Protein Alignment ItgaPS5 and itga6a

DIOPT Version :10

• Sequence 1: NP_611808.2
• Gene: ItgaPS5 / 37732
• FlyBaseID: FBgn0034880
• Length: 1018
• Species: Drosophila melanogaster
• Sequence 2: XP_005167466.2
• Gene: itga6a / 503893
• ZFINID: ZDB-GENE-050309-23
• Length: 1092
• Species: Danio rerio
• Alignment Length: 1153
• Identity: 285/1153 - (24%)
• Similarity: 474/1153 - (41%)
• Gaps: 271/1153 - (23%)

  Fly    34 HLKTRMIQVRS----SYFGYSLVIR-------PTSIFVGAPRAQSTLESQGSINETGAVYRCPLA 87
            :|.|:.:..:|    |.||:|:.:.       .|.:.:|||:|:: |.:||: |.||.:|.|.:.
Zfish    27 NLDTQNVLRKSGQPGSLFGFSIALHRQLQPHDKTILLIGAPKARA-LSNQGA-NVTGGLYSCDIT 89

  Fly    88 S--GSCSHYVLNDKL-----NKQFQWLGGSMD----GGTKDTDKLLVCAPRF----FVPKNKNYG 137
            :  ..||....::.:     ||:.||:|.::.    ||     |::.||.|:    |....:...
Zfish    90 THPNDCSRVDFDNDVDVRVENKENQWMGVTVQSQGPGG-----KIVTCAHRYQRLLFPNTPQEAR 149

  Fly   138 QMRGICYWVR-----DTVADTP----PLSDVRTISLIPSQAEEHF-MLELGLSAHVTDDNSGFLI 192
            .:.|.||.:.     |..:|..    ...|.||      :..|.| ..:.||:|..|.|....:.
Zfish   150 DITGRCYMLSQDLSIDNQSDEDGGNWKFCDGRT------RGHERFGACQQGLAATFTKDYHYVIF 208

  Fly   193 GAPGVRSWKGSVLVHRGED------LAAQGSYAV---KMLDSWDWVKNHFTYVGYALSSGYFSSN 248
            ||||..:|||.|.:.:..:      |...|.|.|   ..||.........:|:|::|.||: |..
Zfish   209 GAPGAYNWKGIVRIEQKNNTLLEMGLFDDGPYEVGDENRLDPNLVPVPANSYLGFSLDSGH-SIT 272

  Fly   249 NRTSLLYVTTAPSSVLNTGKAYIF-DVVGEIVRKL---HVFHGEQLGEYFGYSVVAEDLNGDGLT 309
            .:..|:.|:.||.:  |...|.:| ...||:...|   |:..|..|...|||.|...||||||..
Zfish   273 EKGKLIIVSGAPRA--NHSGAVVFLRKEGELSSMLTPEHILEGPGLASSFGYDVAVVDLNGDGWQ 335

  Fly   310 DVVVSAPLNALGDSYDVGAIYVFINKGLFKFEKKIIRLPLSSGARFGSSLSKVGDINHDGYNDLA 374
            ||||.||.....|....||:||:|||.....:...:||..:..:.||.|:..:||:|.|.:.|:|
Zfish   336 DVVVGAPQFFQRDEEVGGAVYVYINKAGRWRDVTPVRLNGTKDSMFGLSVENIGDVNLDSFEDIA 400

  Fly   375 VGAPFA--GNGAVFIFLGSEHGLRDEPSQRLDAPSREPGPYGAHMFGQGLSRGSDIDGNGFNDLA 437
            ||||:|  |.|:|:|:.||..|:..:|:|.|:...     :...|||..|:...|:|.|.:.|||
Zfish   401 VGAPYADSGFGSVYIYHGSADGISTKPAQILEGKQ-----HNTKMFGYSLAGNMDLDHNSYPDLA 460

  Fly   438 IGAPGAEAVYLYRAYPVVKIHATVRSESRAIRPEQET------ITVTAC--YRLETTSKARQMQQ 494
            :|:. ::.|::||:..|:.|...::...:.|...::|      :||.||  ||....:     ..
Zfish   461 VGSL-SDTVFIYRSKNVISIKKDIKVTPKEIDLTKKTCGNSICLTVEACFSYRANPAT-----YN 519

  Fly   495 QELTFRMTIDE--------LLQRVSFAPMRTNEVSFQAQAGLSGSCRN----FSVGVHYTGGI-- 545
            .::|...|.:.        |..||.|......:..||:...|....:|    :...:....||
Zfish   520 PKITISCTFEAEWYRRKLGLPSRVVFLDKTEIDQDFQSTGILELRGQNKKACYKTKLRLQDGIRD 584

  Fly   546 ---FTPIDLELHYELAKKIPHSHEAFCESCAVVDPLEPKYATGTLSFM-TGCAA-HVCVSDLQL- 604
               ..||::.:..:.||: .....:..:...::|...|......::|: .||.. ::|.|:|.|
Zfish   585 KLRAIPIEVSVAIQSAKR-GKRQSSLPQLVPILDSTVPNKTLTEVNFLKEGCGTDNICQSNLNLQ 648

  Fly   605 -------SSKDVNSSF-IFGSLEVLSFS------YEIT---NSGEPAY----VAQFNVTSSARLP 648
                   |.:|:.... :...:.|:|.|      .|:|   .:|:.|:    |:.|: .|.:...
Zfish   649 YRFCYRESKQDIFPPLPLENGVPVISLSDQKDIALEVTVRNRNGDDAHEAKLVSHFD-DSLSYSG 712

  Fly   649 FAKVPGN-----CRVRHEVMLCDLNGGRALARGDSESLTIIFDVTQLSGQSLTIEAAVSSAGMDQ 708
            |..:..|     |.......|.|...|....|....:..||....::|.::..:|.
Zfish   713 FRSLRTNDKHVICAANQNGSLADCELGNPFKRDSEVTFYIILSTGKISLETKEVEI--------- 768

  Fly   709 NPKDNTMSTTISLREYAEIDAS----------------------GGPIDGHIALKEYPYSAEVNN 751
               |..:.||.|....:::.|.                      ||.:.|..|:|:   ..||.:
Zfish   769 ---DLQLETTSSQEGLSKVKAKAKVVIELLLSVQGVAKPSQVYFGGEVKGMSAMKK---EEEVGS 827

  Fly   752 --SYEF---------KSHGPSIIDELTVYVDVPIAYTVTGSAG--IKSIFNISSLQMQATHGS-- 801
              .|||         ||.|.:.::         |.:....|.|  :..:..|::..:|....|
Zfish   828 LIEYEFRVINLGKPLKSFGTASLN---------IQWPKESSVGKWLLYLMKINTRDLQLVTCSPE 883

  Fly   802 -ELVPIKLYDQTNTLAKEYPLEDSSRRANRKRRELQQ------DQYAIMPDVNISDILTKENLPA 859
             |:.|:||            .||||   .||:|||::      ::.::..|.....||:
Zfish   884 REINPLKL------------REDSS---IRKKRELEERRPSEGNKISLFTDKRKHKILS------ 927

  Fly   860 NRTLVLDCLRGNWTICVRSQMRVQLK-PEQPID--------LRISFKVDLNDFVNTFDYLVIFTN 915
                           |......|::| |.|.:|        .|:.....|.||. :::||.|...
Zfish   928 ---------------CSGDARCVEIKCPLQGLDSTAVIVLKSRLWNSTFLEDFA-SYNYLDIIVK 976

  Fly   916 VEMFKEGDSTSIALKR---NLKPNVIFNYSETP---LPIWYIILSLIAGHLLLGAMTYILYKLRF 974
            ..:..:..:.:|.||.   .::..|....:.||   :|.|.|:::::||.|:|..:..:|:|..|
Zfish   977 ASISLDVSAKNIVLKNPETQVRLTVFPETTATPFGGVPWWIILVAVLAGILMLALLVLLLWKCGF 1041

  Fly   975 FKRGKKEEL------------KRLLEEHR-----SETKEPATDCEGNQ 1005
            |||.|.|:.            .|||::.:     .|.|:..|..:.|:
Zfish  1042 FKRSKYEDSVPKYHAVRIRKETRLLKDGKVMLDPFEKKQWMTSWDENE 1089

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ItgaPS5	NP_611808.2	FG-GAP	294..332	CDD:460357	20/37 (54%)
		Int_alpha	351..403	CDD:214549	23/53 (43%)
		Int_alpha	417..463	CDD:214549	16/45 (36%)
		Integrin_alpha2	453..837	CDD:462478	95/475 (20%)
itga6a	XP_005167466.2	None