DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ItgaPS5 and ITGA4

DIOPT Version :9

Sequence 1:	NP_611808.2	Gene:	ItgaPS5 / 37732	FlyBaseID:	FBgn0034880	Length:	1018	Species:	Drosophila melanogaster
Sequence 2:	NP_000876.3	Gene:	ITGA4 / 3676	HGNCID:	6140	Length:	1032	Species:	Homo sapiens

Alignment Length:	1098	Identity:	277/1098 - (25%)
Similarity:	449/1098 - (40%)	Gaps:	272/1098 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 SSYFGYSLVIRPTS----IFVGAPRAQSTLESQGSINETGAVYRC-----------PLASGS--- 90
            ::.||||:|:....    :.||||.|...  :..|:...||:|||           .|..||
Human    49 NTLFGYSVVLHSHGANRWLLVGAPTANWL--ANASVINPGAIYRCRIGKNPGQTCEQLQLGSPNG 111

  Fly    91 --CSHYVLNDKLNKQFQWLGGSMDGGTKDTDKLLVCAPRF---FVPKNKNYGQMRGICYWVRDTV 150
              |....|.::.|   ||||.::.....:...::.|..|:   |..||:|.....| ||.|
Human   112 EPCGKTCLEERDN---QWLGVTLSRQPGENGSIVTCGHRWKNIFYIKNENKLPTGG-CYGV---- 168

  Fly   151 ADTPPLSDVRT----------ISLIPSQAEEHFMLELGLSAHVTDDNSGFLIGAPGVRSWKGSVL 205
               ||  |:||          ...:....|.....:.|:|:..|.|.  .::||||...|.||:.
Human   169 ---PP--DLRTELSKRIAPCYQDYVKKFGENFASCQAGISSFYTKDL--IVMGAPGSSYWTGSLF 226

  Fly   206 VHRGEDLAAQGSYAVKMLDSWDWVKNHFTYVGYALSSGYFSSNNRTSLLYVTTAPSSVLNTGKAY 270
            |:.    .....|.. .||..:.|| ..:|:||::.:|:|.|.:.|.:  |..||... ..||||
Human   227 VYN----ITTNKYKA-FLDKQNQVK-FGSYLGYSVGAGHFRSQHTTEV--VGGAPQHE-QIGKAY 282

  Fly   271 IFDVVGEIVRKLHVFHGEQLGEYFGYSVVAEDLNGDGLTDVVVSAPLNALGDSYDVGAIYVFINK 335
            ||.:..:.:..||...|::||.|||.||.|.|||.||.:|::|.||:.:  ...:.|.::|:||.
Human   283 IFSIDEKELNILHEMKGKKLGSYFGASVCAVDLNADGFSDLLVGAPMQS--TIREEGRVFVYINS 345

  Fly   336 G----LFKFEKKIIRLPLSSGARFGSSLSKVGDINHDGYNDLAVGAPFAGN--GAVFIFLGSEHG 394
            |    :...|..::... ...||||.|:..:|||::||:.|:|:|||...:  ||::|:.|...|
Human   346 GSGAVMNAMETNLVGSD-KYAARFGESIVNLGDIDNDGFEDVAIGAPQEDDLQGAIYIYNGRADG 409

  Fly   395 LRDEPSQRLDAPSREPGPYGAHMFGQGLSRGSDIDGNGFNDLAIGAPGAEAVYLYRAYPVVKIHA 459
            :....|||::......   ...||||.:|...|.|.||:.|:|:||..:::..|.|..|||.:.|
Human   410 ISSTFSQRIEGLQISK---SLSMFGQSISGQIDADNNGYVDVAVGAFRSDSAVLLRTRPVVIVDA 471

  Fly   460 TVRSESRAIRPEQE---------TITVTACYRLETTSKARQMQQQ-ELTFRMTIDELLQRVSFAP 514
            ::.......|.:.:         .|.:|.|:    :.|.:::... .|.:.|::|  :.|.:.:|
Human   472 SLSHPESVNRTKFDCVENGWPSVCIDLTLCF----SYKGKEVPGYIVLFYNMSLD--VNRKAESP 530

  Fly   515 MR----TNEVSFQAQAGLSGSCRNFSVGVHY------TGGIFTPIDLELHYELAKKIPH-----S 564
            .|    :|..|......:..|.|..:...|.      ...|.|||.:|..|.|.   ||     |
Human   531 PRFYFSSNGTSDVITGSIQVSSREANCRTHQAFMRKDVRDILTPIQIEAAYHLG---PHVISKRS 592

  Fly   565 HEAFCESCAVVDPLEP--------KYATGTLSFMTGCAAHVCVSDLQLSSK------DVNSSFI- 614
            .|.|       .||:|        .....|::|...||...|.:|||:|:|      ..|.:::
Human   593 TEEF-------PPLQPILQQKKEKDIMKKTINFARFCAHENCSADLQVSAKIGFLKPHENKTYLA 650

  Fly   615 FGSLEVLSFSYEITNSGEPAYVAQFNVTSSARLPFAKV------PGNCRVRHE--VMLCDLNGGR 671
            .||::.|..:..:.|:|:.||....:|.....|.|.|:      ..||.|...  |:..|.:.|.
Human   651 VGSMKTLMLNVSLFNAGDDAYETTLHVKLPVGLYFIKILELEEKQINCEVTDNSGVVQLDCSIGY 715

  Fly   672 A----LARGDSESLTIIFDVTQLS----GQSLTIEAAVSSAGMDQNPKDNTMSTTISLREYAEID 728
            .    |:|.|   ::.:.||:.||    ..|:|:.|...:.....|.|.:.::..|.|:...::
Human   716 IYVDHLSRID---ISFLLDVSSLSRAEEDLSITVHATCENEEEMDNLKHSRVTVAIPLKYEVKL- 776

  Fly   729 ASGGPIDGHIALKEYPYSA------------EVNNSYEFKSHGPSIIDELTVYVDVPIAYTVTGS 781
                .:.|.:....:.|.:            ::|.::...:.|.|:...::|.:.||.::    |
Human   777 ----TVHGFVNPTSFVYGSNDENEPETCMVEKMNLTFHVINTGNSMAPNVSVEIMVPNSF----S 833

  Fly   782 AGIKSIFNISSLQMQATHGSELVPIKLYDQTNTLAKEYPLEDSSRRANRKRRELQQDQYAIMPDV 846
            .....:|||  |.:|.|.|                 |...|:..|..     .|:|.:.|:....
Human   834 PQTDKLFNI--LDVQTTTG-----------------ECHFENYQRVC-----ALEQQKSAMQTLK 874

  Fly   847 NISDILTKENLPANRTLVLDCLRGNWTICVRSQMRVQLKPEQPIDLRISFKVDLNDFVNTFDYLV 911
            .|...|:|.:     ..:|.|::.:                                .:..::|.
Human   875 GIVRFLSKTD-----KRLLYCIKAD--------------------------------PHCLNFLC 902

  Fly   912 IFTNVEMFKEG---------------DSTSIALKRNLK--------PNVI-FNYSET-------- 944
            .|..:|..||.               |.|| |||..::        |.|| .|..|.
Human   903 NFGKMESGKEASVHIQLEGRPSILEMDETS-ALKFEIRATGFPEPNPRVIELNKDENVAHVLLEG 966

  Fly   945 ---PLPIWYIILSLIAGHLLLG-----AMTYILYKLRFFKRGKKEELKRLLEEHRSET 994
               ..|..|..:.:|:..||||     .::|:::|..||||..|..|:   ||:|.::
Human   967 LHHQRPKRYFTIVIISSSLLLGLIVLLLISYVMWKAGFFKRQYKSILQ---EENRRDS 1021

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ItgaPS5	NP_611808.2	VCBS	302..375	CDD:338792	26/76 (34%)
		Int_alpha	351..403	CDD:214549	22/53 (42%)
		Int_alpha	417..463	CDD:214549	19/45 (42%)
		Integrin_alpha2	451..836	CDD:337057	96/452 (21%)
ITGA4	NP_000876.3	FG-GAP 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	35..100		16/52 (31%)
		Int_alpha	48..105	CDD:214549	16/57 (28%)
		FG-GAP 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	110..177		22/79 (28%)
		FG-GAP 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	185..237		14/57 (25%)
		FG-GAP 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	238..291		20/56 (36%)
		FG-GAP 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	292..351		25/60 (42%)
		Int_alpha	303..352	CDD:214549	21/50 (42%)
		FG-GAP 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	355..412		21/57 (37%)
		Int_alpha	366..418	CDD:214549	22/51 (43%)
		FG-GAP 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	416..478		21/64 (33%)
		Int_alpha	428..479	CDD:214549	19/50 (38%)
		Integrin_alpha2	463..902	CDD:285619	104/527 (20%)
		SG1	606..616		0/9 (0%)
		GFFKR motif	1003..1007		2/3 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142025
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D105280at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23220
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.950