Protein Alignment ItgaPS5 and Itga2b

DIOPT Version :10

• Sequence 1: NP_611808.2
• Gene: ItgaPS5 / 37732
• FlyBaseID: FBgn0034880
• Length: 1018
• Species: Drosophila melanogaster
• Sequence 2: NP_001413964.1
• Gene: Itga2b / 685269
• RGDID: 1596428
• Length: 1037
• Species: Rattus norvegicus
• Alignment Length: 1140
• Identity: 305/1140 - (26%)
• Similarity: 472/1140 - (41%)
• Gaps: 298/1140 - (26%)

  Fly    18 AMNFSPLPNRVIDAPKHLKTRMIQVRSSYFGYSLVIR-----PTSIFVGAPRAQSTLESQGSINE 77
            |:|...:...|...|          ..|:||:|:...     ..||.||||||.:..:     .|
  Rat    31 ALNLDSVKFSVYTGP----------NGSHFGFSVDFHKDSHGSVSIVVGAPRALNANQ-----EE 80

  Fly    78 TGAVYRCP--LASGSCSH--YVLND---KLN-------KQFQWLGGSMDGGTKDTDKLLVCAPRF 128
            ||.|:.||  ..:|:|:.  :.|.|   ||:       |..|.||.|:   ....|.::.|||..
  Rat    81 TGGVFLCPWKANNGTCTSLLFDLRDETRKLSLQTFQTFKTGQGLGASV---LSWNDVIVACAPWQ 142

  Fly   129 FVPKNKNYGQMR----GICYWVRDTVAD---------TPPLSDVRTISLIPSQ--AEEHFMLELG 178
            .....:.|.:..    |.|:     ||:         :|..|:  |:|.:.||  :.:....|.|
  Rat   143 HWNVLEKYDEAEKTPVGGCF-----VAELQSGGRAEYSPCRSN--TMSSVYSQGFSGDKRYCEAG 200

  Fly   179 LSAHVTDDNSGFLIGAPG----------------VRSWK-GSVLVHRGEDLAAQGSYAVKMLDSW 226
            .|..||.... .::||||                :.|:: |::|.|....   :.||     ||.
  Rat   201 FSLAVTQAGE-LVLGAPGGYFFLGLLVRVPIENIISSYRPGTLLWHVSNQ---RFSY-----DSS 256

  Fly   227 DWVKNHFTYVGYALSSGYFSSNNRTSLLYVTTAPSSVLNTGKAYIFDVVGEIVRKLHVFHGEQLG 291
            :.|..| .|.||:::.|.|..:..|: .|:..||:.....|...|.|   ...:.||..||||:.
  Rat   257 NPVYFH-GYRGYSVAVGEFDGDLSTT-EYIFGAPTWSWTLGAVEILD---SYYQTLHRLHGEQMA 316

  Fly   292 EYFGYSVVAEDLNGDGLTDVVVSAPLNALGDSY----------DVGAIYVFIN-KGLFKFEKKII 345
            .|||:||...|:||||..|::|.|||      |          :||.:|:|:. |||.......:
  Rat   317 SYFGHSVAVTDVNGDGRHDLLVGAPL------YMESRVDRKLAEVGRVYLFLQPKGLQALSSPTL 375

  Fly   346 RLPLSSG----ARFGSSLSKVGDINHDGYNDLAVGAPF---AGNGAVFIFLGSEHGLRDEPSQRL 403
            .|   :|    .||||:::.:||:|.|||||:||.||:   :|.|.|.||||...||...|||.|
  Rat   376 VL---TGTQVYGRFGSAIAPLGDLNRDGYNDVAVAAPYGGPSGQGQVLIFLGQSEGLSPRPSQVL 437

  Fly   404 DAPSREPGPYGAHMFGQGLS-RGS-DIDGNGFNDLAIGAPGAEAVYLYRAYPVVKIHATVR-SES 465
            |:|.    |.|:   |.|.| ||| |||.||:.||.:||.||..|.:|||.|||.  |||: ...
  Rat   438 DSPF----PTGS---GFGFSLRGSVDIDDNGYPDLIVGAYGASKVAVYRAQPVVM--ATVQLMVQ 493

  Fly   466 RAIRPE------QETITVTACYRLETTSKA---RQMQQQELTFRMTIDELLQRVSFAPMRTNEVS 521
            .::.|.      ::|.|..:|:.::....|   ...|:..|...:.:|  ||:    |.:...|.
  Rat   494 DSLNPTLKNCVLEQTKTPVSCFNVQMCVGATGHNIPQKLHLKAELQLD--LQK----PRQARRVL 552

  Fly   522 FQA--QAGLSGSC----RNFSVGVHYTGGIFTPIDLELHYELAKKIPHSHEAFC-ESCAVVDPLE 579
            ..|  ||.|:.|.    ||                        |.|.|:.:||. :.....|.|.
  Rat   553 LLASRQASLTLSLDLGGRN------------------------KPICHTIKAFLRDEADFRDKLS 593

  Fly   580 PKYATGTLSF---MTGCA--------AHV---------------CVSDLQLSSKDVNSSFIFGSL 618
            |...:..:|.   .||.|        .||               ||..|||::...:|..:.|:.
  Rat   594 PIVLSLNVSLPPEETGVAPAVVLHGVTHVQEQTRIILDCGEDNLCVPQLQLTATAGDSPLLIGAD 658

  Fly   619 EVLSFSYEITNSGEPAYVAQFNVTSSARLP--------FAKVPG----NCRVRHE----VMLCDL 667
            .||......:|.||.||.|:..|    .||        |:.|.|    .|..:.|    :.||:|
  Rat   659 NVLELKVNASNDGEGAYEAELAV----HLPPGAHYIRAFSNVKGFERLVCTQKKENESRLALCEL 719

  Fly   668 NGGRALARGDSESLTIIFDVTQL--SGQSLTIEAAVSSAGMDQNPKDNTMSTTISLREYAEIDAS 730
              |..:.:.....:|::..|..|  :|.|::.:..:.|.. .|||....:...:::|..|.::..
  Rat   720 --GNPMKKDTRIGITMLVSVEILEEAGDSVSFQLQIRSKN-SQNPNSEAVLLPVAVRAEAAVELR 781

  Fly   731 GG--PIDGHIALKEY--------PYSAEVNNSYEFKSHGPSIIDELTVYVDVPIAYTVTGSAGIK 785
            |.  |....:|.:|.        .:.:.|.::||..::||..::.|::.:.:|      |.:...
  Rat   782 GNSFPASLVVAAEEVDKEQDGLDSWVSRVEHTYELHNNGPGTVNGLSLIIHLP------GQSQPS 840

  Fly   786 SIFNISSLQMQATHG---SELVPIKLYDQTNTLAKEYPLEDSSRRA--NRKRREL---------Q 836
            .:..|  |.:|...|   |...|.||......|..  |...|.||.  :|.|||.         |
  Rat   841 DLLYI--LDVQPKGGLLCSTQPPPKLLKVDRRLTT--PSPSSIRRIHHDRDRREASPQGSKQTEQ 901

  Fly   837 QDQYAIMPDVNISDILTKENLPANRTLVLDC-----LRGNWT-ICVRSQMRVQLKPEQPIDLRIS 895
            ||           .:|...|..|..| |::|     :||... :.|::.:.:.:..::|.:   .
  Rat   902 QD-----------PVLVSCNGSAPCT-VVECELQEMVRGQRAMVTVQATLGLSILRQRPQE---Q 951

  Fly   896 FKVDLNDF--VNTFDYLVIFTNVEMFKEGDSTSIALKRNLKPNVIFNYSETPLPIWYIILSLIAG 958
            |.:..:.:  |::..|.|   .|.....|...       ::.:::....|..:|:|::::.::.|
  Rat   952 FVLQSHAWFNVSSLPYSV---PVVSLPSGQGL-------VQTHLLRALEERDIPVWWVLVGVLGG 1006

  Fly   959 HLLLGAMTYILYKLRFFKRGKKEELKRLLEEHRSE 993
            .|||..:...::|..||||.:..     |||...|
  Rat  1007 LLLLTLLVLAMWKAGFFKRNRPP-----LEEEEEE 1036

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ItgaPS5	NP_611808.2	FG-GAP	294..332	CDD:460357	18/47 (38%)
		Int_alpha	351..403	CDD:214549	29/58 (50%)
		Int_alpha	417..463	CDD:214549	27/48 (56%)
		Integrin_alpha2	453..837	CDD:462478	106/468 (23%)
Itga2b	NP_001413964.1	None