Protein Alignment ItgaPS5 and ITGA8

DIOPT Version :9

• Sequence 1: NP_611808.2
• Gene: ItgaPS5 / 37732
• FlyBaseID: FBgn0034880
• Length: 1018
• Species: Drosophila melanogaster
• Sequence 2: NP_003629.2
• Gene: ITGA8 / 8516
• HGNCID: 6144
• Length: 1063
• Species: Homo sapiens
• Alignment Length: 1085
• Identity: 281/1085 - (25%)
• Similarity: 442/1085 - (40%)
• Gaps: 206/1085 - (18%)

  Fly    43 RSSYFGYSLVI-----RPTSIFVGAPRAQSTLESQGSINETGAVYRCPL-ASGS--CSHYVLNDK 99
            :.|||||::..     |..|:.||||:|.:   ||..|.|.||||.||. |.||  |.....:..
Human    53 KGSYFGYAVDFHIPDARTASVLVGAPKANT---SQPDIVEGGAVYYCPWPAEGSAQCRQIPFDTT 114

  Fly   100 LNKQF--------------QWLGGSMDGGTKDTDKLLVCAPRFF------VPKNKNYGQMRGICY 144
            .|::.              ||.|.::..   ...|::.|||.:.      .|:....    |.||
Human   115 NNRKIRVNGTKEPIEFKSNQWFGATVKA---HKGKVVACAPLYHWRTLKPTPEKDPV----GTCY 172

  Fly   145 WVRDTVADTPPLSDVRTISLIPSQAEEHFMLELGLSAHVTDDNSGFLIGAPGVRSWKGSVLVHRG 209
            ......:.....|..|..:..|   |.....:.|.|.... .|...::|.||...|:|.|:....
Human   173 VAIQNFSAYAEFSPCRNSNADP---EGQGYCQAGFSLDFY-KNGDLIVGGPGSFYWQGQVITASV 233

  Fly   210 EDLAAQGSYAVKML--------------DSWDWVKNHFTYVGYALSSGYFSSNNRTSLLYVTTAP 260
            .|:.|  :|:.|.:              .|:|     .:|:||::::|.|:.:::..|  |...|
Human   234 ADIIA--NYSFKDILRKLAGEKQTEVAPASYD-----DSYLGYSVAAGEFTGDSQQEL--VAGIP 289

  Fly   261 SSVLNTGKAYIFDVVGEIVRKLHVFHGEQLGEYFGYSVVAEDLNGDGLTDVVVSAPL----NALG 321
            ....|.|  |:..:....:..:..|.|||:..||||:||..|:|.|||.||:|.|||    ....
Human   290 RGAQNFG--YVSIINSTDMTFIQNFTGEQMASYFGYTVVVSDVNSDGLDDVLVGAPLFMEREFES 352

  Fly   322 DSYDVGAIYVFINKGLFKFEKKIIRLPLSSGARFGSSLSKVGDINHDGYNDLAVGAPFAG---NG 383
            :..:||.||:::......|....|.....:..||||:::.:||:|.|||||:|:|.||||   .|
Human   353 NPREVGQIYLYLQVSSLLFRDPQILTGTETFGRFGSAMAHLGDLNQDGYNDIAIGVPFAGKDQRG 417

  Fly   384 AVFIFLGSEHGLRDEPSQRLDAPSREPGPYGAHM----FGQGLSRGSDIDGNGFNDLAIGAPGAE 444
            .|.|:.|::.||..:|||.|.      |.:.:|.    ||..|...||||.|.:.||.:||.|..
Human   418 KVLIYNGNKDGLNTKPSQVLQ------GVWASHAVPSGFGFTLRGDSDIDKNDYPDLIVGAFGTG 476

  Fly   445 AVYLYRAYPVVKIHATVRSESRAIRPEQET------ITVTACYRLETTSKA------------RQ 491
            .|.:|||.|||.:.|.:......|..|.:|      :|..||:.|...:..            .:
Human   477 KVAVYRARPVVTVDAQLLLHPMIINLENKTCQVPDSMTSAACFSLRVCASVTGQSIANTIVLMAE 541

  Fly   492 MQQQELTFRMTIDELLQRVSFAPMRTNEVSFQAQAGLSGSCRNFSVGVHYTGGI---FTPIDLEL 553
            :|...|..:..|...|...:....|...:..:.|.  |..|::|.|.:......   .:||::.|
Human   542 VQLDSLKQKGAIKRTLFLDNHQAHRVFPLVIKRQK--SHQCQDFIVYLRDETEFRDKLSPINISL 604

  Fly   554 HYELAKKIPHSHEAFCESCAVVDPLEPKYATGTLS----FMTGCAA-HVCVSDLQLSSKDVNSSF 613
            :|.|      ....|.|... |.|:...|....:|    .:..|.. ::||.||:||::......
Human   605 NYSL------DESTFKEGLE-VKPILNYYRENIVSEQAHILVDCGEDNLCVPDLKLSARPDKHQV 662

  Fly   614 IFGSLEVLSFSYEITNSGEPAYVAQFNVTSSARLPFAKV--------PGNCRVRHE----VMLCD 666
            |.|....|.......|.||.||.|:..|.......:..:        |.:|..:.|    :::||
Human   663 IIGDENHLMLIINARNEGEGAYEAELFVMIPEEADYVGIERNNKGFRPLSCEYKMENVTRMVVCD 727

  Fly   667 LNGGRALARGDSESLTIIFDVTQL--SGQSLTIEAAVSSAGMDQNPKDNTMSTTISLREYAEIDA 729
            |  |..:..|.:.||.:.|.|.:|  :..|:..:..:.|:..| ||..|.:|..|::...|:::.
Human   728 L--GNPMVSGTNYSLGLRFAVPRLEKTNMSINFDLQIRSSNKD-NPDSNFVSLQINITAVAQVEI 789

  Fly   730 SGGPIDGHIAL-------KEYPYSAE-----VNNSYEFKSHGPSIIDELTVYVDVPIAYTVTGSA 782
            .|......|.|       :|.|:..|     |.:.||..:.|||.|.:..:.|..|.:.......
Human   790 RGVSHPPQIVLPIHNWEPEEEPHKEEEVGPLVEHIYELHNIGPSTISDTILEVGWPFSARDEFLL 854

  Fly   783 GIKSIFNISSLQMQAT---HGSELVPIKLYDQTNTLAKEYPLEDSSRRANRKRRELQQDQYAIMP 844
            .|..|..:..||.|..   :..::.|....:.|..|: .:....:.....|||
Human   855 YIFHIQTLGPLQCQPNPNINPQDIKPAASPEDTPELS-AFLRNSTIPHLVRKR------------ 906

  Fly   845 DVNI--------SDILTKENLPANRTLVLDCLRG------NWTICVRSQMRVQL---KPEQPIDL 892
            ||::        :.||...|:   ..|.:.|..|      :..:.|||::....   :...|..|
Human   907 DVHVVEFHRQSPAKILNCTNI---ECLQISCAVGRLEGGESAVLKVRSRLWAHTFLQRKNDPYAL 968

  Fly   893 R--ISFKVDLNDFVNTFDYLVIFTNVEMFKEGDSTSIALKRNL---KPNVIFNYSETPLPIWYII 952
            .  :||:|....:.:         ......||   ||.:|.::   .|||.|:     :|:|.||
Human   969 ASLVSFEVKKMPYTD---------QPAKLPEG---SIVIKTSVIWATPNVSFS-----IPLWVII 1016

  Fly   953 LSLIAGHLLLGAMTYILYKLRFFKRGKKEELKRLLEEHRSETKEP 997
            |:::.|.|:|..:|..|:|..||.|.:..:......|..:..|.|
Human  1017 LAILLGLLVLAILTLALWKCGFFDRARPPQEDMTDREQLTNDKTP 1061

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ItgaPS5	NP_611808.2	VCBS	302..375	CDD:338792	29/76 (38%)
		Int_alpha	351..403	CDD:214549	27/54 (50%)
		Int_alpha	417..463	CDD:214549	21/49 (43%)
		Integrin_alpha2	451..836	CDD:337057	98/439 (22%)
ITGA8	NP_003629.2	Int_alpha	54..112	CDD:214549	26/60 (43%)
		Int_alpha	263..311	CDD:214549	12/56 (21%)
		Int_alpha	317..>365	CDD:214549	21/47 (45%)
		Int_alpha	383..437	CDD:214549	27/53 (51%)
		Int_alpha	448..492	CDD:214549	20/43 (47%)
		Integrin_alpha2	483..934	CDD:285619	104/478 (22%)
		Integrin_alpha	1035..1049	CDD:278771	4/13 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142007
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840