DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pi3K59F and Pik3c2g

DIOPT Version :9

Sequence 1:	NP_477133.1	Gene:	Pi3K59F / 37733	FlyBaseID:	FBgn0015277	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	NP_446375.1	Gene:	Pik3c2g / 116720	RGDID:	620231	Length:	1505	Species:	Rattus norvegicus

Alignment Length:	945	Identity:	209/945 - (22%)
Similarity:	348/945 - (36%)	Gaps:	314/945 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 YSEEHPSFQVRLQVFNQGRPYC-------LPVTSSYKAFGKRWSWNEWVTLPLQFSDLPRSAMLV 108
            ::..:.:|.....:...|:..|       ||||   |:|....:|||.:..||:...|||.:|||
  Rat   558 WAHSYKAFSFSCWLTYAGKKLCQVKSCRSLPVT---KSFSFSVNWNEIINFPLEIKSLPRESMLV 619

  Fly   109 LTILDCSGAGQT-TVIGGTSISMFGKD---------GMFRQG-----MYDLRVWLGVEGDGNFPS 158
            :.:.....|..: .::..|.:.:|.|:         .|..|.     |....||     ||:.|
  Rat   620 IKLFGIDSATHSANLLAWTCLPLFPKEKSPLGSRLLSMTLQSEPPIEMMAPGVW-----DGSQP- 678

  Fly   159 RTPGKGKESSKSQMQRLGKLAKKHRNGQVQKVDWLDRLTFREIEVINEREKRMSDYMFLMIEFPA 223
             ||                                                     :.|.|:|||
  Rat   679 -TP-----------------------------------------------------LTLQIDFPA 689

  Fly   224 IVVDDMYNYAVVYFEPEGDVKYKLPAKPKLVSVPDSEIQMENLVERKHHRLARSERSGISDRDAK 288
            ...:        |.:||.:                     ||   |..|:              :
  Rat   690 ATWE--------YVKPETE---------------------EN---RTDHQ--------------E 708

  Fly   289 PTASIRDQLHTIVYRYPPTYVLSSEEQDLVWKFRFYLSSHKKALTKFL-KCINWKLEDEVTQALW 352
            |.......:..:..:.|| .:||.|::..:|.:|||.::...:|...| ....|. |..|::...
  Rat   709 PPRECLKHIARLSQKQPP-LLLSVEKRRYLWFYRFYCNNENSSLPLVLGSAPGWD-EGTVSEMHA 771

  Fly   353 MLANWAPMDVEDALELLSPTFTHPQVRKYAVSRLAQAPDEDLLLYLLQLVQALKYEDPRHIVHLH 417
            :|..|......:||.||:..|....:|:.||.:|.....::||..|.|||||:|:|
  Rat   772 VLRRWTFSHPLEALGLLTSRFPDQDIREVAVQQLDNFLTDELLDCLPQLVQAVKFE--------- 827

  Fly   418 GCIFPERDVVRSILDDNGSLLDQSSLSDLSATSSGLHGSVIPANQRAASVLAAIKSDKSVSPGSA 482

  Rat   828 ----------------------------------------------------------------- 827

  Fly   483 GGSGSGGQGSVALPNPSAPATPGSSSLPCDSNSNALMLAEGISFGSVPANLCTFLIQRACTNATL 547
                                                        .|:.:.|...|:.|:..:..:
  Rat   828 --------------------------------------------WSLESPLVELLLHRSLQSIRV 848

  Fly   548 ANYFYWYLSIEVEEVESVRKQDERAHDMYAMVLKMFLKVLE--NGNFNLRGIFYNLRKQRRFIDE 610
            |:..:|.|            :|.:..|.:....:..|..|:  .|    ..:...|.|::
  Rat   849 AHRLFWLL------------RDAQGEDYFKSWYQELLAALQFCAG----EALIEELSKEQ----- 892

  Fly   611 LVKLVKLV------AKEPGNRNKKTEKFQKLLAEQDMFKVNFTNFEPIPFPLDPEIYITKIVPMR 669
              |||||:      .|..|:..:|....:::.:.::.||    :.:....||:|.:.:..|....
  Rat   893 --KLVKLLGDIGEKVKSAGDAQRKDVLKKEIGSLEEFFK----DIKTCHLPLNPALCVKGIDRDA 951

  Fly   670 TSLFKSALMPAKLTFV-TSIAHHEYAAIFKHGDDLRQDQLILQMITLMDKLLRRENLDLKLTPYK 733
            .|.|.|..:|.|:||: .:......:.|||.|||||||.|:||:|.:||.:..:|.||:::..|.
  Rat   952 CSYFTSNALPLKITFINANPMGKNISVIFKAGDDLRQDMLVLQIIQVMDNVWLQEGLDMQMIIYG 1016

  Fly   734 VLATSSKHGFLQYV-DSCTVAEV--------LAREGNIHNFFRKHHPCDNGPYGISAEVMDTYIK 789
            .|||....||::.| |:.|:|::        ..:|..|..:|.:|:.....    ..:.:..:..
  Rat  1017 CLATGKAQGFIEMVPDAVTLAKIHLHSGLIGPLKENTIKKWFSQHNHLKED----YEKALRNFFY 1077

  Fly   790 SCAGYCVITYLLGVGDRHLDNLLLTTNGKLFHIDFGYILG---------RDPKPMPPPMKLSKEM 845
            ||||:||:|::|||.|||.||::||.:|.:||||||..||         ||..|.....::...:
  Rat  1078 SCAGWCVVTFILGVCDRHNDNIMLTKSGHMFHIDFGKFLGHAQTFGGIKRDRAPFIFTSEMEYFI 1142

  Fly   846 VEAMGGISSEHHHEFRKQCYTAYLHLRRHANVMLNLFSLMVDATVPDIALEPDKAVKKVEENLQL 910
            .|  ||.:::|..:|.:.|..||..:|:|:.::|:|..:|:.|.:|::....|  :|.|.:||:.
  Rat  1143 TE--GGKNTQHFQDFVELCCRAYNIVRKHSQLLLSLLEMMLHAGLPELRGIED--LKYVHDNLRP 1203

  Fly   911 GLTDEEAVQHLQSLLDVSITAVMPALVEQIHRFTQ 945
            ..||.||..|..:.:..|:......|...||...|
  Rat  1204 QDTDLEATSHFTTKIKQSLECFPVKLNNLIHTLAQ 1238

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K59F	NP_477133.1	C2_PI3K_class_III	27..186	CDD:176042	34/156 (22%)
		PI3Ka_III	284..561	CDD:238442	43/277 (16%)
		PI3Kc_III	601..945	CDD:270628	114/368 (31%)
Pik3c2g	NP_446375.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..32
		PI3K_rbd	<310..368	CDD:295323
		C2A_PI3K_class_II	535..697	CDD:175979	40/209 (19%)
		PI3Ka	712..879	CDD:294194	46/298 (15%)
		PKc_like	886..1238	CDD:304357	114/370 (31%)
		PX_domain	1267..1367	CDD:295365
		C2	1389..1501	CDD:301316
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D204282at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820