Protein Alignment ItgaPS5 and ITGA1

DIOPT Version :10

• Sequence 1: NP_611808.2
• Gene: ItgaPS5 / 37732
• FlyBaseID: FBgn0034880
• Length: 1018
• Species: Drosophila melanogaster
• Sequence 2: NP_852478.1
• Gene: ITGA1 / 3672
• HGNCID: 6134
• Length: 1179
• Species: Homo sapiens
• Alignment Length: 1055
• Identity: 244/1055 - (23%)
• Similarity: 432/1055 - (40%)
• Gaps: 250/1055 - (23%)

  Fly    56 TSIFVGAPRAQSTLESQGSINETGAVYRCPLASGSCSHYVLNDKLNKQFQ------------WLG 108
            |::.:...|.::..|::|:  ..|......:.:...||.  |.:|.|..|            .:.
Human   250 TALGIDTARKEAFTEARGA--RRGVKKVMVIVTDGESHD--NHRLKKVIQDCEDENIQRFSIAIL 310

  Fly   109 GSMDGGTKDTDKLLVCAPRFFVPKNKNYGQMRGICYWVRDTVADTPP------LSD-VRTISLIP 166
            ||.:.|...|:|        ||.:.|              ::|..|.      :|| :..::::.
Human   311 GSYNRGNLSTEK--------FVEEIK--------------SIASEPTEKHFFNVSDELALVTIVK 353

  Fly   167 SQAEEHFMLE----------------LGLSAHVTDDNSGFLIGAPGVRSWKGSVLVHRGEDLAAQ 215
            :..|..|.||                .|.|||.:.|  ..::||.|...|.|:|::.:...:...
Human   354 TLGERIFALEATADQSAASFEMEMSQTGFSAHYSQD--WVMLGAVGAYDWNGTVVMQKASQIIIP 416

  Fly   216 GSYAVKMLDSWDWVKNH--FTYVGYALSSGYFSSNNRTSLLYVTTAPSSVLNTGKAYIFDVVGEI 278
            .:....:..:   .||.  .:|:||.::|...||.:   :||:...| ...:||:..|:.:....
Human   417 RNTTFNVEST---KKNEPLASYLGYTVNSATASSGD---VLYIAGQP-RYNHTGQVIIYRMEDGN 474

  Fly   279 VRKLHVFHGEQLGEYFGYSVVAEDLNGDGLTDV-VVSAPLNALGDSYDVGAIYVF-INKGLFKFE 341
            ::.|....|||:|.|||..:...|::.|..||: :|.||:....:..:.|.:||: :|:..|:::
Human   475 IKILQTLSGEQIGSYFGSILTTTDIDKDSNTDILLVGAPMYMGTEKEEQGKVYVYALNQTRFEYQ 539

  Fly   342 KKI--IRLPLSS----------------GARFGSSLSKVGDINHDGYNDLAVGAPFAGN--GAVF 386
            ..:  |:....|                |||||::::.|.|:|.||:||:.:|||...:  |||:
Human   540 MSLEPIKQTCCSSRQHNSCTTENKNEPCGARFGTAIAAVKDLNLDGFNDIVIGAPLEDDHGGAVY 604

  Fly   387 IFLGSEHGLRDEPSQRLDAPSREPGPYGAHMFGQGLSRGSDIDGNGFNDLAIGAPGAEAVYLYRA 451
            |:.||...:|.|.:||:  ||...|. ....|||.:....|::|:|..|:.||..|..|::..|.
Human   605 IYHGSGKTIRKEYAQRI--PSGGDGK-TLKFFGQSIHGEMDLNGDGLTDVTIGGLGGAALFWSRD 666

  Fly   452 YPVVKIHATVRSESRAIRPE--------QETITV--TACYRLETTSKARQMQQQELTFRMTIDEL 506
            ..|||:  |:..|...:..:        :||:.:  |.|:.::..||...:.:.:|.:|:|:|.|
Human   667 VAVVKV--TMNFEPNKVNIQKKNCHMEGKETVCINATVCFDVKLKSKEDTIYEADLQYRVTLDSL 729

  Fly   507 LQ--RVSFAPMRTNEVSFQAQAGLSGSCRNFSV-GVHYTGGIFTPID---------LELHYELAK 559
            .|  |..|:..:..:|.           ||.:| ....|...|..:|         :.|.:.|..
Human   730 RQISRSFFSGTQERKVQ-----------RNITVRKSECTKHSFYMLDKHDFQDSVRITLDFNLTD 783

  Fly   560 KIPHSHEAFCESCAVVDPLEPKYATGTLSFMTGCA-AHVCVSDLQL----SSKDV------NSSF 613
            .         |:..|:|...|......:.|...|. ...|:|||.|    :.||:      |..|
Human   784 P---------ENGPVLDDSLPNSVHEYIPFAKDCGNKEKCISDLSLHVATTEKDLLIVRSQNDKF 839

  Fly   614 IFGSLEVLSFSYEITNSGEPAYVAQFNVTSSARLPFAKVPG----NCRVRHEVMLCDLNGGRALA 674
                    :.|..:.|:.:.||..:..|..|..|.|:.:..    :|...|.: .|.: |...|.
Human   840 --------NVSLTVKNTKDSAYNTRTIVHYSPNLVFSGIEAIQKDSCESNHNI-TCKV-GYPFLR 894

  Fly   675 RGDSESLTIIFDV-TQLSGQSLTIEAAVSSAGMDQNPK---DNTMSTTISLREYAEIDASGGPID 735
            ||:..:..|:|.. |....:::||..:.:| ..::.|:   ||.::.:|             |:.
Human   895 RGEMVTFKILFQFNTSYLMENVTIYLSATS-DSEEPPETLSDNVVNISI-------------PVK 945

  Fly   736 GHIALKEYPYSAEVNNSYEFKSHGPSIIDEL-TVYVDVPIAYTVTGSAGIKSIFNISSLQMQATH 799
            ..:.|:.|..::|.:.|.......|.:|:.. .:..::.|.|.:..|..    |.:..|::..:.
Human   946 YEVGLQFYSSASEYHISIAANETVPEVINSTEDIGNEINIFYLIRKSGS----FPMPELKLSISF 1006

  Fly   800 GSELVPIKLYDQTNTLAKEYPL-----EDSSRRANRKRRELQQDQYAIMPDVNISDILTKENLPA 859
                        .|..:..||:     ..||..|| .|..:.:|.::|    |....:|......
Human  1007 ------------PNMTSNGYPVLYPTGLSSSENAN-CRPHIFEDPFSI----NSGKKMTTSTDHL 1054

  Fly   860 NRTLVLDC-------LRGNWTICVRSQMRVQL---KPEQPIDLRISFKVDLNDFVNTFDYLVIFT 914
            .|..:|||       :..|.|....||:.|.|   ||               .|:.::     |:
Human  1055 KRGTILDCNTCKFATITCNLTSSDISQVNVSLILWKP---------------TFIKSY-----FS 1099

  Fly   915 NVEMFKEG----DSTSIAL-KRNLKPNVIFNYSETPL----PIWYIILSLIAGHLLLGAMTYILY 970
            ::.:...|    ::.|:.| ..|.|..:....|:..|    |:|.|:||..||.|||..:...|:
Human  1100 SLNLTIRGELRSENASLVLSSSNQKRELAIQISKDGLPGRVPLWVILLSAFAGLLLLMLLILALW 1164

  Fly   971 KLRFFKRGKKEELKR 985
            |:.||||..|:::::
Human  1165 KIGFFKRPLKKKMEK 1179

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ItgaPS5	NP_611808.2	FG-GAP	294..332	CDD:460357	11/38 (29%)
		Int_alpha	351..403	CDD:214549	25/69 (36%)
		Int_alpha	417..463	CDD:214549	16/45 (36%)
		Integrin_alpha2	453..837	CDD:462478	88/430 (20%)
ITGA1	NP_852478.1	FG-GAP 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	30..91
		FG-GAP 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	101..160
		vWA_integrins_alpha_subunit	171..351	CDD:238746	23/126 (18%)
		FG-GAP 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	365..417		11/53 (21%)
		FG-GAP 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	422..475		14/59 (24%)
		Int_alpha	434..474	CDD:214549	12/43 (28%)
		FG-GAP 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	476..538		20/61 (33%)
		Int_alpha	486..>529	CDD:214549	13/42 (31%)
		FG-GAP 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	557..615		21/57 (37%)
		Int_alpha	568..621	CDD:214549	24/52 (46%)
		FG-GAP 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	619..679		22/64 (34%)
		Integrin_alpha2	665..1033	CDD:462478	89/430 (21%)
		GFFKR motif	1167..1171		2/3 (67%)