DRSC/TRiP Functional Genomics Resources

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Protein Alignment ItgaPS5 and ITGAM

DIOPT Version :10

Sequence 1:NP_611808.2 Gene:ItgaPS5 / 37732 FlyBaseID:FBgn0034880 Length:1018 Species:Drosophila melanogaster
Sequence 2:NP_001139280.1 Gene:ITGAM / 3684 HGNCID:6149 Length:1153 Species:Homo sapiens


Alignment Length:1304 Identity:253/1304 - (19%)
Similarity:431/1304 - (33%) Gaps:464/1304 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 RLLFLIFLALKY-----QSNAMNFSPLPNRVIDAPKHLKTRMIQVRSSYFGYSLV-IRPTSIFVG 61
            |:|.|..|.|.:     ..|||.|                   |..:..||.|:| ::.:.:.||
Human     4 RVLLLTALTLCHGFNLDTENAMTF-------------------QENARGFGQSVVQLQGSRVVVG 49

  Fly    62 APRAQSTLESQGSINETGAVYRCPLASGSCSHYVLNDKLNKQFQWLGGSMDGGTKDTDKLLVCAP 126
            ||      :...:.|:.|::|:|..::|||....|...:......||.|: ..|....:||.|.|
Human    50 AP------QEIVAANQRGSLYQCDYSTGSCEPIRLQVPVEAVNMSLGLSL-AATTSPPQLLACGP 107

  Fly   127 RFFVPKNKNYGQMRGICYWVRDTVADTPPL------------SDVRTI-----SLIP-------- 166
            ......::| ..::|:|:.....:...|..            ||:..:     |:||        
Human   108 TVHQTCSEN-TYVKGLCFLFGSNLRQQPQKFPEALRGCPQEDSDIAFLIDGSGSIIPHDFRRMKE 171

  Fly   167 ------------------SQAEEHFMLELGLSAHVTDDNSGFLI-----------GAPGVR---- 198
                              .|..|.|.:.........:.|...|:           .|.|:|    
Human   172 FVSTVMEQLKKSKTLFSLMQYSEEFRIHFTFKEFQNNPNPRSLVKPITQLLGRTHTATGIRKVVR 236

  Fly   199 ------------SWKGSVLVHRGE----------------------------------------- 210
                        ::|..|::..||                                         
Human   237 ELFNITNGARKNAFKILVVITDGEKFGDPLGYEDVIPEADREGVIRYVIGVGDAFRSEKSRQELN 301

  Fly   211 -----------------------------------------------DLAAQGSYA--------V 220
                                                           :::.:|..|        :
Human   302 TIASKPPRDHVFQVNNFEALKTIQNQLREKIFAIEGTQTGSSSSFEHEMSQEGFSAAITSNGPLL 366

  Fly   221 KMLDSWDWVKNHFTYVGYALSSGYFSSNNRTSLLYVTTAPSSVLNTGKAYIFDVVGEIVRK---- 281
            ..:.|:||....|.|          :|..:::.:.:|...|.:   ..||:......|:|.    
Human   367 STVGSYDWAGGVFLY----------TSKEKSTFINMTRVDSDM---NDAYLGYAAAIILRNRVQS 418

  Fly   282 --------LHV------------------FHGEQLGEYFGYSVVAEDLNGDGLTDVVVSAPLNAL 320
                    .|:                  ..|.|:|.|||.|:.:.|::.:|.||:|:       
Human   419 LVLGAPRYQHIGLVAMFRQNTGMWESNANVKGTQIGAYFGASLCSVDVDSNGSTDLVL------- 476

  Fly   321 GDSYDVGAIYVF-INKGLFKFEKKIIRLPLSSG-------------------ARFGSSLSKVGDI 365
                 :||.:.: ..:|     .::...||..|                   .|||::|:.:||:
Human   477 -----IGAPHYYEQTRG-----GQVSVCPLPRGQRARWQCDAVLYGEQGQPWGRFGAALTVLGDV 531

  Fly   366 NHDGYNDLAVGAPFA--GNGAVFIFLG-SEHGLRDEPSQRLDAPSREPGPYGAHMFGQGLSRGSD 427
            |.|...|:|:|||..  ..|||::|.| |..|:....|||:......|   ....|||.||.|.|
Human   532 NGDKLTDVAIGAPGEEDNRGAVYLFHGTSGSGISPSHSQRIAGSKLSP---RLQYFGQSLSGGQD 593

  Fly   428 IDGNGFNDLAIGAPGAEAVYLYRAYPVVKIHATVRSESRAIRPE-----------QETITVTACY 481
            :..:|..||.:||.|  .|.|.|:.||:::.|.:....|.:...           :|...|..|.
Human   594 LTMDGLVDLTVGAQG--HVLLLRSQPVLRVKAIMEFNPREVARNVFECNDQVVKGKEAGEVRVCL 656

  Fly   482 RLETTSKARQMQ---QQELTFRMTID--ELLQRVSFAPMRTNEVSFQAQA-GLSGSCRNFSVGV- 539
            .::.:::.|..:   |..:|:.:.:|  ....|..|...: |....|.|. ||:.:|....:.: 
Human   657 HVQKSTRDRLREGQIQSVVTYDLALDSGRPHSRAVFNETK-NSTRRQTQVLGLTQTCETLKLQLP 720

  Fly   540 HYTGGIFTPIDLELHYELAKKIPHSHEAFCESCAVVDPLEPKYATGTLSFMTGCA-AHVCVSDLQ 603
            :......:||.|.|::.|. ..|.|  ||.....|:.....:..|....|...|. .::|..||.
Human   721 NCIEDPVSPIVLRLNFSLV-GTPLS--AFGNLRPVLAEDAQRLFTALFPFEKNCGNDNICQDDLS 782

  Fly   604 LSSKDVNSSFIFGSLEVL------SFSYEIT--NSGEPAYVAQFNVTSSARLPFAKV-------- 652
            :       :|.|.||:.|      .|:..:|  |.||.:|..|........|.:.||        
Human   783 I-------TFSFMSLDCLVVGGPREFNVTVTVRNDGEDSYRTQVTFFFPLDLSYRKVSTLQNQRS 840

  Fly   653 ---------------------PGNCRVRHEVMLCDLNGGRALARGDSESLTIIFDVTQLS--GQS 694
                                 ..:|.:.|.:          .......:..|.|||...:  |..
Human   841 QRSWRLACESASSTEVSGALKSTSCSINHPI----------FPENSEVTFNITFDVDSKASLGNK 895

  Fly   695 LTIEAAVSSAGMDQNPKDNTMSTTISLREYAEIDASGGPIDGHIALKEYPYSAEVNNSYEFKSHG 759
            |.::|.|:|        :|.|..|                                |..||:   
Human   896 LLLKANVTS--------ENNMPRT--------------------------------NKTEFQ--- 917

  Fly   760 PSIIDELTVYVDVPI---AYTVTGSAGIKSIFNISSLQMQATHGSELVPIKLYDQTNTLAKEYPL 821
                      :::|:   .|.|..|.|:.:.:    |...|:..:..|....|..:|...:..|:
Human   918 ----------LELPVKYAVYMVVTSHGVSTKY----LNFTASENTSRVMQHQYQVSNLGQRSLPI 968

  Fly   822 EDSSRRANRKRRELQQDQYAIMPDVNISDIL-----TKENLPAN--------RTLVLDCLRGNWT 873
            ........|..:.:..|:    |.|..|:.|     |||.||::        :..|::|   :..
Human   969 SLVFLVPVRLNQTVIWDR----PQVTFSENLSSTCHTKERLPSHSDFLAELRKAPVVNC---SIA 1026

  Fly   874 ICVRSQMRVQLKP----EQPIDLRISFKVDLNDFVNT-FDYLVIFTNVE-MFKEGDSTSI----A 928
            :|.|.|..:   |    ::..:..:...:..:.::.| .::|:|.:..| :|.:...|.:    |
Human  1027 VCQRIQCDI---PFFGIQEEFNATLKGNLSFDWYIKTSHNHLLIVSTAEILFNDSVFTLLPGQGA 1088

  Fly   929 LKRNLKPNVIFNYSETPLPIWYIILSLIAGHLLLGAMTYILYKLRFFKRGKKEELKRLLEEHRSE 993
            ..|:.....:..: |.|.|:..|:.|.:.|.|||..:|..||||.||||    :.|.::.|....
Human  1089 FVRSQTETKVEPF-EVPNPLPLIVGSSVGGLLLLALITAALYKLGFFKR----QYKDMMSEGGPP 1148

  Fly   994 TKEP 997
            ..||
Human  1149 GAEP 1152

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ItgaPS5NP_611808.2 FG-GAP 294..332 CDD:460357 10/37 (27%)
Int_alpha 351..403 CDD:214549 23/73 (32%)
Int_alpha 417..463 CDD:214549 19/45 (42%)
Integrin_alpha2 453..837 CDD:462478 79/444 (18%)
ITGAMNP_001139280.1 FG-GAP 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 18..75 20/81 (25%)
FG-GAP 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 76..135 12/60 (20%)
vWA_integrins_alpha_subunit 149..324 CDD:238746 17/174 (10%)
FG-GAP 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 339..390 8/60 (13%)
FG-GAP 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 391..442 7/53 (13%)
Int_alpha 453..>495 CDD:214549 13/58 (22%)
FG-GAP 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 507..565 20/57 (35%)
Int_alpha 517..563 CDD:214549 19/45 (42%)
FG-GAP 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 570..630 22/64 (34%)
Integrin_alpha2 616..979 CDD:462478 79/440 (18%)
Integrin_alpha 1130..1144 CDD:459778 7/17 (41%)
GFFKR motif 1132..1136 2/3 (67%)

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