Protein Alignment Pi3K59F and Pi3K59F

DIOPT Version :10

• Sequence 1: NP_477133.1
• Gene: Pi3K59F / 37733
• FlyBaseID: FBgn0015277
• Length: 949
• Species: Drosophila melanogaster
• Sequence 2: XP_061516913.1
• Gene: Pi3K59F / 1279696
• VectorBaseID: AGAMI1_009268
• Length: 884
• Species: Anopheles gambiae
• Alignment Length: 951
• Identity: 568/951 - (59%)
• Similarity: 692/951 - (72%)
• Gaps: 82/951 - (8%)

  Fly     9 RYIHSSSLHERVQIKVGTLEGKKRQPDYEKLLEDPILRFSGLYSEEHPSFQVRLQVFNQGRPYCL 73
            |||.||||.:::.||:|||||:.....||||:|.|:|:|||:|:|:.|..:|:||:|:.|.|..|
Mosquito     6 RYIGSSSLLQKISIKIGTLEGENVGYSYEKLIEQPLLKFSGMYTEKTPPLKVKLQIFDNGEPVGL 70

  Fly    74 PVTSSYKAFGKRWSWNEWVTLPLQFSDLPRSAMLVLTILDCSGA-GQTTVIGGTSISMFGKDGMF 137
            ||.:|:|.|..|||||||||||::|:|:.|:|:|.|||.||:|. .|.||:||||||.|..:|:|
Mosquito    71 PVCTSHKHFTTRWSWNEWVTLPMRFTDISRTAVLGLTIYDCAGGREQLTVVGGTSISFFSTNGLF 135

  Fly   138 RQGMYDLRVWLGVEGDGNFPSRTPGKGKESSKSQMQRLGKLAKKHRNGQVQKVDWLDRLTFREIE 202
            |||:|||:||..:|.||...|.||||...:...|||||.||||||||||::|:||||||||||:|
Mosquito   136 RQGLYDLKVWPQMEPDGACNSITPGKAITTGVHQMQRLSKLAKKHRNGQMEKIDWLDRLTFRELE 200

  Fly   203 VINEREKRMSDYMFLMIEFPAIVVDDMYNYAVVYFEPEGDVKYKLPAKPKLVSVPDSEIQMENLV 267
            ||||.|||.|.:::||:|||.:.:.:.. |:|::.|...:......||||:|.|||.||..||||
Mosquito   201 VINEMEKRNSQFLYLMVEFPQVYIHEKL-YSVIHLEKNSNSVVTFIAKPKIVVVPDCEIHQENLV 264

  Fly   268 ERKHHRLARSERSGISDRDAKPTASIRDQLHTIVYRYPPTYVLSSEEQDLVWKFRFYLSSHKKAL 332
            |||||||:||:|||.||||.||.|.:||.|::|||||..||.|||||||::||:|||||||||||
Mosquito   265 ERKHHRLSRSDRSGTSDRDVKPNAIVRDTLNSIVYRYSSTYPLSSEEQDIIWKYRFYLSSHKKAL 329

  Fly   333 TKFLKCINWKLEDEVTQALWMLANWAPMDVEDALELLSPTFTHPQVRKYAVSRLAQAPDEDLLLY 397
            ||||||:||:...||.|||.:|.:|:|||||||||||:.||.||.||.||::||.:|.||.||||
Mosquito   330 TKFLKCVNWETAAEVRQALALLESWSPMDVEDALELLNSTFRHPIVRWYAITRLNEASDEYLLLY 394

  Fly   398 LLQLVQALKYEDPRHIVHLHGCIFPERDVVRSILDDNGSLLDQSSLSDLSATSSGLHGSVI---- 458
            |||||||||||.                            .|:||   .|||.|...|..|
Mosquito   395 LLQLVQALKYEP----------------------------FDESS---NSATRSPTEGKEIFQSY 428

  Fly   459 --PANQRAASVLAAIKSDKSVSPGSAGGSGSGGQGSVALPNPSAPATPGSSSLPCDSNSNALMLA 521
              |.:.:.          ..:.|.|.|.|.:..:..:            ::...|.|.:
Mosquito   429 EEPTDAQF----------DDLQPDSTGISDNNVEEVI------------NNRYQCSSVN------ 465

  Fly   522 EGISFGSVPANLCTFLIQRACTNATLANYFYWYLSIEVEEVESVRKQDERAHDMYAMVLKMFLKV 586
                      ||..||:.|||.|.|||||.||||:||.|: |...|:|.:...||:.||:|||..
Mosquito   466 ----------NLANFLVDRACQNPTLANYLYWYLTIECED-ERSSKKDLKISKMYSNVLRMFLNC 519

  Fly   587 LENGNFNLRGIFYNLRKQRRFIDELVKLVKLVAKEPGNRNKKTEKFQKLLAE---QDMFKVNFTN 648
            |..|...::.....|::|:.|:|.||.|||:||||.|||.:||||||:.|||   .::.|.||.|
Mosquito   520 LYKGTPEMKATHAQLKEQQHFVDRLVTLVKIVAKESGNRKRKTEKFQQFLAESSSSNVTKFNFNN 584

  Fly   649 FEPIPFPLDPEIYITKIVPMRTSLFKSALMPAKLTFVTSIAHHEYAAIFKHGDDLRQDQLILQMI 713
            |.||.|||||.|.||.|...:.|||||||||:||||.|: :..:|.|||||||||||||||||||
Mosquito   585 FGPIVFPLDPSIQITGIAAEKVSLFKSALMPSKLTFRTT-SGTDYVAIFKHGDDLRQDQLILQMI 648

  Fly   714 TLMDKLLRRENLDLKLTPYKVLATSSKHGFLQYVDSCTVAEVLAREGNIHNFFRKHHPCDNGPYG 778
            |||||||::||||||||||:||||||||||:||:||.||||||..||:|||:|||.:||:.||:|
Mosquito   649 TLMDKLLQKENLDLKLTPYRVLATSSKHGFMQYIDSVTVAEVLNTEGSIHNYFRKFNPCETGPFG 713

  Fly   779 ISAEVMDTYIKSCAGYCVITYLLGVGDRHLDNLLLTTNGKLFHIDFGYILGRDPKPMPPPMKLSK 843
            |..|:|||||||||||||||||||:|||||||||||::|||||||||||||||||||||||||||
Mosquito   714 IMPEIMDTYIKSCAGYCVITYLLGIGDRHLDNLLLTSSGKLFHIDFGYILGRDPKPMPPPMKLSK 778

  Fly   844 EMVEAMGGISSEHHHEFRKQCYTAYLHLRRHANVMLNLFSLMVDATVPDIALEPDKAVKKVEENL 908
            |||||||||:||:::.|||.||||:||||||||||||||.|||||:||||||||||:|||||:||
Mosquito   779 EMVEAMGGINSEYYNTFRKLCYTAFLHLRRHANVMLNLFGLMVDASVPDIALEPDKSVKKVEDNL 843

  Fly   909 QLGLTDEEAVQHLQSLLDVSITAVMPALVEQIHRFTQYWRK 949
            :|.|:|||||||||:|||:||||||||||||||:..|||||
Mosquito   844 RLDLSDEEAVQHLQNLLDISITAVMPALVEQIHKLAQYWRK 884

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K59F	NP_477133.1	C2_PI3K_class_III	27..186	CDD:176042	91/159 (57%)
		PI3Ka_III	284..561	CDD:238442	125/282 (44%)
		PI3Kc_III	601..945	CDD:270628	266/346 (77%)
Pi3K59F	XP_061516913.1	None