DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pi3K59F and pik3c3

DIOPT Version :9

Sequence 1:	NP_477133.1	Gene:	Pi3K59F / 37733	FlyBaseID:	FBgn0015277	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	XP_031750800.1	Gene:	pik3c3 / 100485933	XenbaseID:	XB-GENE-6085226	Length:	887	Species:	Xenopus tropicalis

Alignment Length:	950	Identity:	527/950 - (55%)
Similarity:	676/950 - (71%)	Gaps:	73/950 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 DHFRYIHSSSLHERVQIKVGTLEGKKRQPDYEKLLEDPILRFSGLYSEEHPSFQVRLQVFNQGRP 70
            |.|.|::|..|...|::|:|:||||:.|..|:.:||||:|:|||||.|......|..|||.:|:|
Frog     5 DRFYYVYSCDLDISVRLKIGSLEGKREQKSYKAVLEDPMLKFSGLYQETCSDLYVTCQVFAEGKP 69

  Fly    71 YCLPVTSSYKAFGKRWSWNEWVTLPLQFSDLPRSAMLVLTILDCSGAGQTTVIGGTSISMFGKDG 135
            ..|||.:|||||..||:||||:.||::::||||||.:.|||.|..|.|:...:|||::|:|||.|
Frog    70 LALPVRTSYKAFSTRWNWNEWLKLPVKYADLPRSAQVALTIWDVYGPGKAIPVGGTTVSLFGKYG 134

  Fly   136 MFRQGMYDLRVWLGVEGDGNFPSRTPGKGKES-SKSQMQRLGKLAKKHRNGQVQKVDWLDRLTFR 199
            ||||||:||:||..:|.||:.|::|||:...| |:.||.||.||.|.||.|.:.|||||||||||
Frog   135 MFRQGMHDLKVWPNIEADGSEPTKTPGRTSSSASEDQMSRLAKLTKAHRQGHMVKVDWLDRLTFR 199

  Fly   200 EIEVINEREKRMSDYMFLMIEFPAIVVDDMYNYAVVYFEPEGDVKYKLPAKPKLVSVPDSEIQME 264
            |||:|||.|||.|::|:||:|||.:..|:. .|.:||:|.:||....:.:..::|.|||.::.||
Frog   200 EIEMINESEKRSSNFMYLMVEFPCVKSDEK-EYGIVYYEKDGDESTPISSSSEIVRVPDPQMSME 263

  Fly   265 NLVERKHHRLARSERSGISDRDAKPTASIRDQLHTIVYRYPPTYVLSSEEQDLVWKFRFYLSSHK 329
            ||||.|||:||||.|||.||.|.||.|:.||||:.|| .||||..|:|||||||||||.||::.:
Frog   264 NLVESKHHKLARSLRSGPSDHDLKPNAATRDQLNIIV-SYPPTKQLTSEEQDLVWKFRHYLTNQE 327

  Fly   330 KALTKFLKCINWKLEDEVTQALWMLANWAPMDVEDALELLSPTFTHPQVRKYAVSRLAQAPDEDL 394
            |||||||||:||.|..|..|||.:|..|.||||||:|||||..||:|.||:|||:||.||.||||
Frog   328 KALTKFLKCVNWDLPQEAKQALELLGKWKPMDVEDSLELLSSHFTNPTVRRYAVARLQQADDEDL 392

  Fly   395 LLYLLQLVQALKYEDPRHIVHLHGCIFPERDVVRSIL-----DDNGSLLDQSSLSDLSATSSGLH 454
            |:||||||||||||:           |.:   ::|.|     |..|.:|:       |.|:||::
Frog   393 LMYLLQLVQALKYEN-----------FED---IKSGLEPTKKDSQGPMLE-------SMTTSGIN 436

  Fly   455 GSVIPANQRAASVLAAIKSDKSVSPGSAGGSGSGGQGSVALPNPSAPATPGSSSLPCDSNSNALM 519
            .                :||.|              ..::.|.|||.::|..||...|
Frog   437 P----------------ESDSS--------------QVISNPLPSAVSSPAPSSKTKD------- 464

  Fly   520 LAEGISFGSVPANLCTFLIQRACTNATLANYFYWYLSIEVEEVESVRKQDERAHDMYAMVLKMFL 584
               |:...::..:||||||.|||.|:|||||.|||:.:|.|: :..:.:|.:.|:||..|::.|.
Frog   465 ---GLDAENLEQDLCTFLISRACKNSTLANYLYWYVIVECED-QDTQLRDPKTHEMYLNVMRRFS 525

  Fly   585 KVLENGNFNLRGIFYNLRKQRRFIDELVKLVKLVAKEPGNRNKKTEKFQKLLAEQDMFKVNFTNF 649
            :.|..|:.::|.:...|..|:.|:|.||.|:|.|.:|.|||.||.|:.|.||.:.:  |:|.:.|
Frog   526 QALLKGDKSVRVMRSLLATQQTFVDRLVHLMKAVQRESGNRKKKNERLQALLGDNE--KMNLSEF 588

  Fly   650 EPIPFPLDPEIYITKIVPMRTSLFKSALMPAKLTFVTSIAHHEYAAIFKHGDDLRQDQLILQMIT 714
            ||||.||:|::.|..|:|.:.:|||||||||||.|.|... ..|..|||:||||||||||||:|:
Frog   589 EPIPLPLEPQVKIRGIIPEKATLFKSALMPAKLYFKTEDG-GRYPVIFKNGDDLRQDQLILQIIS 652

  Fly   715 LMDKLLRRENLDLKLTPYKVLATSSKHGFLQYVDSCTVAEVLAREGNIHNFFRKHHPCDNGPYGI 779
            |||||||:||||||||||||||||:||||:|::.|..||||||.||:|.|||||:.|.:.|||||
Frog   653 LMDKLLRKENLDLKLTPYKVLATSTKHGFMQFIQSVPVAEVLATEGSIQNFFRKYAPSEKGPYGI 717

  Fly   780 SAEVMDTYIKSCAGYCVITYLLGVGDRHLDNLLLTTNGKLFHIDFGYILGRDPKPMPPPMKLSKE 844
            ||||||||:|||||||||||:||||||||||||||..||||||||||||||||||:||||||:||
Frog   718 SAEVMDTYVKSCAGYCVITYILGVGDRHLDNLLLTKTGKLFHIDFGYILGRDPKPLPPPMKLNKE 782

  Fly   845 MVEAMGGISSEHHHEFRKQCYTAYLHLRRHANVMLNLFSLMVDATVPDIALEPDKAVKKVEENLQ 909
            |||.|||..||.:..||||||||:|||||::|::||||||||||.:|||||||||.||||::..:
Frog   783 MVEGMGGTQSEQYQAFRKQCYTAFLHLRRYSNLILNLFSLMVDANIPDIALEPDKTVKKVQDKFR 847

  Fly   910 LGLTDEEAVQHLQSLLDVSITAVMPALVEQIHRFTQYWRK 949
            |.|:|||||.::|:|:|.|:.|:..|:|||||:|.||||:
Frog   848 LDLSDEEAVHYMQTLIDDSVNALFAAVVEQIHKFAQYWRR 887

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K59F	NP_477133.1	C2_PI3K_class_III	27..186	CDD:176042	87/159 (55%)
		PI3Ka_III	284..561	CDD:238442	128/281 (46%)
		PI3Kc_III	601..945	CDD:270628	234/343 (68%)
pik3c3	XP_031750800.1	C2_PI3K_class_III	26..186	CDD:176042	87/159 (55%)
		PI3Ka_III	283..503	CDD:238442	128/281 (46%)
		PI3Kc_III	539..883	CDD:270628	234/346 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	233	1.000	Domainoid score	I2360
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H1986
Inparanoid	1	1.050	1003	1.000	Inparanoid score	I297
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D204282at2759
OrthoFinder	1	1.000	-	-		FOG0005021
OrthoInspector	1	1.000	-	-		oto105513
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3549
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	8.060