DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ItgaPS5 and Itgax

DIOPT Version :9

Sequence 1:	NP_611808.2	Gene:	ItgaPS5 / 37732	FlyBaseID:	FBgn0034880	Length:	1018	Species:	Drosophila melanogaster
Sequence 2:	XP_574569.3	Gene:	Itgax / 499271	RGDID:	1561123	Length:	1182	Species:	Rattus norvegicus

Alignment Length:	1310	Identity:	284/1310 - (21%)
Similarity:	453/1310 - (34%)	Gaps:	455/1310 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 FLALKYQSNAMNFSPLPNRVIDAPKHLKTRMIQVRSSYFGYSLVIRPTS-IFVGAPRAQSTLESQ 72
            ||.||..::.:.|:      :||.|..:..|   ..:.||:|:|....| :.||||:     |.|
  Rat     8 FLLLKVFASCLGFN------LDAEKPTRFHM---DGAEFGHSVVQYGGSWVVVGAPK-----EIQ 58

  Fly    73 GSINETGAVYRCPLASGSC---------------------------------------------- 91
            .: |:.|.:|:|...:|.|
  Rat    59 AT-NQIGGLYKCGYHTGMCESISLQVPPEAVNMSLGLSLTATNPSWLLACGPTVHHICRENTYLT 122

  Fly    92 ----------------------------------------------------------------- 91

  Rat   123 GLCFLLDSSFRQNQNFPAAQQGCPRQDQDIVFLIDGSGSITYTDFEKMLAFVKAVMSQLQQSSTR 187

  Fly    92 -----------SHYVLND--------KLNKQFQWLGGS-----------------MDGGTKDTDK 120
                       :|:..||        :|......|.||                 ..|..||..|
  Rat   188 FSLMQFSHTFRTHFTFNDFISTSSPLRLLDFVNQLRGSTRTASAIKHVITELFTTQKGARKDATK 252

  Fly   121 LLVC-------APRF----FVPKNKNYGQMR-----GICYW-------VRDTVADTP-------- 154
            :|:.       ..|.    .:|..:..|.:|     |..::       ::| :|.:|
  Rat   253 ILIVITDGRKEGDRLDYGDVIPMAEAAGIIRYAIGVGQAFYQAQSRQELKD-IASSPSREYVFSV 316

  Fly   155 ----PLSDVR--------TISLIPSQAEEHFMLEL---GLSAHVTDDNSGFLIGAPGVRSWKGSV 204
                .|.|::        .|....:.:...|.||:   |.||..|.|  |.::||.|...|.|..
  Rat   317 ENFDALKDIQNQLKEKIFAIEGTETPSSSSFELEMSQEGFSAVFTPD--GPVLGAVGSFGWSGGA 379

  Fly   205 LVHRGEDLAAQGSYAVKMLDSWDWVKNHFTYVGYALSSGYFSSNNRTSLLYVTTAPSSVLNTGKA 269
            .::.........:.:.:.:|..|      :|:||:.:..::...:  ||  :..||.. .:|||.
  Rat   380 FLYPPNTRPTFINMSQENVDMRD------SYLGYSTAVAFWKGVH--SL--ILGAPRH-QHTGKV 433

  Fly   270 YIFDVVGEIVRKLHVFHGEQLGEYFGYSVVAEDLNGDGLTDVVV----------------SAPLN 318
            .||.......|......|.|:|.|||.|:.:.|::.|..||:|:                ..|:.
  Rat   434 VIFTQEARHWRPKSEVRGTQIGSYFGASLCSVDMDRDDSTDLVLIGAPHYYEQTRGGQVSVCPVP 498

  Fly   319 ALGDSYDVGAIYVFINKGLFKFEKKIIRLPLSSG---ARFGSSLSKVGDINHDGYNDLAVGAP-- 378
            .:|..:...|                 .|....|   .|||::|:.:||:|.|...|:|:|||
  Rat   499 GVGSRWQCEA-----------------TLHGEQGHPWGRFGAALTVLGDVNGDDLADVAIGAPGE 546

  Fly   379 FAGNGAVFIFLG-SEHGLRDEPSQRLDAPSREPGPYGAHMFGQGLSRGSDIDGNGFNDLAIGAPG 442
            ....|||:||.| |...:...||||:.|....|   ....|||.||.|.|:.|:|..|||:|:.|
  Rat   547 EESRGAVYIFHGASRLEISPSPSQRISASRIFP---RLQYFGQSLSGGQDLTGDGLVDLAVGSKG 608

  Fly   443 AEAVYLYRAYPVVKIHATVR----SESRA-------IRPEQETITVTACYRLETTSKARQMQQQE 496
              .:.|.|..|::::.:|::    ..||:       :..||...|.|.|.|...:||.::...|.
  Rat   609 --HLLLLRTRPILRMSSTIQFTPTEISRSVFECQGQVTREQTLGTATVCLRTYESSKTQRGDLQS 671

  Fly   497 L-TFRMTID--ELLQRVSFAPMRTNEVSFQAQAGLSGSCRNFSV--------GVHYTGGIFTPID 550
            : ||.:.:|  .|..|..|...:|..::.....|||..|...::        .|       |||.
  Rat   672 IVTFDLALDPGRLSPRAIFKETKTQALTKVRTLGLSSHCEPVTLLLPACVEDSV-------TPIT 729

  Fly   551 LELHYELAKKIPHSHEAFCESCAVVDPLEPKYATGTLSFMTGCAA-HVCVSDLQL--SSKDVNSS 612
            |.|::.|. .:|.......:....||  |..|.|.:|.|...|.| |:|..||.:  ...|:.:.
  Rat   730 LRLNFSLV-GVPIPSLQNLQPMLAVD--EQTYFTASLPFEKNCGADHICQDDLGIIFGFPDLKTL 791

  Fly   613 FIFGSLEVLSFSYEITNSGEPAYVAQFNVTSSARLPFAKVPGNCRV--------------RHEV- 662
            .:..:|| ||.:..:||.||.:|.....:.....|.|.:| ...:|              ||.:
  Rat   792 VVGSNLE-LSVAVTVTNDGEDSYGTTITLFYPVGLSFRRV-AEAQVFLRTEDTQQWQQQGRHSLH 854

  Fly   663 MLCDLNGGRA-------------LARGDSE-SLTIIFDVTQLS--GQSLTIEAAVSSAGMDQNPK 711
            ::||....|:             :.||.|: :..:.|||:..:  |..|.:.|.|||    :|..
  Rat   855 LMCDSTPDRSQGIWSTSCSSRHVIFRGGSQMTFLVTFDVSPKAELGDRLLLRARVSS----ENGV 915

  Fly   712 DNTMSTTISLREYAEIDASGGPIDGHIALKEYPYSAEVNNSYEFKSHGPSIIDELTVYVDVPIAY 776
            ..|..||..|               .:.:|...|:.       ..||     |:.|.|::.
  Rat   916 PETRKTTFQL---------------ELPVKYAVYTV-------ISSH-----DQFTKYLNF---- 949

  Fly   777 TVTGSAGIKSIFNISSLQMQATHGSE---------LVPIKLYDQTN-TLAKEYPLEDSSRRANRK 831
                ||..||..::...:.|..:..:         .||.:|..:|. |:...:| ::.|.:..:.
  Rat   950 ----SASEKSRVSVVEHRFQVNNLGQRDLPVSINFRVPTELKGETVWTVMVSHP-QNPSTQCYQN 1009

  Fly   832 RRELQQDQYAIMPDVNISDILTKENLPANRTLVLDC------------------------LRGN- 871
            |  |:..|:         |:||.    ..::.||||                        |:||
  Rat  1010 R--LKPTQF---------DLLTH----MQKSPVLDCSIADCLHFRCDIPSLGIQDELDFILKGNL 1059

  Fly   872 ---WTICVRSQMRVQLKPEQPIDLRISFKVDLNDFVNTFDYLVIFTNVEMFKEGDSTSIALKRNL 933
               | |....|.:|.|..|..|               :||       ..::.:.......|:...
  Rat  1060 SFGW-ISQTLQKKVLLVSEAEI---------------SFD-------TSVYSQLPGQEAFLRAQA 1101

  Fly   934 KPNVIFNYSETPLPIWYIILSLIAGHLLLGAMTYILYKLRFFKRGKKEELKRLLEEHRSETKEPA 998
            |..:.......|:|:  |:.|.:.|.|||..:|.:|||..||||..||.|.....:..|....|
  Rat  1102 KTTLEMYEVHNPVPL--IVGSSVGGLLLLALITAVLYKAGFFKRQYKEMLAEANGQFASGNGNP- 1163

  Fly   999 TDCEGNQEEI 1008
             :.:..|:|:
  Rat  1164 -NPQVTQQEL 1172

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ItgaPS5	NP_611808.2	VCBS	302..375	CDD:338792	19/91 (21%)
		Int_alpha	351..403	CDD:214549	24/57 (42%)
		Int_alpha	417..463	CDD:214549	18/49 (37%)
		Integrin_alpha2	451..836	CDD:337057	101/450 (22%)
Itgax	XP_574569.3	vWA_integrins_alpha_subunit	150..325	CDD:238746	21/175 (12%)
		Int_alpha	454..510	CDD:214549	13/72 (18%)
		Int_alpha	517..572	CDD:214549	23/54 (43%)
		Int_alpha	582..>606	CDD:214549	12/23 (52%)
		Integrin_alpha2	615..986	CDD:285619	95/421 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335753
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23220
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.940