DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ItgaPS5 and ITGA9

DIOPT Version :9

Sequence 1:	NP_611808.2	Gene:	ItgaPS5 / 37732	FlyBaseID:	FBgn0034880	Length:	1018	Species:	Drosophila melanogaster
Sequence 2:	NP_002198.2	Gene:	ITGA9 / 3680	HGNCID:	6145	Length:	1035	Species:	Homo sapiens

Alignment Length:	1147	Identity:	282/1147 - (24%)
Similarity:	472/1147 - (41%)	Gaps:	269/1147 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 RLLFLIFLALKYQSNAMNFSPLPNRVIDAPKHLKTRMIQVRSSYFGYSLV----IRPTSIFVGAP 63
            |.|.|..:.....:.|.|..|      ..|.|.:    ....|:|||:::    .....:.||||
Human    14 RALLLALVVAGIPAGAYNLDP------QRPVHFQ----GPADSFFGYAVLEHFHDNTRWVLVGAP 68

  Fly    64 RAQSTLESQGSINETGAVYRC-------------PLASG-----SCSHYVLNDKLNKQFQWLGGS 110
            :|.|  :...|:...|||::|             .:|.|     ||......|   :..:|:|.|
Human    69 KADS--KYSPSVKSPGAVFKCRVHTNPDRRCTELDMARGKNRGTSCGKTCRED---RDDEWMGVS 128

  Fly   111 MDGGTKDTDKLLVCAPRFFVPKNKNYGQ----MRGICYWVRDTVADTPPLSDVRTISLIP----- 166
            :....|...::|.||.|:   ||..|..    ..|.||.:       |.....:..:|||
Human   129 LARQPKADGRVLACAHRW---KNIYYEADHILPHGFCYII-------PSNLQAKGRTLIPCYEEY 183

  Fly   167 --SQAEEHFMLELGLSAHVTDDNSGFLIGAPGVRSWKGSVLVHRGEDLAAQGSYAVKMLDSWDWV 229
              ...|||...:.|::...|::.  .::||||...|.|::.|....|    .:| :|:.|  :.:
Human   184 KKKYGEEHGSCQAGIAGFFTEEL--VVMGAPGSFYWAGTIKVLNLTD----NTY-LKLND--EVI 239

  Fly   230 KN-HFTYVGYALSSGYFSSNNRTSLLYVTTAPSSVLNTGKAYIFDV---VGEIVRKLHVFHGEQL 290
            .| .:||:|||:::|:||  :.:::..|..||.. ...||.|||..   .|.:: |:....|:::
Human   240 MNRRYTYLGYAVTAGHFS--HPSTIDVVGGAPQD-KGIGKVYIFRADRRSGTLI-KIFQASGKKM 300

  Fly   291 GEYFGYSVVAEDLNGDGLTDVVVSAPLNALGDSYDVGAIYVFINKGLFKFEKKIIRLPLSS---- 351
            |.|||.|:.|.|||||||:|::|.||:  ..:..|.|.:.|:||:|....|:   :|.|:.
Human   301 GSYFGSSLCAVDLNGDGLSDLLVGAPM--FSEIRDEGQVTVYINRGNGALEE---QLALTGDGAY 360

  Fly   352 GARFGSSLSKVGDINHDGYNDLAVGAP----FAGNGAVFIFLGSEHGLRDEPSQRLDAPSREPGP 412
            .|.||.|::.:.|:::||:.|:|:|||    ||  |||:|:.|...|:..:.|.:|......|
Human   361 NAHFGESIASLDDLDNDGFPDVAIGAPKEDDFA--GAVYIYHGDAGGIVPQYSMKLSGQKINP-- 421

  Fly   413 YGAHMFGQGLSRGSDIDGNGFNDLAIGAPGAEAVYLYRAYPVVKIHATVRSESRAIRPEQETIT- 476
             ...||||.:|.|.|:||||:.|:.:||..:::|.|.||.||:.:..::      ..|....||
Human   422 -VLRMFGQSISGGIDMDGNGYPDVTVGAFMSDSVVLLRARPVITVDVSI------FLPGSINITA 479

  Fly   477 --------------VTACYR----------------LETTSKARQMQQQELTFRM---TIDELLQ 508
                          ||.|:.                :...:|..:.|...:.|.:   |:.::.:
Human   480 PQCHDGQQPVNCLNVTTCFSFHGKHVPGEIGLNYVLMADVAKKEKGQMPRVYFVLLGETMGQVTE 544

  Fly   509 RVSFAPMRTNEVSFQAQAGLSGSCRNFSVGV-HYTGGIFTPIDLELHYELAKKIPHSHEAFCESC 572
            ::....|..             :||::...| .....:.:||..|..|.|::.:....|
Human   545 KLQLTYMEE-------------TCRHYVAHVKRRVQDVISPIVFEAAYSLSEHVTGEEE------ 590

  Fly   573 AVVDPLEP--KYATG-------TLSFMTGCAAHVCVSDLQLSSKDVNSS-------FIFGSLEVL 621
            ..:.||.|  ::..|       ...|...|.:..|.:||||..|.:.||       ...|:::.:
Human   591 RELPPLTPVLRWKKGQKIAQKNQTVFERNCRSEDCAADLQLQGKLLLSSMDEKTLYLALGAVKNI 655

  Fly   622 SFSYEITNSGEPAYVAQFNVTSSARLPFAKVPGNCRVRHEV-MLCDL--------NGGRALARGD 677
            |.:..|:|.|:.||.|..:...|..|.|.    |...:.|: :.|:|        :.|....|..
Human   656 SLNISISNLGDDAYDANVSFNVSRELFFI----NMWQKEEMGISCELLESDFLKCSVGFPFMRSK 716

  Fly   678 SE-SLTIIFDVTQLSGQ----SLTIEAAVSSAGMDQNPKDNTMSTTISLREYAEIDASGGPIDGH 737
            |: ..::|||.:.|||:    |..:.|...:....::..|||:...:.|..  |:|.|   |.|.
Human   717 SKYEFSVIFDTSHLSGEEEVLSFIVTAQSGNTERSESLHDNTLVLMVPLMH--EVDTS---ITGI 776

  Fly   738 IALKEYPYSAEVNNSY-----EFKSHGPSIIDELTVYVDVPIAYTVTGSAGIKSIFNISSLQMQA 797
            ::...:.|...|:.:.     :.:.|...|...|.||...|  .|:.||:     .:||.....:
Human   777 MSPTSFVYGESVDAANFIQLDDLECHFQPINITLQVYNTGP--STLPGSS-----VSISFPNRLS 834

  Fly   798 THGSELVPIKLYDQTNTLAKEYPLEDSSRRANRKRRELQQDQYAIMPDVNISDILTKENLPANRT 862
            :.|:|:..:    |...:.:|  ..:.|.:.|.....:.|:|..|..  .|....||..     .
Human   835 SGGAEMFHV----QEMVVGQE--KGNCSFQKNPTPCIIPQEQENIFH--TIFAFFTKSG-----R 886

  Fly   863 LVLDCLRGNWTICVRSQMRVQLKPEQP----IDLRISFKVDLNDFVNTFD-YLVIFTNVEMFKEG 922
            .||||                   |:|    :....:|.....:...|.| |:::  |.|:.|:.
Human   887 KVLDC-------------------EKPGISCLTAHCNFSALAKEESRTIDIYMLL--NTEILKKD 930

  Fly   923 DSTSIALKRNLK-------------------PNVIFNYSETPLPI-----WYIILSLIAGHLLLG 963
            .|:.|......|                   ..|:|.......|.     |.|.:||:.|.|:..
Human   931 SSSVIQFMSRAKVKVDPALRVVEIAHGNPEEVTVVFEALHNLEPRGYVVGWIIAISLLVGILIFL 995

  Fly   964 AMTYILYKLRFFKRGKKEELKRLLEEHRSETKEPATDCEGNQ 1005
            .:..:|:|:.||:|..||.::  .|::|.|.::.....:.||
Human   996 LLAVLLWKMGFFRRRYKEIIE--AEKNRKENEDSWDWVQKNQ 1035

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ItgaPS5	NP_611808.2	VCBS	302..375	CDD:338792	28/76 (37%)
		Int_alpha	351..403	CDD:214549	21/59 (36%)
		Int_alpha	417..463	CDD:214549	20/45 (44%)
		Integrin_alpha2	451..836	CDD:337057	91/454 (20%)
ITGA9	NP_002198.2	FG-GAP 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	35..96		17/66 (26%)
		Int_alpha	44..101	CDD:214549	15/58 (26%)
		FG-GAP 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	111..174		18/75 (24%)
		FG-GAP 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	182..232		14/56 (25%)
		FG-GAP 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	233..289		20/60 (33%)
		Int_alpha	244..294	CDD:214549	18/53 (34%)
		FG-GAP 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	290..349		25/61 (41%)
		Int_alpha	300..347	CDD:214549	23/48 (48%)
		FG-GAP 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	351..408		22/58 (38%)
		Int_alpha	361..414	CDD:214549	21/54 (39%)
		FG-GAP 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	411..474		24/71 (34%)
		Int_alpha	425..>466	CDD:214549	20/40 (50%)
		Integrin_alpha2	459..903	CDD:285619	103/516 (20%)
		GFFKR motif	1005..1009		2/3 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142022
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D105280at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23220
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.950