DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ItgaPS5 and itga6l

DIOPT Version :9

Sequence 1:	NP_611808.2	Gene:	ItgaPS5 / 37732	FlyBaseID:	FBgn0034880	Length:	1018	Species:	Drosophila melanogaster
Sequence 2:	XP_021336955.1	Gene:	itga6l / 555254	ZFINID:	ZDB-GENE-040914-57	Length:	786	Species:	Danio rerio

Alignment Length:	818	Identity:	191/818 - (23%)
Similarity:	322/818 - (39%)	Gaps:	190/818 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   283 HVFHGEQLGEYFGYSVVAEDLNGDGLTDVVVSAP-LNALGDSYDV-GAIYVFINKGLFKFEKKI- 344
            |:..|..|...|||.:...|||.||..|:||.|| .::.....|| ||:|::||:...:....|
Zfish    42 HILRGPGLASSFGYDLTILDLNADGWDDIVVGAPEFSSKNMDDDVGGAVYIYINQAEGQHWSHIQ 106

  Fly   345 -IRLPLSSGARFGSSLSKVGDINHDGYNDLAVGAP--FAGNGAVFIFLGSEHGLRDEPSQRLDAP 406
             :.|.....:.||.:::.|||:|.|||.|.|..||  .:|.|.|:|:.||..|...:|:. |||
Zfish   107 PVCLYGKKDSMFGLAVAHVGDLNQDGYQDFASSAPNEDSGRGRVYIYHGSAAGFHHKPTV-LDA- 169

  Fly   407 SREPGPYGAHMFGQGLSRGSDIDGNGFNDLAIGAPGAEAVYLYRAYPVVKIHAT-------VRSE 464
                |.:...:||..|:...|:|.||:.:||:|: .::.|.:||..||:.|..|       :..:
Zfish   170 ----GDHSIKLFGYSLAGNMDMDSNGYPELAVGS-FSDTVLIYRTKPVINIEKTLTLTPNKIDFK 229

  Fly   465 SRAIRPEQETITVTACYRLETTSKARQMQQQELTFRMTIDE------LLQRVSFAPMRTNEVSFQ 523
            ::..:.:...||..:|:.. ||.......:..:.:::..|.      |..||.|..........|
Zfish   230 AQDCKRKPCIITAQSCFTY-TTEPQTYNPKLRIEYKLEADTVRRERGLPSRVVFVNSDAANGRQQ 293

  Fly   524 AQAGLSGSCRNFSVGVHYTGGI---FTPIDLELHYELAKKIP-HSHEAFCESCAVVDPLEPKYAT 584
            .:|....||  ....:...|.|   .|.|.:.|...|....| .:.....:...|::.|:.|.:.
Zfish   294 LKAQRQKSC--VQTKLRLLGEIQDKLTSISISLSVSLPSDNPKQTIRNLPDLEPVLNTLQEKTSK 356

  Fly   585 GTLSFM-TGCAA-HVCVSDLQL--------------------------SSKDVNSSFIFGSLEVL 621
            ..:||: :||.: ::|.|:|||                          |..|||.     :|||
Zfish   357 AEVSFLNSGCGSDNICQSNLQLQYSFCTKDQQQDQCDPLAMENGVPVISPGDVNI-----ALEV- 415

  Fly   622 SFSYEITNS-GEPAYVAQFNVTSSARLPFAKV-------------PGNCRVRHEVMLCDLNGGRA 672
                .:||: |:.|:..|..|.....|....|             |...|.:.:   |.|  |..
Zfish   416 ----TVTNTGGDDAHHTQLYVMFPEVLHLTSVVPKKNSVTQVQCNPNENRTQAD---CQL--GNP 471

  Fly   673 LARGDSESLTIIFDVTQLSGQSLTIEAAVSSAGMDQNPKDNTMSTTISLREYAEIDAS------- 730
            |.|....|..::.:..:|   ||.:.||..:..:          .|||:::...:.|.
Zfish   472 LKRDAEVSFFLMLNTEKL---SLRVTAANVTLAL----------KTISIQDVPIVVAEAKIIFEL 523

  Fly   731 ---------------GGPIDGHIALKEYPYSAEVNN--SYEF---------KSHGPSIIDELTVY 769
                           ||.:....|:|.   ..:|.:  .|||         ||.|.::::
Zfish   524 HLNIIGLAKPSQLFFGGEVKDERAMKA---EDDVGSLVQYEFRIFNIGRPLKSFGSAVLN----- 580

  Fly   770 VDVPIAYTVTGSAGIKSIFNISSLQMQAT-HGSELVPIKLYDQTNTLAKEYPLEDSSRRANRKRR 833
                |.:.....||.:.::     .||.| .|..::.....:..|||.       .:..::|.:|
Zfish   581 ----IQWPKATKAGKRLLY-----LMQITDRGKNIIHCTPSEAINTLR-------FNMASSRGKR 629

  Fly   834 ELQQDQYAIMPDVNISDILT-KENLPANRTLVLDCLRGNWTICVRSQMRVQLK-PEQPIDLRISF 896
            ||:::. .:....:.||... ..|....:||.          |......|:|: |.:.:|.....
Zfish   630 ELERES-GLKALASTSDFFPFLGNKRKYKTLT----------CADELSCVELRCPLEALDSSAVI 683

  Fly   897 KVDLNDFVNTF-------DYLVIFTNVEMFKEGDSTSIALKRNLKPNVIFNYSE------TPLPI 948
            .:....:.|||       :||.|..|..:...|...:|.::.:.....:..::|      :.:|.
Zfish   684 LLHARLWNNTFLQEYSSLNYLDIILNASLTLNGTQGNIGMQPSDTKVKLTVFAERRPALLSRVPW 748

  Fly   949 WYIILSLIAGHLLLGAMTYILYKLRFFKRG---KKEEL 983
            |.|:||::...|||..:.|:|:|......|   |::|:
Zfish   749 WLILLSVVTALLLLALLFYLLWKFECLTCGACAKQKEV 786

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ItgaPS5	NP_611808.2	VCBS	302..375	CDD:338792	29/76 (38%)
		Int_alpha	351..403	CDD:214549	21/53 (40%)
		Int_alpha	417..463	CDD:214549	17/52 (33%)
		Integrin_alpha2	451..836	CDD:337057	93/477 (19%)
itga6l	XP_021336955.1	Int_alpha	51..108	CDD:214549	21/56 (38%)
		Int_alpha	115..159	CDD:214549	19/43 (44%)
		VCBS	127..197	CDD:316075	29/75 (39%)
		Integrin_alpha2	209..672	CDD:312071	102/528 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910