DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ItgaPS5 and ITGAV

DIOPT Version :9

Sequence 1:	NP_611808.2	Gene:	ItgaPS5 / 37732	FlyBaseID:	FBgn0034880	Length:	1018	Species:	Drosophila melanogaster
Sequence 2:	NP_002201.2	Gene:	ITGAV / 3685	HGNCID:	6150	Length:	1048	Species:	Homo sapiens

Alignment Length:	1142	Identity:	266/1142 - (23%)
Similarity:	462/1142 - (40%)	Gaps:	287/1142 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 NRVIDAPKHLKTRMIQVRSSYFGYSL-VIRPTS-----IFVGAPRAQSTLESQGSINETGAVYRC 84
            |..:|:|....    ....||||::: ...|::     :.||||:|.:|   |..|.|.|.|.:|
Human    32 NLDVDSPAEYS----GPEGSYFGFAVDFFVPSASSRMFLLVGAPKANTT---QPGIVEGGQVLKC 89

  Fly    85 ---------PL---ASGSCSHYVLNDKLN-KQFQWLGGSMDGGTKDTDKLLVCAPRF-FVPKNKN 135
                     |:   |:|: ..|..:|.|. |..||.|.|:   ....||:|.|||.: :..:.|.
Human    90 DWSSTRRCQPIEFDATGN-RDYAKDDPLEFKSHQWFGASV---RSKQDKILACAPLYHWRTEMKQ 150

  Fly   136 YGQMRGICYWVRDTVADTPPLSD-VRTISLIPSQAEEHFMLELGLSAHVTDDNSGF--------- 190
            ..:..|.|:           |.| .:|:...|.::::           :..|..||
Human   151 EREPVGTCF-----------LQDGTKTVEYAPCRSQD-----------IDADGQGFCQGGFSIDF 193

  Fly   191 ------LIGAPGVRSWKGSVLVHRGEDLAAQ---GSYAVK------------MLDSWDWVKNHFT 234
                  |:|.||...|:|.::..:..::.::   ..|::|            :.|.        :
Human   194 TKADRVLLGGPGSFYWQGQLISDQVAEIVSKYDPNVYSIKYNNQLATRTAQAIFDD--------S 250

  Fly   235 YVGYALSSGYFSSNNRTSLLYVTTAPSSVLNTGKAYIFDVVGEIVRKLHVFHGEQLGEYFGYSVV 299
            |:||:::.|.|:.:....  :|:..|.:....|..||:|  |:.:..|:.|.|||:..|||:||.
Human   251 YLGYSVAVGDFNGDGIDD--FVSGVPRAARTLGMVYIYD--GKNMSSLYNFTGEQMAAYFGFSVA 311

  Fly   300 AEDLNGDGLTDVVVSAPL----NALGDSYDVGAIYVFINKGLFKFEKKIIRLPLSSG----ARFG 356
            |.|:|||...||.:.|||    .:.|...:||.:.|.:.:....|:...:     :|    ||||
Human   312 ATDINGDDYADVFIGAPLFMDRGSDGKLQEVGQVSVSLQRASGDFQTTKL-----NGFEVFARFG 371

  Fly   357 SSLSKVGDINHDGYNDLAVGAPFAG---NGAVFIFLGSEHGLRDEPSQRLD----APSREPGPYG 414
            |:::.:||::.||:||:|:.||:.|   .|.|:||.|...||...|||.|:    |.|..|.
Human   372 SAIAPLGDLDQDGFNDIAIAAPYGGEDKKGIVYIFNGRSTGLNAVPSQILEGQWAARSMPPS--- 433

  Fly   415 AHMFGQGLSRGSDIDGNGFNDLAIGAPGAEAVYLYRAYPVVKIHATVRSESRAIRPEQETITV-- 477
               ||..:...:|||.||:.||.:||.|.:...||||.||:.::|.:......:..:.:|.::
Human   434 ---FGYSMKGATDIDKNGYPDLIVGAFGVDRAILYRARPVITVNAGLEVYPSILNQDNKTCSLPG 495

  Fly   478 ----TACYRLETTSKA--RQMQQQELTFR--MTIDELLQR---------VSFAPMRTNEVSFQAQ 525
                .:|:.:....||  :.:..::|.|:  :.:|:|.|:         .|.:|..:..::. ::
Human   496 TALKVSCFNVRFCLKADGKGVLPRKLNFQVELLLDKLKQKGAIRRALFLYSRSPSHSKNMTI-SR 559

  Fly   526 AGLSGSCRNFSVGVHYTGGI---FTPIDLELHYELAKKIPHSHEAFCESCAVVDPLEPKYATGTL 587
            .||. .|......:......   .|||.:.:.|.|      .:....::.. :.|:..::....:
Human   560 GGLM-QCEELIAYLRDESEFRDKLTPITIFMEYRL------DYRTAADTTG-LQPILNQFTPANI 616

  Fly   588 S----FMTGCAA-HVCVSDLQLSSKDVNSSFIFGSLEVLSFSYEITNSGEPAYVAQFNVTSSARL 647
            |    .:..|.. :||...|::|..........|....|:...:..|.||.||.|:..|:...:.
Human   617 SRQAHILLDCGEDNVCKPKLEVSVDSDQKKIYIGDDNPLTLIVKAQNQGEGAYEAELIVSIPLQA 681

  Fly   648 PFAKVPGN--------CRVRHE----VMLCDLNGGRALARGDSESLTIIFDVTQLS--GQSLTIE 698
            .|..|..|        |..:.|    .::|||  |..:..|......:.|.|.|.|  ..|:..:
Human   682 DFIGVVRNNEALARLSCAFKTENQTRQVVCDL--GNPMKAGTQLLAGLRFSVHQQSEMDTSVKFD 744

  Fly   699 AAVSSAGMDQNPKDNTMSTTISLREYAEIDASGGPIDGHIAL-------KEYPYSAE-----VNN 751
            ..:.|:.:...... .:|..:.|...|.::..|.....|:.|       ||.|.:.|     |.:
Human   745 LQIQSSNLFDKVSP-VVSHKVDLAVLAAVEIRGVSSPDHVFLPIPNWEHKENPETEEDVGPVVQH 808

  Fly   752 SYEFKSHGPSIIDELTVYVDVPIAYTVTGSAGIKSIFNISSL----------QMQATHGSELVPI 806
            .||.:::|||...:..:::..|..|            |.::|          .|..|...|:.|:
Human   809 IYELRNNGPSSFSKAMLHLQWPYKY------------NNNTLLYILHYDIDGPMNCTSDMEINPL 861

  Fly   807 KLYDQTNTLAKEYPLEDSSRRANRKRRELQQDQYAIMPDVNISDILTKENLPAN----RTL---V 864
            ::     .::.....|.:...|.:..|:               .::||.:|..:    .||   |
Human   862 RI-----KISSLQTTEKNDTVAGQGERD---------------HLITKRDLALSEGDIHTLGCGV 906

  Fly   865 LDCLRGNWTICVRSQMRVQLKPEQPIDLRISFKVDLNDFVNTFDYLVIFTNVEMFKEGDSTSIAL 929
            ..||:   .:|...                  ::|.......:...:::|...|.||..:.|.:|
Human   907 AQCLK---IVCQVG------------------RLDRGKSAILYVKSLLWTETFMNKENQNHSYSL 950

  Fly   930 KRNLKPNVI-FNYSETPL------------------------PIWYIILSLIAGHLLLGAMTYIL 969
            |.:...||| |.|...|:                        |:|.|||:::||.|||..:.:::
Human   951 KSSASFNVIEFPYKNLPIEDITNSTLVTTNVTWGIQPAPMPVPVWVIILAVLAGLLLLAVLVFVM 1015

  Fly   970 YKLRFFKRGKKEELKRLLEEHRSETKEPATDCEGNQE 1006
            |::.||||.:..:     ||...|..:|..:.|||.|
Human  1016 YRMGFFKRVRPPQ-----EEQEREQLQPHENGEGNSE 1047

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ItgaPS5	NP_611808.2	VCBS	302..375	CDD:338792	26/80 (33%)
		Int_alpha	351..403	CDD:214549	26/58 (45%)
		Int_alpha	417..463	CDD:214549	19/45 (42%)
		Integrin_alpha2	451..836	CDD:337057	82/447 (18%)
ITGAV	NP_002201.2	FG-GAP 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	32..98		20/72 (28%)
		Int_alpha	46..103	CDD:214549	18/59 (31%)
		WD40 repeat	51..120	CDD:293791	19/72 (26%)
		FG-GAP 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	109..170		20/74 (27%)
		WD40 repeat	126..183	CDD:293791	15/81 (19%)
		FG-GAP 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	173..225		9/62 (15%)
		WD40 repeat	188..248	CDD:293791	8/59 (14%)
		VCBS	221..271	CDD:316075	8/59 (14%)
		FG-GAP 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	237..291		13/65 (20%)
		Int_alpha	248..>288	CDD:214549	12/51 (24%)
		WD40 repeat	254..298	CDD:293791	11/47 (23%)
		FG-GAP 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	292..357		24/64 (38%)
		Int_alpha	302..355	CDD:214549	19/52 (37%)
		WD40 repeat	307..362	CDD:293791	18/59 (31%)
		FG-GAP 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	358..415		23/61 (38%)
		Int_alpha	367..421	CDD:214549	25/53 (47%)
		WD40 repeat	371..422	CDD:293791	22/50 (44%)
		FG-GAP 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	419..482		24/68 (35%)
		Int_alpha	434..476	CDD:214549	18/41 (44%)
		Integrin_alpha2	467..914	CDD:312071	90/493 (18%)
		GFFKR motif	1019..1023		2/3 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1027..1048		8/26 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141977
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840