKVSNYLYWHL 503

  Fly   556 SIEVEEVESVRKQDERAHDMYAMVLKMFLKVLENGNFNLRGIFYNLRKQRRFIDELVKLVKLVAK 620
            .   .|:||.::..|....||..:....::.|.. ..:.|....:|.:|:.|:::|:.|:. .||
Worm   504 K---TEIESTKESKEEHSKMYQNIQDRLMEALVK-RPDTRAQVDSLHQQQIFVEDLIILMN-EAK 563

  Fly   621 EPGNR--NKKTEKFQKLLAEQDMFKVNFTNFEPIPFPLDPEIYITKIVPMRTSLFKSALMPAKLT 683
            ..|.|  ..|:.:|:.:|:...    :..:.:.:..||||...::.::|...|.|||.:||||::
Worm   564 ARGGRLNESKSAEFRTMLSRAK----HMLDLKGVHLPLDPSFRLSSVIPDTASFFKSEMMPAKIS 624

  Fly   684 FVTSIAH--------HEYAAIFKHGDDLRQDQLILQMITLMDKLLRRENLDLKLTPYKVLATSSK 740
            |.....:        .||..|||.||||||||||.||:.|:|.:|::..||||||||.||:|...
Worm   625 FKVLQPNGKADRNIPEEYTVIFKTGDDLRQDQLIQQMVRLIDIILKKGQLDLKLTPYLVLSTGVG 689

  Fly   741 HGFLQYVDSCTVAEVLAREGNIHNF------FRKHHPCDNGPYGISAEVMDTYIKSCAGYCVITY 799
            .||:|.:.|..: ..:..:...|..      .::..|.| ||:||...|:|.|::|.|||.||.|
Worm   690 QGFVQCIKSKPL-RAIQEQYKAHKMDCIREAMKELRPGD-GPFGIEPNVIDNYVRSLAGYSVIMY 752

  Fly   800 LLGVGDRHLDNLLLTTNGKLFHIDFGYILGRDPKPMPPPMKLSKEMVEAMGGISSEHHHEFRKQC 864
            :||:||||||||||..||||||:|||:|||||||||||||||:.|||:.|||:.|:...||.:..
Worm   753 ILGLGDRHLDNLLLCENGKLFHVDFGFILGRDPKPMPPPMKLTSEMVQVMGGVKSKQFLEFVQHV 817

  Fly   865 YTAYLHLRRHANVMLNLFSLMVDATVPDIALEPDKAVKKVEENLQLGLTDEEAVQHLQSLLDVSI 929
            .:||..||||:||:|||||||:||.:||||.|||||:.|:|:.|:|.|:||.|.:|:.:.::.|:
Worm   818 DSAYRILRRHSNVLLNLFSLMLDAGIPDIAAEPDKAIFKIEQRLRLDLSDEAATKHIFTQIESSL 882

  Fly   930 TAVMPALVEQIHRFTQ 945
            .|.|..:.:.||.:.|
Worm   883 NAKMAMISDIIHAYKQ 898

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K59F	NP_477133.1	C2_PI3K_class_III	27..186	CDD:176042	45/172 (26%)
		PI3Ka_III	284..561	CDD:238442	92/284 (32%)
		PI3Kc_III	601..945	CDD:270628	163/359 (45%)
vps-34	NP_491741.1	C2_PI3K_class_III	21..193	CDD:176042	50/183 (27%)
		PI3Ka_III	303..509	CDD:238442	92/284 (32%)
		PI3Kc_III	543..898	CDD:270628	163/361 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167090
Domainoid	1	1.000	161	1.000	Domainoid score	I2454
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1986
Inparanoid	1	1.050	542	1.000	Inparanoid score	I635
Isobase	1	0.950	-	0	Normalized mean entropy	S1375
OMA	1	1.010	-	-		QHG54334
OrthoDB	1	1.010	-	-		D204282at2759
OrthoFinder	1	1.000	-	-		FOG0005021
OrthoInspector	1	1.000	-	-		oto19400
orthoMCL	1	0.900	-	-		OOG6_101850
Panther	1	1.100	-	-	LDO	PTHR10048
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1651
SonicParanoid	1	1.000	-	-		X3549
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	15.890