DRSC/TRiP Functional Genomics Resources

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Protein Alignment ItgaPS5 and ITGA2

DIOPT Version :9

Sequence 1:NP_611808.2 Gene:ItgaPS5 / 37732 FlyBaseID:FBgn0034880 Length:1018 Species:Drosophila melanogaster
Sequence 2:NP_002194.2 Gene:ITGA2 / 3673 HGNCID:6137 Length:1181 Species:Homo sapiens


Alignment Length:1117 Identity:265/1117 - (23%)
Similarity:455/1117 - (40%) Gaps:277/1117 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    30 DAPKHLKTRMIQVRSSYFGYSLVIRPTSIFVGA------PRAQSTLESQGSINETGAVYRCPLAS 88
            ||.|:...:.:|        .|.|.||...||.      ||....|.:..:..|      ..:|:
Human   189 DAVKNFLEKFVQ--------GLDIGPTKTQVGLIQYANNPRVVFNLNTYKTKEE------MIVAT 239

  Fly    89 GSCSHYVLNDKLNKQF-------QWLGGSMDGGTKDTDKLLVCAPRFFVPKNKNY-GQMR----- 140
            ...|.|  ...|...|       ::...:..||.:...|::|     .|...::: |.|.     
Human   240 SQTSQY--GGDLTNTFGAIQYARKYAYSAASGGRRSATKVMV-----VVTDGESHDGSMLKAVID 297

  Fly   141 ----------GIC---YWVRDTVADTPPLSDVRTISLIPS------------------------- 167
                      ||.   |..|:.:.....:.:::.|:.||:                         
Human   298 QCNHDNILRFGIAVLGYLNRNALDTKNLIKEIKAIASIPTERYFFNVSDEAALLEKAGTLGEQIF 362

  Fly   168 ------QAEEHFMLEL---GLSAHVTDDNSGFLIGAPGVRSWKGSVL--VHRGEDLAAQGSYAVK 221
                  |..::|.:|:   |.||..:..|...::||.|...|.|:::  ...|..:..:.::...
Human   363 SIEGTVQGGDNFQMEMSQVGFSADYSSQNDILMLGAVGAFGWSGTIVQKTSHGHLIFPKQAFDQI 427

  Fly   222 MLDSWDWVKNHFTYVGY---ALSSGYFSSNNRTSLLYVTTAPSSVLNTGKAYIFDV--VGEIVRK 281
            :.|     :||.:|:||   |:|:|       .|..:|..||.:.. ||:..::.|  .|.|. .
Human   428 LQD-----RNHSSYLGYSVAAISTG-------ESTHFVAGAPRANY-TGQIVLYSVNENGNIT-V 478

  Fly   282 LHVFHGEQLGEYFGYSVVAEDLNGDGLTDV-VVSAPLNALGDSYDVGAIYVF-INKGLFKFEKKI 344
            :....|:|:|.|||..:.:.|::.|.:||| :|.||:.......:.|.:|:| |.:|:.. :.:.
Human   479 IQAHRGDQIGSYFGSVLCSVDVDKDTITDVLLVGAPMYMSDLKKEEGRVYLFTIKEGILG-QHQF 542

  Fly   345 IRLPLS-SGARFGSSLSKVGDINHDGYNDLAVGAPF--AGNGAVFIFLGSEHGLRDEPSQRLDAP 406
            :..|.. ...||||:::.:.|||.||:||:.||:|.  ..:|||:|:.|.:..:|.:.||::   
Human   543 LEGPEGIENTRFGSAIAALSDINMDGFNDVIVGSPLENQNSGAVYIYNGHQGTIRTKYSQKI--- 604

  Fly   407 SREPGPYGAHM--FGQGLSRGSDIDGNGFNDLAIGAPGAEAVYLY-RAYPVVKIHATVRSESRAI 468
            ....|.:.:|:  ||:.|....|::|:...|::|||.| :.|.|: ::...|.|.|:...|...:
Human   605 LGSDGAFRSHLQYFGRSLDGYGDLNGDSITDVSIGAFG-QVVQLWSQSIADVAIEASFTPEKITL 668

  Fly   469 RPEQETITVTACYRLETTSKAR---QMQQQELTFRMTIDE-----------LLQRVSFAPMRTNE 519
            ..:...|.:..|:    ::|.|   |..|..:.:.:|:|.           |.:..:...::.|.
Human   669 VNKNAQIILKLCF----SAKFRPTKQNNQVAIVYNITLDADGFSSRVTSRGLFKENNERCLQKNM 729

  Fly   520 VSFQAQAGLSGSCRNFSVGVHYTGGIFTPIDLELHYELAKKIPHSH---EAFCESCAVVDPLEPK 581
            |..|||     ||....:.:.....:...:||.:  :::.:.|.:.   ||:.|:..|.      
Human   730 VVNQAQ-----SCPEHIIYIQEPSDVVNSLDLRV--DISLENPGTSPALEAYSETAKVF------ 781

  Fly   582 YATGTLSFMTGCAAH-VCVSDLQLSSKDVNSS----FIFGSL-EVLSFSYEITNSGEPAYVAQFN 640
                ::.|...|... :|:|||.|..:.:.::    ||..:. :.|:||..:.|..|.||.....
Human   782 ----SIPFHKDCGEDGLCISDLVLDVRQIPAAQEQPFIVSNQNKRLTFSVTLKNKRESAYNTGIV 842

  Fly   641 VTSSARLPFAK----VPG---NCRV--RHEVMLCDLNGGRALARGDSESLTIIFDVTQLSGQSLT 696
            |..|..|.||.    |.|   .|:|  ..:.:.||: |..||.|....:.||.||   .:.|:|.
Human   843 VDFSENLFFASFSLPVDGTEVTCQVAASQKSVACDV-GYPALKREQQVTFTINFD---FNLQNLQ 903

  Fly   697 IEAAVS----SAGMDQNPKDNTMSTTISLREYAEIDASGGPIDGHIALKEYPYSAEVN-NSYEFK 756
            .:|::|    |...::|..||.::..|.|...|||         |:       :...| |.||..
Human   904 NQASLSFQALSESQEENKADNLVNLKIPLLYDAEI---------HL-------TRSTNINFYEIS 952

  Fly   757 SHG--PSIIDELTVYVDVPIAYTVTGSAGIKSIFNISSLQMQATHGSELVPIKLYDQTNTLAKEY 819
            |.|  |||:..   :.||          |.|.||:     ::.|.||  ||:.:    .|:....
Human   953 SDGNVPSIVHS---FEDV----------GPKFIFS-----LKVTTGS--VPVSM----ATVIIHI 993

  Fly   820 PLEDSSRRANRKRRELQQDQ---YAIMPDVNISDI--------LTKENLPANRTLVLDC------ 867
            |.....:........:|.|:   .:...|:|...|        ...||.  ..|..|:|      
Human   994 PQYTKEKNPLMYLTGVQTDKAGDISCNADINPLKIGQTSSSVSFKSENF--RHTKELNCRTASCS 1056

  Fly   868 ----------LRGNWTICVRSQM---RVQLKPEQPIDLRISFKVDLNDFVNTFDYLVIFTNVEMF 919
                      ::|.:.:.|.:::   .......|.:.|..:.:      :||:       |.|::
Human  1057 NVTCWLKDVHMKGEYFVNVTTRIWNGTFASSTFQTVQLTAAAE------INTY-------NPEIY 1108

  Fly   920 KEGDSTSIALKRNLKPNVIFNYSETPLPIWYIILSLIAGHLLLGAMTYILYKLRFFKRGKKEELK 984
            ...|:|.......:||:     .:..:|...||.|:|||.|||.|:..||:||.|||| |.|::.
Human  1109 VIEDNTVTIPLMIMKPD-----EKAEVPTGVIIGSIIAGILLLLALVAILWKLGFFKR-KYEKMT 1167

  Fly   985 RLLEEHRSETKE 996
            :..:| ..||.|
Human  1168 KNPDE-IDETTE 1178

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ItgaPS5NP_611808.2 VCBS 302..375 CDD:338792 25/75 (33%)
Int_alpha 351..403 CDD:214549 22/53 (42%)
Int_alpha 417..463 CDD:214549 15/48 (31%)
Integrin_alpha2 451..836 CDD:337057 98/423 (23%)
ITGA2NP_002194.2 FG-GAP 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 34..92
Int_alpha 47..95 CDD:214549
FG-GAP 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 101..161
vWA_integrins_alpha_subunit 173..353 CDD:238746 33/184 (18%)
FG-GAP 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 366..420 13/53 (25%)
FG-GAP 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 423..475 16/64 (25%)
Int_alpha 433..475 CDD:214549 14/49 (29%)
FG-GAP 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 477..539 19/63 (30%)
Int_alpha 487..>532 CDD:214549 15/44 (34%)
FG-GAP 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 540..598 20/57 (35%)
Int_alpha 551..604 CDD:214549 22/52 (42%)
FG-GAP 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 602..664 18/65 (28%)
Int_alpha 614..>642 CDD:214549 10/27 (37%)
Integrin_alpha2 655..1060 CDD:285619 108/471 (23%)
Interaction with HPS5 1155..1161 4/5 (80%)
GFFKR motif 1157..1161 2/3 (67%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165141992
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR23220
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.940

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