Protein Alignment Pi3K59F and pik3ca

DIOPT Version :9

• Sequence 1: NP_477133.1
• Gene: Pi3K59F / 37733
• FlyBaseID: FBgn0015277
• Length: 949
• Species: Drosophila melanogaster
• Sequence 2: NP_001119972.1
• Gene: pik3ca / 100144924
• XenbaseID: XB-GENE-998106
• Length: 1065
• Species: Xenopus tropicalis
• Alignment Length: 1023
• Identity: 219/1023 - (21%)
• Similarity: 374/1023 - (36%)
• Gaps: 344/1023 - (33%)

  Fly     4 PDDHFRYIHS---------------SSLHERVQIKVGTLEGKKRQPDYEKLLEDPILRFSGLYS- 52
            |...::||.|               .||:.::.:.|.|:      |.|.:.:.......:|..|
 Frog   266 PLSQYKYIRSCIMLGRMPNLMLMAKDSLYSQIPVDVFTM------PSYSRRISTAAPYMNGEASA 324

  Fly    53 ------------------------EEHPSFQVRLQVFNQGRPYCLPV-TSSYKAFGKRWSWNEWV 92
                                    .:.....||..:::...|.|..| |........|  ||||:
 Frog   325 KSLWAINSTLRIKILCATYVNVNIRDIDKIYVRTGIYHGVEPLCDNVNTQRVPCSNPR--WNEWL 387

  Fly    93 TLPLQFSDLPRSAMLVLTILDCSGAGQTTV------IGGTSISMFGKDGMFRQGMYDLRVW---- 147
            ...:...||||:|.|.|:|  ||..|:...      :...:|::|........|...|.:|
 Frog   388 LYDMFIPDLPRAARLCLSI--CSVKGRKGAKEEHCPLAWGNINLFDYTDTLVSGKMALNLWPVPH 450

  Fly   148 --------LGVEGDGNFPSRTPGKGKESSKSQMQRLGKLAKKHRNGQVQKVDWLDRLTFREIEVI 204
                    :||.| .|....||
 Frog   451 GLEDLLNPIGVSG-SNPNKETP------------------------------------------- 471

  Fly   205 NEREKRMSDYMFLMIEFPAIVVDDMYNYAVVYFEPEGDVKYKLPAKPKLVSVPDSEIQMENLVER 269
                       .|.:||      |.::..|.:              |.:.::.|   ....::||
 Frog   472 -----------CLELEF------DCFSSPVKF--------------PDMTAIED---HANKVLER 502

  Fly   270 K----------HHRLARSERSGISDRDAKPTASIRDQLHTIVYRYPPTYVLSSEEQDLVWKFRFY 324
            :          .:|:.|......||::.....|.||.|..|          :.:|::.:|..|.|
 Frog   503 EMGYNYSHSGLSNRIVRENEVRESDKEQLKAISNRDPLSEI----------TEQEKEFLWSHRLY 557

  Fly   325 LSSHKKALTKFLKCINWKLEDEVTQALWMLANWAPMDVEDALELLSPTFTHPQ--VRKYAVSRLA 387
            ..:..:.|.|.|..:.|...|:|:|...:|..|..:..|.|:|||.  |.:|.  ||.:|||.|.
 Frog   558 CRNIPEILPKLLLSVKWNCRDDVSQMYCLLKEWPAIRPEQAMELLD--FNYPDRIVRSFAVSCLE 620

  Fly   388 Q-APDEDLLLYLLQLVQALKYEDPRHIVHLHGCIFPERDVVRSILDDNGSLLDQSSLSDLSATSS 451
            : ..|:.|..||:||||.:|||                    ..||:
 Frog   621 KYLTDDKLSQYLIQLVQVMKYE--------------------QYLDN------------------ 647

  Fly   452 GLHGSVIPANQRAASVLAAIKSDKSVSPGSAGGSGSGGQGSVALPNPSAPATPGSSSLPCDSNSN 516
                                                                             
 Frog   648 ----------------------------------------------------------------- 647

  Fly   517 ALMLAEGISFGSVPANLCTFLIQRACTNATLANYFYWYLSIEVEEVESVRKQDERAHDMYAMVLK 581
                           :|..||:::|..|..:.::|:|.|..|:.. ::|.::.....:.|.....
 Frog   648 ---------------HLVRFLLKKALVNQRIGHFFFWLLKSEMHN-KTVSQRFGLLLESYCRACG 696

  Fly   582 MFLKVLENGNFNLRGIFYNLRKQRRFIDELVKLVKLVAKEPGNRNKKTEKFQ-KLLAEQDMFKVN 645
            |:||              :|.||...:::|:.|..::.:|   :..:|:|.| |.|.|| |.:.:
 Frog   697 MYLK--------------HLSKQVEAMEKLINLTDILKQE---KKDETQKVQMKFLVEQ-MKRPD 743

  Fly   646 FTN-FEPIPFPLDPEIYITKIVPMRTSLFKSALMPAKLTF-----VTSIAHHEYAAIFKHGDDLR 704
            |.: .:....||:|...:..:......:..||..|..|.:     ::.:.......|||:|||||
 Frog   744 FMDALQGFTSPLNPAHQLGNLRLEECRIMSSAKRPLWLNWENPDIMSEMLFLNNEIIFKNGDDLR 808

  Fly   705 QDQLILQMITLMDKLLRRENLDLKLTPYKVLATSSKHGFLQYVD-SCTVAEVLAREG-------- 760
            ||.|.||:|.:|:.:.:.:.|||::.||..|:.....|.::.|. |.|:.::..:.|
 Frog   809 QDMLTLQIIRIMENIWQNQGLDLRMLPYGCLSIGDCVGLIEVVRCSHTIMQIQCKGGLKGALQFN 873

  Fly   761 --NIHNFFRKHHPCDNGPYGISAEVMDTYIKSCAGYCVITYLLGVGDRHLDNLLLTTNGKLFHID 823
              .:|.:.:     |..........:|.:.:|||||||.|::||:||||..|:::..||:|||||
 Frog   874 SHTLHQWLK-----DKNKGETYDAAIDLFTRSCAGYCVATFILGIGDRHNSNIMVKDNGQLFHID 933

  Fly   824 FGYILGRDPKPM-----PPPMKLSKE-MVEAMGGI----SSEHHHEFRKQCYTAYLHLRRHANVM 878
            ||:.|....|..     ..|..|::: ::....||    .:.....|::.||.|||.:|:|||:.
 Frog   934 FGHFLDHKKKKFGYKRERVPFVLTQDFLIVISKGIQECTKTRDFERFQEMCYKAYLAIRQHANLF 998

  Fly   879 LNLFSLMVDATVPDIALEPDKAVKKVEENLQLGLTDEEAVQHLQSLLD 926
            :||||:|:.:.:|::....|  :..:.:.|.|..|::||:::....::
 Frog   999 INLFSMMLGSGMPELQSFDD--IAYIRKTLALDKTEQEALEYFMKQMN 1044

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K59F	NP_477133.1	C2_PI3K_class_III	27..186	CDD:176042	37/202 (18%)
		PI3Ka_III	284..561	CDD:238442	54/279 (19%)
		PI3Kc_III	601..945	CDD:270628	103/354 (29%)
pik3ca	NP_001119972.1	PI3K_p85B	34..107	CDD:280372
		PI3K_rbd	173..292	CDD:295323	4/25 (16%)
		C2_PI3K_class_I_alpha	325..484	CDD:176043	37/223 (17%)
		PI3Ka_I	525..696	CDD:238444	57/301 (19%)
		PI3Kc_IA_alpha	695..1064	CDD:270719	106/375 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D204282at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920