Protein Alignment ItgaPS5 and itga3a

DIOPT Version :10

• Sequence 1: NP_611808.2
• Gene: ItgaPS5 / 37732
• FlyBaseID: FBgn0034880
• Length: 1018
• Species: Drosophila melanogaster
• Sequence 2: XP_017210291.1
• Gene: itga3a / 407685
• ZFINID: ZDB-GENE-090805-3
• Length: 1073
• Species: Danio rerio
• Alignment Length: 1127
• Identity: 285/1127 - (25%)
• Similarity: 453/1127 - (40%)
• Gaps: 284/1127 - (25%)

  Fly    45 SYFGYSLVI-------RPTSIFVGAPRAQSTLESQGSINETGAVYRCPLASGS--CS-------- 92
            |.||.|:.:       :...:.||||:.::  ||..|.||||.||.||:::.|  |:
Zfish    43 SLFGLSVALHEQVVNEKRHMLLVGAPKEKA--ESGLSANETGDVYACPISADSKDCARLNLISSN 105

  Fly    93 --------HYVLNDKLNKQFQWLGGSMDGGTKDTDKLLVCAPRFFVPKNKNYGQMRGICY----- 144
                    :||::.      .|||.|:...::...:::.|..|:......|: :|.|.||
Zfish   106 PEDKPDLKNYVIDG------MWLGVSIVSQSQPGGRVVACGHRYIRNFTSNF-RMIGRCYVRGND 163

  Fly   145 ---------WVR-DTVADTPPLSDVRTISLIPSQAE-EHFMLELGLSAHVTDDNSGFLIGAPGVR 198
                     |.. |.:.|             |.:|: ...|..||:||.||  .|....||||..
Zfish   164 LQLNLSDYQWQSYDEICD-------------PREAQNSEGMCLLGMSAAVT--FSEIFFGAPGCF 213

  Fly   199 SWKGSVLV--HRGED----LAAQGSYAVKMLDSWDWVKNHFTYVGYA--LSSGYFSSNNRTSLLY 255
            :|:|::..  |...|    |.:      |:.||    :....|:||:  :..........|   .
Zfish   214 NWQGNIFSKWHNPADEFHLLKS------KLPDS----RKGNIYIGYSTIVDQDVLVKGKDT---V 265

  Fly   256 VTTAP----------SSVLNTGKAYIFDVVGEIVRKLHVFHGEQLGEYFGYSVVAEDLNGDGLTD 310
            ||.||          :.||.:|.:      ||:..|:.| .|||:|.|||.||...|||.||..|
Zfish   266 VTGAPRDEAKGSVMMAEVLKSGGS------GEVKIKVTV-TGEQVGSYFGNSVAVVDLNNDGWKD 323

  Fly   311 VVVSAPLNALGDSYDVGAIYVFINK-GLFKFEKKIIRL-PLSSGARFGSSLSKVGDINHDGYNDL 373
            ::|.||..........||:||::|: |.|:.:..::.. |..||  ||.|:..:||:|.||:.|.
Zfish   324 LIVGAPFYFDRKMDKGGAVYVYMNQNGSFRNKSDVVLTGPKDSG--FGMSVVAIGDVNQDGFQDF 386

  Fly   374 AVGAPFAGNGAVFIFLGSEHGLRDEPSQRLDAPSREPGPYGAHMFGQGLSRGSDIDGNGFNDLAI 438
            |||||:...|.|.|:.||:.|:..||||.:|......|  |...||..:|||.|:|.||:.|:|:
Zfish   387 AVGAPYHSTGRVSIWTGSKTGISQEPSQVIDGKDIPGG--GFQTFGYSISRGLDVDRNGYPDIAV 449

  Fly   439 GAPGAEAVYLYRAYPVVKIHATVRSESRAIRPEQ--ETITVTACYRLETTSKARQMQQQELTFRM 501
            |:.. :.|.|.|:.||:.:..|.......|..|.  ..|....|:.. |.|......|:.:|.:.
Zfish   450 GSLD-DRVVLLRSRPVIHLKNTFTVTPMVINLEDCVACIEAKVCFSY-TYSTGTASSQKAVTLQY 512

  Fly   502 TIDELLQ-----RVSFAPMRTNEVSFQAQAGLSGSCRNFSVGVHYTGGIFTPIDLELHYELAKKI 561
            |::...|     ||||......:.:.:.....||.|.:                  |..|||.|.
Zfish   513 TVEADQQSSRSPRVSFLDNNKGKYTGKMSVNPSGDCHS------------------LKLELASKT 559

  Fly   562 PH---SHEAFCESCAVVDP-------LEPKYATGTLS---FMTGCA-AHV---------CVSDLQ 603
            ..   |...|..|.:||||       ||...|...:|   .:||.| .|:         |.|:||
Zfish   560 IQDKVSAIIFQLSVSVVDPPPSGGKMLEDLSAFPVISQRDALTGRAEIHIQKACGLDNKCESNLQ 624

  Fly   604 LS---SKDVNSSF-------IFG---SLEVLSFSYEITN------SGEPAYVAQFNVTSSARLPF 649
            ::   :.:.|:.|       ||.   .::.|.....::|      ..|.||.|..|:|..:.|.|
Zfish   625 MTAAFTDEKNTPFLMQEDHQIFNYTTDIKKLKLLVNVSNVPSEGRKAEDAYNAILNITIPSSLSF 689

  Fly   650 A----KVP----GNCRVRHEVMLCDLNGGRALARGDSESLTIIFDVTQLSGQSLTIEAAVS-SAG 705
            :    |:|    |:.......:||.|  |..........:.|.|:.:.:|.....||..:. |..
Zfish   690 SSLNPKLPSTLNGDPSSGGSYLLCTL--GDPFKSNQRVEIEITFETSGISIDMQEIETELQLSTL 752

  Fly   706 MDQNP---------KDNTMSTTISLREYAEIDASGGPIDGHIALKEYPYSAEVNNSYEFKSHGPS 761
            .|||.         .:..:....:|..|...:.||..: |..|:|.   ::::.:..||.
Zfish   753 SDQNDLRPLSRVLLVEYILQPLFNLIPYFRAEFSGNVV-GESAMKS---TSDIGSPVEFN----- 808

  Fly   762 IIDELTVYVDVPIAYTVTGSAGI--------------KSIFNISSLQMQATHGSELVPIKLYDQT 812
                    :.|.|:....|:.|.              |.:..:|.:||..|..|..|...:.:..
Zfish   809 --------ISVDISGKPLGNLGFLEVVFQWPSAVANEKWLLYLSEIQMTGTSESFCVAKGIVNPL 865

  Fly   813 NTLAKEYPLEDSSRRANRKRRE--LQQDQYAIMPDVNISDILTKENLPANRTLVLDCLRGNWTI- 874
            |       |..|.|::.|::|:  |.:.:.|:.....     ..:|.|..   ||:|.:|....
Zfish   866 N-------LTVSERKSRRRKRDEVLSESKLAMSQKTR-----QGQNKPRE---VLNCTKGTARCQ 915

  Fly   875 ---CVRSQMRVQLKPEQPIDLRISFKVDLNDFVNTFDY----LVIFTNVEMFKEGDSTSIALKRN 932
               |..|.|:....      |.:..:|..:..:.  ||    :.:..:|.:..:.|..:|.:..|
Zfish   916 TFSCPLSAMKTSAM------LTVRARVWNSTMLE--DYRAKGVSVQGSVMLTLKTDKKNIKMNNN 972

  Fly   933 LK-------PNVIFNYSETP--LPIWYIILSLIAGHLLLGAMTYILYKLRFFKRGKKEELKRLLE 988
            ::       |.|.   .|.|  .|:|.||:|:::|.::||.:..:|:|..||.|         ::
Zfish   973 IREFTVEIDPAVA---EELPYEAPLWIIIVSVLSGVVMLGVIVILLWKSGFFTR---------ID 1025

  Fly   989 EHRSETK-EPATDCEGNQEEIN 1009
            ..|:..| :....|:..|.::|
Zfish  1026 YFRAMPKYKGVRICKKEQYQVN 1047

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ItgaPS5	NP_611808.2	FG-GAP	294..332	CDD:460357	16/37 (43%)
		Int_alpha	351..403	CDD:214549	26/51 (51%)
		Int_alpha	417..463	CDD:214549	18/45 (40%)
		Integrin_alpha2	453..837	CDD:462478	101/466 (22%)
itga3a	XP_017210291.1	Int_alpha	41..102	CDD:214549	21/60 (35%)
		Int_alpha	304..360	CDD:214549	22/55 (40%)
		Int_alpha	365..416	CDD:214549	26/52 (50%)
		Int_alpha	429..>451	CDD:214549	11/21 (52%)
		Integrin_alpha2	462..919	CDD:462478	108/509 (21%)