DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ItgaPS5 and ITGAD

DIOPT Version :9

Sequence 1:	NP_611808.2	Gene:	ItgaPS5 / 37732	FlyBaseID:	FBgn0034880	Length:	1018	Species:	Drosophila melanogaster
Sequence 2:	XP_011544137.1	Gene:	ITGAD / 3681	HGNCID:	6146	Length:	1190	Species:	Homo sapiens

Alignment Length:	1281	Identity:	262/1281 - (20%)
Similarity:	423/1281 - (33%)	Gaps:	441/1281 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 MIQVRSSYFGYSLVIRPTSIF--------------------VGAPRAQSTLESQGSINETGAVYR 83
            ::.|.:||.|::|.:...:||                    ||||     ||...: |:||.:|.
Human     8 LLSVLASYHGFNLDVEEPTIFQEDAGGFGQSVVQFGGSRLVVGAP-----LEVVAA-NQTGRLYD 66

  Fly    84 CPLASGSCSHYVLNDKLNKQFQWLGGSMDGGTKDTDKLLVCAPRFF------------------- 129
            |..|:|.|....|:.:.......||.::...|..: :||.|.|...
Human    67 CAAATGMCQPIPLHIRPEAVNMSLGLTLAASTNGS-RLLACGPTLHRVCGENSYSKGSCLLLGSR 130

  Fly   130 ------VP-----------------------KNKNYGQMRGICYWVR------------------ 147
                  ||                       ...::.||:|....|.
Human   131 WEIIQTVPDATPECPHQEMDIVFLIDGSGSIDQNDFNQMKGFVQAVMGQFEGTDTLFALMQYSNL 195

  Fly   148 ----------------------------------------------------------------- 147

Human   196 LKIHFTFTQFRTSPSQQSLVDPIVQLKGLTFTATGILTVVTQLFHHKNGARKSAKKILIVITDGQ 260

  Fly   148 ----------------------------------------DTVADTPP------LSDVRTISLIP 166
                                                    :|::..||      :.:...:..|.
Human   261 KYKDPLEYSDVIPQAEKAGIIRYAIGVGHAFQGPTARQELNTISSAPPQDHVFKVDNFAALGSIQ 325

  Fly   167 SQAEE-----------------HFMLELGLSAHVT---------DDNSGFLIGAPGVRSWKGSVL 205
            .|.:|                 |.|.:.|.|..:|         ....|..:||.|..||.|...
Human   326 KQLQEKIYAVEGTQSRASSSFQHEMSQEGFSTALTMSLPSPGILSSQDGLFLGAVGSFSWSGGAF 390

  Fly   206 VH---RGEDLAAQGSYAVKMLDSWDWVKNHFTYVGYALSSGYFSSNNRTSLLYVTTAPSSVLNTG 267
            ::   ............|.|.||         |:||:.....:.....    .|..|| ...:||
Human   391 LYPPNMSPTFINMSQENVDMRDS---------YLGYSTELALWKGVQN----LVLGAP-RYQHTG 441

  Fly   268 KAYIFDVVGEIVRKLHVFHGEQLGEYFGYSVVAEDLNGDGLTDVVVSAPLNALGDSYDVGAIYVF 332
            ||.||..|....||.....|.|:|.|||.|:.:.|::.||.||:::            :||.:.:
Human   442 KAVIFTQVSRQWRKKAEVTGTQIGSYFGASLCSVDVDSDGSTDLIL------------IGAPHYY 494

  Fly   333 -INKGLFKFEKKIIRLPLSSG-------------------ARFGSSLSKVGDINHDGYNDLAVGA 377
             ..:|     .::...||..|                   .|||::|:.:||:|.|...|:|:||
Human   495 EQTRG-----GQVSVCPLPRGQRVQWQCDAVLRGEQGHPWGRFGAALTVLGDVNEDKLIDVAIGA 554

  Fly   378 P--FAGNGAVFIFLG-SEHGLRDEPSQRLDAPSREPGPYGAHMFGQGLSRGSDIDGNGFNDLAIG 439
            |  ....|||::|.| ||.|:....|||:.:....|   ....|||.||.|.|:..:|..|||:|
Human   555 PGEQENRGAVYLFHGASESGISPSHSQRIASSQLSP---RLQYFGQALSGGQDLTQDGLMDLAVG 616

  Fly   440 APGAEAVYLYRAYPVVKIHATVR----SESRAI------RPEQ-ETITVTACYRLETTSKARQMQ 493
            |.|  .|.|.|:.||:|:...:|    ..::|:      :|.. |....|.|..::.:|..:...
Human   617 ARG--QVLLLRSLPVLKVGVAMRFSPVEVAKAVYRCWEEKPSALEAGDATVCLTIQKSSLDQLGD 679

  Fly   494 -QQELTFRMTID--ELLQRVSFAPMRTNEVSFQAQAGLSGSCRNFSVGV-HYTGGIFTPIDLELH 554
             |..:.|.:.:|  .|..|..|...:...::.:...||...|....:.: .....:.:||.|.|:
Human   680 IQSSVRFDLALDPGRLTSRAIFNETKNPTLTRRKTLGLGIHCETLKLLLPDCVEDVVSPIILHLN 744

  Fly   555 YELAKK-IPHSHEAFCESCAVVDPLEPKYATG-------TLSFMTGCAAH-VCVSDL--QLSSKD 608
            :.|.:: ||....           |.|..|.|       :|.|...|... :|..||  .||...
Human   745 FSLVREPIPSPQN-----------LRPVLAVGSQDLFTASLPFEKNCGQDGLCEGDLGVTLSFSG 798

  Fly   609 VNSSFIFGSLEVLSFSYEITNSGEPAYVAQFNVTSSARLPFAKVPGNCRVRHEVML---CD---- 666
            :.:..:..||| |:....:.|:||.:|....::...|.|...:|.|..:..|:..|   |:
Human   799 LQTLTVGSSLE-LNVIVTVWNAGEDSYGTVVSLYYPAGLSHRRVSGAQKQPHQSALRLACETVPT 862

  Fly   667 ----LNGGRA------LARGDSESLTIIFDVTQLS--GQSLTIEAAVSSAGMDQNPKDNTMSTTI 719
                |...|.      ...|.:.:..:.|||:..:  |..:.:.|:.||    :|.|.::...|.
Human   863 EDEGLRSSRCSVNHPIFHEGSNGTFIVTFDVSYKATLGDRMLMRASASS----ENNKASSSKATF 923

  Fly   720 SLR---EYA------EIDASGGPIDGHIALKEYPYSAEVNNSYEFKSHGPSIIDELTVYVDVPIA 775
            .|.   :||      .....|.|: |.:|.. |.:..|....:.|.:.....:.|      ....
Human   924 QLELPVKYAVYTMISRCPVPGLPL-GPLAFL-YAWQEESTKYFNFATSDEKKMKE------AEHR 980

  Fly   776 YTVTGSAGIKSIFNISSLQMQATHGSELVPIKL-----YDQTNTLAKEYPLEDSSRRANRKRREL 835
            |.|.         |:|...: |...:..||:.|     :|    :..|.|.:.....:.||
Human   981 YRVN---------NLSQRDL-AISINFWVPVLLNGVAVWD----VVMEAPSQSLPCVSERK---- 1027

  Fly   836 QQDQYAIMPDVNISDILTKENLPANRTLVLDCLRGNWTICVRSQMRV-QLKPEQPIDLRISFKVD 899
                    |..: ||.||:    .:|:.:|||...:   |::.:..| ....::.:|..:...:.
Human  1028 --------PPQH-SDFLTQ----ISRSPMLDCSIAD---CLQFRCDVPSFSVQEELDFTLKGNLS 1076

  Fly   900 LNDFVNTFDYLVIFTNV----------------EMFKEGDSTSIALKRNLKPNVIFNYSETPLPI 948
            ......|....|:..:|                |.|.......:     |:.:.::|    .:||
Human  1077 FGWVRETLQKKVLVVSVAEITFDTSVYSQLPGQEAFMRAQMEMV-----LEEDEVYN----AIPI 1132

  Fly   949 WYIILSLIAGHLLLGAMTYILYKLRFFKRGKKEELKRLLEEHRSET 994
              |:.|.:...|||..:|..||||.||||..||    :||:...:|
Human  1133 --IMGSSVGALLLLALITATLYKLGFFKRHYKE----MLEDKPEDT 1172

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ItgaPS5	NP_611808.2	VCBS	302..375	CDD:338792	20/92 (22%)
		Int_alpha	351..403	CDD:214549	24/73 (33%)
		Int_alpha	417..463	CDD:214549	21/49 (43%)
		Integrin_alpha2	451..836	CDD:337057	90/443 (20%)
ITGAD	XP_011544137.1	vWA_integrins_alpha_subunit	149..324	CDD:238746	7/174 (4%)
		Int_alpha	464..>506	CDD:214549	13/58 (22%)
		Int_alpha	528..583	CDD:214549	23/54 (43%)
		Int_alpha	593..>625	CDD:214549	16/33 (48%)
		Integrin_alpha2	628..>933	CDD:285619	68/320 (21%)
		Integrin_alpha	1153..1167	CDD:278771	9/17 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142013
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23220
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.940