DRSC/TRiP Functional Genomics Resources

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Protein Alignment ItgaPS5 and ITGAM

DIOPT Version :9

Sequence 1:NP_611808.2 Gene:ItgaPS5 / 37732 FlyBaseID:FBgn0034880 Length:1018 Species:Drosophila melanogaster
Sequence 2:NP_001139280.1 Gene:ITGAM / 3684 HGNCID:6149 Length:1153 Species:Homo sapiens


Alignment Length:1304 Identity:253/1304 - (19%)
Similarity:431/1304 - (33%) Gaps:464/1304 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 RLLFLIFLALKY-----QSNAMNFSPLPNRVIDAPKHLKTRMIQVRSSYFGYSLV-IRPTSIFVG 61
            |:|.|..|.|.:     ..|||.|                   |..:..||.|:| ::.:.:.||
Human     4 RVLLLTALTLCHGFNLDTENAMTF-------------------QENARGFGQSVVQLQGSRVVVG 49

  Fly    62 APRAQSTLESQGSINETGAVYRCPLASGSCSHYVLNDKLNKQFQWLGGSMDGGTKDTDKLLVCAP 126
            ||      :...:.|:.|::|:|..::|||....|...:......||.|: ..|....:||.|.|
Human    50 AP------QEIVAANQRGSLYQCDYSTGSCEPIRLQVPVEAVNMSLGLSL-AATTSPPQLLACGP 107

  Fly   127 RFFVPKNKNYGQMRGICYWVRDTVADTPPL------------SDVRTI-----SLIP-------- 166
            ......::| ..::|:|:.....:...|..            ||:..:     |:||        
Human   108 TVHQTCSEN-TYVKGLCFLFGSNLRQQPQKFPEALRGCPQEDSDIAFLIDGSGSIIPHDFRRMKE 171

  Fly   167 ------------------SQAEEHFMLELGLSAHVTDDNSGFLI-----------GAPGVR---- 198
                              .|..|.|.:.........:.|...|:           .|.|:|    
Human   172 FVSTVMEQLKKSKTLFSLMQYSEEFRIHFTFKEFQNNPNPRSLVKPITQLLGRTHTATGIRKVVR 236

  Fly   199 ------------SWKGSVLVHRGE----------------------------------------- 210
                        ::|..|::..||                                         
Human   237 ELFNITNGARKNAFKILVVITDGEKFGDPLGYEDVIPEADREGVIRYVIGVGDAFRSEKSRQELN 301

  Fly   211 -----------------------------------------------DLAAQGSYA--------V 220
                                                           :::.:|..|        :
Human   302 TIASKPPRDHVFQVNNFEALKTIQNQLREKIFAIEGTQTGSSSSFEHEMSQEGFSAAITSNGPLL 366

  Fly   221 KMLDSWDWVKNHFTYVGYALSSGYFSSNNRTSLLYVTTAPSSVLNTGKAYIFDVVGEIVRK---- 281
            ..:.|:||....|.|          :|..:::.:.:|...|.:   ..||:......|:|.    
Human   367 STVGSYDWAGGVFLY----------TSKEKSTFINMTRVDSDM---NDAYLGYAAAIILRNRVQS 418

  Fly   282 --------LHV------------------FHGEQLGEYFGYSVVAEDLNGDGLTDVVVSAPLNAL 320
                    .|:                  ..|.|:|.|||.|:.:.|::.:|.||:|:       
Human   419 LVLGAPRYQHIGLVAMFRQNTGMWESNANVKGTQIGAYFGASLCSVDVDSNGSTDLVL------- 476

  Fly   321 GDSYDVGAIYVF-INKGLFKFEKKIIRLPLSSG-------------------ARFGSSLSKVGDI 365
                 :||.:.: ..:|     .::...||..|                   .|||::|:.:||:
Human   477 -----IGAPHYYEQTRG-----GQVSVCPLPRGQRARWQCDAVLYGEQGQPWGRFGAALTVLGDV 531

  Fly   366 NHDGYNDLAVGAPFA--GNGAVFIFLG-SEHGLRDEPSQRLDAPSREPGPYGAHMFGQGLSRGSD 427
            |.|...|:|:|||..  ..|||::|.| |..|:....|||:......|   ....|||.||.|.|
Human   532 NGDKLTDVAIGAPGEEDNRGAVYLFHGTSGSGISPSHSQRIAGSKLSP---RLQYFGQSLSGGQD 593

  Fly   428 IDGNGFNDLAIGAPGAEAVYLYRAYPVVKIHATVRSESRAIRPE-----------QETITVTACY 481
            :..:|..||.:||.|  .|.|.|:.||:::.|.:....|.:...           :|...|..|.
Human   594 LTMDGLVDLTVGAQG--HVLLLRSQPVLRVKAIMEFNPREVARNVFECNDQVVKGKEAGEVRVCL 656

  Fly   482 RLETTSKARQMQ---QQELTFRMTID--ELLQRVSFAPMRTNEVSFQAQA-GLSGSCRNFSVGV- 539
            .::.:::.|..:   |..:|:.:.:|  ....|..|...: |....|.|. ||:.:|....:.: 
Human   657 HVQKSTRDRLREGQIQSVVTYDLALDSGRPHSRAVFNETK-NSTRRQTQVLGLTQTCETLKLQLP 720

  Fly   540 HYTGGIFTPIDLELHYELAKKIPHSHEAFCESCAVVDPLEPKYATGTLSFMTGCA-AHVCVSDLQ 603
            :......:||.|.|::.|. ..|.|  ||.....|:.....:..|....|...|. .::|..||.
Human   721 NCIEDPVSPIVLRLNFSLV-GTPLS--AFGNLRPVLAEDAQRLFTALFPFEKNCGNDNICQDDLS 782

  Fly   604 LSSKDVNSSFIFGSLEVL------SFSYEIT--NSGEPAYVAQFNVTSSARLPFAKV-------- 652
            :       :|.|.||:.|      .|:..:|  |.||.:|..|........|.:.||        
Human   783 I-------TFSFMSLDCLVVGGPREFNVTVTVRNDGEDSYRTQVTFFFPLDLSYRKVSTLQNQRS 840

  Fly   653 ---------------------PGNCRVRHEVMLCDLNGGRALARGDSESLTIIFDVTQLS--GQS 694
                                 ..:|.:.|.:          .......:..|.|||...:  |..
Human   841 QRSWRLACESASSTEVSGALKSTSCSINHPI----------FPENSEVTFNITFDVDSKASLGNK 895

  Fly   695 LTIEAAVSSAGMDQNPKDNTMSTTISLREYAEIDASGGPIDGHIALKEYPYSAEVNNSYEFKSHG 759
            |.::|.|:|        :|.|..|                                |..||:   
Human   896 LLLKANVTS--------ENNMPRT--------------------------------NKTEFQ--- 917

  Fly   760 PSIIDELTVYVDVPI---AYTVTGSAGIKSIFNISSLQMQATHGSELVPIKLYDQTNTLAKEYPL 821
                      :::|:   .|.|..|.|:.:.:    |...|:..:..|....|..:|...:..|:
Human   918 ----------LELPVKYAVYMVVTSHGVSTKY----LNFTASENTSRVMQHQYQVSNLGQRSLPI 968

  Fly   822 EDSSRRANRKRRELQQDQYAIMPDVNISDIL-----TKENLPAN--------RTLVLDCLRGNWT 873
            ........|..:.:..|:    |.|..|:.|     |||.||::        :..|::|   :..
Human   969 SLVFLVPVRLNQTVIWDR----PQVTFSENLSSTCHTKERLPSHSDFLAELRKAPVVNC---SIA 1026

  Fly   874 ICVRSQMRVQLKP----EQPIDLRISFKVDLNDFVNT-FDYLVIFTNVE-MFKEGDSTSI----A 928
            :|.|.|..:   |    ::..:..:...:..:.::.| .::|:|.:..| :|.:...|.:    |
Human  1027 VCQRIQCDI---PFFGIQEEFNATLKGNLSFDWYIKTSHNHLLIVSTAEILFNDSVFTLLPGQGA 1088

  Fly   929 LKRNLKPNVIFNYSETPLPIWYIILSLIAGHLLLGAMTYILYKLRFFKRGKKEELKRLLEEHRSE 993
            ..|:.....:..: |.|.|:..|:.|.:.|.|||..:|..||||.||||    :.|.::.|....
Human  1089 FVRSQTETKVEPF-EVPNPLPLIVGSSVGGLLLLALITAALYKLGFFKR----QYKDMMSEGGPP 1148

  Fly   994 TKEP 997
            ..||
Human  1149 GAEP 1152

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ItgaPS5NP_611808.2 VCBS 302..375 CDD:338792 20/92 (22%)
Int_alpha 351..403 CDD:214549 23/73 (32%)
Int_alpha 417..463 CDD:214549 19/45 (42%)
Integrin_alpha2 451..836 CDD:337057 79/445 (18%)
ITGAMNP_001139280.1 FG-GAP 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 18..75 20/81 (25%)
FG-GAP 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 76..135 12/60 (20%)
vWA_integrins_alpha_subunit 149..324 CDD:238746 17/174 (10%)
FG-GAP 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 339..390 8/60 (13%)
FG-GAP 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 391..442 7/53 (13%)
Int_alpha 453..>495 CDD:214549 13/58 (22%)
FG-GAP 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 507..565 20/57 (35%)
Int_alpha 517..563 CDD:214549 19/45 (42%)
FG-GAP 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 570..630 22/64 (34%)
Integrin_alpha2 615..979 CDD:285619 79/441 (18%)
Integrin_alpha 1130..1144 CDD:278771 7/17 (41%)
GFFKR motif 1132..1136 2/3 (67%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165142016
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR23220
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.940

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