Protein Alignment ItgaPS5 and ITGA6

DIOPT Version :10

• Sequence 1: NP_611808.2
• Gene: ItgaPS5 / 37732
• FlyBaseID: FBgn0034880
• Length: 1018
• Species: Drosophila melanogaster
• Sequence 2: NP_001381857.1
• Gene: ITGA6 / 3655
• HGNCID: 6142
• Length: 1130
• Species: Homo sapiens
• Alignment Length: 1218
• Identity: 279/1218 - (22%)
• Similarity: 456/1218 - (37%)
• Gaps: 335/1218 - (27%)

  Fly     4 LLFLIFLALKYQSNAMNFSPLPNRVIDAPKHLKTRMIQVRSSYFGYSLV----IRPTS---IFVG 61
            ||:|....|.....|.|.....:.||        |......|.||:||.    ::|..   :.||
Human     9 LLYLSAGLLSRLGAAFNLDTREDNVI--------RKYGDPGSLFGFSLAMHWQLQPEDKRLLLVG 65

  Fly    62 APRAQSTLESQGSINETGAVYRCPL-ASGSCSHYVLNDKL-----NKQFQWLGGSMD----GGTK 116
            ||||:: |..|.: |.||.:|.|.: |.|.|:....::..     :|:.||:|.::.    ||
Human    66 APRAEA-LPLQRA-NRTGGLYSCDITARGPCTRIEFDNDADPTSESKEDQWMGVTVQSQGPGG-- 126

  Fly   117 DTDKLLVCAPRFFVPKNKNYGQ----MRGICYWVRDTVADTPPLS-------DVRTISLIPSQAE 170
               |::.||.|:...::.|..|    :.|.||.:...:.....:.       |.|.      :..
Human   127 ---KVVTCAHRYEKRQHVNTKQESRDIFGRCYVLSQNLRIEDDMDGGDWSFCDGRL------RGH 182

  Fly   171 EHF-MLELGLSAHVTDDNSGFLIGAPGVRSWKGSVLVHRGE------DLAAQGSYAV-------- 220
            |.| ..:.|::|..|.|....:.||||..:|||.|.|.:..      ::...|.|.|
Human   183 EKFGSCQQGVAATFTKDFHYIVFGAPGTYNWKGIVRVEQKNNTFFDMNIFEDGPYEVGGETEHDE 247

  Fly   221 -----------------------------------KMLDSW-DWVKNHFTYVGYALSSGYFSSNN 249
                                               :..|:: |.:.|  :|:|::|.||. ...:
Human   248 SLVPVPANSYLGLLFLTSVSYTDPDQFVYKTRPPREQPDTFPDVMMN--SYLGFSLDSGK-GIVS 309

  Fly   250 RTSLLYVTTAPSSVLNTGKAYIF---DVVGEIVRKLHVFHGEQLGEYFGYSVVAEDLNGDGLTDV 311
            :..:.:|:.||.:  |...|.:.   |:....:...|:|.||.|...|||.|...|||.||..|:
Human   310 KDEITFVSGAPRA--NHSGAVVLLKRDMKSAHLLPEHIFDGEGLASSFGYDVAVVDLNKDGWQDI 372

  Fly   312 VVSAPLNALGDSYDVGAIYVFINKGLFKFEKKIIRLPLSSGARFGSSLSKVGDINHDGYNDLAVG 376
            |:.||.....|....||:||::|:.......|.|||..:..:.||.::..:||||.|||.|:|||
Human   373 VIGAPQYFDRDGEVGGAVYVYMNQQGRWNNVKPIRLNGTKDSMFGIAVKNIGDINQDGYPDIAVG 437

  Fly   377 APFAGNGAVFIFLGSEHGLRDEPSQRLDAPSREPGPYGAHMFGQGLSRGSDIDGNGFNDLAIGAP 441
            ||:...|.|||:.||.:|:..:|:|.|...|    ||    ||..::...|:|.|.:.|:|:|:.
Human   438 APYDDLGKVFIYHGSANGINTKPTQVLKGIS----PY----FGYSIAGNMDLDRNSYPDVAVGSL 494

  Fly   442 GAEAVYLYRAYPVVKIHATVRSESRAIRPEQET---------ITVTACYR--------------- 482
             :::|.::|:.||:.|..|:......|...|:|         :.|.:|:.
Human   495 -SDSVTIFRSRPVINIQKTITVTPNRIDLRQKTACGAPSGICLQVKSCFEYTANPAGYNPSISIV 558

  Fly   483 --LETTSKAR------------QMQQQELTFRMTIDELLQRVSFAPMRTNEVSFQAQAGLSGSCR 533
              ||...:.|            |..:.:.|..:|:....|:|..      |.:...|..:....|
Human   559 GTLEAEKERRKSGLSSRVQFRNQGSEPKYTQELTLKRQKQKVCM------EETLWLQDNIRDKLR 617

  Fly   534 NFSVGVHYTGGIFTPIDLELHYELAKKIPHSH---EAFCESCAVVDPLEPKYATGTLSFM-TGCA 594
                          ||.:....|:.:  |.|.   .:..|...:::..|||.|...:.|: .||.
Human   618 --------------PIPITASVEIQE--PSSRRRVNSLPEVLPILNSDEPKTAHIDVHFLKEGCG 666

  Fly   595 -AHVCVSDLQLSSKDVNSSFIFGSLEVLSFSYEITNSGEPAYVAQFNVTSSARLPFAKVPGNCR- 657
             .:||.|:|:|..|.....   |:.:  .|||.....|.|..|.:.....:..:.....|.|.|
Human   667 DDNVCNSNLKLEYKFCTRE---GNQD--KFSYLPIQKGVPELVLKDQKDIALEITVTNSPSNPRN 726

  Fly   658 ------VRHEVML------------------------------------CDLNGGRALARGDSES 680
                  ..||..|                                    |:|  |....|..:.:
Human   727 PTKDGDDAHEAKLIATFPDTLTYSAYRELRAFPEKQLSCVANQNGSQADCEL--GNPFKRNSNVT 789

  Fly   681 LTIIFDVTQLSGQSLTIEAAVSSAGMDQNPK-------DNTMSTTISLREYAEIDAS-------- 730
            ..::...|         |....:..:|.|.|       ||....|...:...|:..|
Human   790 FYLVLSTT---------EVTFDTPDLDINLKLETTSNQDNLAPITAKAKVVIELLLSVSGVAKPS 845

  Fly   731 ----GGPIDGHIALKEYPYSAEVNN--SYEFKSHGPSIIDELTVYVDVPIAYTVTGSAGI---KS 786
                ||.:.|..|:|.   ..||.:  .|||:          .:.:..|:....|.:..|   |.
Human   846 QVYFGGTVVGEQAMKS---EDEVGSLIEYEFR----------VINLGKPLTNLGTATLNIQWPKE 897

  Fly   787 IFN---ISSLQMQATHGSELVPIKLYDQTNTLAKEYPLEDSSRRANRKRRELQQDQYAIMPDVNI 848
            |.|   :..|....:.|.|.|..:...:.|:|    .|.:|..  :||:||
Human   898 ISNGKWLLYLVKVESKGLEKVTCEPQKEINSL----NLTESHN--SRKKRE-------------- 942

  Fly   849 SDILTKENLPANRTLVLDCLRGNWTI-CVRSQMRVQLK-PEQPIDLRISFKVDLNDFVNTF---- 907
               :|::.:..||...|...|...|: |..:...|.:: |.:.:|.:.|..:....:.:||
Human   943 ---ITEKQIDDNRKFSLFAERKYQTLNCSVNVNCVNIRCPLRGLDSKASLILRSRLWNSTFLEEY 1004

  Fly   908 ---DYLVIF-----------TNVEMFKEGDSTSIALKRNLKPNVIFNYSETPLPIWYIILSLIAG 958
               :||.|.           .|:.:...|....:.:   .....:..||  .:|.|.|:::::||
Human  1005 SKLNYLDILMRAFIDVTAAAENIRLPNAGTQVRVTV---FPSKTVAQYS--GVPWWIILVAILAG 1064

  Fly   959 HLLLGAMTYILYKLRFFKRGKKEE------LKRLLEEHRSETKEPATD 1000
            .|:|..:.:||:|..||||.:.::      ..|:.:|.|....|...|
Human  1065 ILMLALLVFILWKCGFFKRSRYDDSVPRYHAVRIRKEEREIKDEKYID 1112

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ItgaPS5	NP_611808.2	FG-GAP	294..332	CDD:460357	17/37 (46%)
		Int_alpha	351..403	CDD:214549	24/51 (47%)
		Int_alpha	417..463	CDD:214549	14/45 (31%)
		Integrin_alpha2	453..837	CDD:462478	94/496 (19%)
ITGA6	NP_001381857.1	FG-GAP 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	30..95		24/74 (32%)
		Int_alpha	40..100	CDD:214549	22/61 (36%)
		FG-GAP 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	101..166		15/69 (22%)
		FG-GAP 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	176..229		17/58 (29%)
		FG-GAP 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	283..339		14/60 (23%)
		Int_alpha	293..345	CDD:214549	12/56 (21%)
		FG-GAP 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	340..402		24/61 (39%)
		Int_alpha	353..406	CDD:214549	20/52 (38%)
		FG-GAP 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	403..458		26/54 (48%)
		Int_alpha	413..464	CDD:214549	24/50 (48%)
		FG-GAP 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	459..518		20/67 (30%)
		Int_alpha	470..>493	CDD:214549	8/26 (31%)
		Integrin_alpha2	504..978	CDD:462478	102/547 (19%)
		Interaction with HPS5	1077..1083		3/5 (60%)
		GFFKR motif	1079..1083		2/3 (67%)