DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pi3K59F and pik3c2b

DIOPT Version :10

Sequence 1:NP_477133.1 Gene:Pi3K59F / 37733 FlyBaseID:FBgn0015277 Length:949 Species:Drosophila melanogaster
Sequence 2:XP_031752708.1 Gene:pik3c2b / 100489532 XenbaseID:XB-GENE-481489 Length:598 Species:Xenopus tropicalis


Alignment Length:612 Identity:161/612 - (26%)
Similarity:250/612 - (40%) Gaps:164/612 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   353 MLANWAPMDVEDALELLSPTFTHPQVRKYAVSRLAQAPDEDLLLYLLQLVQALKYEDPRHIVHLH 417
            :|..|..|:..|||.||...:...:||..|...:....|.:||.||.|||||||||         
 Frog    39 LLGQWTEMNHHDALRLLHARYPDQEVRDTAKQWIDSISDAELLEYLPQLVQALKYE--------- 94

  Fly   418 GCIFPERDVVRSILDDNGSLLDQSSLSDLSATSSGLHGSVIPANQRAASVLAAIKSDKSVSPGSA 482
             |                 .||                                      ||   
 Frog    95 -C-----------------YLD--------------------------------------SP--- 100

  Fly   483 GGSGSGGQGSVALPNPSAPATPGSSSLPCDSNSNALMLAEGISFGSVPANLCTFLIQRACTNATL 547
                                                              |..||::||..:..:
 Frog   101 --------------------------------------------------LVRFLLKRAICDLRI 115

  Fly   548 ANYFYWYLSIEVEEVE-SVRKQDERAHDMYAMVLKMFLKVLENGNFNLRGIFYNLRKQRRFIDEL 611
            .:||:|.|...:::.: |:|         |..:|...|.....|   ||..|.:   |...::.|
 Frog   116 THYFFWLLKDCLKDSQFSIR---------YQYLLAALLCCCGKG---LREEFDH---QCWLVNTL 165

  Fly   612 VKLVKLVAKEPGNRNKKTEKFQKLLAEQDMFKVNFTNFEPIPFPLDPEIYITKIVPMRTSLFKSA 676
            .||.:.| :|....:::....:.|...:..|.||.:    ...||:|.:.:..|||...|.|.|.
 Frog   166 SKLAQKV-REGAPSSRRAILREGLEEVKRFFNVNGS----CRLPLNPSLLVKGIVPEECSHFNSN 225

  Fly   677 LMPAKLTF--VTSIAHHEYAAIFKHGDDLRQDQLILQMITLMDKLLRRENLDLKLTPYKVLATSS 739
            .:|.||||  |.::..: ...|||.|||||||.|.||||.:|:|:..:|.||:::..::..:|..
 Frog   226 AVPLKLTFQNVDTLGGN-IQIIFKCGDDLRQDMLTLQMIRIMNKIWVQEGLDMQMVIFRCFSTGR 289

  Fly   740 KHGFLQYVDSC-TVAEVLAREGNIHNF--------FRKHHPCDNGPYGISAEVMDTYIKSCAGYC 795
            ..|.::.:.|. |:.::.|..|...:|        .:||:|..| .|   .:.:..:|.||||.|
 Frog   290 GRGMVEMIPSAETLRKIQAEHGVTGSFMDRPLADWLQKHNPTVN-EY---EKAVVNFIYSCAGCC 350

  Fly   796 VITYLLGVGDRHLDNLLLTTNGKLFHIDFGYILGR-----DPKPMPPPMKLSKEMVEAMGG--IS 853
            |.||:||:.|||.||::|.|:|.:||||||..||.     :.|....|...:.:|...:.|  ..
 Frog   351 VATYVLGICDRHNDNIMLKTSGHMFHIDFGRFLGHAQMFGNIKRDRAPFVFTSDMAYVINGGDKP 415

  Fly   854 SEHHHEFRKQCYTAYLHLRRHANVMLNLFSLMVDATVPDIALEPDKAVKKVEENLQLGLTDEEAV 918
            |....:|...|..||..:|:|.::.|||..||:...:|:::...|  :|.|.:.|:...::.:|.
 Frog   416 SSRFQDFVDLCCQAYNLIRKHTHLFLNLLGLMLSCGIPELSDLRD--LKYVYDALRPQDSESDAA 478

  Fly   919 QHLQSLLDVSITAVMPALVEQIHRFTQ 945
            .:...|::.|:.:|...|...||...|
 Frog   479 TYFTRLIESSLGSVATKLNFFIHNLAQ 505

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pi3K59FNP_477133.1 C2_PI3K_class_III 27..186 CDD:176042
PI3Ka_III 284..561 CDD:238442 39/207 (19%)
PI3Kc_III 601..945 CDD:270628 112/361 (31%)
pik3c2bXP_031752708.1 PI3Ka 11..146 CDD:412275 44/233 (19%)
Protein Kinases, catalytic domain 152..505 CDD:473864 114/367 (31%)
PX_domain 534..>593 CDD:470617
Blue background indicates that the domain is not in the aligned region.

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