DRSC/TRiP Functional Genomics Resources

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Protein Alignment ItgaPS5 and ITGAL

DIOPT Version :9

Sequence 1:NP_611808.2 Gene:ItgaPS5 / 37732 FlyBaseID:FBgn0034880 Length:1018 Species:Drosophila melanogaster
Sequence 2:NP_002200.2 Gene:ITGAL / 3683 HGNCID:6148 Length:1170 Species:Homo sapiens


Alignment Length:1234 Identity:264/1234 - (21%)
Similarity:438/1234 - (35%) Gaps:407/1234 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    18 AMNFSPLPNRVIDAPKHLKTRMIQVRSSYFGYSLVIRPTSIFVGAPRAQSTLESQGSINETGAVY 82
            |.:||| |.    |.:|            |||.::.....:.||||         |..|.||::|
Human    33 ARSFSP-PR----AGRH------------FGYRVLQVGNGVIVGAP---------GEGNSTGSLY 71

  Fly    83 RCPLASGSCSHYVLNDKLNKQFQWLGGSMDGGTKDTD-KLLVCAPRFFVPKNKNYGQMRGICYWV 146
            :|...:|.|....|... |...::||  |...|..|| .:|.|.|......::| ..:.|:||..
Human    72 QCQSGTGHCLPVTLRGS-NYTSKYLG--MTLATDPTDGSILACDPGLSRTCDQN-TYLSGLCYLF 132

  Fly   147 RDTVADTPPLSDVR-------------------TISLIPSQ------------------------ 168
            |..:..  |:...|                   ::||.|.:                        
Human   133 RQNLQG--PMLQGRPGFQECIKGNVDLVFLFDGSMSLQPDEFQKILDFMKDVMKKLSNTSYQFAA 195

  Fly   169 ---------------------------------------------AEEHFMLELGLSAH------ 182
                                                         |.|.|..|||....      
Human   196 VQFSTSYKTEFDFSDYVKRKDPDALLKHVKHMLLLTNTFGAINYVATEVFREELGARPDATKVLI 260

  Fly   183 -VTD---DNSG----------FLIG-APGVRSWKGSVLVHRGEDLAAQGSYAVKMLDSWDWVKNH 232
             :||   .:||          ::|| ....::.:....:|:.....|  |..||:||:::.:|:.
Human   261 IITDGEATDSGNIDAAKDIIRYIIGIGKHFQTKESQETLHKFASKPA--SEFVKILDTFEKLKDL 323

  Fly   233 FT--------------------------------------------------------------- 234
            ||                                                               
Human   324 FTELQKKIYVIEGTSKQDLTSFNMELSSSGISADLSRGHAVVGAVGAKDWAGGFLDLKADLQDDT 388

  Fly   235 --------------YVGYALSSGYFSSNNRTSLLYVTTAPSSVLNTGKAYIFDVV--GEIVRKLH 283
                          |:||.::  :..|..:|||| .:.|| ...:.|:..:|...  |....::.
Human   389 FIGNEPLTPEVRAGYLGYTVT--WLPSRQKTSLL-ASGAP-RYQHMGRVLLFQEPQGGGHWSQVQ 449

  Fly   284 VFHGEQLGEYFGYSVVAEDLNGDGLTD-VVVSAPLNALGDSYDVGAIYVFINKGLFKFEKKIIRL 347
            ..||.|:|.|||..:...|::.||.|: :::.||| ..|:... |.::::..:.| .|| ::..|
Human   450 TIHGTQIGSYFGGELCGVDVDQDGETELLLIGAPL-FYGEQRG-GRVFIYQRRQL-GFE-EVSEL 510

  Fly   348 PLSSG---ARFGSSLSKVGDINHDGYNDLAVGAPFAGNGAVFIFLGSEHGLRDEPSQRLDAPSRE 409
            ....|   .|||.:::.:.|||.||..|:|||||....|||:||.|...||..:||||::.....
Human   511 QGDPGYPLGRFGEAITALTDINGDGLVDVAVGAPLEEQGAVYIFNGRHGGLSPQPSQRIEGTQVL 575

  Fly   410 PGPYGAHMFGQGLSRGSDIDGNGFNDLAIGAPGAEAVYLYRAYPVVKIHATVRSESRAIRPEQET 474
            .   |...||:.:....|::|:|..|:|:||.....|...|  |||.: .|:.|.|.|..|..|.
Human   576 S---GIQWFGRSIHGVKDLEGDGLADVAVGAESQMIVLSSR--PVVDM-VTLMSFSPAEIPVHEV 634

  Fly   475 -------------ITVTACYRLETTSKARQMQQQ---ELTFRMTID-ELLQRVSFAPMRTNEVSF 522
                         :.:|.|::::  |...|.|.:   .||:.:.:| ...:|....|...:|:..
Human   635 ECSYSTSNKMKEGVNITICFQIK--SLIPQFQGRLVANLTYTLQLDGHRTRRRGLFPGGRHELRR 697

  Fly   523 QAQAGLSGSCRNFSVGVHY---TGGIFTPIDLELHYELAKKIPHSHEAFCESCAVVDPLEPKYAT 584
            ......|.||.:||  .|:   ...:.:||::.|::.|.::.....:...:...:...|.|...:
Human   698 NIAVTTSMSCTDFS--FHFPVCVQDLISPINVSLNFSLWEEEGTPRDQRAQGKDIPPILRPSLHS 760

  Fly   585 GT--LSFMTGCAA-HVCVSDLQLSSKDVNSSFI----FGSLEVLSFSYEITNSGEPAYVAQFNVT 642
            .|  :.|...|.. ..|.::|::|.....|..:    |.||.|   ...::|..|.||..|.::.
Human   761 ETWEIPFEKNCGEDKKCEANLRVSFSPARSRALRLTAFASLSV---ELSLSNLEEDAYWVQLDLH 822

  Fly   643 SSARLPFAKV---------PGNC-------RVRHEVMLCDLNGGRALARGDSESLTIIFD--VTQ 689
            ....|.|.||         |.:|       |:....:.|::: ......|.|.:|.::|:  |..
Human   823 FPPGLSFRKVEMLKPHSQIPVSCEELPEESRLLSRALSCNVS-SPIFKAGHSVALQMMFNTLVNS 886

  Fly   690 LSGQSLTIEAAVSSAGMDQN-PKDNTMSTTISL----------REYAEIDASGGPIDGHIALKEY 743
            ..|.|:.:.|.|:....|.: .:||:.:|.|.:          :|.:.:..|..|        :.
Human   887 SWGDSVELHANVTCNNEDSDLLEDNSATTIIPILYPINILIQDQEDSTLYVSFTP--------KG 943

  Fly   744 PYSAEVNNSYEFKSHGPSIIDELTVYVDVPIAYTVTG-----SAGIKSIFNISSLQMQATHGSEL 803
            |...:|.:.|:.:.. |||.|.     ::|....|.|     |.|  .|.:..|:||:.      
Human   944 PKIHQVKHMYQVRIQ-PSIHDH-----NIPTLEAVVGVPQPPSEG--PITHQWSVQMEP------ 994

  Fly   804 VPIKLYDQTNTLAKEYPLEDSSRRANRKRRELQQDQYAIMPDVNISDILTKENLPANRTLVLDCL 868
             |:..:           .||..|                :||.                 ...||
Human   995 -PVPCH-----------YEDLER----------------LPDA-----------------AEPCL 1014

  Fly   869 RGNWTIC---VRSQMRVQ----------LKPEQPIDLRISFKVDLNDFVNTFDYLVIFTNVEMFK 920
            .|....|   .|.::.||          ::......|..|..:..|...:...|           
Human  1015 PGALFRCPVVFRQEILVQVIGTLELVGEIEASSMFSLCSSLSISFNSSKHFHLY----------- 1068

  Fly   921 EGDSTSIALKRNLKPNVIFNYSETPLPIWYIILSLIAGHLLLGAMTYILYKLRFFKRGKKEELK 984
             |.:.|:| :..:|.:|::...    .::..:||.|.|.|||..:..:|||:.||||..||:::
Human  1069 -GSNASLA-QVVMKVDVVYEKQ----MLYLYVLSGIGGLLLLLLIFIVLYKVGFFKRNLKEKME 1126

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ItgaPS5NP_611808.2 VCBS 302..375 CDD:338792 23/76 (30%)
Int_alpha 351..403 CDD:214549 26/54 (48%)
Int_alpha 417..463 CDD:214549 15/45 (33%)
Integrin_alpha2 451..836 CDD:337057 93/445 (21%)
ITGALNP_002200.2 FG-GAP 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 31..82 22/74 (30%)
FG-GAP 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 83..141 17/63 (27%)
vWA_integrins_alpha_subunit 155..323 CDD:238746 23/169 (14%)
I-domain (insertion domain) 170..349 22/180 (12%)
FG-GAP 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 390..445 13/58 (22%)
Int_alpha 402..451 CDD:214549 13/52 (25%)
FG-GAP 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 446..506 19/63 (30%)
Int_alpha 456..503 CDD:214549 14/49 (29%)
FG-GAP 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 507..563 24/55 (44%)
Int_alpha 517..569 CDD:214549 25/51 (49%)
FG-GAP 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 567..627 20/65 (31%)
Int_alpha 579..>603 CDD:214549 7/23 (30%)
Integrin_alpha2 612..983 CDD:285619 86/397 (22%)
GFFKR motif 1115..1119 2/3 (67%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1128..1170
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165141996
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR23220
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.940

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