Protein Alignment Pi3K59F and pik3ca

DIOPT Version :10

• Sequence 1: NP_477133.1
• Gene: Pi3K59F / 37733
• FlyBaseID: FBgn0015277
• Length: 949
• Species: Drosophila melanogaster
• Sequence 2: NP_001119972.1
• Gene: pik3ca / 100144924
• XenbaseID: XB-GENE-998106
• Length: 1065
• Species: Xenopus tropicalis
• Alignment Length: 1024
• Identity: 219/1024 - (21%)
• Similarity: 372/1024 - (36%)
• Gaps: 346/1024 - (33%)

  Fly     4 PDDHFRYIHS---------------SSLHERVQIKVGTLEGKKRQPDYEKLLEDPILRFSGLYS- 52
            |...::||.|               .||:.::.:.|.|:      |.|.:.:.......:|..|
 Frog   266 PLSQYKYIRSCIMLGRMPNLMLMAKDSLYSQIPVDVFTM------PSYSRRISTAAPYMNGEASA 324

  Fly    53 ------------------------EEHPSFQVRLQVFNQGRPYCLPV-TSSYKAFGKRWSWNEWV 92
                                    .:.....||..:::...|.|..| |........|  ||||:
 Frog   325 KSLWAINSTLRIKILCATYVNVNIRDIDKIYVRTGIYHGVEPLCDNVNTQRVPCSNPR--WNEWL 387

  Fly    93 TLPLQFSDLPRSAMLVLTILDCSGAGQTTV------IGGTSISMFGKDGMFRQGMYDLRVW---- 147
            ...:...||||:|.|.|:|  ||..|:...      :...:|::|........|...|.:|
 Frog   388 LYDMFIPDLPRAARLCLSI--CSVKGRKGAKEEHCPLAWGNINLFDYTDTLVSGKMALNLWPVPH 450

  Fly   148 --------LGVEGDGNFPSRTPGKGKESSKSQMQRLGKLAKKHRNGQVQKVDWLDRLTFREIEVI 204
                    :||.| .|....||
 Frog   451 GLEDLLNPIGVSG-SNPNKETP------------------------------------------- 471

  Fly   205 NEREKRMSDYMFLMIEFPAIVVDDMYNYAVVYFEPEGDVKYKLPAK-PKLVSVPDSEIQMENLVE 268
                       .|.:||..                     :..|.| |.:.::.|   ....::|
 Frog   472 -----------CLELEFDC---------------------FSSPVKFPDMTAIED---HANKVLE 501

  Fly   269 RK----------HHRLARSERSGISDRDAKPTASIRDQLHTIVYRYPPTYVLSSEEQDLVWKFRF 323
            |:          .:|:.|......||::.....|.||.|..|          :.:|::.:|..|.
 Frog   502 REMGYNYSHSGLSNRIVRENEVRESDKEQLKAISNRDPLSEI----------TEQEKEFLWSHRL 556

  Fly   324 YLSSHKKALTKFLKCINWKLEDEVTQALWMLANWAPMDVEDALELLSPTFTHPQ--VRKYAVSRL 386
            |..:..:.|.|.|..:.|...|:|:|...:|..|..:..|.|:|||.  |.:|.  ||.:|||.|
 Frog   557 YCRNIPEILPKLLLSVKWNCRDDVSQMYCLLKEWPAIRPEQAMELLD--FNYPDRIVRSFAVSCL 619

  Fly   387 AQ-APDEDLLLYLLQLVQALKYEDPRHIVHLHGCIFPERDVVRSILDDNGSLLDQSSLSDLSATS 450
            .: ..|:.|..||:||||.:|||                    ..||:
 Frog   620 EKYLTDDKLSQYLIQLVQVMKYE--------------------QYLDN----------------- 647

  Fly   451 SGLHGSVIPANQRAASVLAAIKSDKSVSPGSAGGSGSGGQGSVALPNPSAPATPGSSSLPCDSNS 515
                                                                             
 Frog   648 ----------------------------------------------------------------- 647

  Fly   516 NALMLAEGISFGSVPANLCTFLIQRACTNATLANYFYWYLSIEVEEVESVRKQDERAHDMYAMVL 580
                            :|..||:::|..|..:.::|:|.|..|:.. ::|.::.....:.|....
 Frog   648 ----------------HLVRFLLKKALVNQRIGHFFFWLLKSEMHN-KTVSQRFGLLLESYCRAC 695

  Fly   581 KMFLKVLENGNFNLRGIFYNLRKQRRFIDELVKLVKLVAKEPGNRNKKTEKFQ-KLLAEQDMFKV 644
            .|:||              :|.||...:::|:.|..::.:|   :..:|:|.| |.|.|| |.:.
 Frog   696 GMYLK--------------HLSKQVEAMEKLINLTDILKQE---KKDETQKVQMKFLVEQ-MKRP 742

  Fly   645 NFTN-FEPIPFPLDPEIYITKIVPMRTSLFKSALMPAKLTF-----VTSIAHHEYAAIFKHGDDL 703
            :|.: .:....||:|...:..:......:..||..|..|.:     ::.:.......|||:||||
 Frog   743 DFMDALQGFTSPLNPAHQLGNLRLEECRIMSSAKRPLWLNWENPDIMSEMLFLNNEIIFKNGDDL 807

  Fly   704 RQDQLILQMITLMDKLLRRENLDLKLTPYKVLATSSKHGFLQYVD-SCTVAEVLAREG------- 760
            |||.|.||:|.:|:.:.:.:.|||::.||..|:.....|.::.|. |.|:.::..:.|
 Frog   808 RQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLSIGDCVGLIEVVRCSHTIMQIQCKGGLKGALQF 872

  Fly   761 ---NIHNFFRKHHPCDNGPYGISAEVMDTYIKSCAGYCVITYLLGVGDRHLDNLLLTTNGKLFHI 822
               .:|.:.:     |..........:|.:.:|||||||.|::||:||||..|:::..||:||||
 Frog   873 NSHTLHQWLK-----DKNKGETYDAAIDLFTRSCAGYCVATFILGIGDRHNSNIMVKDNGQLFHI 932

  Fly   823 DFGYILGRDPKPM-----PPPMKLSKE-MVEAMGGI----SSEHHHEFRKQCYTAYLHLRRHANV 877
            |||:.|....|..     ..|..|::: ::....||    .:.....|::.||.|||.:|:|||:
 Frog   933 DFGHFLDHKKKKFGYKRERVPFVLTQDFLIVISKGIQECTKTRDFERFQEMCYKAYLAIRQHANL 997

  Fly   878 MLNLFSLMVDATVPDIALEPDKAVKKVEENLQLGLTDEEAVQHLQSLLD 926
            .:||||:|:.:.:|::....|  :..:.:.|.|..|::||:::....::
 Frog   998 FINLFSMMLGSGMPELQSFDD--IAYIRKTLALDKTEQEALEYFMKQMN 1044

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K59F	NP_477133.1	C2_PI3K_class_III	27..186	CDD:176042	37/202 (18%)
		PI3Ka_III	284..561	CDD:238442	54/279 (19%)
		PI3Kc_III	601..945	CDD:270628	103/354 (29%)
pik3ca	NP_001119972.1	PI3K_p85B	34..107	CDD:460483
		PI3K_rbd	173..292	CDD:413336	4/25 (16%)
		C2_PI3K_class_I_alpha	325..484	CDD:176043	36/238 (15%)
		PI3Ka_I	525..696	CDD:238444	57/301 (19%)
		Protein Kinases, catalytic domain	695..1064	CDD:473864	106/375 (28%)