Protein Alignment ItgaPS5 and itga5

DIOPT Version :10

• Sequence 1: NP_611808.2
• Gene: ItgaPS5 / 37732
• FlyBaseID: FBgn0034880
• Length: 1018
• Species: Drosophila melanogaster
• Sequence 2: NP_001004288.2
• Gene: itga5 / 386787
• ZFINID: ZDB-GENE-031116-52
• Length: 1053
• Species: Danio rerio
• Alignment Length: 1166
• Identity: 280/1166 - (24%)
• Similarity: 459/1166 - (39%)
• Gaps: 310/1166 - (26%)

  Fly     4 LLFLIFLALKYQSNAMNFSPLPNRVIDAPKHLKTRMIQVRSSYFGYSLVIRPT----SIFVGAPR 64
            |..||.|.|   |.|.|.......|.:.|.          .||||||:....|    ||.||||:
Zfish    21 LSLLILLPL---SVAFNLDVENPAVYNGPS----------GSYFGYSVDFYMTDSSVSIIVGAPK 72

  Fly    65 AQSTLESQGSINETGAVYRCP--LASGSCSHYV------LNDKLN--------KQFQWLGGSMDG 113
            |.:   ||..|.|.|:|:.||  |:...||...      ||..:|        |..||.|.::
Zfish    73 ANT---SQPKITEGGSVFYCPWSLSQSQCSSIEFDRLGDLNMSVNDTDHQGEFKSHQWFGATV-- 132

  Fly   114 GTKDTDKLLVCAPRFF--VPKNKNYGQMRGICYW-VRDTVADTPPLSDVRTISLIPSQAE----- 170
             ....|.:|.|||.:.  ..::..:....|.|:. |::.         .:.:...|.:.|
Zfish   133 -RVHQDSVLACAPLYSWRTKEDTPHADTTGSCFMSVKNF---------TKFVEYAPCRTEFRGRK 187

  Fly   171 EHFMLELGLSAHVTDDNSGFLIGAPGVRSWKGSVLVHRGEDL-----------AAQGSYAVKMLD 224
            .....:.|.||..|.:.. .::|.||...|:|.|:....:::           :..|....|...
Zfish   188 GQGYCQGGFSADFTQEGK-VVLGGPGSYFWQGQVITAFKQEIVKAYYPGYFLTSVGGQIQTKQRK 251

  Fly   225 SWDWVKNHFTYVGYALSSGYFSSNNRTSLLYVTTAPSSVLNTGKAYIFDVVGEIVRKLHVFHGEQ 289
            .   ::...||:||:::.|.|:.::...  :||..|..|...|:..|.:...::   |.:|.|||
Zfish   252 E---IRFDDTYMGYSVAVGEFTGDDDED--FVTGVPRGVRLHGQVSILNSSLDV---LKMFTGEQ 308

  Fly   290 LGEYFGYSVVAEDLNGDGLTDVVVSAPLNALGDS----YDVGAIYVFINKGLFKFEKKIIRLPLS 350
            :|.|:||||.|.|:|.||:.|::|.||:..:.||    .::|.:||::.||....   |.:||..
Zfish   309 MGSYYGYSVAATDINNDGMMDLLVGAPMFMVRDSDGRLEELGRVYVYMQKGPLDL---IPQLPHL 370

  Fly   351 SG----ARFGSSLSKVGDINHDGYNDLAVGAPFAG---NGAVFIFLGSEHGLRDEPSQRLDAPSR 408
            :|    ||||||::.:||:|.|||||:|:.:||.|   .|.|.|:.|:..|||::|||.:.....
Zfish   371 TGTQMFARFGSSITPLGDLNQDGYNDVAISSPFGGEDKQGLVLIYNGNAGGLREKPSQVISGQWA 435

  Fly   409 EPG----PYGAHMFGQGLSRGSDIDGNGFNDLAIGAPGAEAVYLYRAYPVVKIHATVRSESRAIR 469
            ..|    |..   ||..|..|.|:|.||:.||.:||.||:...|||:.|:|...|.:......|.
Zfish   436 SAGLSAIPAS---FGYALRGGKDLDNNGYPDLIVGAFGADKAVLYRSRPIVNTSAILNVYPIMIN 497

  Fly   470 PEQETITVT--------ACYRLE--TTSKARQMQQQ-ELTFRMTIDELLQRVSFAPMRTNEVSFQ 523
            ||::...::        :|..|.  .::..:.:... |....:.:|.|.|:...|..|...:..|
Zfish   498 PEEKVCAISRGNETLHVSCVNLSFCLSANGKHLPNHLEFNVEVQLDRLKQQQKGAVRRALFLETQ 562

  Fly   524 AQAGLSGSCRNFSVGVHYTGGI-----------------------FTPIDLELHYELAKKIPHSH 565
            ..|            :|.|..:                       .:||.:.|::.|..
Zfish   563 LPA------------LHRTLTVPNGARVCSDTKIYLRDEKDFRDKLSPIFVALNFSLNP------ 609

  Fly   566 EAFCESCAVVDPLEP--KYATGTL-----SFMTGCAA-HVCVSDLQLSSKDVNSSFIFGSLEVLS 622
                ::.|....|:|  .|.|..|     ..:..|.. ::||.||:||..........|....|:
Zfish   610 ----QAAADRHGLQPILNYQTAELIEQKAQILLDCGEDNICVPDLKLSVHGDRKEVYMGDDNSLT 670

  Fly   623 FSYEITNSGEPAYVAQFNVTSSARLPFAKVPGN--------CRVRHE----VMLCDLNGGRALAR 675
            .::...|.|..||.|:..|.......::.:..|        |....|    .:.|||  |..:..
Zfish   671 LTFNAKNDGGGAYEAELYVVLPPEADYSGIARNNESLTQLTCSYETENQTRYLSCDL--GNPMKS 733

  Fly   676 GDSESLTIIFDVTQLSGQSLTIEAAVSSAGMDQNPKDNTMSTTI--------------------- 719
            |.|....:.|.|.:|......::..:.....::|   |:.|..:
Zfish   734 GTSLWAGLRFTVPRLKDTHNFVQFDLQIRSKNEN---NSQSEVVPYKLEVVVRSDVILQGVSRPD 795

  Fly   720 ---------SLREYAEIDASGGPIDGHIALKEYPYSAEVNNSYEFKSHGPSIIDELTVYVD---- 771
                     .|.:...::.:.||              .|.::||..::|||.|....:.:.
Zfish   796 KVFFPPPNWKLTKNVMVEQNVGP--------------SVQHTYELVNNGPSRISHTLLQLKCPMR 846

  Fly   772 -------VPIAYTVTG--SAGIKSIFNISSLQMQATHGSELVPIKLYDQTNTLAKEYPLEDSSRR 827
                   .|:..|..|  :....:|.|..:|::|              |::|  ::.|:.||...
Zfish   847 LHSNRFIYPLEVTTEGPVNCTTHNIINPLNLKLQ--------------QSST--EQPPVRDSGHE 895

  Fly   828 ANRKRRELQQDQYAIMPDVNISDILTKENLPANRTLVLDCLRGNWTI-C--------------VR 877
            .:.::|:..:.:.:.:.:::.|.:              ||    ||: |              ||
Zfish   896 HHIEKRDTHKGELSQLTNLSCSSV--------------DC----WTLMCNVGLLERGTSAILHVR 942

  Fly   878 SQMRVQLKPEQP-----IDLRISFKVDLNDFVNTFDYLVIFTNVEMFKEGDSTSIALKRNLKPNV 937
            |::..:...|..     ::...|:||:...:       .|...|        |....|:.:.| |
Zfish   943 SRIWAETFMENTYKNFILECHASYKVEKMPY-------AILPKV--------TPSGSKKMVTP-V 991

  Fly   938 IFNY--SETPLPIWYIILSLIAGHLLLGAMTYILYKLRFFKR---GKKEELKRLLEEHRSE 993
            ::|.  |...:|:|.|||:::||.|||..:.|:||||.||||   |...|..:|..:..||
Zfish   992 VWNKPDSSYAVPLWIIILAILAGLLLLALLIYVLYKLGFFKRTPYGTAMEKAQLKPQAASE 1052

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ItgaPS5	NP_611808.2	FG-GAP	294..332	CDD:460357	17/41 (41%)
		Int_alpha	351..403	CDD:214549	29/58 (50%)
		Int_alpha	417..463	CDD:214549	20/45 (44%)
		Integrin_alpha2	453..837	CDD:462478	81/480 (17%)
itga5	NP_001004288.2	Int_alpha	47..104	CDD:214549	25/69 (36%)
		FG-GAP	260..294	CDD:460357	9/35 (26%)
		Int_alpha	309..>357	CDD:214549	20/47 (43%)
		Int_alpha	375..430	CDD:214549	28/54 (52%)
		Int_alpha	446..>484	CDD:214549	18/37 (49%)
		Integrin_alpha2	480..926	CDD:462478	86/520 (17%)