DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ItgaPS5 and ITGA2B

DIOPT Version :9

Sequence 1:	NP_611808.2	Gene:	ItgaPS5 / 37732	FlyBaseID:	FBgn0034880	Length:	1018	Species:	Drosophila melanogaster
Sequence 2:	NP_000410.2	Gene:	ITGA2B / 3674	HGNCID:	6138	Length:	1039	Species:	Homo sapiens

Alignment Length:	1141	Identity:	272/1141 - (23%)
Similarity:	432/1141 - (37%)	Gaps:	299/1141 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 AMNFSPLPNRVIDAPKHLKTRMIQVRSSYFGYSLVIRPTS-----IFVGAPRAQSTLESQGSINE 77
            |:|..|:.......|          ..|.||:||.....|     |.|||||....     |..|
Human    31 ALNLDPVQLTFYAGP----------NGSQFGFSLDFHKDSHGRVAIVVGAPRTLGP-----SQEE 80

  Fly    78 TGAVYRCP--LASGSCSH--YVLNDKLN----------KQFQWLGGSMDGGTKDTDKLLVCAP-- 126
            ||.|:.||  ...|.|..  :.|.|:..          |..|.||.|:   ...:|.::.|||
Human    81 TGGVFLCPWRAEGGQCPSLLFDLRDETRNVGSQTLQTFKARQGLGASV---VSWSDVIVACAPWQ 142

  Fly   127 RFFVPKNKNYGQMR--GICYWVRDTVADTPPLSDVRTISLIPSQAEEHF-----MLELGLSAHVT 184
            .:.|.:.....:..  |.|:..:.........|..|..:|.....|..|     ..|.|.|:.||
Human   143 HWNVLEKTEEAEKTPVGSCFLAQPESGRRAEYSPCRGNTLSRIYVENDFSWDKRYCEAGFSSVVT 207

  Fly   185 DDNSGFLIGAPG----------------VRSWK-GSVLVHRGEDLAAQGSYAVKMLDSWDWVKNH 232
            .... .::||||                ..|:: |.:|.|......:..|...:..|.
Human   208 QAGE-LVLGAPGGYYFLGLLAQAPVADIFSSYRPGILLWHVSSQSLSFDSSNPEYFDG------- 264

  Fly   233 FTYVGYALSSGYFSSNNRTSLLYVTTAPSSVLNTGKAYIFDVVGEIVRKLHVFHGEQLGEYFGYS 297
              |.||:::.|.|..:..|: .||..||:.....|...|.|   ...::||...|||:..|||:|
Human   265 --YWGYSVAVGEFDGDLNTT-EYVVGAPTWSWTLGAVEILD---SYYQRLHRLRGEQMASYFGHS 323

  Fly   298 VVAEDLNGDGLTDVVVSAPL----NALGDSYDVGAIYVFINKGLFKFEKKIIRLPLSSGA----- 353
            |...|:||||..|::|.|||    .|.....:||.:|:|:..          |.|.:.||
Human   324 VAVTDVNGDGRHDLLVGAPLYMESRADRKLAEVGRVYLFLQP----------RGPHALGAPSLLL 378

  Fly   354 -------RFGSSLSKVGDINHDGYNDLAVGAPF---AGNGAVFIFLGSEHGLRDEPSQRLDAPSR 408
                   ||||:::.:||::.|||||:||.||:   :|.|.|.:|||...|||..|||.||:|.
Human   379 TGTQLYGRFGSAIAPLGDLDRDGYNDIAVAAPYGGPSGRGQVLVFLGQSEGLRSRPSQVLDSPF- 442

  Fly   409 EPGPYGAHMFGQGLSRGSDIDGNGFNDLAIGAPGAEAVYLYRAYPVVK----------IHATVRS 463
               |.|: .||..|....|||.||:.||.:||.||..|.:|||.||||          ::..|:|
Human   443 ---PTGS-AFGFSLRGAVDIDDNGYPDLIVGAYGANQVAVYRAQPVVKASVQLLVQDSLNPAVKS 503

  Fly   464 ESRAIRPEQETITVTACYRLETTSKARQMQQQELTFRMTIDELLQRVSFAPMRTNEV----SFQA 524
               .:.|  :|.|..:|:.::....|   ....:..:::::..||.....|.:...|    |.||
Human   504 ---CVLP--QTKTPVSCFNIQMCVGA---TGHNIPQKLSLNAELQLDRQKPRQGRRVLLLGSQQA 560

  Fly   525 QAGLSGSCRNFSVG------VHYTGGI----------FTPIDLELHYELAKKIPHSHEAFCESCA 573
                 |:..|..:|      .|.|...          .:||.|.|:..|    |.:......:..
Human   561 -----GTTLNLDLGGKHSPICHTTMAFLRDEADFRDKLSPIVLSLNVSL----PPTEAGMAPAVV 616

  Fly   574 VVDPLEPKYATGTLSFMTGCAA-HVCVSDLQLSSKDVNSSFIFGSLEVLSFSYEITNSGEPAYVA 637
            :......:..|   ..:..|.. .|||..|||::....|..:.|:..||....:..|.||.||.|
Human   617 LHGDTHVQEQT---RIVLDCGEDDVCVPQLQLTASVTGSPLLVGADNVLELQMDAANEGEGAYEA 678

  Fly   638 QFNVTSSARLPFAKVPGN--------CRVRHE----VMLCDLNGGRALARGDSESLTIIFDVTQL 690
            :..|.......:.:...|        |..:.|    |:||:|  |..:.:.....:.::..|..|
Human   679 ELAVHLPQGAHYMRALSNVEGFERLICNQKKENETRVVLCEL--GNPMKKNAQIGIAMLVSVGNL 741

  Fly   691 --SGQSLTIEAAVSSAGMDQNPKDNTMSTTISLREYAEIDASGG--PIDGHIALKE--------Y 743
              :|:|::.:..:.|.. .|||....:...:.:|..|:::..|.  |....:|.:|        .
Human   742 EEAGESVSFQLQIRSKN-SQNPNSKIVLLDVPVRAEAQVELRGNSFPASLVVAAEEGEREQNSLD 805

  Fly   744 PYSAEVNNSYEFKSHGPSIIDELTVYVDVPIAYTVTGSAGIKSIFNISSLQ----MQATHGSELV 804
            .:..:|.::||..::||..::.|.:.:.:|      |.:....:..|..:|    :|......:.
Human   806 SWGPKVEHTYELHNNGPGTVNGLHLSIHLP------GQSQPSDLLYILDIQPQGGLQCFPQPPVN 864

  Fly   805 PIKLYDQTNTLAKEYPLEDSSRRANRKRRELQQDQYAIMPDVNISDILTKENLPANRTLVLDCLR 869
            |:|: |....:....|:..:..:  |.||::      .:|:
Human   865 PLKV-DWGLPIPSPSPIHPAHHK--RDRRQI------FLPE------------------------ 896

  Fly   870 GNWTICVRSQMRVQLKPEQPIDLRISFKVDLNDFVNTFDYLVIFTNVEMFKEGDSTSIAL----- 929
                            ||||..|:....|..:....|    |:..:::....|....:.:
Human   897 ----------------PEQPSRLQDPVLVSCDSAPCT----VVQCDLQEMARGQRAMVTVLAFLW 941

  Fly   930 -----KRNLKPNVI-----FNYSETP---------------------------LPIWYIILSLIA 957
                 :|.|...|:     ||.|..|                           :|||::::.::.
Human   942 LPSLYQRPLDQFVLQSHAWFNVSSLPYAVPPLSLPRGEAQVWTQLLRALEERAIPIWWVLVGVLG 1006

  Fly   958 GHLLLGAMTYILYKLRFFKRGKKEELKRLLEEHRSE 993
            |.|||..:...::|:.||||.:..     |||...|
Human  1007 GLLLLTILVLAMWKVGFFKRNRPP-----LEEDDEE 1037

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ItgaPS5	NP_611808.2	VCBS	302..375	CDD:338792	30/88 (34%)
		Int_alpha	351..403	CDD:214549	29/66 (44%)
		Int_alpha	417..463	CDD:214549	23/55 (42%)
		Integrin_alpha2	451..836	CDD:337057	89/443 (20%)
ITGA2B	NP_000410.2	FG-GAP 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	35..96		22/75 (29%)
		Int_alpha	46..102	CDD:214549	21/60 (35%)
		FG-GAP 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	110..173		12/65 (18%)
		FG-GAP 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	187..238		11/51 (22%)
		FG-GAP 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	251..305		15/66 (23%)
		Int_alpha	262..>302	CDD:214549	13/49 (27%)
		FG-GAP 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	306..371		27/74 (36%)
		Int_alpha	316..367	CDD:214549	20/60 (33%)
		FG-GAP 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	373..432		24/58 (41%)
		Int_alpha	384..438	CDD:214549	27/53 (51%)
		FG-GAP 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	435..496		29/65 (45%)
		Int_alpha	445..>485	CDD:214549	20/40 (50%)
		Integrin_alpha2	481..921	CDD:285619	98/521 (19%)
		Integrin_alpha	1020..1034	CDD:278771	7/18 (39%)
		GFFKR motif	1022..1026		2/3 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142019
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840