Protein Alignment ItgaPS5 and ITGAE

DIOPT Version :9

• Sequence 1: NP_611808.2
• Gene: ItgaPS5 / 37732
• FlyBaseID: FBgn0034880
• Length: 1018
• Species: Drosophila melanogaster
• Sequence 2: XP_024306508.1
• Gene: ITGAE / 3682
• HGNCID: 6147
• Length: 1217
• Species: Homo sapiens
• Alignment Length: 1074
• Identity: 236/1074 - (21%)
• Similarity: 392/1074 - (36%)
• Gaps: 279/1074 - (25%)

  Fly    58 IFVGAPRAQSTLESQGSINETGAVYRCPLASGSCSHYVLNDKLNKQFQWLGGSMDGGTKDTDKLL 122
            :.....|.|: :...||:.:|.:..:..|.|...|.:....|.:|....|   .|||.
Human   279 VMASLARVQN-ITQVGSVTKTASAMQHVLDSIFTSSHGSRRKASKVMVVL---TDGGI------- 332

  Fly   123 VCAPRFFVPKNK----NYGQMRGICYWVRDTVADTPPLSDVRTISLIPSQAEE------------ 171
                 |..|.|.    |..:|:|:..:......:.......|.::||.|..:|
Human   333 -----FEDPLNLTTVINSPKMQGVERFAIGVGEEFKSARTARELNLIASDPDETHAFKVTNYMAL 392

  Fly   172 ----------------------HFML-ELGLSAHVTDDNSGFLIGAPGVRSWKGSVLVH-----R 208
                                  |:.| ::|.||.:.|:.. .|:||.|...|.|..|::     |
Human   393 DGLLSKLRYNIISMEGTVGDALHYQLAQIGFSAQILDERQ-VLLGAVGAFDWSGGALLYDTRSRR 456

  Fly   209 GEDLAAQGSYAVKMLDSWDWVKNHFTYVGYALSSGYFSSNNRTSLLYVTTAPSSVLNTGKAYIFD 273
            |..|....:.|.      |.....::|:|||::    ..:...||.|:..|| ...:.|..:...
Human   457 GRFLNQTAAAAA------DAEAAQYSYLGYAVA----VLHKTCSLSYIAGAP-RYKHHGAVFELQ 510

  Fly   274 VVGEIVRKLHVFHGEQLGEYFGYSVVAEDLNGDGLTD-VVVSAPLNALGDSYDV----GAIYVF- 332
            ..|.....|.|..|||:|.|||..:...|::.||.|| ::|:||.      |.|    |.:||:
Human   511 KEGREASFLPVLEGEQMGSYFGSELCPVDIDMDGSTDFLLVAAPF------YHVHGEEGRVYVYR 569

  Fly   333 --INKGLFKFEKKIIRLPLSSGARFGSSLSKVGDINHDGYNDLAVGAPFAGNGA--------VFI 387
              ...|.|...:.:...|..:.||||.:::.:||::.|...|:|:|||..|.||        |:|
Human   570 LSEQDGSFSLARILSGHPGFTNARFGFAMAAMGDLSQDKLTDVAIGAPLEGFGADDGASFGSVYI 634

  Fly   388 FLGSEHGLRDEPSQRLDAPSREPGPYGAHMFGQGLSRGSDIDGNGFNDLAIGAPGAEAVYLYRAY 452
            :.|...||...||||:.|.:..|   |...||..::.|.||.|:|..|:.:|..|...|  :|:.
Human   635 YNGHWDGLSASPSQRIRASTVAP---GLQYFGMSMAGGFDISGDGLADITVGTLGQAVV--FRSR 694

  Fly   453 PVVKIHATVRSESRAIRPE------QETITVTACYRLETTSKARQMQQQELTFRMTID----ELL 507
            |||::..     |.|..|.      ...:.|..|:.:.:.:.|.:...:|.....|:|    :..
Human   695 PVVRLKV-----SMAFTPSALPIGFNGVVNVRLCFEISSVTTASESGLREALLNFTLDVDVGKQR 754

  Fly   508 QRVSFAPMRTNEVSFQAQAGLSGSCRNFSVGVHY--------TGG------IFTPIDLELHYELA 558
            :|:..:.:|:          ..|..|.:|.|...        |.|      .|:...:::.|:|
Human   755 RRLQCSDVRS----------CLGCLREWSSGSQLCEDLLLMPTEGELCEEDCFSNASVKVSYQL- 808

  Fly   559 KKIPHSHEAFCESCAVVDPLEPKYATGTLSFMTGCAAHV-CVSDLQLSSKDVNSSFIFGSLEVLS 622
             :.|.......:  .::|.....:|...|.:...|...: ||::|||::.......:.|..:.|:
Human   809 -QTPEGQTDHPQ--PILDRYTEPFAIFQLPYEKACKNKLFCVAELQLATTVSQQELVVGLTKELT 870

  Fly   623 FSYEITNSGEPAYVAQF-------------------NVTSSARLPFAKV-PGNCRVRHEVMLCDL 667
            .:..:|||||.:|:...                   |:......|.|.| ..|||:.|.|:....
Human   871 LNINLTNSGEDSYMTSMALNYPRNLQLKRMQKPPSPNIQCDDPQPVASVLIMNCRIGHPVLKRSS 935

  Fly   668 NGGRALARGDSE----------SLTIIFDVTQLSGQSLTIEAAVSSAGMDQNPKDNTMSTTISLR 722
            .....|.|....          .:::::.:.:.:..:.|.:..|:....::.......:.|:..|
Human   936 VSRFGLIRSSHHPAVGVFCILAHVSVVWQLEENAFPNRTADITVTVTNSNERRSLANETHTLQFR 1000

  Fly   723 EYAEIDASGGPIDGHIALKEYPYSAEVN--------NSYEFKSHGPSIID-ELTVYVDVPIAYTV 778
            .            |.:|:...|....||        ..:.|..||.::.. |..:.:.||
Human  1001 H------------GFVAVLSKPSIMYVNTGQGLSHHKEFLFHVHGENLFGAEYQLQICVP----- 1048

  Fly   779 TGSAGIKSIFNISSLQMQATHGSELVPIKLYDQTN-----TLAKEYPLEDSSRRANRKRRELQQD 838
                             ....|.::|.:|...:|.     |.::|.....||.:        ..:
Human  1049 -----------------TKLRGLQVVAVKKLTRTQASTVCTWSQERACAYSSVQ--------HVE 1088

  Fly   839 QYAIMPDVNISDILTKENLPANRTLVLDCLRGNWTICVRSQMRVQLKPEQPIDLRISFKVDLNDF 903
            ::..:..|..||   |||:.....:..|          .|:..::...|..|...|||...|.:.
Human  1089 EWHSVSCVIASD---KENVTVAAEISWD----------HSEELLKDVTELQILGEISFNKSLYEG 1140

  Fly   904 VNTFDYLVIFTNVEMFKEGDSTSIALKRNLKPNVIFNYSET--PLPIWYIILSLIAGHLLLGAMT 966
            :|.              |...|.|        .|:|...|.  .|||  ||...:.|.|:|..:.
Human  1141 LNA--------------ENHRTKI--------TVVFLKDEKYHSLPI--IIKGSVGGLLVLIVIL 1181

  Fly   967 YILYKLRFFKRG---------KKEELK--RLLEE 989
            .||:|..||||.         :|.:||  .||||
Human  1182 VILFKCGFFKRKYQQLNLESIRKAQLKSENLLEE 1215

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ItgaPS5	NP_611808.2	VCBS	302..375	CDD:338792	24/80 (30%)
		Int_alpha	351..403	CDD:214549	23/59 (39%)
		Int_alpha	417..463	CDD:214549	15/45 (33%)
		Integrin_alpha2	451..836	CDD:337057	75/453 (17%)
ITGAE	XP_024306508.1	vWA_integrins_alpha_subunit	218..395	CDD:238746	25/131 (19%)
		Int_alpha	527..578	CDD:214549	18/56 (32%)
		Int_alpha	591..650	CDD:214549	23/58 (40%)
		Int_alpha	660..>695	CDD:214549	12/36 (33%)
		Integrin_alpha2	693..>942	CDD:312071	50/267 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141987
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23220
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.940