Protein Alignment ItgaPS5 and ITGA5

DIOPT Version :10

• Sequence 1: NP_611808.2
• Gene: ItgaPS5 / 37732
• FlyBaseID: FBgn0034880
• Length: 1018
• Species: Drosophila melanogaster
• Sequence 2: NP_002196.4
• Gene: ITGA5 / 3678
• HGNCID: 6141
• Length: 1049
• Species: Homo sapiens
• Alignment Length: 1150
• Identity: 298/1150 - (25%)
• Similarity: 457/1150 - (39%)
• Gaps: 282/1150 - (24%)

  Fly     4 LLFLIFLALKYQSNAMNFSPLPNRV------IDAPKHLKTRMIQVRSSYFGYSL-VIRP----TS 57
            ||.|:.|.|          |.|.||      .:||..|.    ....|:||:|: ..||    .|
Human    25 LLPLLLLLL----------PPPPRVGGFNLDAEAPAVLS----GPPGSFFGFSVEFYRPGTDGVS 75

  Fly    58 IFVGAPRAQSTLESQGSINETGAVYRCPLASG----------SCSHYVLNDKLN----------K 102
            :.||||:|.:   ||..:.:.||||.||..:.          |....:|...|:          |
Human    76 VLVGAPKANT---SQPGVLQGGAVYLCPWGASPTQCTPIEFDSKGSRLLESSLSSSEGEEPVEYK 137

  Fly   103 QFQWLGGSMDGGTKDTDKLLVCAPRF-FVPKNKNYGQMRGICYWVRDTVADTPPLSDVRTISLIP 166
            ..||.|.::   ......:|.|||.: :..:.:......|.||...|..        .|.:...|
Human   138 SLQWFGATV---RAHGSSILACAPLYSWRTEKEPLSDPVGTCYLSTDNF--------TRILEYAP 191

  Fly   167 -----SQAEEHFMLELGLSAHVTDDNSGFLIGAPGVRSWKGSVLVHRGEDLA-----------AQ 215
                 |.|......:.|.||..| .....::|.||...|:|.:|....|.:|           .|
Human   192 CRSDFSWAAGQGYCQGGFSAEFT-KTGRVVLGGPGSYFWQGQILSATQEQIAESYYPEYLINLVQ 255

  Fly   216 GSYAVKMLDS-WDWVKNHFTYVGYALSSGYFSSNNRTSLLYVTTAPSSVLNTGKAYIFDVVGEIV 279
            |....:...| :|     .:|:||:::.|.||.::...  :|...|...|..|  |:..:.|..:
Human   256 GQLQTRQASSIYD-----DSYLGYSVAVGEFSGDDTED--FVAGVPKGNLTYG--YVTILNGSDI 311

  Fly   280 RKLHVFHGEQLGEYFGYSVVAEDLNGDGLTDVVVSAPL----NALGDSYDVGAIYVFIN--KGLF 338
            |.|:.|.|||:..||||:|.|.|:|||||.|::|.|||    ...|...:||.:||::.  .|:
Human   312 RSLYNFSGEQMASYFGYAVAATDVNGDGLDDLLVGAPLLMDRTPDGRPQEVGRVYVYLQHPAGI- 375

  Fly   339 KFEKKIIRLPLSSG---ARFGSSLSKVGDINHDGYNDLAVGAPFAG---NGAVFIFLGSEHGLRD 397
               :....|.|:..   .||||||:.:||::.|||||:|:||||.|   .|.||:|.|...||..
Human   376 ---EPTPTLTLTGHDEFGRFGSSLTPLGDLDQDGYNDVAIGAPFGGETQQGVVFVFPGGPGGLGS 437

  Fly   398 EPSQRLD---APSREPGPYGAHMFGQGLSRGSDIDGNGFNDLAIGAPGAEAVYLYRAYPVVKIHA 459
            :|||.|.   |.|..|     ..||..|..|.|:||||:.||.:|:.|.:...:||..|:|...|
Human   438 KPSQVLQPLWAASHTP-----DFFGSALRGGRDLDGNGYPDLIVGSFGVDKAVVYRGRPIVSASA 497

  Fly   460 TVRSESRAIRPEQETITV----TACYRLETTSKARQMQQQE---LTFRMTIDELLQ-----RVSF 512
            ::........||:.:.::    .||..|.....|......:   .|..:.:|...|     |..|
Human   498 SLTIFPAMFNPEERSCSLEGNPVACINLSFCLNASGKHVADSIGFTVELQLDWQKQKGGVRRALF 562

  Fly   513 APMR--TNEVSFQAQAGLSGSCRNFSVGVHYTGGI---FTPIDLELHYELAKKIP-HSHEAFCES 571
            ...|  |...:...|.|....||...:.:......   .:||.:.|::.|..:.| .||
Human   563 LASRQATLTQTLLIQNGAREDCREMKIYLRNESEFRDKLSPIHIALNFSLDPQAPVDSH------ 621

  Fly   572 CAVVDPLEPKYATGTLS-------FMTGCAA-HVCVSDLQLSSKDVNSSFIFGSLEVLSFSYEIT 628
                 .|.|.....:.|       .:..|.. ::||.||||......:....|....|:.::...
Human   622 -----GLRPALHYQSKSRIEDKAQILLDCGEDNICVPDLQLEVFGEQNHVYLGDKNALNLTFHAQ 681

  Fly   629 NSGE-PAYVAQFNVTSSARLPFA---KVPGN-----CRV----RHEVMLCDLNGGRALARGDSES 680
            |.|| .||.|:..||:.....::   :.|||     |..    :..:::|||  |..:..|.|..
Human   682 NVGEGGAYEAELRVTAPPEAEYSGLVRHPGNFSSLSCDYFAVNQSRLLVCDL--GNPMKAGASLW 744

  Fly   681 LTIIFDVTQLSGQSLTI--EAAVSSAGMDQNPKDNTMSTTISLREYAEIDASG--------GPI- 734
            ..:.|.|..|.....||  :..:.|..:: |.:.:.:|..:|:...|::..:|        .|:
Human   745 GGLRFTVPHLRDTKKTIQFDFQILSKNLN-NSQSDVVSFRLSVEAQAQVTLNGVSKPEAVLFPVS 808

  Fly   735 DGHIALKEYPYSAE-----VNNSYEFKSHGPSIIDELTVYVDVPIAYTVTGSAGIKSIFNISSLQ 794
            |.|  .::.|...|     |::.||..:.|||.|.:..:.:..|
Human   809 DWH--PRDQPQKEEDLGPAVHHVYELINQGPSSISQGVLELSCP--------------------- 850

  Fly   795 MQATHGSELVPIKLYDQTNTLAKEYPLEDSSRRANRKRRELQQDQYAIMPDVNISDILTKENLPA 859
             ||..|.:|:.:......| ....:|:       |.|..||.       |:.::.. ..|...|:
Human   851 -QALEGQQLLYVTRVTGLN-CTTNHPI-------NPKGLELD-------PEGSLHH-QQKREAPS 898

  Fly   860 NRTL-----VLDCLRGNWTICVRSQMRVQLKP---EQPIDLRISFKVDLNDFVNTFDYLVIFTNV 916
            ..:.     :|.|....   |.|  :|.:|.|   ::...|::.|:|    :..||
Human   899 RSSASSGPQILKCPEAE---CFR--LRCELGPLHQQESQSLQLHFRV----WAKTF--------- 945

  Fly   917 EMFKEGDSTSI-------ALK--------------RNLKPNVIFNYSETP--LPIWYIILSLIAG 958
             :.:|....|:       |||              |.:...|.:..:|..  :|:|.|||:::.|
Human   946 -LQREHQPFSLQCEAVYKALKMPYRILPRQLPQKERQVATAVQWTKAEGSYGVPLWIIILAILFG 1009

  Fly   959 HLLLGAMTYILYKLRFFKR----GKKEELKRLLEEHRSETKEPAT 999
            .||||.:.||||||.||||    |...|        :::.|.|||
Human  1010 LLLLGLLIYILYKLGFFKRSLPYGTAME--------KAQLKPPAT 1046

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ItgaPS5	NP_611808.2	FG-GAP	294..332	CDD:460357	20/41 (49%)
		Int_alpha	351..403	CDD:214549	29/57 (51%)
		Int_alpha	417..463	CDD:214549	18/45 (40%)
		Integrin_alpha2	453..837	CDD:462478	91/438 (21%)
ITGA5	NP_002196.4	FG-GAP 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	43..108		23/71 (32%)
		Int_alpha	56..114	CDD:214549	20/60 (33%)
		FG-GAP 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	128..188		13/70 (19%)
		FG-GAP 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	192..245		14/53 (26%)
		FG-GAP 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	259..311		14/60 (23%)
		Int_alpha	268..>310	CDD:214549	13/50 (26%)
		FG-GAP 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	312..377		29/68 (43%)
		Int_alpha	322..379	CDD:214549	23/60 (38%)
		FG-GAP 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	378..437		28/58 (48%)
		Int_alpha	389..443	CDD:214549	29/53 (55%)
		FG-GAP 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	441..504		23/67 (34%)
		Int_alpha	455..498	CDD:214549	17/42 (40%)
		Integrin_alpha2	490..921	CDD:462478	98/489 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	877..907		6/37 (16%)
		Interaction with HPS5. /evidence=ECO:0000269|PubMed:10094488	1021..1028		5/6 (83%)
		GFFKR motif. /evidence=ECO:0000305	1024..1028		2/3 (67%)