Protein Alignment ItgaPS5 and ITGA3

DIOPT Version :10

• Sequence 1: NP_611808.2
• Gene: ItgaPS5 / 37732
• FlyBaseID: FBgn0034880
• Length: 1018
• Species: Drosophila melanogaster
• Sequence 2: NP_002195.1
• Gene: ITGA3 / 3675
• HGNCID: 6139
• Length: 1051
• Species: Homo sapiens
• Alignment Length: 1132
• Identity: 292/1132 - (25%)
• Similarity: 450/1132 - (39%)
• Gaps: 249/1132 - (21%)

  Fly    23 PLPNRVIDAPK--------------------HLKTRMIQVR-----SSYFGYSLVI-RPTS---- 57
            |.|:|...||:                    :|.||.:.|:     .|.||||:.: |.|.
Human     3 PGPSRAPRAPRLMLCALALMVAAGGCVVSAFNLDTRFLVVKEAGNPGSLFGYSVALHRQTERQQR 67

  Fly    58 --IFVGAPRAQSTLESQGSINETGAVYRCPLAS--GSC-----------SHYVLNDKLNKQFQWL 107
              :..||||..:.  ..|..|.|||||.|||.:  ..|           .|:::.|      .||
Human    68 YLLLAGAPRELAV--PDGYTNRTGAVYLCPLTAHKDDCERMNITVKNDPGHHIIED------MWL 124

  Fly   108 GGSMDGGTKDTDKLLVCAPRF---FVPKNKNYGQMRGICYWVRDTVADTPPLSDVRTI--SLIPS 167
            |.:: .......::||||.|:   ....:::..:|.|.|| ||....:.....|.:|.  .:..|
Human   125 GVTV-ASQGPAGRVLVCAHRYTQVLWSGSEDQRRMVGKCY-VRGNDLELDSSDDWQTYHNEMCNS 187

  Fly   168 QAE--EHFMLELGLSAHVTDDNSGFLIGAPGVRSWKG-SVLVHRGE-DLAAQGSYAVKMLDSWDW 228
            ..:  |..|.:||.|...|.:...|  ||||..:||| |.::.|.| ||:   .|:.|     |.
Human   188 NTDYLETGMCQLGTSGGFTQNTVYF--GAPGAYNWKGNSYMIQRKEWDLS---EYSYK-----DP 242

  Fly   229 VKNHFTYVGYALSSGYFSSNNRTSLLYVTTAPSSVLNTGKAYIF-DVVGEIVRKLHVFHGEQLGE 292
            ......|:||.:..|.|..:.: ::..||.||.. .:.|..::. ...|..:|:..|..|.|:|.
Human   243 EDQGNLYIGYTMQVGSFILHPK-NITIVTGAPRH-RHMGAVFLLSQEAGGDLRRRQVLEGSQVGA 305

  Fly   293 YFGYSVVAEDLNGDGLTDVVVSAPLNALGDSYDVGAIYVFINKGLFKF---EKKIIRLPLSSGAR 354
            |||.::...|||.||..|::|.||..........||||||:|:....|   ...::..|  ||:.
Human   306 YFGSAIALADLNNDGWQDLLVGAPYYFERKEEVGGAIYVFMNQAGTSFPAHPSLLLHGP--SGSA 368

  Fly   355 FGSSLSKVGDINHDGYNDLAVGAPFAGNGAVFIFLGSEHGLRDEPSQ-----RLDAPSREPGPYG 414
            ||.|::.:||||.||:.|:||||||.|.|.|:|:..|..||..:|.|     :|..|       |
Human   369 FGLSVASIGDINQDGFQDIAVGAPFEGLGKVYIYHSSSKGLLRQPQQVIHGEKLGLP-------G 426

  Fly   415 AHMFGQGLSRGSDIDGNGFNDLAIGAPGAEAVYLYRAYPVVKI-HATVRSESRAIRPEQETITVT 478
            ...||..||...|:|.|.:.||.:|:. ::.:.|.||.||:.| |.|:......:.|  ...|.|
Human   427 LATFGYSLSGQMDVDENFYPDLLVGSL-SDHIVLLRARPVINIVHKTLVPRPAVLDP--ALCTAT 488

  Fly   479 ACYRLE-----TTSKARQMQQQELTFRMTI----DELLQRVSFA--------------PMRTNEV 520
            :|.::|     ..|......::.:|...|:    |....|:.||              .||..::
Human   489 SCVQVELCFAYNQSAGNPNYRRNITLAYTLEADRDRRPPRLRFAGSESAVFHGFFSMPEMRCQKL 553

  Fly   521 SFQAQAGLSGSCRNFSVGVHYTGGIFTPIDLELHYELAKKIPHSHEAFCESCAVVDPLEPKYATG 585
            .......|....|              ||.:.::|.|..::|........|......|....|..
Human   554 ELLLMDNLRDKLR--------------PIIISMNYSLPLRMPDRPRLGLRSLDAYPILNQAQALE 604

  Fly   586 T---LSFMTGCAA-HVCVSDLQLS----------------SKDVNSSFIFGSLEVLSFSYEITN- 629
            .   :.|...|.. :.|.|:||:.                |:||..         |..|..:||
Human   605 NHTEVQFQKECGPDNKCESNLQMRAAFVSEQQQKLSRLQYSRDVRK---------LLLSINVTNT 660

  Fly   630 -----SGEPAYVAQFNVTSSARLPFAKV--PGNCRVRHEVMLCDLNGGRALARGDSESLTIIFDV 687
                 |||.|:.|...:.....|..:.|  ||.|:. :|.:.|:|  |....|.....|.|.|:|
Human   661 RTSERSGEDAHEALLTLVVPPALLLSSVRPPGACQA-NETIFCEL--GNPFKRNQRMELLIAFEV 722

  Fly   688 --TQLSGQSLTIEAAVSSAGMDQN--PK------DNTMSTTISLREYAEIDASGGPIDGHIALKE 742
              ..|..:.|.::..:|::....|  |.      |.|:.|::|:..:......||.:.|...:|.
Human   723 IGVTLHTRDLQVQLQLSTSSHQDNLWPMILTLLVDYTLQTSLSMVNHRLQSFFGGTVMGESGMKT 787

  Fly   743 YPYSAEVNN--SYEFK--SHGPSIIDELTVYVDVPIAYTVTGSAGIKSIFNISSLQMQATHGSEL 803
            .   .:|.:  .|||:  ..|..::...|:.:.:...|.|:....:.....|:      .||:..
Human   788 V---EDVGSPLKYEFQVGPMGEGLVGLGTLVLGLEWPYEVSNGKWLLYPTEIT------VHGNGS 843

  Fly   804 VPIK-LYDQTNTLAKEYPLEDSSRRAN---RKRRELQQDQYAIMPDVNISDILTKENLPANRTLV 864
            .|.: ..|..|.|  ...|.|...|.:   |:||:|........|.|.::  ..|:   |....|
Human   844 WPCRPPGDLINPL--NLTLSDPGDRPSSPQRRRRQLDPGGGQGPPPVTLA--AAKK---AKSETV 901

  Fly   865 LDCLRGN----WTICVRSQMRVQLKPEQPIDLRISFKV---------DLNDF----VNTFDYLVI 912
            |.|..|.    |..|.        .|:.|:...::.|.         |..||    ||.:..|.:
Human   902 LTCATGRAHCVWLECP--------IPDAPVVTNVTVKARVWNSTFIEDYRDFDRVRVNGWATLFL 958

  Fly   913 FTNVEMFKEGDST---SIALKRNLKPNVIFNYSETP--LPIWYIILSLIAGHLLLGAMTYILYKL 972
            .|::......:.|   |:.:...|       ..|.|  :.:|.:::::.||.||||.:..:|:|.
Human   959 RTSIPTINMENKTTWFSVDIDSEL-------VEELPAEIELWLVLVAVGAGLLLLGLIILLLWKC 1016

  Fly   973 RFFKRGKKE---ELKRLLEEHRSETKE 996
            .||||.:..   |.||...|.:|:..|
Human  1017 GFFKRARTRALYEAKRQKAEMKSQPSE 1043

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ItgaPS5	NP_611808.2	FG-GAP	294..332	CDD:460357	15/37 (41%)
		Int_alpha	351..403	CDD:214549	27/56 (48%)
		Int_alpha	417..463	CDD:214549	18/46 (39%)
		Integrin_alpha2	453..837	CDD:462478	96/453 (21%)
ITGA3	NP_002195.1	FG-GAP 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	38..103		23/66 (35%)
		Int_alpha	48..108	CDD:214549	22/61 (36%)
		FG-GAP 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	110..171		16/68 (24%)
		FG-GAP 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	185..235		19/51 (37%)
		FG-GAP 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	236..292		14/62 (23%)
		FG-GAP 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	293..354		24/60 (40%)
		Int_alpha	304..352	CDD:214549	20/47 (43%)
		FG-GAP 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	356..411		26/56 (46%)
		Int_alpha	365..417	CDD:214549	27/51 (53%)
		FG-GAP 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	415..477		22/69 (32%)
		Int_alpha	430..481	CDD:214549	18/51 (35%)
		Integrin_alpha2	463..916	CDD:462478	105/496 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	855..889		9/35 (26%)
		Interaction with HPS5	1015..1021		3/5 (60%)
		GFFKR motif	1017..1021		2/3 (67%)