DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pi3K59F and BOLA2-SMG1P6

DIOPT Version :9

Sequence 1:NP_477133.1 Gene:Pi3K59F / 37733 FlyBaseID:FBgn0015277 Length:949 Species:Drosophila melanogaster
Sequence 2:NP_001307551.1 Gene:BOLA2-SMG1P6 / 107282092 HGNCID:53563 Length:305 Species:Homo sapiens


Alignment Length:354 Identity:66/354 - (18%)
Similarity:109/354 - (30%) Gaps:122/354 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   465 ASVLAAIKSDKSVSPGSAGGSGSGGQGSVALPNPSAPATPGSSSLPCDSNSNALM------LAEG 523
            |.|.|.:.....|:|....||.:|.:..|.            |.|.|.|:..|.|      |.|.
Human    25 ALVRAEVSFPAEVAPVRQQGSVAGARAGVV------------SLLGCRSSWTAAMELSAEYLREK 77

  Fly   524 I--------------SFGSVPANLC---TFLIQRACTNATLANYFYWYLSIEVEEVESV----RK 567
            :              ..|.|.....   |.::.|.....|.||..::..::.....|.|    ..
Human    78 LQRDLEAEHVLPSPGGVGQVRGETAASETQVLYRVMRCVTAANQVFFSEAVLTAANECVGVLLGS 142

  Fly   568 QDERAHDMYAMVLKMFLKVLENGNFNLRGIFYNLRKQRRFIDELVKLVKLVAKEPGNRNKKTEKF 632
            .|........||:...|..|||             .|....|.::.::.|:.             
Human   143 LDPSMTIHCDMVITYGLDQLEN-------------CQTCGTDYIISVLNLLT------------- 181

  Fly   633 QKLLAEQDMFKVNFTNFEPIPFPLDPEIYITKI-VPMRTSLFKSALMPAKLTFVTSIAHHEYAAI 696
              |:.||...|:             |..::.|: :|....||   |...|...|.::||..|.| 
Human   182 --LIVEQINTKL-------------PSSFVEKLFIPSSKLLF---LRYHKEKEVVAVAHAVYQA- 227

  Fly   697 FKHGDDLRQDQLILQMITLMDKLLRRENLDLKLTPYKVL------ATSSKHGFLQYVDSCTVAEV 755
                                  :|..:|:.:..|.||::      |.::....||..::|:..: 
Human   228 ----------------------MLSLKNIPVLETAYKLILGEMTCALNNLLHSLQLPEACSEIK- 269

  Fly   756 LAREGNIHNFFRKH-HPCDNGPYGISAEV 783
                   |..|:.| ...||..:.:..::
Human   270 -------HEAFKNHVFNVDNAKFVVKFDL 291

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pi3K59FNP_477133.1 C2_PI3K_class_III 27..186 CDD:176042
PI3Ka_III 284..561 CDD:238442 24/118 (20%)
PI3Kc_III 601..945 CDD:270628 33/191 (17%)
BOLA2-SMG1P6NP_001307551.1 None
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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